Manager, FP&A

Job Description

Crescent Biopharma’s vision is to build a world leading oncology company bringing the next wave of therapies for cancer patients. The Company’s clinical-stage pipeline includes its lead program, a PD-1 x VEGF bispecific antibody, as well as novel antibody-drug conjugates. By leveraging multiple modalities and established targets, Crescent aims to rapidly advance potentially transformative therapies either as single agents or as part of combination regimens to treat a range of solid tumors. For more information, visit and follow the Company on LinkedIn and X.

We are seeking a Manager of FP&A to support corporate and program level planning, budgeting, and forecasting. This individual will partner closely with R&D, Program Management, Clinical, Tech Ops, and G&A teams to deliver high quality financial insights, support decision making, and ensure disciplined financial management in a dynamic, science-driven environment.

This role is ideal for someone who thrives in high growth biotech, can balance strategic thinking with hands on execution, and is excited to build scalable FP&A processes. Please note, this person must be local to the Waltham, MA office and have experience in the life sciences FP&A-space.Responsibilities

Lead the annual operating plan, long-range planning (LRP), and quarterly forecasting cycles across all functions

Build driver based financial models to support forecasting accuracy and scenario analysis

Support implementation and optimization of ERP and planning tools to build scalable FP&A reporting infrastructure, including dashboards, forecast templates, and process improvements

Prepare monthly and quarterly financial reporting packages for leadership, highlighting key variances, trends, and actionable insights

Partner with Program Management and functional leads to manage cross-functional program budgets and timelines

Support accruals related to external CRO/CMO partners, milestone based spend, and clinical site activity

Partner with Accounting on monthly close, accruals, cost center reporting, and flux analysis

Support headcount planning, hiring forecasts, and workforce modeling in partnership with HR and hiring managers

Assist with vendor contract reviews for financial accuracy and budget alignment Education & Experience

Bachelor’s degree in Finance, Accounting, Economics, or related field.

6+ years of progressive FP&A or Finance experience, ideally within biotech or pharma

Experience supporting R&D, clinical development, or other multiprogram environments

Experience with biotech planning cycles (e.g., program budgeting, CRO/CMO forecasting) preferred

Familiarity with ERP systems, planning tools, and business intelligence platforms (e.g., NetSuite, Adaptive Insights a plus)

Demonstrated ability to partner cross-functionally and communicate complex concepts clearly

Ability to manage competing priorities and operate in a fast-paced, high-growth environment

Highly analytical with strong attention to detail

Proactive problem solver who anticipates needs

Strong interpersonal skills and business judgment

Collaborative team player What We Offer

Opportunity to join a mission-driven team where you'll contribute to impactful work, take on varied responsibilities, and grow quickly in a dynamic environment

Competitive compensation, including base salary, performance bonus, and equity

100% employer-paid benefits package

Flexible PTO; also, two, one-week company-wide shutdowns each year

A commitment to your professional development, with access to resources, mentorship, and growth opportunities

Additional Description for Pay Transparency:

The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, and geography. Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability. Subject to the terms of their respective plans, employees are eligible to participate in the Company’s savings plan (401(k)). This position is eligible to participate in the Company’s long-term incentive program. Subject to the terms of their respective policies and date of hire, Employees are eligible for the following time off benefits: Vacation – Unlimited PTO; Sick time – 10 days per calendar year; Holiday pay, including two Company shut downs; Parental Leave – 16 weeks within one year of the birth/adoption/foster care of a child; FMLA; Military Leave. Additional information can be found -

Crescent Biopharma is an Equal Opportunity Employer. We are committed to fostering a diverse, inclusive, and equitable workplace where all individuals are valued and respected. Employment decisions are based on qualifications, merit, and business needs, without regard to race, color, religion, gender, sexual orientation, national origin, disability, veteran status, or any other protected status.

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.

Full-time