Assistant Engineering

NAME: YUN HAN

CONTACT INFORMATION

Mail Address: 10 Fairway Rd., Apt. 3C, Newark, DE 19711

Telephone: 302-***-****

Email: ******@****.***

SUMMARY OF QUALIFICATIONS

Experienced and knowledgeable NMR Specialist with substantial background in protein characterization using solid and solution-state NMR, mass spectroscopy and imaging techniques (TEM, SEM and confocal microscopy). Familiar with analytical methods (GC-MS, LC-MS, IR, TG, pore size measurement) for constituents from automobile exhaust and natural products samples.

EDUCATION

Ph.D., 2006-current, Analytical Chemistry, University of Delaware, USA

Dissertation: Solid-state NMR studies on structure and dynamics of HIV-1 CA and related proteins

M.E., 2003-2006, Environmental Engineering, Research Center for Environmental and Ecology Sciences, Chinese Academy of Sciences, Beijing, China

B.S., 1999-2003, Applied Chemistry, University of Science and Technology Beijing, Beijing, China

Minor, 2001-2003, Scientific English, University of Science and Technology Beijing, Beijing, China

PROFESSIONAL EXPERIENCE

University of Delaware, Department of Chemistry and Biochemistry, Analytical Division

Research Assistant

• Systematically studied on the structure and backbone dynamics of HIV-1 Capsid (CA) protein using 2D, 3D homo- and hetero- nuclear correlation spectra with MAS solid-state and solution NMR.

• Developed an imaging method for characterizing various morphologies of HIV-1 CA protein assemblies with confocal microscope.

• Proficient in expression, purification and characterization of protein samples.

• Involved in the work of improving low-E probe performance on high salt concentration samples.

Teaching Assistant

• Gave lab sessions on chemistry lessons at various levels, e.g. Chem 101, Chemistry lessons for nurse major, Analytical Chemistry for honor students etc.

Chinese Academy of Sciences, Research Center for Environmental and Ecology Sciences

Research Assistant

• Prepared and characterized the Pd catalysts derived from MgAl hydrotalcite precursors for total oxidation of propane using IR, TG etc.

• Evaluated several catalyst systems for improving the three-way catalysts performance at automobile idle speed state employing GC-MS, IR and other techniques.

Tsinghua University

Visiting Student

• Used high through-put screening methods to separate and purify chemical constituents from the rhizome of Arundina graminifolia (mainly used column chromatography and HPLC).

• Utilized NMR, MS, and IR spectroscopy to characterize the structures of the purified compounds. We discovered two novel compounds from the derived substances.

BOOK CHAPTERS

1. S. Sun, S. Paramasivam, S. Yan, Y. Han, C. Lightcap, J.C. Williams, I.J. Byeon, J. Ahn, A.M. Gronenborn, T. Polenova (2011) In “Protein NMR Techniques”, “Methods in Molecular Biology” book series, Eds. Alexander Shekhtman and David Burz, Humana Press

PUBLICATIONS

1. Y. Han, C.L. Suiter, G. Hou, J. Ahn, I.J. L. Byeon, A. S. Lipton, S. Burton, I. Hung, P. Gor'kov, Z. Gan, W. Brey, D. Rice, A. M. Gronenborn, T. Polenova, Ultrahigh resolution solid-State NMR reveals that spacer peptide 1 (SP1) is unstructured in HIV-1 CA-SP1 tubular assemblies (2012) PNAS in preparation

2. S. Sun, Y. Han S. Paramasivam, S. Yan, A.E. Siglin, J.C. Williams, I.J. Byeon, J. Ahn, A.M. Gronenborn, T. Polenova, Solid-state NMR spectroscopy of protein complexes, (2012) Methods Mol. Biol., 831, p. 303-331.

3. I.J. Byeon, G. Hou, Y. Han, C.L. Suiter, J. Ahn, J. Jung, C.H. Byeon, A.M. Gronenborn, T. Polenova, Motions on the millisecond timescale and multiple conformations of HIV-1 capsid protein: Implications for structural polymorphism of CA assemblies (2011) J. Am. Chem. Soc. Accepted

4. G. Hou, S. Yan, S. Sun, Y. Han, I.J. L. Byeon, J. Ahn, J. Concel, A. Samoson, A. M. Gronenborn, T. Polenova, Spin diffusion driven by R-Symmetry sequences: Applications to homonuclear correlation spectroscopy in MAS NMR of biological and organic solids (2011) J. Am. Chem. Soc. 133 (11), p. 3943-3953

5. Y. Han, J. Ahn, J. Concel, I.J. Byeon, A. M. Gronenborn, J. Yang, T. Polenova Solid-state NMR studies of HIV-1 capsid protein assemblies (2010) J. Am. Chem. Soc. 132 (6), p. 1976-1987.

6. P.L. Gor’kov, I. Hung, C. Qian, J. A. Kitchen, W. W. Brey, Z. Gan G. Hou, Y. Han, T. Polenova, Efficient tripleresonant 1H/X/Y LowE MAS probe for bological applications (2010) National High Magnetic Field Laboratory 2010 Research Report

7. Y. Han, K. Zhou, H. Liu, Y. Sun, H. Chen, J. Su, Q. Tian, Effects of preparation methods on Pd catalysts derived from MgAl hydrotalcite precursors for total oxidation of propane, (2007) Chinese Journal of Environmental Engineering 1(4), p. 90-95 (in Chinese)

8. Q. Yao, Q. Tian, H. Chen, S. Fang, Y. Han, Preparation and Characterization of CeO2-ZrO2 Solid Solutions Prepared by Citric Acid Sol-Gel Method, (2006) Journal of the Graduate School of the Chinese Academy of Sciences 23(1), p. 64-69 (in Chinese)

9. Q. Yao, Q. Tian, H. Chen, Y. Han, Impact of Ce-Zr-Al Mixed Oxide Modified by Potassium on Pd-Only Three-Way Catalysts, (2006) Journal of the Graduate School of the Chinese Academy of Sciences 23(3), p. 331-336 (in Chinese)

10. Q. Yao, Q. Tian, H. Chen, S. Fang, Y. Han, D. Shen, Alkali metal promotion of Pd/γ Al2O3 catalysts operated under simulated three-way conditions, (2005) Acta Scientae Circumstantia 24(4), p. 370-373 (in Chinese)

11. S. Fang, H. Chen, Q. Tian, Q. Yao, Y. Han, Study on Preparation, Characterization and Three Way Catalytic Performance for Pd/CZ/Al2O3 Catalyst, (2005) Journal of Environmental Sciences 5(5), p. 60-62 (in Chinese)

12. M.F. Liu, Y. Han, D.M. Xing, W. Wang, L.Z. Xu, L.J. Du, Y. Ding, One new benzyldihydrophenanthrene from Arundina graminifolia, (2005) J. Asian Nat. Prod. Res. 7 (5), p. 767-770

13. M.F. Liu, Y. Han, D.M. Xing, Y. Shi, L.Z. Xu, L.J. Du, Y. Ding, A new stilbenoid from Arundina graminifolia, (2004) J. Asian Nat. Prod. Res. 6 (3), p. 229-232

14. M.F. Liu, Y. Han, D.M. Xing, W. Wang, L.Z. Xu, L.J. Du, Y. Ding, Chemical constituents from the rhizome of Arundina graminifolia, (2004) China Journal of Chinese Materia Medica 29(2) 147-149 (in Chinese)

HONORS AND REWARDS

• Professional Development Award, University of Delaware, 2009

• ENC Student Travel Award, 51st ENC committee, 2010

• Honored Graduate in Beijing District, 2003

HEADLINES

• Solid-state NMR studies of HIV-1 capsid protein assemblies (Han et al., 2010) were reported by EMSL news. (http://www.emsl.pnl.gov/news/viewArticle.jsp?articleId=80)

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