Process Development

Jin Zhao, Ph.D.

** ***** ******* ******

Lexington, MA 02420

Home: 781-***-****; cell: 781-***-****

e-mail: *********@***.***

Objective:

A highly motivated synthetic chemist is seeking an opportunity to work in a successful pharmaceutical company. With my experience, from synthetic research to process development to GMP production, from medicinal chemistry to out-sourcing, will greatly benefit your organization.

Summary:

Process chemistry: Synthetic route design, scale up, technical transfer and GMP production; synthesis of active pharmaceutical ingredients, generic drugs and reference compounds; identification and synthesis of drug metabolites, process impurities; crystallization condition and polymorph screening; good communication skill and ability to work within cross-functional teams with aggressive timelines.

Medicinal chemistry: SAR and modeling study in small molecule drug discovery; making large scale intermediate in house on time; solid phase combinatorial chemistry in new drug discovery; outsourcing co-ordinate.

Natural product synthesis: Synthesis and modification of steroid compounds, synthesis of oligonucleotides, carbohydrates, peptides and heterocyclic compounds.

Broad knowledge and hands-on experience: Spectroscopic methodologies, such as NMR, MS, IR, UV, TGA, DSC and fluorescence; HPLC, GC. Experience with Reaction Colorimeter and Flow Reactor.

Working Experience:

Genzyme: (Waltham, MA. From Sept. 2004 – present)

Sr. Scientist – Process Chemistry: Process development and scale up; synthetic route design, optimization and technical transfer; synthesis of reference compounds, drug metabolites and process impurities; crystal salt formation and polymorph screening; medicinal chemistry and large scale intermediates synthesis; participating CMC meetings; mentoring junior chemists. I have completed three cGMP projects, from medicinal chemistry to kilograms (100 L reactor) GMP phase I material production.

Prime Organics: (Lowell, MA. From May, 1999 – August, 2004)

Sr. Scientist - Custom synthesis from mg to kg scale (100 L) in broad chemistry; synthesis and scale up of advanced intermediates; process development of generic drugs (Clopidogrel, Gleevec, Taxol); making oligonucleosides, peptides and phosphoramidites; synthesis and modification of cardiac steroids.

Sepracor: (Marlborough, MA. From July, 1998 – May, 1999)

Synthetic Chemist – Worked on several process developments of highly enantiomerically pure intermediates and drug candidates; synthesizing metabolites of anti-depressant drug, such as Desipramine, Metoclopramide, Zolpidem and Venlafaxine.

Biogen: (Cambridge, MA. From Dec. 1997 – June, 1998)

Medicinal Chemist - Synthesis 1, 3, 7 and 8-substituted xanthine derivatives as adenosine receptor antagonists and SAR studies; using solid phase combinatorial techniques synthesizing peptides in new drug discovery.

Education and Post-Doctoral Experience:

Southern Mississippi University, Post-doctoral Fellowship (from Dec. 1996 - Dec. 1997)

Study photo-degradation and photo-stability of polystyrene and acrylate / styrene co-polymer. Study radical polymerization and photo-initiator effect on polymerization. (Advisor: Professor C. E. Hoyle)

University of Bristol, UK. Post-doctoral Fellowship (from Oct. 1994 – Nov. 1996)

Synthesis and modeling study of bi-cyclic medium-ring compounds with N, P and B bridgeheads. Synthesis of C-13 labeled fatty acids and N-14 labeled amino acids. (Advisor: Professor R. W. Alder)

University of Wales, Swansea, UK Ph.D. and Master Degrees in Organic Synthesis

Ph.D. Advisors: A. Pelter and K. Smith; Master Degree Advisors: R. Khan and K. Smith.

Study novel organoborane reactions and their application in asymmetric synthesis (1990 – 1994).

Carbohydrate chemistry. Improvement and patented of synthesis of Sucralose (1989 -1990).

Honors:

Vice President Awards: Process development GCS inhibitor; GMP manufacture of MZ-21 project;

Spot Award: New anti-malaria drug synthesis and technical transfer;

Fulton Scholarship; Overseas Research Scholarship and SERC fellowship.

Patents and Publications:

1. Kiesman, William F.; Zhao, Jin; Conlon, Patrick R.; Dowling, James E.; Petter, Russell C.; Lutterodt, Frank; Jin, Xiaowei; Smits, Glenn; Fure, Mary; Jayaraj, Andrew; Kim, John; Sullivan, Gail; Linden, Joel. Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists. Journal of Medicinal Chemistry (2006), 49(24), 7119-7131.

2. Kiesman, William F.; Zhao, Jin; Conlon, Patrick R.; Petter, Russell C.; Jin, Xiaowei; Smits, Glenn; Lutterodt, Frank; Sullivan, Gail W.; Linden, Joel. Norbornyllactone-substituted xanthines as adenosine A1 receptor antagonists. Bioorganic & Medicinal Chemistry (2006), 14(11), 3654-3661.

3. Zhao, J.; Orler, B. E.; Hoyle, C. E.; McDonald, C. J. Photodegradation of copolymers of styrene -methyl methacrylate and styrene - phenyl acetylene. Polymeric Materials Science and Engineering, 78, 109-110 (1997).

4. Hoyle, C. E.; Zhao, Jin; Orler, B.; Kuang, W.; McDonald, C. L. Photodegradation of St-MMA copolymers: correlation of degradation, styrene content, and photophysics. Journal of Macromolecular Science, Pure and Applied Chemistry A38(5 & 6), 527-541(2001).

5. R. W. Alder and Zhao Jin,The Methylation and Protonation of 1-Aza-5-bora-4,6,11-trioxabicylo [3.3.3] undecane and 1-Aza-5-borabicyclo [3.3.3] undecane, J. Chem. Soc., Perkin Trans. 2. 1996, 583.

6. R. W. Alder and Zhao Jin, 1,5 - Diborabicyclo[3.3.3]undecane; Thermolysis of the product from hydroboration of triallylborane with triethylamine-borane, J. Chem. Soc., Perkin Trans. 1. 657(1996).

7. K. Smith, A. Pelter and Zhao Jin, Synthesis and Properties of 2,4,6-Trimethylphenylborane (Mesitylborane), a Stable Alternative to Thexylborane, Angew. Chem. Int. Ed. Engl., 33, 851, (1994).

8. K. Smith, A. Pelter and Zhao Jin, Some Interesting Properties of 2,4,6-Triisopropylphenylborane, A New Useful Monoarylborane, J.Chem. Soc. Perkin Trans. 1, 395, (1993).

9. R. Khan, K. Smith, A. Pelter and Zhao Jin, Process for the Preparation of Sucrose 6-esters from sucrose and ketene acetals, Brit.UK Pat. Appl. GB 2,255,975, (Cl.C07D407/12), 25 Nov. 1992.

10. A. Pelter, K. Smith and Zhao Jin, Synthesis of 2,4,6-Triisopropylphenylborane, A Useful Alternative to Thexylborane, Heteroatom Chem., 3, 275 (1992).

11. R. Khan, K. Smith, A. Pelter and Zhao Jin, Proces for the Preparation of Sucrose 6-esters from sucrose and ketene acetals, GB Appl. 91/10, 931, 21, May 1991.

Contact this candidate