Chemist

Date: March **, ****

Name: Brian J. Weir

Home Address: *** ******* ** *** *

Braintree, MA 02184

Phone Number: 781-***-****

E-Mail: ********@*****.***

Education:

****-******* *.*., ***mistry Northeastern University, Boston, MA.

2006-2009 B.S., Chemistry Bridgewater State College, Bridgewater, MA.

Employment History:

2010-Present Research Technician I Massachusetts General Hospital

DF/HCC Cancer Pharmacology Core

Boston, MA

Assist in the development and validation of analytical methods to measure anticancer drugs in biological fluids by HPLC with conventional detection and various LC/MS techniques. Use validated analytical methods to assay samples from pharmacokinetic studies. Maintain findings in scientific notebook and compose data reports. Prepare analytical stocks, working solutions, mobile phases, and pretreatment of biological samples. Perform routine calibration and maintenance of analytical instrumentation.

2006-2007 Research Assistant Bridgewater State College

Department of Chemistry

Bridgewater, MA

Perform trace level analysis of Arsenic contamination in soils using Graphite Furnace Atomic Absorption Spectroscopy. Conduct sample preparation prior to testing.

Technical Experience and Training:

A. Major Instrumentation Operation and Maintenance

2010: HP 1050 Series modular LC systems with isocratic and quaternary pumps, degassing unit, autosampler with a 100-vial external sample tray, model G1306A Diode Array Detector

Agilent 1100 Series modular LC systems with isocratic and quaternary pumps, autosamplers, thermostatted autosamplers, column heater/6-position automated switching valve, model G1314A Variable Wavelength Detector, model G1321A Fluorescence Detector

Agilent 1100 Series LC/MSD system, single quadrupole mass spectrometer (model G1946D) equipped with an atmospheric pressure / electrospray ionization interface

Agilent 1100 Series LC/MSD system, triple quadrupole mass spectrometer (model G6410B) with an atmospheric pressure / electrospray ionization interface

2006: Perkin Elmer AAnalyst 600 Graphite Furnace Atomic Absorption Spectrometer

B. Laboratory Equipment

Cahn model C-34 Microbalance

Mettler Toledo Excellence XS Series Analytical balance

ATI Orion model 920A pH/ISE/mV meter with ROSS combination pH electrode

Eppendorf model 5415D microcentrifuge

Jouan model CR4i thermostatted microprocessor controlled centrifuge

Organomation Multivap 118 and N-EVAP 112 nitrogen evaporators

Labconco CentriVap model 79700-00 centrifugal concentrator

Büchi Rotavapor model R-124

C. Computer Programs

Microsoft Excel and Word

WinNonlin v. 5.0.1

Hewlett-Packard Chemstation rev. A.04.03.

Agilent ChemStation rev. A.09.03 and rev. A.10.02

Agilent MassHunter Workstation Acquisition B.04.01

Agilent MassHunter Quantitative Analysis B.04.00

D. Study Sample Analysis Using Validated Analytical Methods

2011: BBI608 in human plasma by LC/MS/MS (triple quadrupole)

Temsirolimus and Sirolimus in human blood by LC/MS (single quadrupole)

Non-clinical study of Paclitaxel in mouse blood, tumor, and tissue by LC/MS

(single quadrupole)

Pyrimethamine in human plasma by LC/MS (single quadrupole)

Pralatrexate in human plasma by LC/MS (single quadrupole)

Dinaciclib in human plasma by LC/MS (single quadrupole)

ACY1215 and Bortezomib in human plasma by LC/MS/MS (triple quadrupole)

Verteporfin long-term stability study in human plasma by LC/MS/MS (triple quadrupole)

2010: Paclitaxel in human plasma by LC/MS (single quadrupole)

Bardoxalone in human plasma by LC/MS (single quadrupole)

MGH Hazardous Drug Safety Task Force: 5-fluorouracil and Gemcitabine contamination by LC/MS (single quadrupole)

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