Chemist

OBJECTIVE: To utilize my skills as a medicinal chemist to develop biologically active molecules.

EXPERIENCE:

*/**** – 7/2009 Icagen, Inc. RTP, NC

Scientist III

-Research areas include development of SK inhibitors toward treatment of learning and memory disorders.

-Development of IK1 inhibitors for the treatment of glaucoma

3/2001 – 6/2002 Arena Pharmaceuticals, San Diego, CA

Research Associate

- Synthesis and derivitization of various heterocycles to determine structure activity relationships with respect to 5HT-2A receptors and other GPCR's.

-Responsible for 100+ gram scale synthesis of lead compound for clinical studies.

3/1999 – 3/2001 Trega Biosciences, San Diego, CA

Research Associate

-Primary research involved the development of two and three diversity combinatorial libraries utilizing solid phase chemistry.

- Successfully developed multi-step synthetic routes which allowed for the synthesis of libraries which contained 200 -8000+ medicinally interesting heterocycles.

SKILLS:

-Experienced in developing SAR and solving problems within a series of molecules such as solubility, CYP 450, hERG, plasma protein binding, etc.

-Knowledgeable and competent synthetic organic chemist able to develop syntheses independently and efficiently.

-Expert in the set up and maintence of various automated equipment such as ISCO purification systems, Gilson prep system, Genevac evaporator, and Biotage microwave systems.

EDUCATION:

12/1998 University of Central Florida, US-FL-Orlando

Master's Degree, University of Central Florida, Orlando, FL

Master of Science Degree in Industrial Chemistry (Organic Synthesis) Thesis title: “Synthesis and characterization of aromatic amino acid molecular recognition systems.”

4/1995 Rensselaer Polytechnic Institute, US-NY-Troy

Bachelor's Degree

Bachelor of Science Degree in Chemistry

AFFILIATIONS:

10/1991 – Present American Chemical Society, member

ADDITIONAL INFORMATION:

Presentations:

Discovery and SAR of novel 5HT2A receptor inverse-agonists. Strah-Pleynet, Sonja; Teegarden, Bradley R.; Drouet, Keith; Jayakumar, Honnappa; Thomsen, William; Reyes, Hazel; Foster, Jonathan; Maffuid, Paul; Elwell, Katie; Feichtinger, Konrad; Davidson, Jarrod; Kato, Naomi; Selaya, Susan D.; Shin, Young-Jun; Seconi, Darrick; Foster, Richard; Smith, Julian; Menzaghi, Frederique; Whelan, Kevin; Behan, Dominic; Chalmers, Derek; Beeley, Nigel R. A. Arena Pharmaceuticals, Inc, San Diego, CA, USA. 227th ACS National Meeting, Anaheim, CA, United States, March 28-April 1, 2004 (2004)

“Synthesis and Characterization of Aromatic Diamide Diacid Self Assembling Systems.” American Chemical Society, Florida Section Annual Meeting. (Orlando, Fl, May 3, 1997)

“Synthesis and Analysis of Supramolecular Assemblies Containing Aromatic Amino Acids.” Twenty First Annual Cancer Research Seminar in Florida sponsored by the American Cancer Society, Florida Division. (Orlando, Fl, March 21, 1998)

“Self Assembly Characteristics of 1,1 Cyclobutane Diamide Diacids Compromised of Aromatic Amino Acids.” American Chemical Society, 215th National Meeting. (Dallas, TX, March 29, 1998)

“The Self-Assembly of Cyclobutane Diamide Diacids” Florida American Chemical Society Meeting and Exposition. (Orlando, FL, May 8, 1998)

“Synthesis of 1,2,6-trisubstituted-1H-quinazolin-4-ones on Solid Support.” American Chemical Society, 221st National Meeting. (San Diego, CA, April 4, 2001)

Publications

Preparation of polycyclic pyrazines as potassium ion channel modulators. Wang, Xiaodong; Spear, Kerry Leigh; Fulp, Alan Bradley; Seconi, Darrick; Suzuki, Takeshi; Ishii, Takahiro; Moritomo, Ayako. (Icagen, Inc., USA; Astellas Pharma Inc.). U.S. Pat. Appl. Publ. (2005), 29 pp. CODEN: USXXCO US 200-***-**** A1 20051027 Patent written in English. Application: US 200*-****** 20050413

Preparation of polycyclic pyridines as potassium ion channel modulators. Wang, Xiaodong; Spear, Kerry Leigh; Fulp, Alan Bradley; Seconi, Darrick; Suzuki, Takeshi; Ishii, Takahiro; Moritomo, Ayako; Kubota, Hideki; Kazami, Jun-Ichi. (Icagen, Inc., USA; Astellas Pharma Inc.; et al.). PCT Int. Appl. (2005), 122 pp. CODEN: PIXXD2 WO 200-***-****

Preparation of polycyclic pyrimidines as potassium ion channel modulators. Wang, Xiadong; Spear, Kerry Leigh; Fulp, Alan Bradley; Seconi, Darrick; Suzuki, Takeshi; Ishii, Takahiro; Moritomo, Ayako; Kubota, Hideki; Kazami, Jun-Ichi. (Icagen, Inc., USA; Astellas Pharma Inc.; et al.). PCT Int. Appl. (2005), 64 pp. CODEN: PIXXD2 WO 200-***-****

Preparation of thiazoles and their metal complexes as potassium ion channel modulators. Wang, Xiaodong; Spear, Kerry Leigh; Fulp, Alan Bradley; Seconi, Darrick; Suzuki, Takeshi; Ishii, Takahiro; Moritomo, Ayako; Kubota, Hideki. (Icagen, Inc., USA; Astellas Pharma Inc.). U.S. Pat. Appl. Publ. (2005), 22 pp. CODEN: USXXCO US 200-***-**** A1 20051013

Preparation of pyridines and their metal complexes as potassium ion channel modulators. Wang, Xiaodong; Spear, Kerry Leigh; Fulp, Alan Bradley; Seconi, Darrick. (Icagen, Inc., USA). U.S. Pat. Appl. Publ. (2005), 21 pp. CODEN: USXXCO US 200-***-**** A1 20051013 Patent written in English. Application: US 200*-****** 20050413. Priority: US 200*-****** 20040413.

Nanoconstruction of microspheres and microcapsules using proton-induced phase transitions: molecular self-recognition by diamide diacids in water. Phanstiel, O., IV; Lachicotte, R. J.; Torres, D.; Richardson, M.; Matsui, H.; Schaffer, H.; Adar, F.; Liu, J.; Seconi, D.. Center for Discovery of Drugs and Diagnostics Department of Chemistry and Center for Research and Education in Optics and Lasers, University of Central Florida, Orlando, FL, USA. Chemistry of Materials (2001), 13(2), 264-272

Mechanism of Crystalline Dicarboxamide Microsphere Self-Assembly Probed by in Situ Raman Microscopy and Raman Imaging. Matsui, H.; Gologan, B.; Schaffer, H.; Adar, F.; Seconi, D.; Phanstiel, O. Center for Discovery of Drugs and Diagnostics Department of Chemistry, University of Central Florida, Orlando, FL, USA. Langmuir (2000), 16(7), 3148-3153.

O. Phanstiel IV,* R. J. Lachicotte, and D. Seconi Nanoconstruction of Microspheres and Microcapsules Using Proton-Induced Phase Transitions: Molecular Self-Recognition by Diamide Diacids in Water, Chemistry of Materials; 2001; 13(2); 264-272

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