Medical Manager

*. Educational and professional history

A. List of institutions attended

Nanjing Medical University, Nanjing, China, 1988-1993. Major: Medicine. Bachelor of Medicine. June 1993 (M.D. equivalent). Nanjing Medical University, Nanjing, China. 1998-2000. Major: General Surgery. Master of Medicine. June 2000. University of Iowa, August 2001 – December, 2006. Free Radical & Radiation Biology Program, Department of Radiation Oncology, Ph.D.

B. Professional and academic positions held

*Pediatric Surgeon. Nanjing Children’s Hospital, Nanjing, China. July, 1993 – July 1999. *Graduate Research Assistant. Nanjing Medical University, 1999-2000.

*Graduate Research Assistant. University of Iowa. August, 2001 – November 2006. *Postdoctoral Research Fellow, NorthShore University HealthSystem, Evanston, IL. November 2006 – June 2010. Basic medical science research, including flow cytometry and high speed cell sorter, molecular biology and neurology.

*Lab manager, NorthShore University HealthSystem, Evanston, IL. July 2010-present. In charge of research lab and flow cytometry facility including BD Calibur (Cell Quest pro) and BD Aria II (Diva). Totally near 6 years experience in cell sorter and flow cytometry.

C. Honors

*Scholarship from Nanjing Medical University (1988 to 1993). *Scholar in training (SIT) travel award for Radiation Research Society 52nd annual meeting 2005.

*Scholar in training (SIT) travel award for Radiation Research Society 53nd annual meeting 2006.

*Scholar presentation award, University of Iowa Student Government 2005.

*Scholar presentation award, University of Iowa Student Government 2006.

*Travel award from Graduate Student Senate (University of Iowa) 2006, twice.

*American Society of Biochemistry and Molecular Biology (ASBMB) 2006 Graduate/Postdoctoral Travel Fellowship.

*Scholarship from the University of Iowa.

Research Grant:

PI: NorthShore University HealthSystem Research Institution Pilot Grant, 2011-2012, $40000.

Speech at international conference:

1. Society of Free Radical Biology and Medicine 2007.

2. Society for Neuroscience 2008.

3. Hershey Conference on Developmental Brain Injury 2010.

4. Society for Neuroscience 2010.

Review for the following international journals: a) Blood Cells, Molecules, & Diseases, ISSN: 1079-9796 b) Recent Patents on DNA and Gene Sequences, ISSN: 1872-2156 c) International Journal of Molecular Science, ISSN: 1422-0067

d) Neurochemical Research, ISSN: 0364-3190

e) Radiation Research, ISSN: 0033-7587

f) The International Journal of Biochemistry & Cell Biology, ISSN: 1357-2725

g) Cancer Cell International, ISSN: 14752867

h) J of Oncology

2. Peer Reviewed Publications

a) Yu L, Domann FE. Rapid and Direct Quantitative RT-PCR Method to Measure Promoter Activity. Biotechnol. Prog. 2006 Sep-Oct; 22(5):1461-3.

b) Yu L, Venkataraman S, Coleman MC, Spitz DR, Wertz PW, Domann FE. Glutathione peroxidase-1 inhibits UVA-induced AP-2a expression in human keratinocytes. Biochem. Biophys. Res. Commun 2006 Dec 29; 351(4):1066-71.

c) Hitchler MJ, Wikainapakul K, Yu L, Powers K, Attatippaholkun W, Domann FE. Epigenetic regulation of Manganese Superoxide Dismutase expression in human breast cancer cells. Epigenetics 2006 Oct; 1(4):163-171.

d) Provenzano MJ, Yu L, Hitchler MJ, Fitzgerald MP, Robinson RA, Wayne S, Meer MV, Domann FE. AP-2 participates in the transcriptional control of the amyloid precursor protein (APP) gene in oral squamous cell carcinoma. Exp Mol Pathol. 2007 Oct; 83(2):277-82.

e) Yu L, Hitchler MJ, Sun W, Sarsour EH, Goswami PC, Klingelhutz AJ, Domann FE. AP-2alpha Inhibits c-MYC Induced Oxidative Stress and Apoptosis in HaCaT Human Keratinocytes. Journal of Oncology, vol. 2009, Article ID

780874, 9 pages, 2009. doi:10.1155/2009/780874

f) Vásquez-Vivar J, Whitsett J, Derrick M, Ji X, Yu L, Tan S. Tetrahydrobiopterin in the prevention of hypertonia in hypoxic fetal brain. Ann Neurol. 2009 Sep;66(3):323-31.

g) Rao, S.; Lin, Z.; Drobyshevsky, A.; Chen, L.; Ji, X.; Ji, H.; Yang, Y.; Yu, L.; Derrick, M.; Silverman, R. B.; Tan, S. Involvement of Neuronal Nitric Oxide Synthase in Ongoing Fetal Brain Injury Following Near-Term Rabbit Hypoxia-Ischemia. Dev Neurosci. 2011;33(3-4):288-98.

h) Yu L, Derrick M, Ji H, Silverman RB, Whitsett J, Vasquez-Vivar J, Tan S. Neuronal nitric oxide synthase inhibition prevents cerebral palsy following hypoxia-ischemia in fetal rabbits: Comparison between JI-8 and 7-nitroindazole. Dev Neurosci. 2011;33(3-4):312-9.

i) Sun WQ, Weydert CJ, Zhang YP, Yu L, Liu JR, Spit DR, Cullen JJ, Oberley, LW. Superoxide Enhances the Antitumor Combination of AdMnSOD plus BCNU in Breast Cancer. Cancer 2010; 2(1): 68-87.

j) Derrick M, Englof I, Drobyshevsky A, Luo K, Yu L, and Tan S. Intrauterine fetal demise can be remote from the inciting insult in an animal model of hypoxia-ischemia. Ped Res 2012; 72:154-160

k) Drobyshevsky A, Luo K, Derrick M, Yu L, Du H, Prasad PV, Vasquez-Vivar J, Batinic-Haberle I, and Tan S. Motor Deficits are Triggered by Reperfusion-Reoxygenation Injury as Diagnosed by MRI and by a Mechanism Involving Oxidants. J of Neuroscience 2012; 32(16): 5500-5509

l) Drobyshevsky A, Yu L, Yang Y, Khalid S, Luo K, Jiang R, Ji H, Derrick M, Kay L, Silverman RB, Tan S. Antenatal Insults Modify Newborn Olfactory Function By Nitric Oxide Produced From Neuronal Nitric Oxide Synthase. Experimental Neurology 2012, in press. The following articles were published in Chinese journals that circulating national wide in China:

m) Yu L, Zhang JL, Xu XR. Protective effects of N-acety-1-cysteine in rabbit endotoxic shock. Jiangsu Medical Journal 2000, 26: 111-113. (in Chinese)

n) Zhang JL, Xu XR, Yu L. Effects of dobutamine in dogs with endotoxin shock. Jiangsu Medical Journal 2000, 26: 604-606 (in Chinese)

o) Zhang JL, Xu XR, Yu L. Effects of pentoxifylline in dogs with endotoxic shock. Emergency Medicine 2000, 9: 101-103 (in Chinese).

p) Zeng Y, Hou M, Yu L, Zhang YG, Zhang ZH. Preliminary Application of the Preparation of McAbs Against Antigen of Adult Clonorchis sinensis in Detecting CAg in Serum and Urine of Guinea Pigs with Infection of Cs. Journal of Nanjing Medical University 2001, 21: 484-487. (in Chinese)

q) Zhang JL, Yu L, Xu XR. Protective effects of GSH in rabbits with endotoxic shock. Modern Medical Journal 2004, 32: 288 – 292. (in Chinese)

r) Yu L, Xu XR. Reducing glutathione protective effects in septic shock. International Medicine: Trauma and Fundamental Surgical Issue 2000, 21:22-24. (in Chinese)

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