Analytical Research Chemist

MOHAMMED ZAMIRUDDIN

** ****** **., *******, **, Canada, M9V 5B2

C 416-***-**** / H 416-***-****

******@******.***

OBJECTIVE

Objective: To obtain an Analytical Chemist position in an organization where I can apply my hands-on technical and professional skills to improve the quality and productivity of the company.

QUALIFICATIONS

A dependable professional with 10+ years of analytical research and quality control experience having strong scientific knowledge and technical skills. Proficient in communication at all levels within the organization. Dynamic team player, strongly focused on regulatory and compliance issues with

• United State Pharmacopoeia (USP),

• Food and Drug Administration (FDA),

• International Conference on Harmonization of Technical Requirement for registration of pharmaceuticals for human use (ICH),

• Good Manufacturing Practice (GMP) and Good Laboratory Practice (GLP).

Achieved success through:

• Planning, organizing, and prioritizing tasks/resources to optimize productivity, meet deadlines, and deliver results

• Building strong working relationships to gain people’s trust and cooperation and motivate people by building their trust and confidence through training, teaching and practical demonstration.

• Problem/issue identification, root cause and alternative solutions analysis and decisive action to bring resolution.

• Excellent command of operation and trouble shooting of laboratory instruments, like High Performance Liquid Chromatography (HPLC), Tandem Mass Spectrometry (LC-MS/MS), Fourier Transform Infra-Red Spectroscopy (FTIR), Thin Layer Chromatography (TLC), Gas Chromatography (GC), Karl Fisher Titration, Ultra Violet and Visible Spectrometry (UV-Vis), Dissolution Apparatus and Wet Chemistry process.

• Multitasking in a competitive and fast paced environment.

• Effective development of open oral/written communication channels; fluent in English and able to communicate in most South Asian languages.

• Good command of public speaking and oral presentation in class room situation.

• Very good knowledge of MS office and analytical software.

ACHIEVEMENTS

• Developed a simple HPLC-FL analytical method for Gabapentin to quantify the drug in the plasma through an off-line derivatization procedure. The method was applied for clinical study of the drug on 12 human subjects.

• Quantified Phosphatidyl Inositol (PI) and related compounds by developing a LC-MS method by using normal phase isocratic chromatography. In addition a simple extraction procedure for the drug from aqueous phase was developed for these unstable compounds. The method was successfully applied to support the product formulation development and stability study of the drug.

• Isolated and purified new drug compound from a plant source which is a potential lead compound. A synthesis procedure was developed for this compound. This work led to a successful patent application to the Canada Patent Office for a probable Investigational New Drug (IND) submission.

• Developed LC-MS/MS method to quantify Metformin (a type-2 diabetic drug), in plasma sample. The method was applied for clinical study of 24 hours-release product formulation development of the drug.

• Derivatized successfully the poorly soluble Sebacic acid directly in the aqueous media (without extraction) and then a chromatographic (HPLC-UV) analytical method was developed to quantify the acid. This analytical method was applied to develop a pro-drug, in which structure Sebacic acid is a ligand.

• Developed Ibuprofen immediate release (IR) and Ranitidine controlled release (CR) solid dosage form as student project to pursue pharmaceutical research and development diploma in drug product formulation development.

MOHAMMED ZAMIRUDDIN

PROFESSIONAL EXPERIENCE

TORONTO INSTITUTE OF PHARMACEUTICAL TECHNOLOGY (TIPT), Toronto, Ontario, Canada 2002 – Present

Analytical Research and Development Associate

• Conduct research work to develop and validate analytical methods by using HPLC, LC-MS/MS, FTIR, UV-Visible spectrometry, and wet chemistry methods such as dissolution, disintegration, Karl Fisher Titration and physical methods such as Viscosity, Surface Tension, particle size analysis.

• Analyze samples as routine or non routine basis of pharmaceutical solid dosage form, raw material characterization, in process samples, finished product, drugs product stability evaluation samples. Also analyze biological samples from clinical studies, environmental and health care product samples from outside clients.

• Write experimental proposal and protocol for various project works.

• Teach chemistry to TIPT students. Guide QA/QC students for HPLC analytical method development and validation projects.

• Set up and conduct complex chemical experiments, tests and analyses, operate and maintain laboratory equipment, prepare solution, reagents, and samples.

• Compile records and interpret experimental or analytical results,

• Assists in development of standards, health and safety measures

• Investigate, identify and resolve problem for OOS (out of specification) results; troubleshoot and resolve analytical issues,

CPI PLASTIC, Mississauga, Ontario, Canada. 2000-2001

ROYAL PLASTIC, Wood Bridge, Ontario, Canada 1998-2000

Machine operator

• Setting up extruder machine, operated the machine and checked the quality of the products.

WATER AND ELECTRICITY DEPARTMENT, Abu – Dhabi, United Arab Emirates 1994-1998

Supervisor:

• Supervised and operated 10 units of multi-stage flash water distillation units involving 10 operator stuffs

• Operated electronic control panel. Monitored and optimized physical and chemical process parameters and control quality of distilled water, brine concentration and maintain over all safe operation of all control devices.

• Start-up, shut down and trouble shoot the operation of distillation units.

• Issued defect card for any defective equipments for maintenance with due care to isolation procedures.

• Operated, and trouble shoot various small and big pumps; manual, electrical, and pneumatic valves; turbine pumps, chlorination plants and ejector systems, Worked with high pressure water and high pressure steam system.

• Organized, supervised and conducted acid cleaning of heat exchangers.

• Sampled and perform chemical and physical tests. Record data and used control chart to determine efficiency of the process and equipments.

• Arranged and conducted training program for junior employees.

Prior to 1994 gained experience with Water and Electricity Department, Abu-Dhabi, United Arab Emirates (UAE) as

JUNIOR AND SENIOR CHEMIST

EDUCATION AND PROFESSIONAL DEVELOPMENT

Training on operation software of HPLC, GC, LC-MS, LC-MS/MS from different Vendors

Diploma in Pharmaceutical Research and Development

Toronto Institute of Pharmaceutical Technology (TIPT), Toronto, Ontario, Canada

M.Sc in Organic Chemistry

B. Sc (Hons.) in Chemistry

University of Chittagong, Chittagong, Bangladesh

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