Reyhane Hoshyar, Ph.D.

Michigan State University

Department of East Microbiology Lansing, MI & 48824, Molecular USA Genetics Tel: 517-***-****

adg70i@r.postjobfree.com, adg70i@r.postjobfree.com

https://scholar.google.com/citations?user=KTH0Iq8AAAAJ&hl=en LinkedIn: https://www.linkedin.com/in/reyhane-hoshyar-51019940/ SUMMARY:

Searching for the next opportunity to work with a diverse team of talented individuals. Skilled in a diverse range of the sciences, including Biotechnology, Analytical Biochemistry, Molecular Biology, Cancer Immunology, and Stem Cell Biology. Acknowledged for having abilities to work on multiple projects in parallel, good organizational skills, problem solving, and effective written and oral communication skills. Motivated professionally, working well individually and with teams, with a proven record to innovate and deliver as demonstrated by strong publication and conference record. KEY SKILLS

In vitro experimentation utilizing mammalian cell culture (normal, cancer and stem cells)

In vivo experimentation utilizing animal models (e.g., p53ko mammary gland transplantation, tumor challenges)

Gene expression analysis (Microarray, RT-qPCR, and Northern Blot)

Protein characterization (SDS PAGE, Western Blot, and ELISA)

Immunocytochemistry, Immunofluorescence, and Biological Imaging

Flow Cytometry

Molecular Biology Techniques (PCR, Cloning, Transfection/Transduction, Golden Gate, and Gibson assembly)

Enzyme Kinetics and Pharmacokinetics

Protein and DNA structure analysis by Spectrometric Methods (Fluorescence, Circular Dichroism, TUNEL and DNA Fragmentation assays)

High Performance Liquid Chromatography (HPLC) and Gas Chromatography (GC)

Statistical analysis by SPSS or PRISM software

HONORS AND AWARDS

BCERP (Breast Cancer Environmental Research Program) Travel Award, NIH, USA 2019

BCERP Young Investigator Highlight, NIH, USA 2019

Fellowship (Sponsored by France’s government) Sorbonne University, Paris, France 2016

IX European Symposium of the Protein Society, Young Scientist, Stockholm, Sweden 2011

Exchange Student Internship Grant, Konstanz University, Konstanz, Germany 2008

DNA and Cell Biology Journal, Young Scholar Award, USA 2008 EDUCATION

Ph. D. Clinical Biochemistry 2008-2013, TMU, Tehran, Iran M.Sc. Clinical Biochemistry 2005-2008, TMU, Tehran, Iran B.Sc. Cellular & Molecular Biology 1999-2003, KHU, Tehran, Iran EMPLOYMENT AND RESEARCH EXPERIENCE

Michigan State University 1/2019-Present

Department of Microbiology and Molecular Genetics

Post-Doctoral Research Associate, Advisor: Prof. Richard Schwartz Research on effects of environmental factors on breast cancer (e.g., high fat diet, oxybenzone). Performing in vitro and in vivo experiments for gene profiling and immune histopathology, elucidating molecular and cellular mechanisms of immune cytokines in mammary tumorigenesis, writing papers, and presenting technical talks.

University of Maryland Baltimore 8/2018-1/2019

Department of Biochemistry and Molecular Biology

Visiting Researcher, Advisor: Prof. Lindsay Black

Research on “using DNA and protein packaging to inhibit diseases without side effects on normal cells” Birjand University of Medical Sciences 7/2013-8/218 Department of Biochemistry, Birjand, Iran

Associate Professor

Teaching topics in biochemistry, molecular biology, stem cell signaling, enzymology and toxicology. Performed research on effects of some complementary drugs on cancer and involved molecular mechanisms. University of Massachusetts Amherst 1/2012-1/2013

Department of Molecular & Cellular Biology

Visiting Researcher, Advisor: Prof. Joseph Jerry

Research on “use of let7/microRNA biosensor to access dynamic of progenitor cells during differentiation”. Performed mammalian cell transfection, labeling stem cells by viral vector, gene expression, luciferase Detection and scientific talk’s presentation.

University of Kharazmi 6/2003-7/2005

Department of Biology, Tehran, Iran

Volunteer Lab Technician

Lab manager and training of biology undergraduate students. SELECTED REFEREED PUBLICATIONS (38 articles published, 4 in preparation/under review)

Kariagina, A., E. Morozova, R. Hoshyar, M. D. Aupperlee, M. A. Borin, S. Z. Haslam, R. C. Schwartz. Benzophenone-3 promotion of mammary tumorigenesis is diet-dependent. (submitted)

Arash Ghorbani, Mohammad Hanafi, Negin Parsamanesh, Zahra Tayarani, Homa Mollaei, Reyhane Hoshyar. Anticancer and apoptotic activities of parthenolide in combination with epirubicin in mda-mb- 468 breast cancer cells. Molecular Biology Reports, 2020

Zahra Nezamdoost, Marziyeh Saghebjoo, Reyhane Hoshyar, Anna Keska. High-Intensity Training and Saffron: Effects on Breast Cancer-related Gene Expression. Med Sci Sports Exerc, 2020

Laleh Arzi, Reyhane Hoshyar, Nazli Jafarzadeh, Gholamhossein Riazi, Majid Sadeghizadeh. Anti- metastatic properties of a potent herbal combination in cell and mice models of triple negative breast cancer. Life Sciences, 243 (2020) 117245, 2020

Roshana Sattari, Gholam Reza Khayati, Reyhane Hoshyar. Biosynthesis and characterization of silver nanoparticles capped by biomolecules by fumaria parviflora extract as green approach and evaluation of their cytotoxicity against human breast cancer MDA-MB-468 cell lines. Materials Chemistry and Physics, 241 (2020),122438, 2020

Mahdjoube Goldani Moghadam, Reyhane Hoshyar, Marcin Mikulewicz, Katarzyna Chojnacka, Geir Bjørklund, Joeri J. Pen, Nammam Ali Azadi, Maghdad Pirsaheb, Borhan Mansouri, Biomonitorization of metal ions in the serum of Iranian patients treated with fixed orthodontic appliances in comparison with controls in eastern Iran, Environmental Science and Pollution Research, 26(32):333**-*****,2019

Mary Beth Terry, Karin B. Michels, Julia Green Brody, Celia Byrne, on behalf of Breast Cancer and the Environment Research Program (BCERP), Environmental exposures during windows of susceptibility for breast cancer: a framework for prevention research. Breast Cancer Research, 21(96), 2019

Banafsheh Safizadeh, Reyhane Hoshyar, Masoud Mehrpour, Mehrdad Eftekhar, Vahid Salimi, Shaghayegh Yazdani, Bita Bijari, Farshad Khodakhah, Masoumeh Tavakoli-Yaraki. The role of expression and activity of 15-Lipoxygenase isoforms and related cytokines in patients with Multiple Sclerosis and healthy controls. Journal of Neuroimmunology, 325, 32-42, 2018.

Laleh Arzi, Ali Farahi, Nazli Jafarzadeh, Gholamhossein Riazi, Majid Sadeghizadeh, Reyhane Hoshyar. Inhibitory Effect of Crocin on Metastasis of Triple Negative Breast Cancer via Interfering with Wnt/β- catenin Pathway in Murine Model. DNA and Cell Biology, 37(12), 1068–1075, 2018

Sabine Hombach-Klonisch, Maryam Mehrpour, Shahla Shojaei, Craig Harlos, Marshall Pitz, Ahmed Hamai, Krzysztof Siemianowicz, Wirginia Likus, Emilia Wiechec, Brian D. Toyota, Reyhane Hoshyar, Saeid Ghavami. Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response. Pharmacology and Therapeutics. 184,13-41, 2018

Homa Mollaei, Reza Safaralizadeh, Esmail Babaei, Mohammadreza Abedini, Reyhane Hoshyar. The anti-proliferative and apoptotic effects of crocin on chemosensitive and chemoresistant cervical cancer cells. Biomedicine & Pharmacotherapy.94,307-316, 2017

Mohammad Hashemi, Reyhane Hoshyar, Anne Zuse, Sudarshan Rao, Mevalonate cascade and its regulation in cholesterol metabolism in different tissue in health and disease. Current Molecular Pharmacology. 10(1),13-26, 2017

Reyhane Hoshyar, Reza Khayati, Maliheh Poorgholami, Masoud Kheykhaii. A novel green one- step synthesis of gold nanoparticles using crocin and their anti-cancer activities. Journal of Photochemistry and Photobiology, B: Biology. 159,237-242, 2016

Reyhane Hoshyar, Zahra Mahboob, Asghar Zarban. The antioxidant and chemical properties of Berberis vulgaris and its cytotoxic effect on human breast carcinoma cells. Cytotechnology Journal, 68(4),1207- 1213,2016

Reyhane Hoshyar, S.Zahra Bathaie, Majid Sadeghizadeh. Crocin triggers the apoptosis the Bax/Bcl2 ratio and caspase activation in human gastric cancer AGS cells, DNA & Cell Biology, 32(2): 50-57, 2013

Maryam Yousef Elahi, S.Zahra Bathaie, Reyhane Hoshyar, Saeid Ghasemi. A new DNA-nanobiosensor based on G-quadruplex immobilized on carbon nanotubes modified glassy carbon electrode. Electrochimica Acta, 82: 143-151, 2012

SELECTED CONFERENCE PRESENTATIONS: (8 domestic and 10 International presentations)

14th Annual BCERP Meeting, “Effect of oxybenzone on eosinophil recruitment and expression of immune-related gene products in p53-null mice exposed to a high saturated animal fat diet”7-8 November 2019, Atlanta, GA, USA (Poster)

2th International Conference on Food Chemistry and Nutrition “Anticancer and apoptotic effects of crocin of saffron and cisplatin on cervical cancer cells; Rapid green synthesis of gold nanoparticles using crocetin and their anticancer activity” 24-26 July 2017 Vancouver, Canada (Oral)

18th conversation Journal of Biomolecular Structure and Dynamics. Vol. 31, No. S1, 1– 142. Taylor

& Francis “Circular dichroism (CD) studies of the interaction between G-quadruple/ I-motif with saffron secondary active metabolites” 11-15 June 2013, Albany, NY, USA (Poster)

Annual Retreat VASCI “Use of Let7c sensor to assess dynamics of progenitor cells in normal mammary epithelium and breast cancers” 24th May 2012, UMass Amherst, MA, USA (Poster)

IX European Symposium of The Protein Society “Effect of Saffron Components on Histone H1 Structure and H1-DNA Interaction” 24-28 May 2011, Stockholm, Sweden (Oral) REFERENCES

Dr. Richard Schwartz

Professor

Department of Microbiology and Molecular Genetics, College of Natural Science, Michigan State University, East Lansing, MI 48824, USA

Associate Dean

Phone: +1-517-***-****

Email: adg70i@r.postjobfree.com

Dr. Joseph Jerry

Professor

Department of Veterinary and animal sciences, UMass Amherst, USA Science Director, Pioneer Valley Life Sciences Institute, Amherst, MA, USA

Co-Director, Rays of Hope Center for Breast Cancer Research Phone: +1-413-***-****

Email: adg70i@r.postjobfree.com

Dr. Saeid Ghavami

Associate Professor

Department of Human Anatomy and Cell Science, Faculty of Medicine University of Manitoba, Winning, Canada

Phone: +1-204-***-****

Email: adg70i@r.postjobfree.com

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