Engineering Pharmacy

Location:

Detroit, MI

Posted:

August 12, 2020

Contact this candidate

Resume:

Mohd.Ahmar Rauf

School of Pharmacy

Wayne State University

Detroit, Michigan, USA

Email: **********@*****.***, *********@*****.***

Research Experience

Postdoctoral Fellow: School of Pharmacy, Wayne State University, USA PhD: Biotechnology (Nanotherapuetics and drug delivery) 2017 Title: Nanoparticles mediated targeted delivery of Drug and Antigen Master of Science- Biochemistry 2013

Bachelor of Science – Biochemistry 2011

Relevant Hand-on expertise

Animal Handling: Mice (I.P, I.V. and Subcutaneous Injection) and Rabbit (Subcutaneous Injection) Cell Culture: Isolation of primary cells (peripheral blood mononuclear cells, peritoneal and spleenic macrophages and T-cells) from various organs, Maintenance of cell lines, Apoptotic Assays involving Cell lines, Surface marker analysis by FACS and Florescence Microscopy etc. Immunology: ELISA, Dot Blot, Western blotting, cytokine profiling, antibody isotyping and cell surface marker (co-stimulatory as well as memory) analysis, DTH response analysis Protein Sciences: PAGE-SDS & Native, Ion- exchange chromatography, Affinity chromatography etc.

Nanoparticle synthesis: Hands on experience in Biological and chemical methods, Nano- composites preparation, Drug Delivery macroparticles (PLGA, SLNPs etc) characterization (TEM, XRD, FTIR, EDX etc).

Bioinformatics: Basic Bioinformatics, Molecular docking, Structural Modelling, Phylogenetic tree etc.

List of Research Publications

Peer Reviewed Articles

1. Tatiparti K, Rauf MA, Sau S, Alzhrani R, Iyer A. Ultra Small Biomimetic Nanoparticles for Alzheimer’s Disease Targeted Drug Delivery. The FASEB Journal. 2020 Apr 1;34(S1):1- 2. Rehman FU, Bao J, Muhammad P, He W, Hanif S, Rauf MA. Blood-brain barrier amenable gold nanoparticles bio-fabrication in aged cell culture medium. Mater Today Bio. 2020:100072. 3. Ultrasound activated nano TiO2 loaded with Temozolomide paves the way for resection of chemo- resistant glioblastoma multiforme. Rehman FU, Rauf MA, Sana Shaikh, Muhammad P, Hanif S.

[Accepted in Cancer Nanotechnology][ Equal contribution as first author]. 4. Bhise K, Sau S, Rauf MA, Alzhrani R, Iyer A. Hypoxia Targeting Nanoparticles for Immunogenic Cell Death of Triple Negative Breast Cancer. The FASEB Journal. 2020 Apr 1;34(S1):1-. 5. Tatiparti, Katyayani; Rauf, Mohd A.; Sau, Samaresh; Iyer, Arun K. 2020. "A Biomimetic Drug Delivery System Targeting Tumor Hypoxia in Triple-Negative Breast Cancers." Appl. Sci. 10, no. 3: 1075.

6. Tatiparti K, Rauf MA, Sau S, Iyer AK. Carbonic Anhydrase-IX Guided Albumin Nanoparticles for Hypoxia-mediated Triple-Negative Breast Cancer Cell Killing and Imaging of Patient-derived Tumor. Molecules. 2020 Jan;25(10):2362.

7. Rauf MA, Ahamad S, Hassan I, Azhar A, Oves M. A Recepto-Informatics Study of the Natural Nutraceuticals having Potential Anticancer Efficacy for Breast Cancer. Acta Scientific Pharmaceutical Sciences. 2020 Jan 8;4(1).

8. Oves, Mohammad; Rauf, Mohd. A.; Ansari, Mohammad O.; Aslam Parwaz Khan, Aftab; A Qari, Huda; Alajmi, Mohamed F.; Sau, Samaresh; Iyer, Arun K. 2020. "Graphene Decorated Zinc Oxide and Curcumin to Disinfect the Methicillin-Resistant Staphylococcus aureus." Nanomaterials 10, no. 5: 1004 [equal contribution].

9. Bano N, Rauf MA, Owais M, Shakir M. Pharmacologically bio-relevant N-functionalized homo- binuclear macrocyclic complexes: synthesis, spectral studies, biological screening, HSA binding, and molecular docking. Inorganic and Nano-Metal Chemistry. 2019 Dec 2;49(12):413-30. 10. Rauf M.A., Rehman F.U., Zheng M., Shi B. (2019) The Strategies of Nanomaterials for Traversing Blood-Brain Barrier. In: Xue X. (eds) Nanomedicine in Brain Diseases. Springer, Singapore

11. Mohammad O, Faisal SM, Ahmad N, Rauf MA, Umar MS, Mujeeb AA, Pachauri P, Ahmed A, Kashif M, Ajmal M, Zubair S. Bio-mediated synthesis of 5-FU based nanoparticles employing orange fruit juice: a novel drug delivery system to treat skin fibrosarcoma in model animals. Scientific reports. 2019 Aug 23;9(1):1-4.

12. Ahmar Rauf, M., Oves, M., Ur Rehman, F., Rauf Khan, A. & Husain, N. Bougainvillea flower extract mediated zinc oxide’s nanomaterials for antimicrobial and anticancer activity. Biomed. Pharmacother. 116, 108983 (2019).

13. Rauf, M. A., et al. Antibacterial Silver Nanomaterial Synthesis From Mesoflavibacter zeaxanthinifaciens and Targeting Biofilm Formation . Frontiers in Pharmacology 10, 801 (2019). 14. Alam, M. T., Rauf, M. A., Siddiqui, G. A., Owais, M. & Naeem, A. Green synthesis of silver nanoparticles, its characterization, and chaperone-like activity in the aggregation inhibition of α- chymotrypsinogen A. Int. J. Biol. Macromol. 120, 2381–2389 (2018). 15. Shoeb, M., Mobin, M., Rauf, M. A., Owais, M. & Naqvi, A. H. In Vitro and in Vivo Antimicrobial Evaluation of Graphene–Polyindole (Gr@PIn) Nanocomposite against Methicillin-Resistant Staphylococcus aureus Pathogen. ACS Omega 3, 9431–9440 (2018). 16. Ashraf GM, Azhar A, Zia Q, Ali A, Rehan M, Owais M, Alexiou A, Rauf A, Ganash M, Kamal MA, Rajeh N. Relationship between CNS and immunology: correlation with psychology. Current drug metabolism. 2018 Aug 1;19(10):847-55.

17. Oves M, Aslam M, Rauf MA, Qayyum S, Qari HA, Khan MS, Alam MZ, Tabrez S, Pugazhendhi A, Ismail IM. Antimicrobial and anticancer activities of silver nanoparticles synthesized from the root hair extract of Phoenix dactylifera. Materials Science and Engineering: C. 2018 Aug 1;89:429-43. 18. Alam MT, Rizvi A, Rauf MA, Owais M, Naeem A. Thermal unfolding of human lysozyme induces aggregation: recognition of the aggregates by antisera against the native protein. International journal of biological macromolecules. 2018 Jul 1;113:976-82. 19. Ansari A, Ali A, Asif M, Rauf MA, Owais M. Facile one-pot multicomponent synthesis and molecular docking studies of steroidal oxazole/thiazole derivatives with effective antimicrobial, antibiofilm and hemolytic properties. Steroids. 2018 Jun 1;134:22-36. 20. Rauf MA, Zubair S, Ateeq H, Dabeer K, Pachauri S, Ajmal M, Owais M. Synergistic effect of diallyl sulfide with zinc oxide nanorods: A novel and effective approach for treatment of acute dermatitis in model animals. Frontiers in microbiology. 2018 Apr 18;9:586. 3

21. Shakir M, Jolly R, Khan AA, Ahmed SS, Alam S, Rauf MA, Owais M, Farooqi MA. Resol based chitosan/nano-hydroxyapatite nanoensemble for effective bone tissue engineering. Carbohydrate polymers. 2018 Jan 1;179:317-27.

22. Shakir M, Mirza S, Jolly R, Rauf A, Owais M. Synthesis, characterization and in vitro screening of a nano-hydroxyapatite/chitosan/Euryale ferox nanoensemble–an inimitable approach for bone tissue engineering. New Journal of Chemistry. 2018;42(1):363-71. 23. Shakir M, Bano N, Rauf MA, Owais M. Pharmacologically significant tetraaza macrocyclic metal complexes derived from isatin and 3, 4-diaminobenzophenone: Synthesis, spectral studies and comparative in vitro biological assessment. Journal of Chemical Sciences. 2017 Dec 1;129(12):1905- 20.

24. Zia Q, Rauf MA, Mohammad O, Khan W, Zubair S. Biomimetically engineered Amphotericin B nano-aggregates circumvent toxicity constraints and treat systemic fungal infection in experimental animals. Scientific reports. 2017 Sep 19;7(1):1-9. 25. Azhar A, Ahmad E, Zia Q, Rauf MA, Owais M, Ashraf GM. Recent advances in the development of novel protein scaffolds based therapeutics. International journal of biological macromolecules. 2017 Sep 1;102:630-41.

26. Bukhari MH, Raza Y, Batool S, Razzaki T, Bukhari A, Memon F, Rauf MA, Rizvi A, Bagasra O. DNA Electromagnetic Properties and Interactions. arXiv preprint arXiv:1704.06819. 2017 Apr 22. 27. Bukhari MH, Batool S, Raza DY, Bagasra O, Rauf MA, Rizvi A, Shah A, Razzaki T, Sultan T. DNA electromagnetic properties and interactions-An investigation on intrinsic bioelectromagnetism within DNA. Electromagnetic biology and medicine. 2018 Jul 3;37(3):169-74. 28. Shakir M, Bano N, Rauf A, Kazmi S, Alam M. Synthesis and characterization of pharmacologically active 18-membered tetraamide macrocyclic complexes of Mn (II), Co (II), Ni (II), Cu (II), and Zn

(II): In vitro antimicrobial, anticancer screening, DNA interaction and docking studies. Inorganic and Nano-Metal Chemistry. 2017 Apr 3;47(4):576-90.

29. Rauf MA, Owais M, Rajpoot R, Ahmad F, Khan N, Zubair S. Biomimetically synthesized ZnO nanoparticles attain potent antibacterial activity against less susceptible S. aureus skin infection in experimental animals. RSC advances. 2017;7(58):36361-73. 30. Shakir M, Jolly R, Khan MS, Rauf A, Kazmi S. Nano-hydroxyapatite/β-CD/chitosan nanocomposite for potential applications in bone tissue engineering. International journal of biological macromolecules. 2016 Dec 1;93:276-89.

31. Mohammad O, Kaur J, Singh G, Faisal SM, Azhar A, Rauf MA, Gupta UD, Gupta P, Pal R, Zubair S. TLR agonist augments prophylactic potential of acid inducible antigen Rv3203 against Mycobacterium tuberculosis H37Rv in experimental animals. PloS one. 2016;11(3). 32. Akhtar M, Tahir MN, Saleem M, Mazhar M, Rauf A, Isab AA, Ahmad S, Nadeem S. Crystal structure and biological properties of a tetranuclear zinc (II) complex of cysteamine,[Zn 4 Cym 4 Cl 4] prepared in the presence of diamines. Russian Journal of Inorganic Chemistry. 2015 Dec 1;60(12):1568-72. 33. Rauf MA, Zubair S, Azhar A. Ligand docking and binding site analysis with pymol and autodock/vina. International Journal of Basic and Applied Sciences. 2015 Apr 1;4(2):168. Awards and Fellowships

Awarded UGC prestigious BSR Fellowship from UGC, Govt. of India during my Ph.D. program (2014- 2017).

Qualified National level competitive test GATE for eligibility to take admission in IIT in 2012 and 2013, organized by Indian Institute of Technology, Kanpur. 4

Winner of Research Fund for International Talent at Henan University, China of Rs.1 million INR, 2018. Winner of International Research Fund for International Talent at Henan Province, China of Rs.0.5 million INR,2019[http://www.ha.hrss.gov.cn/sitegroup/root/html/ff8080813451610b01346f2e3c2229a9/11c179baa 5e040bc8ea5ea1f49447a26.html]

References

1. Dr. Asfar Azmi

Assistant Professor

Department of Oncology

Karmanos Cancer Institute

4100 John R St, HWCRC 732

Detroit MI 48201, USA

Tel: +1-313-***-****

Email id: *****@********.***

2. Mohammad Oves

Associate Professor

Centre of Excellence