VASANTH KUMAR NALAM

M.Sc,Ph.D.

Mobile: +91-998******* ~ E-Mail: add3xm@r.postjobfree.com

Seeking senior level assignments in the domain of Research & Development with a growth oriented organization of high repute.

CAREER PRÉCIS

A seasoned Scientist/ Researcher with 27 years of extended experience in Research & Development across Medicinal Chemistry, Process Research & Scale-up for Generic API’s development for US, EU, JP and other regulatory & emerging markets, New Chemical Entities (NCE’s), Custom Chemical Synthesis (CCS) and Contract Research & Manufacturing Services (CRAMS) with reputed pharmaceutical organizations.

Broad knowledge of state-of-the-art research techniques, technology, analytical, equipment and systems.

Demonstrated excellence in research areas (Medicinal Chemistry & Process Research) and different business.

Wealth of knowledge on Analytical, IPR, quality, regulatory, ICH, cGMP & USFDA guidelines.

Exceptional communication, presentation & mentoring skills.

About 8 publications in national and international journals and eight patents & patent applications are added in to my credit.

SCHOLASTICS

Ph.D (Chemistry) from Mumbai University, Mumbai in 2005. Thesis: Synthesis of 2H-pyranopyridine-2-one heterocyclic and their Biological activity

M.Sc. (Organic Chemistry) from Kakatiya University, Warangal, India in 1991; secured 1st class.

B.Sc. (Chemistry) from Kakatiya University, Warangal, India in 1989; secured 1st class. EMPLOYMENT RECITAL

Head Process R&D- 2018-Till Date: Ridhi Laboratories, Hyderabad.

Deputy General Manager - 2008 June –March 2018: Suven Life Sciences Ltd, Hyderabad (10 Years).

Principal Scientist-2006 July –June 2008: Glenmark Research Centre, Mumbai (1 Year & 11 months).

Research Scientist - 2003 Sep. –Jul. 2006: Lupin Limited. (Research Park), Pune (2 years & 10 months).

Group Leader - 2001 July – 2003 Sep: Unichem Laboratories Ltd., Mumbai (2 Years & 2 months).

Sr. Research Associate - 1992 Mar- 2001 Jun: Dr. Reddy’s Research Foundation, Hyderabad (9 Years & 4 months).

AREAS OF EXPERTISE

Technology development for Generic APIs entailing multiple-step chemistry and Scale-up (from Kg to ton level) cost effective process & technology Documentation and proper maintenance (Preparing of standard operating procedures to final regulatory requirement for DMF filling and filling of patents and publications).

Expertise in new synthetic route ideation, identifying non-infringing processes, creation of intellectual property.

Selecting cost effective suitable synthetic route for commercialization (process research) and reducing cost of existing projects.

Managing process optimization and process robustness demonstration from lab scale to commercial supplies

(process development).

Research & Development

Identifying, collecting, processing, analysing and cataloguing data according to established protocol, procedures

& standards, as appropriate to specific objectives of the research study.

Planning and organising day-to-day research activities and resolving procedural problems as appropriate to the timely completion of research objectives.

Ensuring appropriate procedures & standards for the collection & preservation of data as well as maintaining a broad knowledge of state-of-the-art research techniques, technology and / or systems. Team Management

Directing, leading & motivating workforce and imparting continuous on job training for accomplishing greater operational effectiveness/ efficiency.

Effectively interfacing with people at all levels, managing healthy work environment and inculcating bonded teamwork with high work ethics.

Monitoring, motivating and guideding team members by identifying core competencies and defining a scheduled growth plan.

Highlights:

Handled all the project management activities working in various kinds of projects.

Significantly reduced cost & boosted value addition in all on-going APIs & Intermediates.

Developed & commercialised APIs with competitive raw material cost.

Identifying non-infringing process for APIs for regulatory filings

Troubleshot Kilo lab/PP/Plant as well as handled cGMP projects for Global Innovator Companies.

Developing process for multistep liner synthesis projects (15 Steps) & scale up

Expertise in polymorphism and salt screening studies

Development of Study of the impurity profile and stability of the drug.

Identified cost contributors and reduced cost for better project margins and competitive advantage during the execution of projects.

Evaluated and developed new routes.

Built Technology Platforms & contributed in additional revenue growth Achievements

DMF Filed for following products

1.Armodafinil - Excessive sleepiness. 21. Calcium acetate API. 2. Ropinirole HCl - Anti-parkinsonian.

3. Strontium Ranelate - Bone Formation Stimulants. 22. Oxcarbazipine - Anti-epileptic.

23. Sertaconazole - Anti fungal.

4. Rimonabant - Anti obesity, Anti arrhythmic. 24. Olmesartan medoxomil- Antihypertensive agents. 5. Lornoxicam - Anti-inflammatory. 25. Felbamate Anti-epileptic. 6. Riluzole - CNS Agent. 26. Ziprasidone - Anti psychotic. 7. Linezolid - Anti-bacterial. 27. Desloratadine - Anti Histaminic. 8. Aripiprazole - Anti psychotic. 28. Sumatriptan Succinate - Anti migraine. 9. Pioglitazone - Anti Diabetic. 29. Bicalutamide – Antiandrogen. 10. Carvedilol- Anti-hypertensive. 30. Risperidone – Antipyschotic. 11. Memantine - Anti parkinsoninan; antispasmodic 31. Valacyclovir – Antiviral. 12. Levetiracetam - Anti-epileptic. 32. Atorvastatin Calcium - lipid-lowering agent. 13. Rosiglitazone HCL - Anti-diabetic. 33. Trospium Chloride - Anticholinergic. 14. Colistimethate Sodium – Antibiotic. 34. Mefloquine Hydrochloride - Anti Malarial. 15. Esomeprazole Magnesium - Anti Ulcer. 35. Clopidogrel Hydrogen sulphate - Anti thrabotic. 16. ProPofol - Anesthetic intravenous. 36. Paroxetine - Anti depressant. 17. Nefazadone - Anti depressant. 37. Lamivudine - Anti viral. 18. Melatonin - Control of estrus. 38. Entacapone - Anti-parkinsonian. 19. Alminoprofen - Anti-inflammatory. 39. Pelubiprofen - Anti-inflammatory. 20. Balaglitazone (DRF – 2593). 40. Ragaglitazar (DRF – 2725). National & International Symposiums

Participated in a course on chemical development and scale-up in the fine chemical industry by Dr. TREOVR LAIRD (Scientific Update U.K.)

Participated in Second National Symposium in Chemistry at II CT, Hyderabad

The New International Conference on Developing Chemical Processes for Active Pharmaceutical Ingredients. A two-day Conference & Exhibition at the National Chemical Laboratory in Pune, India, 13-14 December 2006

(Scientific Update U.K.)

Fifth BASF Boron conference Hyderabad, India, 3-4 March 2009.

One day conference on “Green chemistry Environmentally sustainable Manufacturing” 2 March 23, 2011 (AP Pollution control Board (APPCB))

Research Publications

Process Research and Development of Melatonin

C. Prabhakar, N.Vasanth Kumar, M. Ravikanth Reddy, M.R. Sarma and G. Om Reddy. Organic Process Research & Development 1999, 3, 155-160

Synthesis and Biological activity of novel Anti-bacterial Quinolones M R Sarma, N Vasanth Kumar, A S R Prasad, S Eswaraiah, C Prabhakar, G Om Reddy, M Sitaram Kumar, A K Sadhukhan, A Venkateswarlu & K Anji Reddy. Indian Journal of Chemistry. Vol. 40B, 2001, 331-335

Synthesis of some novel ethyl 6-cyano-7-substituted-5-methyl-2-oxo-2H-pyrano [2, 3-b] pyridine-3-carboxylate derivatives. N Vasanth Kumar & Uday C Mashelker. Indian J Chem. 45B, 2006, 1770.

Diasteroselective synthesis of some novel Benzopyranopyridine derivatives. Pradeep K Mohakhud, Sujeet Kumar, N Vasanth Kumar, V. Ravi Kumar, J. Moses Babu, K. Vyas and G Om Reddy, Beilstein Journal of Organic Chemistry 2006, 2:25

Synthesis of novel 1,2,4-oxadiazole heterocyclic compounds contain 2-H-pyranopyridine-2-one moiety and related compounds. N Vasanth Kumar & Uday C Mashelker. Indian Journal of Chemistry, 46B, 2007, 216.

Synthesis of novel 3-substituted derivatives of 2H-pyrano[2,3-b]pyridine-2-one moiety N Vasanth Kumar & Uday C Mashelkar. Journal of Indian Chemical Society, Vol. 84,October 2007, 1048-1051.

Synthesis of new heterocyclic compounds containing 2H-pyrano-[2,3-b]pyridine-2-one moiety N Vasanth Kumar & Uday C Mashelkar, Indian Journal of Heterocyclic Chemistry, Vol. 17, July-Sept., 2007, 99- 100

Synthesis of some novel 1,2,4-triazolo[4,3-a]-2H-pyrano[3,2-e] pyridine derivatives. N Vasanth Kumar & Uday C Mashelkar, Heterocyclic Communications, Vol. 13, No. 4, 2007, 211-214. Patents & Patent Applications

A novel method for the preparation of aryl piperazinyl heterocyclic compounds. Tyagi Om dutt; Srivastava Tushar kumar; Chauhan Yogendra Kumar; Nalam Vasanth Kumar WO 2006/011157 A2.

Preparation of [2-Methyl-5Phenyl-3-(Piperazin-1-yl Methyl)] Pyrrole Derivatives Arora Sudershan Kumar; Sinha Neelima; Jain Sanjay; Upadhayaya Ram Shankar; Tyagi Om Dutt; Nalam Vasanth; Chauhan Yogendra Kumar WO 2006/ 109323 A1.

Preparation of (2-methyl-5-phenyl-3-(piperazin-1-ylmethyl)) pyrrole derivatives Nalam Vasanth; Chauhan yogendra Kumar; Upadhayaya Ram Shankar; Sinha Neelima; Jain Sanjay; Tyagi Om Dutt; Arora Sudershan Kumar AU2006233943

Novel Method for the Preparation of Aryl Piperazinyl-Heterocyclic Compounds Tyagi Om D; Srivastava Tushar k ; Chauhan Yogendra K ; Nalam Vasanth K US2007238877

Improved Process for the preparation of 7-amino-3-alkyl-3-cephem-4-carboxylic acid compounds. Application 961/MUM/2004 published 2007-04-27, filed 2004-09-08

A process for the preparation of novel crystalline form of Ziprasidone base. Application 1118/MUM/2004 published 2007-06-08, filed 2004-10-19

A process for the preparation of novel crystalline form of Ziprasidone Hydrochloride Monohydrate Salt. Application 1119/MUM/2004 published 2007-06-08, filed 2004-10-19.

Improved Process for the manufacture of Ziprasidone. Tyagi Om D; Srivastava Tushar k ; Chauhan Yogendra K ; Nalam Vasanth K, Patil Sadanand Nilkanth. WO2010010566A1.

Personal Vitae

Date of Birth 10th May, 1968

Address Nalam Vasanth Kumar

Villa No 256, APR Pranav Antilia,

Bachupally, Hyderabad- 500090

Telangana, India.

Languages Telugu, Hindi & English

References

1. Dr. V.M. Sharma

Adviser Biological E Ltd

Mobile No: +919*********

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