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Senior Analytical Scientist, Professor, Proteomics, HPLC, Mass Spec.

Location:
Karachi, Sindh, Pakistan
Salary:
6 digit
Posted:
October 12, 2019

Contact this candidate

Resume:

Bushra Amin, Curriculum Vitae

AUGUST **th

, **** 1

CURRICULUM VITAE

Academics:

Post-doctoral Associate

Analytical Chemistry

Department of Chemistry,

Vanderbilt University Nashville, TN, USA

Title: Enhance Multiplexing in Quantitative Proteomics to Understand the Molecular Basis of Aging Process.

Mentor: Prof. Dr. Rena A. S. Robinson

Post-doctoral Associate

Analytical Chemistry

Department of Chemistry,

University of Pittsburgh, Pittsburgh, PA, USA

Title: Enhance Sample Multiplexing Techniques for

Quantitative Proteomics in Alzheimer’s Disease.

Mentor: Prof. Dr. Rena A. S. Robinson

Post-doctorate Fellow

Biochemistry

Chair of Biochemistry, Department of Biology

Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany

Title: Advance Proteomics Techniques to Map Post-

Translational Modifications in Reprogrammed Host-cells induced by Microbial Effectors.

Mentor: Prof. Dr. Uwe Sonnewald

Doctorate (PhD)

Biochemistry

Interfaculty Institute of Biochemistry

University of Tuebingen, Germany

Title: Multiplex Proteomics and Detection of Distinct Post-Translational Modifications in Autoimmunity.

Supervisor: Prof. Dr. Dr. Wolfgang Voelter

Dr. Hubert Kalbacher

Sept. 2017 – Current

April2016 – August 2017

Jan2015-March2016

April2009-Dec2014

Master of Science (M. Sc)

Biochemistry

Department of Biochemistry,

University of Karachi. Pakistan.

Title: Neuropharmacological Effect of Stress on

Learning and Memory in Rats.

Supervisor: Prof. Dr. Darakshan J. Haleem

Prof. Dr. Tahira Perveen

Jan2002-Dec2005

Distinction

Tel: +1-615-***-****

Fax: +1-615-***-****

e-mail: adakl3@r.postjobfree.com

adakl3@r.postjobfree.com

Dr. Bushra Amin

Postdoctoral Associate,

Stevenson Center SC5433, Department of Chemistry,

Vanderbilt University.

Nashville 37235, TN, USA.

Bushra Amin, Curriculum Vitae

AUGUST 20th

, 2019 2

Technical:

Sensitive Detection of Post-Translationally Modified Proteins by High Resolution Mass Spectrometer.

Prof. Dr. Matthias Trost

Programme Leader & Head of Proteomics,

MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Scotland, UK. Advance Proteomics Techniques and Mass Spectrometry. Prof. Dr. Martina M. Deschmann

Institute of Chemical Technology and Analytics

Vienna University of Technology, Austria.

August 17-28, 2015

April 22-25, 2014

Training on ESI-Q-TOF and MALDI-TOF-TOF MS.

Prof. Dr. Syed G. Musharraf

Mass spectrometry Research Unit

H.E.J. Research Institute of Chemistry,

University of Karachi, Pakistan.

Jun 2007-Jul 2008

Modern Mass Spectrometers.

Prof. Dr. David Smith (University of Nebraska, USA) H.E.J. Research Institute of Chemistry,

International Center for Chemical and Biological Sciences, University of Karachi. Pakistan.

Feb 7-29, 2008

Soft Skills:

Mass Spectrometry Software for Proteomics

Evaluation and PTM Identification Software Training Program.

Thermofisher Scientific, Germany.

Mass Spectrometry Software for Proteomics

PEAKS Software Training Program.

Bioinformatics Solution Inc. Milan, Italy.

Diploma in Computer Application and

Programming (DCAP)

Trade Testing Board, Govt. of Sindh. Pakistan.

August 10-14, 2015

June 29-30, 2015

Jan2006-Dec2006

Distinction

Certificate Course in Information Technology (CIT) Skill Development Council, Govt. of Sindh. Pakistan. May2002-Sep2002

Writing Workshops:

Effective Research Writing of NIH Proposals

Grant Writing Workshop. Houston, TX

Write NSF Research Proposals

Grant Writing Workshop, Houston, TX

Professional Grant Writing Workshop

Grantsmanship Center. Los Angeles, CA

February 8th, 2018

February 9th, 2018

December 3rd–7th, 2018

Bushra Amin, Curriculum Vitae

AUGUST 20th

, 2019 3

Research & Teaching Experience:

Guest Lectures

Intensive Mass Spectrometry for graduates

Department of Chemistry,

University of Pittsburgh, PA

Guest Lectures

Mass Spectrometry for Undergraduates

Department of Chemistry,

University of Pittsburgh, PA

Teaching Assistance

Undergraduate Practical Module

Diverse Applications of Mass Spectrometry

Interfaculty Institute of Biochemistry (IFIB),

University of Tuebingen, Germany.

Jan. 20th- 2017

Nov. 8th-10th- 2016

Oct.2012-March2014

Mentoring Assistance

Bachelors and Diploma Research Fellows

Interfaculty Institute of Biochemistry (IFIB),

University of Tuebingen, Germany.

April2010-Dec2014

Research Internship

H.E.J. Research Institute of Chemistry,

ICCBS, University of Karachi.

Title: “Development of Proteomics Techniques for Complex Mixtures like Plasma using ESI-Q-TOF-MS and MALDI-TOF- TOF MS.

Supervisor: Prof. Dr. Syed G. Musharraf

Jun2007-Jul2008

Research Experience:

Research Analyst

Dr. Panjwani Center for Molecular Medicine and Drug Research, ICCBS, University of Karachi.

Title: High-throughput Mass Spectrometric Approaches for the Detection of Breast Cancer Biomarkers.

Supervisor: Prof. Dr. Syed G. Musharraf

April 2008-March2009

Research Internship

H.E.J. Research Institute of Chemistry,

ICCBS, University of Karachi.

Title: “Development of Proteomics Techniques for Complex Mixtures like Plasma using ESI-Q-TOF-MS and MALDI-TOF- TOF MS.

Supervisor: Prof. Dr. Syed G. Musharraf

Jun2007-Jul2008

Funding and Awards:

American Society of Mass Spectrometry Post-Doctoral Career Development Award - 2017. June 2017 – May 2018. Indianapolis, IN.

Funding: $10,000

Title: Combatting the challenges of sample multiplexing for high-resolution mass spectrometry analyses.

Graduate Research Funding: Catholic Academic Foreigners Service (KAAD), October 2010 - Bushra Amin, Curriculum Vitae

AUGUST 20th

, 2019 4

Sept 2012, Bonn, Germany.

Funding: Euro 21,600

Title: Development of a sensitive and reliable clinical assay for the early diagnosis of autoimmune diseases.

Graduate Research and Development Award: German Academic Exchange Serviece (DAAD), July2 013 – Sept 2013, Germany.

Funding: Euro 1,800

Title: Identification of post-translational modifications of proteins in patients with multiple sclerosis using high performance liquid chromatography coupled to mass spectrometry.

Graduate Research Funding by Interfaculty Institute of Biochemistry (IFIB) April 2009 – Dec 2014, University of Tuebingen, Germany.

2nd Place Best Poster Award in Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy (Spectroscopy Society of Pittsburgh). 2017. Pittsburgh, PA.

Best Poster Award in Proteomics Summer School, 2011, South Tirol, Italy.

Research Internship Funding by Government of Sindh, Pakistan for 12 months (June 2007- July 2008).

Best Student Award in M. Sc Biochemistry, University of Karachi, Pakistan (December 2005).

Outstanding Student Award in Computer Application and Programming by Trade Testing Board, Government of Sindh, Pakistan (December 2006).

Dissertation:

Amin B.

Proteomics and Post-Translational Modification Studies in Patients with Multiple Sclerosis. 2014. University of Tubingen, Germany.

https://bibliographie.uni-tuebingen.de/xmlui/handle/10900/58887 Selected Peer-reviewed Publications:

Complete list is available at: https://www.ncbi.nlm.nih.gov/pubmed/?term=bushra+amin Book Chapters:

Amin B, and Voelter W.

Human Deiminases: isoforms, substrate specificities, kinetics, and detection.

© Springer International Publishing AG 2017, Editors: Kinghorn, A.D., Falk, H., Gibbons, S., Kobayashi, J. Progress in the Chemistry of Organic Natural Products, 2017, Volume 106, DOI: 10.1007/978-3-319-59542-9_2

Robinson, A. S., Amin B, Guest, PC.

Multiplexing Biomarker Methods, Proteomics and Considerations for Alzheimer’s disease.

© Springer International Publishing AG 2017, P.C. Guest (ed.), Proteomic Methods in Neuropsychiatric Research, Advances in Experimental Medicine and Biology, DOI: 10.1007/978-3-319-52479-5_2

Just Submitted:

Amin B, Renã AS Robinson. Quantitative proteomics to study aging in rabbit liver. [manuscript submitted]

Amin B, Renã AS Robinson. Dataset of quantitative proteomic analysis to understand aging processes in rabbit liver. [manuscript submitted]

Bushra Amin, Curriculum Vitae

AUGUST 20th

, 2019 5

Amin B, Vishwajit L Nimgaonkar, Renã AS Robinson. Proteomic analysis for the identification of anti-HSV drug targets in iPSC. [manuscript submitted] In Preparation:

Amin B, Renã AS Robinson. Multiplexing quantitative proteomics to study functional relation of aging in rabbit spleen. [manuscript in preparation]

Amin B, Renã AS Robinson. Optimization in cPILOT workflow for enhanced quantification.

[manuscript in preparation]

Peer-Reviewed Articles:

Hansen M, Peltier J, Killy B, Amin B, Bodendorfer B, Härtlova A, Uebel S, Bosmann M, Hofmann J, Büttner C, Ekici AB, Kuttke M, Franzyk H, Foged C, Beer-Hammer S, Schabbauer G, Trost M, Lang R. Macrophage phosphoproteome analysis reveals MINCLE-dependent and - independent mycobacterial cord factor signaling. Mol Cell Proteomics. 2019 Jan 11. pii: mcp.RA118.000929. doi: 10.1074/mcp.RA118.000929. [Epub ahead of print].

Bittel M, Gastiger S, Amin B, Hofmann J, Burkovski A. Surface and extracellular proteome of the emerging pathogen Corynebacterium ulcerans. Proteomes. 2018, 6(2), pii: E18.

Amin B, Andreas Maurer, Wolfgang Voelter, Arthur Melms, Hubert Kalbacher. New potential serum biomarkers in multiple sclerosis identified by proteomic strategies. Curr Med Chem. 2014, 21(13), 1544-56.

Krapp S, Greiner E, Amin B, Sonnewald U, Krenz B. The stress granule component G3BP is a novel interaction partner for the nuclear shuttle proteins of the nanovirus pea necrotic yellow dwarf virus and geminivirus abutilon mosaic virus. Virus Res. 2017, 227, 6-14.

Sonntag E, Milbradt J, Svrlanska A, Strojan H, Häge S, Kraut A, Hesse AM, Amin B, Sonnewald U, Couté Y, Marschall M. Protein kinases responsible for the phosphorylation of the nuclear egress core complex of human cytomegalovirus. J Gen Virol. 2017 Oct;98(10):2569- 2581. doi: 10.1099/jgv.0.000931. Epub 2017 Sep 27.

Steingruber M, Kraut A, Socher E, Sticht H, Reichel A, Stamminger T, Amin B, Couté Y, Hutterer C, Marschall M. Proteomic Interaction Patterns between Human Cyclins, the Cyclin- Dependent Kinase Ortholog pUL97 and Additional Cytomegalovirus Proteins. Viruses. 2016. PMID: 27548200.

Lamm CE, Scherer M, Reuter N, Amin B, Stamminger T, Sonnewald U. Human promyelocytic leukemia protein is targeted to distinct subnuclear domains in plant nuclei and colocalizes with nucleolar constituents in a SUMO-dependent manner. FEBS Open Bio. 2016, 6(11), 1141-1154.

Schäfer W, Eckart R A, Schmid B, Cagköylü H, Hof K, Muller Y, Amin B, Lührmann A. Nuclear trafficking of the anti-apoptotic Coxiella burnetii effector protein AnkG requires binding to p32 and Importin-α1. Cell Microbiol. 2016. PMID: 27328359. Presentations / Meetings Abstracts:

Bushra Amin, Jasmine Daniels, Rena AS Robinson.

Title: Development of novel tags for enhanced sample multiplexing and application of cPILOT to understand aging mechanisms.

45th Annual Conference of National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (NOBCChE), September 17-20, 2018. Orlando, FL.

Albert A Baskar, Bushra Amin, Rena AS Robinson.

Title: Automation of sample preparation steps in a cPILOT quantitative proteomics workflow. 45th Annual Conference of National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (NOBCChE), September 17-20, 2018. Orlando, FL. Bushra Amin, Curriculum Vitae

AUGUST 20th

, 2019 6

Bushra Amin, Lindsay Osentoski, Yaphet Geadion, Rena A.S. Robinson Title: Novel tagging strategies for a modified cPILOT workflow with higher sample multiplexing capabilities.

65th Annual American Society of Mass Spectrometry (ASMS) Conference, June 4-8, 2017. Indianapolis, IN.

Bushra Amin.

Title: Site-specific peptide labeling–Optimized conditions for Isotope-coded labeling (ICPL) reagents.

BioMS Center for Proteomics and Metabolomics Work-in-Progress Seminar, November 16, 2016. University of Pittsburgh, PA.

Anna Großkopf, Alexander Hahn, Florian Full, Doris Jungnickl, Bushra Amin, Elke Bogner, Kevin Brulois, Simone König, Brigitte Scholz, Jae U Jung, Thomas Stamminger and Armin Ensser.

Title: Herpesviral tegument proteins interfering with host cell proteins indicate multiple functions in critical pathways of antiviral defense and stress response that are dependent on ubiquitin and related modifiers. International SFB-796 Conference, Oct 4– 6, 2015, University Clinic Erlangen, Germany.

Bushra Amin, H Kalbacher.

Title: Citrullination, a PTM of small change but large consequences. Research Day at Interfaculty Institute of Biochemistry (IFIB). February 6th-2014. Tuebingen, Germany.

Bushra Amin.

Title: Citrullination and autoimmunity.

Internal Seminar Series, Interfaculty Institute of Biochemistry (IFIB). January 25th- 2013.Tuebingen, Germany.

Bushra Amin.

Title: Specific enrichment of citrullinated peptides from complex biological samples by chemical modification.

11th Annual World Congress, Human Proteome Organization (HUPO), September 10th-2012, Boston, MA.

Bushra Amin, Hubert Kalbacher.

Title: Specific identification of citrullinated proteins in complex biological samples by Mass spectrometry.

11th Annual World Congress, Human Proteome Organization (HUPO), September 09th-13th- 2012, Boston, MA.

Bushra Amin, Hubert Kalbacher.

Title: Identification of candidate disease markers for the early diagnosis of autoimmune diseases utilizing proteomics and post translational modification approaches. 5th European Summer School, July 31st-August 06th-2011, Brixen, South Tirol, Italy.

Bushra Amin, Verena Schultz, Andreas Maurer, Wolfgang Voelter, Hubert Kalbacher. Title: Identification of Candidate Disease Markers for the Early Diagnosis of Autoimmune Diseases Based on Citrullination of Proteins

1st Young Scientist Symposium, Interfaculty Institute of Biochemistry (IFIB), June 4th- 6th-2010. Heinrich-Fabri-Institute, Blaubeuren, University of Tuebingen, Germany.

Bushra Amin, Syed Ghulam Musharraf and Mohammad Iqbal Choudhary. Title: Body Fluid Proteome Mining of Breast Cancer and Healthy Population Utilizing Multi- Dimensional Separation Strategies in Combination with Modern Mass Spectrometry. 2nd International Symposium and Workshop-cum-Training on Molecular Medicine and Drug Research, Jan 12th-15th-2009. International Center for Chemical and Biological Sciences, University of Karachi, Pakistan.

Bushra Amin, Curriculum Vitae

AUGUST 20th

, 2019 7

Dr. Wade-Marion Calcutt

Associate Director

Department of Biochemistry,

Vanderbilt University, Nashville, TN.

Phone: +1-615-***-****

Email: adakl3@r.postjobfree.com

Dr. Hubert Kalbacher

Interfaculty Institute of Biochemistry,

University of Tuebingen, Germany.

Phone: +49-707*-**-*****

Email: adakl3@r.postjobfree.com

Prof. Dr. Dr. Wolfgang Voelter

Interfaculty Institute of Biochemistry,

University of Tuebingen, Germany.

Phone: +49-707*-**-*****

Email: adakl3@r.postjobfree.com



Contact this candidate