RODRIGO FERNANDES DA SILVA

**** ***** ***** *** ***

Houston, Texas, USA 77030

E-mail: acz4a5@r.postjobfree.com

Phone: 281-***-****

ACADEMIC DEGREES

Bachelor of Science, 2004-2009.

Entity: UCA – University of Central Arkansas (USA) Master of Science, Gynecological Pathophysiology/Immunology, 2011-2013. Entity: UNICAMP – University of Campinas (Brazil)

Doctorate of Science, Gynecological Pathophysiology/Immunology, 2014–2017 Entity: UNICAMP – University of Campinas (Brazil)

Exchange PhD program, Department of Pediatrics/Human Immunobiology, 2016- 2017

Entity: Baylor College of Medicine (USA)

SCHOLARSHIP AWARDS

Master Study Scholarship from Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP-2010/17202-7.

Doctorate Study Scholarship from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – CAPES-2014.

Doctorate Study Scholarship from Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP-2014/07401-3.

PRIZES

2015 Prize Ricardo Pasquini, Brazilian Society of Bone Marrow Transplantation. PUBLICATIONS

1.

da Silva RF, Yoshida A, Cardozo DM, Jales RM, Paust S, Derchain S, Guimarães F. Natural killer cells response to IL-2 stimulation is distinct between ascites with the presence or absence of malignant cells in ovarian cancer patients. International Journal of Molecular Sciences 2017. 2. Cardozo DM, Marangon AV, da Silva RF, Aranha FJ, Visentainer JE, Bonon, SH, Costa SC, Miranda EC, de Souza CA, Guimarães F. Synergistic effect of KIR ligands missing and cytomegalovirus reactivation in improving outcomes of haematopoietic stem cell transplantation from HLA-matched sibling donor for treatment of myeloid malignancies. Human Immunology 2016;70:861-8. 3. Yoshida A, Derchain SF, Pitta DR, Crozatti N, Andrade LA, da Silva RF, Sarian LO. Preoperative measurement of serum C-reactive protein: is it useful in the differential diagnosis of adnexal masses? The International Journal of Biological Markers 2016;32:e83-e89.

4. da Silva RF, Petta CA, Derchain SF, Alici E, Guimarães F. Up-regulation of DNAM-1 and NKp30, associated with improvement of NK cells activation after long-term culture of mononuclear cells from patients with ovarian neoplasia. Human Immunology 2014;75:777-784.

5. da Silva RF, Alves PCM, Guimarães F. NK cell-mediated targeting of human ovarian cancer and possibilities for immunotherapy. ARBS. Annual Review of Biomedical Sciences 2011;13:23-29.

CONFERENCE ABSTRACS

1. DA SILVA, RODRIGO FERNANDES; YOSHIDA, A. ; CARDOZO, D. M. ; JALLES, R. M. ; DERCHAIN, SOPHIE FRANÇOISE; GUIMARÃES, FERNANDO. Ascites containing ovarian cancer cells impair NK cells functionality and hinder their activation after IL-2 stimulation. In: ICI 2016 International Congress of Immunology, 2016, Melbourne. ICI 2016 International Congress of Immunology, 2016.

2.

2. CARDOSO, M. R. ; DA SILVA, RODRIGO FERNANDES; GUIMARÃES, FERNANDO; HEINRICH-MUCOUCAH, J. ; BARINI, R. . Experimental evaluation of a gas analyzer in the detection of fetal maternal hemorrhage. In: ICI 2016 International Congress of Immunology, 2016, Melbourne. ICI 2016 International Congress of Immunology, 2016.

3. DA SILVA, RODRIGO FERNANDES; YOSHIDA, A. ; CARDOZO, D. M. ; DERCHAIN, SOPHIE FRANÇOISE; GUIMARÃES, FERNANDO. Ascites from ovarian cancer patients with the presence of cancer cells is a more accurate model for a immune impaired tumor microenvironment. In: INNATE IMMUNITY 2015 XL Congress of the Brazilian Society of Immunology, 2015, Guarujá. INNATE IMMUNITY 2015 XL Congress of the Brazilian Society of Immunology, 2015.

4. CARDOZO, D. M. ; MARANGON, A. V. ; DA SILVA, RODRIGO FERNANDES; ARANHA, J. F. P. ; MIRANDA, E. ; VISENTAINER, J. E. L. ; SOUZA, C. A. ; GUIMARÃES, FERNANDO. Influencia da ausência dos ligantes HLA para os receptores KIR na incidência de DECH agudo no TCPH alogênico, HLA compatível, aparentado e sem depleção de linfócitos T. In: XIX Congresso da Sociedade Brasileira de transplante de Medula Óssea SBTMO, 2015, Foz do Iguaçu. XIX Congresso da Sociedade Brasileira de transplante de Medula Óssea SBTMO, 2015.

5. DA SILVA, RODRIGO FERNANDES; CARDOZO, D. M. ; ALVES, P. C. M. ; DERCHAIN, SOPHIE FRANÇOISE; GUIMARÃES, FERNANDO. NK cells expansion model from PBMC led to a decrease of CD4+ and an increase of CD8+ and CD25+CD127- T-reg lymphocytes in patients with ovarian neoplasia. In: 16th International Conference on Immunology, 2014, Bangkok. 16th International Conference on Immunology, 2014.

6. CARDOZO, D. M. ; MARANGON, A. V. ; DA SILVA, RODRIGO FERNANDES; ARANHA, J. F. P. ; VISENTAINER, J. E. L. ; SOUZA, C. A. ;GUIMARÃES, FERNANDO. Comparison of frequencies and function of Natural Killer cells between donors and patients referred for allogeneic hematopoietic stem cell transplantation. In: Natural Killer Cell Symposium, 2014, Hannover. Natural Killer Cell Symposium, 2014.

7. CARDOZO, D. M. ; MARANGON, A. V. ; DA SILVA, RODRIGO FERNANDES; ARANHA, J. F. P. ; VISENTAINER, J. E. L.; GUIMARÃES, FERNANDO; SOUZA, C. A. . The diversity of KIR genes and the impact of donor-patient KIR/HLA genotypes on the outcome of HLA-identical allogeneic hematopoietic stem cell transplantation on patients with hematological malignancies. In: Natural Killer Cell Symposium, 2014, Hannover. Natural Killer Cell Symposium, 2014. 8. SILVA, R. F.; PETTA, C. A. ; Guimaraes, F. Improvement of NK cells functional activation after long-term IL-2 stimulation in vitro from ovarian neoplasia patients. In: 15th International Congress of Immunology, 2013, Milan. 15th International Congress of Immunology, 2013.

9. DA SILVA, RODRIGO FERNANDES; PETTA, CARLOS ALBERTO ; GUIMARÃES, FERNANDO. Up-regulation of DNAM-1 and NKp30, associated with improved activation of NK cells after long-term culture of mononuclear cells from patients with ovarian neoplasia. In: NK 2013 14th Meeting of the Society for Natural Immunity, 2013, Heidelberg. NK 2013 14th Meeting of the Society for Natural Immunity, 2013.

10. SILVA, R. F.; PETTA, C A ; Guimaraes, F. INNATE ACTIVATION OF NK AND NK-LIKE T LYMPHOCYTES FROM OVARIAN CANCER PATIENTS. In: IMMUNO 2012 XXXVII Congress of the Brazilian Society of Immunology, 2012, Campos do Jordão. IMMUNO 2012 XXXVII Congress of the Brazilian Society of Immunology, 2012.

11. CARDOZO, D. M. ; MARANGON, A. V. ; ARANHA, J. F. P. ; VIGORITTO, A. C. ; GUIMARÃES, FERNANDO; DA SILVA, RODRIGO FERNANDES; VISENTAINER, J. E. L. ; SOUZA, C. A. . Influence of Natural Killer cells alloreactivity on the outcome of allogeneic bone marrow transplant based on genotyping KIR/HLA. In: 38th EBNT annual meeting, 2012, Geneva. 38th EBNT annual meeting, 2012.

12. MARANGON, A. V. ; CARDOZO, D. M. ; CAMPOS, P. M. ; DA SILVA, RODRIGO FERNANDES; ARANHA, J. F. P. ; GUIMARÃES, FERNANDO; SOUZA, C. A. . Avaliação da função das células Natural Killer de doadores de medula no transplante haploidêntico. In: Congresso Brasileiro de Hematologia e Hemoterapia, 2011, São Paulo. Congresso Brasileiro de Hematologia e Hemoterapia, 2011.

LANGUAGES

PORTUGUESE

Level: Advanced

ENGLISH

Level: Advanced

SPANISH

Level: Intermediate

GERMAN

Level: Basic

TECHNIQUES

Cancer immunology researcher with experience mainly in NK cell- based immunotherapy studies with strong flow cytometric knowledge, cell sorting, cell culture, in vitro immuno-assays, mouse models, tumor histology, immunofluorescence and immunohistochemistry. PROFESSIONAL EXPERIENCES

(05/2008 – 08/2008) – UCA Chemistry Department, Arkansas, USA Organic chemistry Lab assistant

Job activities: Grade pre-lab reports, prepare and organize the components for the experiment, help students to understand and finish the experiment.

(08/2007 – 04/2008) – UCA Biology Department, Arkansas, USA Research with medicinal plants

Job activities: Analyze plants with potential antibacterial components, isolate the components, analyze their antibacterial effect on different types of bacteria.

(04/2010 – 12/2010) – UNICAMP/CAISM Women’s

Hospital,Campinas, Brazil

Laboratory Assistant

Job activities: Immunophenotype mononuclear cells from patients with acute myeloid leukemia before bone marrow transplant and after transplant. Maintenance of cell lines K562, OVCAR3 and other freshly isolated ovarian carcinoma cells.

(01/2012 – 02/2012) – Karolinska Institutet/HERM, Stockholm, Sweden

Visiting Researcher Internship

Job activities: Expansion of primary NK cell and flow cytometric analysis of NK cells.

(01/2015 – 05/2015) – Faculty of Medical Sciences/UNICAMP, Campinas, Brazil.

Professor Internship

Job activities: Assist the main lecturer professor with his lecture, grade tests and quizzes. Conduct laboratory classes for first year medical school students.

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