State University Research
Resume:
Diana Cedeno, Ph.D
El Cerrito, CA 94530
*************@*****.***
EXPERTISE
• Analytical Chemistry (HPLC Method development and LCMS), Protein-based Assays in a GxP environment and Organic Chemistry (Synthesis).
EXPERIENCE
Principal Scientist. Integrated Analytical Solutions Berkeley, CA. July-Dec, 2016.
• Work in the development, validation and implementation of bioanalytical and biopharmaceutical test methods in a GxP environment (i.e., GLP, GCP and cGMP) at a contract research organization (CRO).
• Execution of biopharmaceutical analyses such as: analysis of dose formulations and mass verification using LC-MS as well as purity using HCP ELISA and SDS-PAGE. Senior Research Chemist. PTRL West (a division of Evans Analytical Group) Hercules, CA. 2014-2016.
• Study Director in charge of long-term studies for pesticide analysis in plants and animals.
• Responsible for writing reports and interacting with the clients as well as training and managing research assistants.
• Used and qualified a diverse range of analytical methods and derivatization reactions for determination of structure of molecules including radiolabeled compounds in a GLP environment.
• Responsible for the proper operation of mass spectrometers in the Metabolism Group. Postdoctoral Research Associate. Lawrence Berkeley National Laboratory Berkeley, CA. 2013-2014.
• Synthesized new photocathodes composed of polymeric materials, light absorbers and catalysts for energy production.
• Tested the stability of interfacial materials under extreme pH conditions and electrochemical potentials. Research Associate. DSM Biomedical Berkeley, CA. 2012-2013.
• Synthesized novel polymers composed of polyurethane and polysiloxane fragments for contact lens applications.
• Formulation development in support of the ophthalmic materials business projects. Postdoctoral Research Associate. The University of Tennessee Knoxville, TN, 2010-2012.
• Synthesized new organometallic cobalt catalyst for the oxidation of lignin (plant polymer) into value-added chemicals.
• Synthesized a novel catalyst composed of a glycal-based bolaform (noncovalently bound nanoscale polymer) attached to a cobalt catalysts that can potentially deconstruct lignin in vivo. Ph.D. research. The University of Arizona Tucson, AZ, 2007-2010.
• Purified after expression in homologous system the cytochrome bc1 enzyme from Rhodobacter sphaeroides as well as a mutant of cytochrome b.
• Synthesized new quinones to be used as substrate analogs for the cytochrome bc1 complex. Determined the midpoint potentials of synthesized quinones, as well as commercially available quinones.
• Using stopped-flow techniques, developed a new method for determining the kinetic rate of reduction of cytochrome c by the cytochrome bc1 complex from Rhodobacter sphaeroides. Page-2
M.S. research. The University of Arizona Tucson, AZ, 2004-2007.
• Synthesized Fe(II) porphyrins (oxygen-sensitive compounds) using glove box and Schlenck line techniques and characterized them using low temperature 2D NMR (NOESY/EXSY). Undergraduate research, Willamette University, Salem, OR, 2004.
• Grew Eichhornia crassipes in a hydroponic solution to determine lead accumulation in the leaves and roots of the plant using voltammetry measurements.
• Synthesized Pb-S chelated compounds (complexes formed by Pb+2 ions bound to cysteine), to study the mechanisms involved in heavy metal accumulation in Eichhornia crassipes. TA, Chemistry I and Organic. The University of Arizona Tucson, AZ, 2004- 2007.
• Taught 2 lab sections of ~25 students in General Chemistry. Graded examinations for General Chemistry I.
• Taught 2 lab sections of ~15 students in Honors Organic Chemistry. Graded examinations for Organic Chemistry I and II.
• Held tutoring sessions once a week in Organic Chemistry. Lab Technician. White Environmental Consultants, Inc. Anchorage, AK, 2002-2004.
• Determined the concentration of lead in paint, soil and air samples using Flame Atomic Absorption Spectroscopy.
• Determined asbestos fiber concentrations in air samples using Polarized Light Microscopy. EDUCATION
• Ph. D., Chemistry, The University of Arizona, Tucson, AZ, 2010.
• M. S., Chemistry, The University of Arizona, Tucson, AZ, 2007.
• B. A., Chemistry, Willamette University, Salem, OR, 2004. SKILLS
Chemistry and Analytical Chemistry
• Analytical methods: LC-MS (Thermo Scientific Orbitrap Q-exactive; Applied Biosystems/Sciex API 4000 tandem quadrupole), HPLC (Agilent, Dionex and Shimadzu), 1D and 2D NMR (Bruker and Varian; HMQC, NOESY/EXSY), EPR, X-ray, IR, GC-MS, UV/Vis, AA, ICP, XPS and GATR-FTIR.
• Bioanalytical methods: ELISA, enzymatic assays and SDS-PAGE.
• Separation/purification methods: Affinity Chromatography for proteins; preparative TLC and HPLC, flash chromatography, recrystallization, extraction and distillation for small molecules.
• Multi-step synthesis of small organic molecules (small and large scale), organometallic complexes and polyurethane polymers.
• Chemical and enzymatic derivatization of compounds.
• Expertise with homogeneous and heterogeneous catalysis.
• Expertise with oxygen-free synthesis and manipulations (glove-box and schlenk line techniques).
• Electrochemical methods: Cyclic Voltammetry, Spectroelectrochemistry in aqueous media and organic solvents, Linear Sweep Voltammetry, Photoelectrochemistry. Page-3
Software
• Laura, Chemstation and Analyst for HPLC; ClassVP and Xcalibur for LCMS; ChemDraw, MestRenova for NMR, SoftMax Pro for Plate reader; Microsoft Word, Excel and Power Point. HONORS AND AWARDS
• The Carl Storm Underrepresented Minority (URM) Fellowship, 2009, GRS.
• Gates Millenium Scholar, funded by the Bill and Melinda Gates Foundation, 2000. PROFESSIONAL AFFILIATIONS
• Member, American Chemical Society, Division of Organic Chemistry, 2008 PUBLICATIONS
• “Hybrid Photocathodes for Solar Fuel Production: Coupling Molecular Fuel-Production Catalysts with Solid- State Light Harvesting and Conversion Technologies.” Cedeno, D.; Krawicz, A.; Moore, G. F., Interface focus, 2015, 5, 20140085.
• “Using Molecular Design to Control the Performance of Hydrogen-Producing Polymer-Brush-Modified Photocathodes.” Cedeno, D.; Krawicz, A.; Doak, P.; Yu, M.; Neaton, J.; Moore, G.; J. Phys Chem. Lett. 2014, 5, 3222-3226.
• “Energetics and Efficiency Analysis of a Cobaloxime-Modified Semiconductor Under Simulated Air Mass 1.5 Illumination.” Krawicz, A.; Cedeno D.; Moore, G. F.; Phys. Chem. Chem. Phys. 2014, 16, 158**-*****.
• “The Effect of Axial Ligand on the Oxidation of Syringyl Alcohol by Cobalt-Salen Adducts.” Elder, T. J., Bozell J. J., Cedeno, D. Phys. Chem. Chem. Phys. 2013, 15, 7328.
• “Catalytic Oxidation of para-Substituted Phenols by a Cobalt-Schiff Base Complex/O2-Selective Conversion of Syringyl and Guaiacyl Lignin Models to Benzoquinones.” Cedeno, D.; Bozell, J. J. Tetrahedron Lett. 2012, 53, 2380.
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REFERENCES
Dr. Thomas Fleischmann, Ph.D.
Director of Metabolism
PTRL West – Evans Analytical Group
625-B Alfred Nobel Drive,
Hercules, CA 94547
Phone: 510-***-****
Email: ************@********.***
Dr. Gary F. Moore
Assistant Professor
Department of Chemistry and Biochemistry
Arizona State University
Tempe, AZ 85287-1604
Phone: 480-***-****
Email: ****.*.*****@***.***
Dr. Joseph J. Bozell
Center for Renewable Carbon
The University of Tennessee
2506 Jacob Drive
Knoxville, TN
Phone: 865-***-****
Email: *******@***.***
Professor F. Ann Walker
Department of Chemistry & Biology
P. O. Bo 210041
The University of Arizona
Tucson, AZ 85721
Email: *******@*****.*******.***
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