Research Scientist

Claire da Silva Santos

**** ******** **** ***, *********, PA 18104

Cell: 484-***-****; Email: *******@*******.***

PROFESSIONAL PROFILE

A committed and motivated Researcher Scientist highly organized, self-motivated, having excellent multi-tasking and interpersonal communication skills and interdisciplinary science knowledge, with a strong focus on Infection Diseases, Immunology and Cellular Biology.

SKILL

•Design, perform and implement experiments

•Work independently and manage multiple experiments

•Compile, analyze and interpret data

•Prepare scientific publication

•Perform different cell culture and cell based viral and retroviral assays

•Clear and professional verbal and write communication

WORK EXPERIENCE

09/2014 to 08/2016 Postdoctoral Research

International Center for Infectious Disease Research, Lyon, France

Advisor: Andrea Cimarelli

Identification of novel cellular restriction factors involved in the different susceptibility of primate lentiviruses to Type I IFN.

•Screening over 400 interferon-stimulated genes to identify and characterize novel cellular proteins involved in the HIV life cycle.

•Development a novel entry/uncoating assay for HIV-1 that is based on the direct translation of a viral genomic RNA mimic bearing a luciferase reporter.

04/2014 to 08/2014 Professors

Federal University of Bahia, Salvador, Brazil

Professor in charge of the classroom planning for theoretical and practical teaching of the discipline Histology for the graduation course on Pharmacy and Nutrition

08/2009 to 12/2013 PhD Fellows

Federal University of Bahia, Salvador, Brazil

Advisor: Claudia Brodskyn

•Evaluate the role of T lymphocytes in the modulation of the mechanisms associated with the tissue damage in cutaneous leishmaniasis patients

•Designed and directed experiments using multiple lab techniques such as flow cytometric, immunohistochemistry and in vitro assays to study the role of CD8 and CD4 T cells obtained from the blood and skin tissues from cutaneous leishmaniasis patients.

02/2013 to 07/2013 PhD Fellowships

Karolinska Institute, Stockholm, Sweden

Advisor: Serhiy Souchelnytskyi

•Use of proteomics approach to identify proteins differentially expressed in biopsies from cutaneous leishmaniasis patients

•Use biological network analysis to evaluate the potential biological processes and components present in the proteins identified

ACADEMIC QUALIFICATION

December 2013 PhD. Immunology/ Experimental Pathology / Infection Diseases

Federal University of Bahia, Salvador, Brazil

Thesis: The role of CD8 T cells in the modulating of the immune response in

biopsy from cutaneous leishmaniasis patients infected by Leishmania braziliensis.

July 2009 Master: Immunology/Experimental Pathology/ Infection Diseases

Federal University of Bahia, Salvador, Brazil

Dissertation: Evaluate the role of T lymphocytes in cutaneous leishmaniasis patients infected by Leishmania braziliensis.

August 2006 Graduate Degree: Pharmacy

Federal University of Bahia, Salvador, Brazil

LANGUAGES

Portuguese (mother Tongue), Fluent in English and French

PUBLISHED ARTICLES

Da Silva Santos C, Tartour T, Cimarelli A. Novel Entry/Uncoating Assay Based on Core- Packaged RNA Availability and translation Indicates that at Least Two species of Capsid are Present During Synchronized HIV-1 Infection. Plos Pathogen-2016 Sep 30;12(9):e1005897. doi: 10.1371/journal.ppat.1005897

França-Costa J, Andrade BB, Khouri R, Van Weyenbergh J, Malta-Santos H, da Silva Santos C, Brodyskn CI, Costa JM, Barral A, Bozza PT, Boaventura V, Borges VM. Differential Expression of the Eicosanoid Pathway in Patients With Localized or Mucosal Cutaneous Leishmaniasis. J Infect Dis. 2015 Nov 17.

Da Silva Santos C, Attarha S, Saini RK, Boaventura V, Costa J, Khouri R, Barral-Netto M, Brodskyn CI, Souchelnytskyi S. Proteome profiling of human cutaneous leishmaniasis lesion. J Invest Dermatol. 2015 Feb; 135(2):400-10. doi: 10.1038/jid.2014.396.

Saini RK, Attarha S, Da Silva Santos C, Kolakowska J, Funa K, Souchelnytskyi S. Proteomics of dedifferentiation of SK-N-BE2 neuroblastoma cells. Biochem Biophys Res Commun. 2014 Nov 7;454(1):202-9. doi: 10.1016/j.bbrc.2014.10.065

Da Silva Santos C, Brodskyn CI. The Role of CD4 and CD8 T Cells in Human Cutaneous Leishmaniasis. Front Public Health. 2014 Sep 29;2:165. doi: 10.3389/fpubh.2014.00165

Santos Cda S, Boaventura V, Ribeiro Cardoso C, Tavares N, Lordelo MJ, Noronha A, Costa J, Borges VM, de Oliveira CI, Van Weyenbergh J2, Barral A, Barral-Netto M, Brodskyn CI.. CD8+ Granzyme B+ T cells-mediated tissue injury versus CD4+IFNγ+ T cells-mediated parasite killing in human cutaneous leishmaniasis. J Invest Dermatol. 2013 Jun;133(6):1533-40. doi: 10.1038/jid.2013.4

Boaventura VS, Santos CS, Cardoso CR, de Andrade J, Dos Santos WL, Clarêncio J, Silva JS, Borges VM, Barral-Netto M, Brodskyn CI, Barral A. Human mucosal leishmaniasis: Neutrophils infiltrate areas of tissue damage that express high levels of Th17-related cytokines. Eur J Immunol. 2010 Oct;40(10):2830-6. doi: 10.1002/eji.200940115

Campanelli AP, Brodskyn CI, Boaventura V, Silva C, Roselino AM, Costa J, Saldanha AC, de Freitas LA, de Oliveira CI, Barral-Netto M, Silva JS, Barral A. Chemokines and chemokine receptors coodinate the inflammatory immune response in human cutaneous leishmanaises. Hum Immunol. 2010 Dec; 71(12):1220-7. doi: 10.1016/j.humimm.2010.09.002

Rodrigues CA, Batista LF, Filho RS, Santos Cda S, Pinheiro CG, Almeida TF, Freitas LA, Veras PS. IFN-γ expression is up-regulated by peripheral blood mononuclear cells (PBMC) from non-exposed dogs upon Leishmania chagasi promastigote stimulation in vitro. Vet Immunol Immunopathol. 2009 Feb 15;127(3-4):382-8. doi: 10.1016/j.vetimm.2008.10.324

Gomes R1, Teixeira C, Teixeira MJ, Oliveira F, Menezes MJ, Silva C, de Oliveira CI, Miranda JC, Elnaiem DE, Kamhawi S, Valenzuela JG, Brodskyn CI. Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model. PNAS. 2008 Jun 3;105(22):7845-50. doi: 10.1073/pnas.071*******.

Teixeira CR1, Teixeira MJ, Gomes RB, Santos CS, Andrade BB, Raffaele-Netto I, Silva JS, Guglielmotti A, Miranda JC, Barral A, Brodskyn C, Barral-Netto M. Saliva from Lutzomyia longipalpis Induces CC Chemokine Ligand 2/Monocyte Chemoattractant Protein-1 Expression and Macrophage Recruitment. J Immunol. 2005 Dec 15;175(12):8346-53.

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