*

Shirley Samuel, M.Sc., M.S., Ph.D.

847-***-****

acxvst@r.postjobfree.com

Experienced professional with training in basic science and clinical research seeking medical writing opportunities. Published in peer-reviewed journals as both first author and co-author. Technically proficient in MS Word, PowerPoint, Excel, GraphPad Prism and EndNote, as well as writing, editing, proofreading peer-reviewed journal articles, manuscripts, protocols, grants, posters, scientific presentations (local and international) and abstracts. EDUCATION

2002 – 2007 Baylor University, Dallas, Texas

Ph.D.: Biomedical Studies (Cancer Immunology)

2002 – 2005 Baylor University, Dallas, Texas

Master of Science: Biomedical Studies

1998 – 1999 University of Nottingham, Nottingham, United Kingdom Master of Science: Immunology and Allergy

1995 – 1998 Madras University, Chennai, India

Bachelor of Science: Microbiology

RESEARCH / WORK EXPERIENCE

2014- present Clinical Research Coordinator, Northwestern Medicine Chicago Proton Center, Warrenville, Illinois

Managing all aspects of Phase 1, 2 and 3 Oncology clinical trials in strict compliance with study protocols, Central DuPage Hospital policies as well as State and Federal regulations. Supporting the team in literature reviews, creating and reviewing presentations, abstracts, posters, presentations and manuscripts. Supporting and collaborating with Data Management, Dosimetry and Regulatory Affairs to ensure the effective conduct of protocols. Participating in the review of all supporting documents for clinical studies. Assisting investigators and other site personnel regarding clinical and study conduct questions to help ensure patient safety while maintaining proper adherence to the protocol. Participating in the review of SAE reports, safety and efficacy data, morbidity and mortality data.

2011 - 2013 Clinical Research Fellow, Feinberg School of Medicine, Northwestern University, Chicago, Illinois

Participated in the conception, design, execution, analyses and interpretation of clinical research projects to improve quality and efficiency of clinical care, prepared documentation for IRB approval, database management (REDCap, DataTrak, MS Access) including validations and edits, ensured project was administered according to research protocol, gathered data and conducted literature searches, served as project liaison to other departments, assisted in submitting grant proposals, presentations and reports using MS Word, Excel, PowerPoint and GraphPad Prism, supervised staff by orienting, training and giving them ongoing performance feedback, assisted PI in judging test data validity. Developed outlines, presentations, meeting reports, clinical summaries for internal and external communication. Completed all activities by strictly following Good Clinical Practices and relevant current local, state and federal laws, regulations, guidance, policies and procedures developed by the IRB, FDA, Code of Federal Regulations and the International Conference on Harmonization. 2

2008 - 2011 Post-doctoral Fellow, Feinberg School of Medicine and McCormick School of Engineering, Northwestern University, Evanston, Illinois Involved in the development of novel biomolecules to activate the Toll-like Receptor 3, a potent regulator of immunity. Investigated the molecular mechanisms of breast and prostate cancer bone metastasis. Conducted experiments in vitro and in vivo, proactively reviewed and interpreted pertinent and emerging scientific literature. First-authored and co-authored peer-reviewed journal articles and presentations for both local and international conferences, adjudicated reviewer comments with co-authors, assisted PI in grant-writing and preparation of figures for grant submission. Extensively used MS Word, Excel, PowerPoint, GraphPad Prism and EndNote. 2010 - 2011 NU INVO Intern at Innovation and New Ventures (Patent) Office, Northwestern University, Evanston, Illinois

Assisted in analysis of documentation for patent submission. Used MS Word and Excel. 2003 - 2007 Graduate student, Charles A. Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas

Validated the molecular integrity and biological activities of oncolytic adenoviruses, examined the contribution of oncogene knockdown by RNA interference towards the anti-tumor effect in vitro. Validated the anti-tumor activity of armed oncolytic viral vectors in vivo and elucidated the underlying molecular events contributing to the enhanced anti-cancer outcome. Conducted experiments in vitro and in vivo, proactively reviewed and interpreted pertinent and emerging scientific literature. First-authored and co-authored peer-reviewed journal articles, posters, abstracts and presentations, adjudicated reviewer comments with co-authors, assisted PI in grant- writing and preparation of figures for grant submission. Extensively used MS Word, Excel, PowerPoint, GraphPad Prism and EndNote.

2000 - 2002 Scientific Assistant, Department of Obstetrics and Gynecology, Faculty of Medicine, Kuwait University, Kuwait

Investigated the immunomodulation of spermatozoal function by trace elements namely, zinc, copper, cadmium and selenium, as well as macro-elements such as magnesium and calcium. Conducted experiments in vitro and in vivo, proactively reviewed and interpreted pertinent and emerging scientific literature. Co-authored peer-reviewed article, posters and presentations using MS Word, Excel and PowerPoint.

1998 - 1999 Graduate student, Division of Molecular and Clinical Immunology, School of Clinical Laboratory Sciences, University of Nottingham, Nottingham, UK Mapping the epitope specificity of an anti-idiotypic antibody recognizing a mouse monoclonal anti- Der p 1 with similar epitope specificity to human IgE. Conducted experiments in vitro. Assisted PI in grant-writing using MS Word, Excel and PowerPoint. TEACHING EXPERIENCE

2003 - 2004 Graduate Teaching Assistant, Department of Biology, Baylor University, Waco, Texas. RESEARCH PUBLICATIONS

Samuel-Abraham S and Leonard JN. Staying on message: design principles for controlling nonspecific responses to siRNA. FEBS J. 2010; 277(23): 4828-36. Kai L*, Samuel SK* and Levenson AS. Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1/NuRD complex. International Journal of Cancer 2010; 126(7): 1538-48.

* joint first authors

3

Samuel SK and Tong AW. RNA interference: Applications and relevance in experimental therapy against Ras and Ras-related pathways in human cancer. Cell Science Reviews 2007; 4(1). Zhang Y-A, Nemunaitis J, Samuel SK, Chen P, Shen Y and Tong AW. Antitumor activity of an oncolytic adenovirus-delivered oncogene small interfering RNA. Cancer Research 2006; 66(19): 9736-43. Omu AE, Al-Azemi MK, Fatinikun T, Nirmala ASM, Samuel SK and George S. Delay in sperm capacitation by magnesium and interleukin-4. Trace Elements and Electrolytes 2003; 20(3): 181-6. Abstract publications:

Samuel SK, Kai L and Levenson AS. A novel epigenetic mechanism of resveratrol: Reversal of metastasis-associated protein 1-mediated deacetylation of p53 in prostate cancer. The Journal of Urology 2009; 181 (4): 515.

Tong AW, Zhang Y-A, Samuel SK, Chen P, Shen Y and Nemunaitis J. Target-specific knockdown and enhanced anti-tumor outcome by an oncolytic virus-delivered small interfering RNA (siRNA). Molecular Therapy 2006; 13 (1): S118-9.

RESEARCH PRESENTATIONS

Oral presentations:

Samuel SK, Zhang Y-A, Chen P, Shen Y, Nemunaitis J and Tong AW. Enhanced anti-tumor activity of a novel oncolytic adenovirus-siRNA construct.15th International Conference on Gene Therapy of Cancer, Dallas, Texas, 2007.

Samuel SK, Chen P, Zhang Y-A, Nemunaitis J and Tong AW. Delivery of oncogene-reactive small interfering RNA (siRNA) by an oncolytic adenovirus produced additive antitumor effects through modulation of gene expression. Interdisciplinary Scholarship Forum, Baylor University, Waco, Texas, 2006.

Samuel SK, Chen P, Zhang Y-A, Nemunaitis J and Tong AW. Construction of a novel oncolytic adenovirus armed with a silencing-RNA sequence with K-ras oncogene knockdown activities. 5th Annual Student Research Symposium, Baylor University, Waco, Texas, 2004. Poster presentations:

Chuang Y, Daringer N, Samuel-Abraham S, Hataway N, Leites C and Leonard JN. Engineering immunity. IBIS Scientific Retreat, Lake Geneva, Wisconsin, 2009. Kai L, Samuel SK and Levenson AS. Metastasis-associated protein 1 (MTA1) as a molecular target of resveratrol in prostate cancer. 18th International Symposium of the Journal of Steroid Biochemistry and Molecular Biology, Seefeld, Tyrol, Austria, 2008.

Tong AW, Zhang Y-A, Samuel SK, Chen P, Shen Y and Nemunaitis J. Cancer cytotoxic activity of an oncolytic adenovirus-K-ras small interfering (siRNA) construct. 14th International Conference on Gene Therapy of Cancer, Dallas, Texas, 2006.

Zhang Y-A, Samuel SK, Chen P, Shen Y, Nemunaitis J and Tong AW. Arming with a K-ras oncogene- reactive siRNA enhanced antitumor efficacy of ONYX-411, a selective replicative oncolytic adenovirus. 13th International Conference on Gene Therapy of Cancer, San Diego, California, 2005. 4

Zhang Y-A, Nemunaitis J, Cunningham C, Senzer N, Samuel SK, Chen P and Tong AW. Growth suppression of human non-small cell lung cancer cells by small interfering RNA (siRNA) with mutant K- ras knockdown activity. 12th International Conference on Gene Therapy of Cancer, San Diego, California, 2003.

AWARDS AND RECOGNITIONS

2009 IBiS Post-doctoral Travel award

2006 Graduate Student Association award, Baylor University to present at the Interdisciplinary Scholarship Forum

1997 Topper in Immunology and Molecular Biology during undergraduate program. MEMBERSHIPS

2008 – present The Science Advisory Board

1998 – 2000 British Society of Immunology

PATENTS

“Anti-tumor activity of an oncolytic adenovirus-delivered oncogene siRNA”. Inventors: AW Tong, Y-A Zhang, J Neumanitis, Y Shen, SK Samuel and P Chen. November 8, 2007. United States Patent 200********.

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