Bogdan Draghici Ph. D.

Siemens Healthcare Diagnostics

*** *** *****

Newark, DE 19702

acxs52@r.postjobfree.com

acxs52@r.postjobfree.com

*** ******** ******** ***** *** D.

Phone: (267) 650 - 4395

US Green card holder

PRESENT POSITION: Biochemist III

OBJECTIVE: Senior scientist in a major pharmaceutical/biotech company.

RESEARCH EMPHASIS:

Opiate-G6PDH bioconjugates, ADCs, protein purification, conjugates characterization;

Organic synthesis, microwave assisted synthesis, peptide synthesis, biodegradable amphiphiles (Gemini surfactants, lipids, dendrimers), bioconjugates;

Structure characterization NMR, IR, UV-VIS, HPLC-MS, SFC-MS, MALDI;

Synthesis and reactivity studies of small heterocycles: 1,2,4-oxadiazoles, acridines, benzotriazole, imidazoles, triazoles, benzotriazoles, tacries, tetrazoles.

Formulation of small amphiphiles for drug / gene delivery;

Structure elucidation by 2D NMR, (1H 1H COSY, 1H 1H NOESY, 1H 13C gHMQC, 1H 13C gHMBC, 1H 15N CIGAR) – VARIAN (AGILENT) and BRUKER;

Analytical method development, LC purification (ISCO Combiflash Rf, Grace Reveleris, Gilson GX-281, puriFlash 450), protein characterization (HPLC waters, MALDI-TOF).

RESEARCH EXPERIENCE:

Biochemist III, Siemens Healthcare Diagnostics

2015-present

Prepared/purified several libraries of opiate-G6PDH conjugates to support the EMIT project

Prepared opiates-immunogens for antibody developing group.

Prepared documentation for protocol transfer to manufacturing department.

Post-doctoral Fellow, Temple University, School of Pharmacy,

2013 -2015

Designed, synthesized and characterized small heterocyclic amphiphiles as carbonic anhydrase activators with nanomolar potency against hCA VA and hCA VII;

Mentored two graduate students – organic synthesis, LC purification and NMR characterization

Prepared and formulated two series of cationic lipids and biodegradable Gemini surfactants, investigated the transfection efficiency and stability of these molecules including pre-formulation.

Principal investigator: Professor Marc A. Ilies

Post-doctoral Fellow, University of Pennsylvania, Department of Chemistry,

2011-2012

Synthesized, formulated bio-degradable amphiphilic Janus dendrimers for drug delivery applications;

Investigated the supramolecular self-assembly properties of Janus dendrimers and their aqueous formulation (DLS, CryoTEM, confocal microscopy), and SAR.

Principal Investigator: Professor Virgil Percec.

Graduate researcher, University of Florida, Department of Chemistry,

2007-2011

Designed and prepared small conjugates via microwave irradiation using benzotriazole mediated peptide coupling methodology;

Investigated heterocyclic rearrangements of 1,2,4-Oxadiazoles

Assigned and characterized complex heterocyclic systems by 2D NMR, investigated the azole tautomerism in solution by CIGAR;

Performed NMR training for new group members, instrument maintenance.

Principal Investigator: Professor Alan R. Katritzky.

Teaching Assistant for Undergraduate Organic Laboratory Coordinator Dr. Tammy Davidson

Undergraduate researcher, “C.D. Nenitzescu” Institute of Organic Chemistry of the Romanian Academy,

2004-2007

Synthesis of tetrahydroacridine derivatives as Acetylcholinesterase inhibitors for Alzheimer's disease.

NMR characterization of 5 and 6 membered ring heterocyclic systems

Principal Investigator: Professor Florea Dumitrascu.

EDUCATION:

Ph. D. Chemistry, University of Florida, Department of Chemistry,

2007-2011

Thesis: “NMR and Synthetic studies of Heterocycles”

Mentor: Professor Alan R. Katritzky

B.S. Chemistry, POLITEHNICA University of Bucharest, Romania Department of Applied Chemistry and Material Science,

2001-2006

Thesis: “Tacrine derivatives used in neurodegenerative diseases”

Mentor: Professor Florea Dumitrascu

EDITORIAL ACTIVITY: Reviewer for Organic & Biomolecular Chemistry, Nanoscale, Polymer Chemistry, RSCAdvances (Royal Society of Chemistry, UK). Grant reviewer for CRDF Global

PUBLICATIONS: 31 scientific papers published in peer-reviewed journals, 1 submitted, 2 in preparation

KEYWORDS: bioconjugates, opiate-conjugates, protein/conjugate purification, hapten synthesis, analytical chemistry, medicinal chemistry, heterocycles, LC-MS, NMR, UV, DLS, HPLC, FT-IR, SAR, MALDI-TOF, NMR instructor, surfactants, scale-up reactions, microfluidic formulations, preparative HPLC.

WEBSITE: https://scholar.google.com/citations?hl=en&user=zFwWo9YAAAAJ

REFERENCES:

Dr. Marc A. Ilies, Temple University https://pharmacy.temple.edu/about/school-pharmacy-directory/marc-ilies Phone: 215-***-****; Email: acxs52@r.postjobfree.com;

Dr. Ronald K. Castellano, University of Florida, http://www.chem.ufl.edu/~castellano/ Phone: 352-***-**** Fax: 352-***-****; E-mail: acxs52@r.postjobfree.com;

Dr. Dennis C. Hall, University of Florida, Lab: 352-***-****, Mobile: 352-***-****; Email: acxs52@r.postjobfree.com; (continuator of late Katritzky A. R.)

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