Resume

Scientist

Location:

Houston, TX

Salary:

100,000

Posted:

August 20, 2016

Contact this candidate

Resume:

Andrey A. Bednov, Ph.D.

**** **** ******, *******, ***** 77074

409-***-**** ● acv9dn@r.postjobfree.com ● acv9dn@r.postjobfree.com

SUMMARY: Biophysicist experienced in physiology (human placenta), biomedical engineering and imaging, DoE, cellular biology, biochemistry

Core Competencies: Independent research, SOPs, standard lab techniques, animal study/surgery (mice, rats, gerbils, rabbits, turtles, frogs); histology. Electrophysiology. Microscopy (electron, confocal, fluorescent, laser-Doppler). Data management and analysis. Interpersonal scientific and technical communication.

EDUCATION:

Philosophy Doctor in Biophysics; Saratov State University (SSU), Saratov, Russia (2006).

Master of Science in Physiology and Biophysics; UTMB, Galveston, TX (2003);

Master of Science in Physics; SSU, Saratov, Russia (1992).

Bachelor of Science in Physics/Optics; SSU, Saratov, Russia (1990).

EMPLOYMENT:

2012 – present: Staff Scientist, OB/GYN, Baylor College of Medicine, Texas Medical Center, Houston, TX

(Placental and vascular physiology research, placental double perfusion system, pressurized vessel system; project management, biomedical engineering.)

2008 – 2011: Post Doctoral Fellow, University of Texas, MB, Galveston, TX

(Validated and standardized various diagnostic methods used in scientific research. Lab management, project management, DoE, QC activities data processing & management.)

2007 – 2008: Research Associate III, University of Texas MB, Galveston, TX

(Planned and conducted brain electrophysiological experiments.)

2005 – 2007: Research Associate II, University of Texas MB, Galveston, TX

(Designed and adapted video oculography technique to the research project. Standard lab technique. Review and statistical analysis of data using custom-made and standard software (MS Excel, SPSS). Project management, DoE.)

2003 – 2005: Research Assistant II, University of Texas MB, Galveston, TX

(UTMB-NASA/JSC research project. Scanning electron microscopy. Project management, DoE. Data processing & management. Technical writing.)

1999 – 2003: Graduate Research Assistant, University of Texas MB, Galveston, TX

(Developed a prototype of imaging system based on time-resolved optoacoustic approach. Optoacoustic monitoring of optical properties of multilayered absorbing and scattering media. Development of bio-physical models. Market analysis.)

1998-1999: Visiting Scientist, University of Pennsylvania, Philadelphia, PA

(Adapted dynamic light scattering approach to study optical properties of scattering polydisperse media. Designed corresponding biophysical models. Computerized statistical analysis (MathCAD)).

1992– 1998: Research Scientist II, Russian Academy of Sciences, Precise Mechanics and Control Institute, Saratov, Russia

(Developed and modified Laser Doppler method to study dynamics of biological fluids. Adapted speckle-interferometry for quality control of surface treatment in industry. Strategic analysis.)

LAB EXPERIENCE:

Certifications

Standard Biological Lab Techniques

Protein techniques

Good Laboratory Practices Program Training

Basic Principles of GLP

AALAS Learning Library – Euthanasia of Research Animal: AVMA Guidelines

AALAS Learning Library – Pain Recognition and Alleviation in Laboratory Animals

Basic Mice Handling and Techniques

Basic Rabbit Handling and Techniques

Rabbit Gavage and Ear Arterial Catheters

Drew Scientific – Routine Operator Training Checklist – Lysis

Society of Quality Assurance: Basic Training: Good Laboratory Practices

Society of Quality Assurance: Selected Topics in Bioanalytical Auditing

Society of Quality Assurance: Laboratory Controls in the GMP/GLP Environment

Laboratory Biosafety Level 2 Training Program

Laboratory Biosafety Level 3 Training Program

Equipment Validation

Molecular/Cellular Biology techniques

Cell Culture

Protein purification

PCR

Immunocytochemistry

ELISA

Immunohistochemistry

Western blotting

Electrophysiology

PAGE

Neurophysiology

Agarose colony formation assay

Flow Cytometry

Study of blood and lymph microcirculation (Laser-Doppler Microscopy)

Study of erythrocyte morphology (Confocal and Scanning Electron Microscopy)

Animal Techniques

Head surgery (mice, gerbils)

Live brain preparation, sectioning (turtles)

Immunization

Drug Administration: subcutaneous, intraperitoneal, intravenous, oral gavages

Breeding (mice)

Study of vestibuloocular reflex; mice (Video Oculography)

Monitoring of glucose levels in bio tissues in vivo (blood, sclera, skin) in live rabbits (Laser Optoacoustics)

Measurement of skeletal muscle strength (mice)

WORKING EXPERIENCE:

Development and optimization of the ex vivo human placenta dual perfusion system for the study of placental vascular physiology and transplacental drug transfer. Development of a biophysical model for dual perfusion of a singular placental cotyledon. Complex evaluation of the perfusion aspects at multiple levels: from physiological to molecular. Evaluation of the vascular reactivity of placenta to the vasoactive agents. Quantitative analysis of the transplacental drug transfer using a placenta dual perfusion system.

Design and development of experimental setup to study the adhesive force of biopatches cold-welded to biological tissue as part of the departmental research program in human fetoscopic surgery for the treatment of spina bifida.

Building a simulation model of the human uterus for fetoscopic surgery simulation and training.

Study of vascular physiology of singular omental and chorionic placental vessels at the pressurized and “flow-through” perfusion modes using Pressure Servo System.

Study of vestibular organs in turtles, frogs and gerbils using electrophysiological methods and vestibuloocular reflex technique, neurophysiology and brain sectioning.

Experimental ocular Myasthenia Gravis (MG) project: mice immunization with AChR followed by the study of MG pathogenesis. Vestibuloocular reflex study in mice using video oculography to evaluate the severity of MG development; mouse head surgery.

Evaluation of localization of immunoglobulins and complement factors in the muscle tissue of transgenic mice by immunofluorescence microscopy. Study the abnormalities in the morphology of both the postsynaptic cleft membrane and neural muscular junctions using transmission electron microscopy.

The study of glucose- and mannitol- induced changes in the morphology of red blood cells caused by the hyperosmotic conditions using scanning electron microscopy. Antibody monitoring (ELISA, radioimmunoassays) in mice with ocular MG. Development of a specific therapy for effective MG treatment.

Study of Epstein-Barr virus (EBV) re-activation in astronauts after landing: stimulation of EBV gene expression in EBV-positive cell lines followed by antibody analysis using immunofluorescence methods; testing of clinical trial samples; cell lines handling; analysis of three-dimensional cell cultures affected by EBV using scanning electron microscopy; histological study.

Development of a combined laser optoacoustics and fluorescence method for colon cancer diagnostics. Optoacoustic study of physiological, biochemical and physical aspects of glucose interaction with biological tissue (collagenous tissue, blood) in vitro and in vivo; monitoring of tissue optical properties at various conditions as a function of glucose concentration; tissue sample preparation; animal study (rabbits).

Study of optical properties of skin burns for precise measurement of burn depth using dynamic light scattering; development of biophysical model of skin burns; experiments with tissue and tissue phantoms. Computerized statistical analysis of auto- and cross-correlation functions of scattered intensity to distinguish between dead and live skin layers (MS Access, Mathcad).

Development of hydrogel-based glucose sensor; application of optical coherence tomography in precise measurements of a hydrogel thickness as a function of glucose concentration.

Study of blood and lymph flow dynamics in vivo using laser Doppler method. Calculation of statistical momenta of the 2nd (correlation functions) and 4th (regression) orders of scattered light intensity for the qualitative and quantitative characterization of dynamic parameters of blood and lymph microcirculation (Mathcad, MS Excel). Animal study (white rats; mice).

RELEVANT EXPERIENCE:

Department of Space Medicine, Johnson Space Center (Houston, Texas) within the framework of the NASA-UTMB project: “Study of the EB virus re-activation in astronauts”.

TEACHING RESPONSIBILITIES:

“Placenta Vascular Physiology” and “Human placenta dual perfusion system” courses for undergraduate students, OB&GYN, Baylor College of Medicine (2014-present).

“Speckle-Interferometry” short courses and seminars for undergraduate students, Laboratory of Laser Diagnostics of Technical and Living Systems, Precise Mechanics and Control Institute RAS, Saratov, Russia (1992-1998).

Presentations and introductory courses on Applied Optics for undergraduate students, Optics Dept., SSU, Saratov, Russia (1994-1998)

COMPUTER SKILLS:

Operating Systems: IBM (Windows), Macintosh; MS Office, KaleidaGraph, Adobe Photoshop. Statistical software: SPSS. Data analysis; data fitting.

Programming languages: Matlab, HTML.

EDUCATION:

Philosophy Doctor in Biophysics; Saratov State University (SSU), Saratov, Russia.

Master of Science in Physiology and Biophysics; UTMB, Galveston, TX;

Master of Science in Physics; SSU, Saratov, Russia.

Bachelor of Science in Physics/Optics; SSU, Saratov, Russia.

HONORS AND AWARDS:

Personal travel grant of the U.S. Air Force Office of Scientific Research (2002)

Personal travel grant of International Exchange Program "New opportunities for young investigators" within the International Co-operative Russian Ministry of Science and U.S. Civilian Research and Development Foundation grant (1998)

Personal travel grant of Russian Federal Program "Integration'2000" (1998)

International Co-operative Russian Ministry of Science and U.S. Civilian Research and Development Foundation grant RB1-230; co-investigator (1997-1998)

International Soros Scientific Education Program grant for graduate students (1997)

International Soros Scientific Education Program grant for graduate students (1996)

Number of All-Russian Scientific grants; co-investigator

PRESENTATIONS:

1.International Conference SPIE on Holography and Coherent Optics, Chernovtsy, Ukraine, 1993.

2.5th International Conference SPIE "Laser Applications in Life Sciences" (LALS 1994), Minsk, Belarus, June 28 - July 2, 1994.

3.International Symposium on Biomedical Optics BiOS Europe`1994, Lille, France, Sept. 6-10, 1994.

4.5th Congress of the Asian-Pacific Association for Laser Medicine and Surgery, Tel Aviv, Israel, Nov. 20-25, 1994.

5.International Congress on Laser in Medicine and Surgery "Laser - 95", Munchen, Germany, June 21-23, 1995.

6.International Conference SPIE "Light & Biological Systems", Wroclaw, Poland, July 3-7, 1995.

7.International Conference "BiOS Europe' 95", Barcelona, Spain, Sept.12-16, 1995.

8.International Workshop on Nonlinear Dynamics and Structures in Biology and Medicine: Optical and Laser Technologies, Saratov, Russia, July 8-14, 1996.

9.International Conference SPIE BiOS'97 "Coherence Domain Optical Methods in Biomedical Science and Clinical Application", San Jose, CA, USA, Feb. 8-14, 1997.

10.International Conference SPIE's BiOS'97 "Coherence Domain Optical Methods in Biomedical Science and Clinical Application", San Jose, CA, USA, Feb. 8-14, 1997.

11.International Conference on Laser Physics, Berlin, Germany, July 6-10, 1998.

12.17th Annual Houston Conference on Biomedical Engineering Research, Univ. of Houston, Houston, Texas, USA, Feb. 11-12, 1999.

13.International Conference “Advances in Optics for Biotechnology, Medicine and Surgery”, Kailua-Kona, Hawaii, USA, 1-6 August 1999.

14.International Conference SPIE BiOS'2000, San Jose, CA, Jan. 20-26, 2000.

15.2002 Gordon Research Conference on Lasers in Medicine and Biology, July14-19 Kimball Union Academy, Meriden, NH, 2002

16.International Conference SPIE BiOS'2003, San Jose, CA, Jan. 25-31, 2003.

17.Saratov Fall Meeting (SFM’05) Saratov, Russia, Sept. 2005.

18.2006 McLaughlin Colloquium on Infection & Immunity, Galveston, TX, Jan.19, 2006.

19.Society of Quality Assurance. GLP and GCP training. San Diego, CA; April 19-24, 2009.

20.Saratov Fall Meeting, Saratov, Russia, September 22-25, 2015.

21.Society for Maternal-Fetal Medicine, San Diego, CA; February 2-7, 2015.

22.Society for Reproductive Investigation, San Francisco, CA; March 25-28, 2015.

23.Society for Maternal-Fetal Medicine, Atlanta, GE; February 1-6, 2016.

24.Society for Reproductive Investigation, Montreal, QC, Canada; March 16-19, 2016.

LIST OF PUBLICATIONS:

1. Bednov A.A., Ul'yanov S.S. Investigation of dependence of dynamic partially developed speckle-fields contrast on rough surfaces statistical characteristics // Proc. SPIE. 1993. Vol.2008. P.273-279.

2. Ul'yanov S.S., Tuchin V.V., Bednov A.A. Investigation of spatial-temporal correlation functions of dynamic spatially inhomogeneous speckles and their applications in blood flow diagnostics // Proc. SPIE. 1995. Vol.2326. P.452-458.

3. Bednov A.A., Brill G.E., Tuchin V.V., Ul’yanov S.S., Zakharova E.I. Blood and lymph flow measurements in microvessels using focused laser beam diffraction phenomenon // Proc. SPIE. 1995. Vol.2370. P.379-383.

4. Ul’yanov S.S., Kuzmin S.Yu., Bednov A.A., Tuchin V.V. Practical works in the speckle optics for the subspecialities: physics of laser measurements and biomedical optics // Proc. SPIE. 1995. Vol.2525. P.427-432.

5. Ul’yanov S.S., Tuchin V.V., Kuzmin S.Yu., Bednov A.A. Teaching of optical diffraction methods in biomedicine to undergraduates specializing in optics // Proc. SPIE. 1995. Vol.2525. P.117-122.

6. Bednov A.A., Zakharova E.I., Tuchin V.V., Brill G.E., Ul’yanov S.S. Lymph flow diagnostics using speckle-microscopy // Proc. SPIE. 1996. Vol.2630. P.134-141.

7. Bednov A.A., Ul’yanov S.S., Tuchin V.V., Brill G.E., Zakharova E.I. Speckle diagnostics of shuttle-stream lymph and blood flows // Proc. SPIE. 1996. Vol.2678. P.416-422.

8. Bednov A.A., Ulyanov S.S., Tuchin V.V. Brill G.E., Zakharova E.I. In-vivo laser measurements of blood and lymph flow with a small number of scatterers // Proc. SPIE. 1996. Vol.2732. P.27-33.

9. Беднов А.А., Ульянов С.С., Тучин В.В., Брилль Г.Е., Захарова Е.И. Исследование динамики лимфотока методами спекл-интерферометрии // Изв. вузов. Прикл. нелинейная динамика. 1996. Т.4, 6. C.45-54.

10. Bednov A.A., Galanzha E.I., Tuchin V.V., Ulyanov S.S., Brill G.E. Investigation of statistical properties of lymph-flow dynamics using speckle-microscopy // Proc. SPIE. 1997. Vol. 2981. P.181-190.

11. Bednov A.A., Ul’yanov S.S., Tuchin V.V., Brill G.E., Galanzha E.I. Investigation of lymph flow dynamics using methods of speckle-interferometry // Proc. SPIE. 1997. Vol. 3177. P. 89-96.

12. Ul'yanov S.S., Tuchin V.V., Bednov A.A., Brill G.E., Zakharova E.I. The application of seckle-interferometry for the monitoring of blood and lymph flow in microvessels // Lasers in Medical Science. 1997. Vol.12. P.31-41.

13. Zimnyakov D.A., Mishin A.B., Bednov A.A., Cheung C., Tuchin V.V., Yodh A.G. Time-dependent speckle contrast measurements for blood microcirculation monitoring // Proc.SPIE. 1999. Vol.3599. P.157-166.

14. Bednov A.A., Cheng C., Ul’yanov S.S., Yodh A.G. Coherent diagnostics of burned skin: experiments with phantoms // Proc. SPIE. 2000. Vol.3915. P.275-284.

15. Bednov A.A., Karabutov A.A., Savateeva E.V., March W.F., Oraevsky A.A. Monitoring glucose in vivo by measuring laser-induced acoustic profiles // Proc. SPIE. 2000. Vol.3916. P.9-18.

16. Bednov A.A., Tuchin V.V., Brill G.E., Galanzha E.I., Ul’yanov S.S. Investigation of lymph flow characteristics using speckle-interferometrical method // Proc. SPIE. 2001. Vol.4515. P.177-184.

17. Bednov A.A., Savateeva E.V., Oraevsky A.A. Opto-acoustic monitoring of blood optical properties as a function of glucose concentration // Proc. SPIE. 2003. Vol.4960. P.21-29.

18. Bednov A.A., Ulyanov S.S., Cheng C., Yodh A.G. Correlation properties of multiple scattered light: Implication to coherent diagnostics of burned skin // J. Biomed. Opt. 2004. Vol.9, No.2. P.347-352.

19. Ulianova O.V., Ulyanov S.S., Sazanova E.V., Zhang Zh., Zhou S., Luo Qi., Zudina I., Bednov A.A. Inactivation of bacterial cells by dynamic low-coherent speckles: mathematical model of photoprocessing // Proc. SPIE. 2005. Vol.5771. P.357-364.

20. Bednov A.A., Oraevsky A.A. Comparison of glucose effect in model media and biological tissue measured using time-resolved optoacoustic method // Asian Journal of Physics. 2006. Vol.15, No.1. P.55-66.

21. Ulianova O.V., Ulyanov S.S., Sazonova E.V., Zhihong Zh., Sibo Z., Luo Q., Zudina I., Bednov A. Photoinactivation of bacteria of Francisella tularensis by dynamic low-coherent speckles // Asian Journal of Physics. 2006. Vol. 25, No.1. P.101-117.

22. Bednov A, Espinoza J, Betancourt A, et al. L-arginine prevents hypoxia-induced vasoconstriction in dual-perfused human placental cotyledons. Placenta (2015); 36(11):1254-9.

STATUS: U.S. citizen

REFERENCES:

Dr. Michael Belfort, MBBCH, D.A. (S), M.D., Ph.D. Professor, OB&GYN, Chairman; Baylor College of Medicine

Phone: 832-***-****