Project Management
Resume:
Emma Bee aka Xiaohui Bi, Ph.D.
Plainfield, NJ 07060
********@*****.***
Profile Well-published cancer research scientist, trained in highly regarded research institutions, with broad knowledge in biosciences and substantial expertise in scientific writing. Task driven and highly responsible with efficient project management skills. Genuine interest in medical writing.
Professional Experience:
08/2014 – 10/2015 Technical Linguist (Chinese to English, QC)
TransPerfect Legal Solutions, 3 Park Ave., New York, NY 10016
Served as an integral member of a team working on a large-scale pharmaceutical legal/regulatory matter with strict time constraints. Translated from Chinese to written English and proofread scientific materials on drug discovery, pharmaceutical reports and regulatory documents.
08/2012 – 09/2015 Founder and Principal
BC LifeStyle LLC, Plainfield, NJ
02/2007 – 10/2012 Research Teaching Specialist
University Hospital - Cancer Center, New Jersey Medical School, Newark, NJ
Primary research projects:
-Characterizing interferon regulatory factor-5’s tumor suppressing functions in human breast cancer for the development of new biomarkers and novel targets in cancer treatment (collaboration with Dr. Meera Hameed, Memorial Sloan-Kettering Cancer Center, and colleagues from Pathology Department and Radiation Center; see publication 2).
-IRF5's roles and mechanisms in DNA damage induced population variation of hematopoietic stem cells, radiation induced thymic lymphomagenesis and pristane induced lupus (see publications 1, 3-5).
-Research grant application: Project initiation, design and budgeting; primary data preparation; drafting and revision.
Student supervision:
-Supervised research students (high school, undergraduate, MD and PhD students) from various short-term educational programs. Duties included management of administrative paperwork and project assignments, technique training, performance monitoring, evaluation and reporting, editing and critiquing students’ presentations and assays.
Lab management:
-Budget and account management; purchase ordering; bookkeeping;
-Equipment and lab supply management; safety support; filing; and other organizational matters.
09/2005 – 10/2006 Research Fellow
Nghiem Laboratory, Cutaneous Biology Research Center, Massachusetts General Hospital, Boston, MA
Project 1: Genomic identification of the most malignant skin cancer, Merkel Cell Carcinoma (MCC). Using array-comparative genomic hybridization, 25 common genomic variations and 3 candidate genes REC8L1, IPO4, and L-Myc were discovered from DNA samples of 56 MCC patients for functional study (collaboration with scientists at Center of Applied Science, Dana-Farber Cancer Institute).
Project 2, High throughput screening targeting replication checkpoint ATR/Chk1 kinases for cancer treatment (collaboration with scientists at Broad Institute). Our study shows that checkpoint inhibitor caffeine protects skin from UV induced photodamage and skin tumor development in hairless mice by increasing damage induced apoptosis in the basal layer epidermis. By high throughput screening, we identified other small molecule compounds for potential cancer therapy.
03/2003 – 09/2005 Research Fellow
Vaziri Laboratory, Department of Genetics & Genomics, Boston University School of Medicine, Boston, MA
Project: Identification of cellular defense mechanisms against tobacco smoke and UV light induced DNA damage. The work contributed to the understanding of DNA damage induced carcinogenesis by identifying several interacting signal pathways that link DNA replication initiation, DNA damage repair, and the cell cycle checkpoint together.
Teaching Assistant: Critical Thinking class of the department’s PhD program.
Education (and TA Experience):
2002, Ph.D.: Molecular Biology
Helle Ulrich Laboratory, Max-Planck Institute for Microbiology, Germany (2001-2002)
Huang Baiqu laboratory, Institute of Genetics & Cytology, NENU, China (1999-2000)
Project 1: Roles and Mechanisms of the DNA post-replication repair factors Rad18 and Rad5 in DNA double strand break repair in S. Cerevisiae. Project 2: Regulation of Hsp90 promoter by histone acetyltransferase p300 and deacetylase HDAC1.
Director’s Assistant: (09/99 – 12/00): Administrative paperwork; class and seminar scheduling; conference room booking; office supply maintenance and purchase ordering.
1999, M.S.: Genetics, NENU, China
Project: The transcription activities in nucleolus during cell cycle in plant cells.
Electron Microscopy Lab Assistant (06/97 - 06/99): Customer record keeping and lab maintenance.
1996, B.S.: Life Science, Northeast Normal University (NENU), Changchun, China
Management and Scientific Expertise:
Project and business plan management and execution in collaboration with leadership; strong administrative, organizational and supervisory skills; excellent multi-tasking and problem-solving skills;
Interpersonal skills: effective communication skills with all personnel in science, education and other industries; productive business negotiation skills; and excellent customer service skills;
Project budgeting and product/service pricing; data and account management; bookkeeping and accounting;
Advanced skills in Excel, Word, Outlook, Adobe Acrobat, PowerPoint, and Photoshop; proficient with Visio and QuickBooks;
Substantial experience in basic and translational research with in vitro and in vivo methodologies; solid knowledge in microbiology, cell and molecular biology, genetics, genomics, immunology and medicine related technologies in scientific research; advanced data analysis skills;
Scientific presentations (oral/written); technical writing; grant application drafting and proofreading; critic and constructive thinking in science;
Broad knowledge in FDA regulatory affairs and ICH guidelines, GCP, IND, NDA, GMP, GLP, and LIMS.
Honors and Professional Affiliations:
Seymour and Vivian Milstein Travel Awards, ISICR, 2010
Retreat Award, Department of G&G, BUSM, 2006
Standing Trustee of Genetics Society of Jilin Province, China, 2002-2003
Academic Excellence Student Award 1999 - 2000, NENU, China
Reviewer and Editor of Journal of NENU, Science Edition, 1998-1999
Member of Association of Clinical Research Professionals 2009-2012
Member of International Interferon/Cytokine Society and American Aging Association 2009-2011
Volunteer of Overseas China Education Foundation 2004-2008
Selected Presentations:
‘The tumor suppressor function of Interferon Regulatory Factor-5 in human breast cancer’. Joint Meeting of the International Cytokine Society and the International Society for Interferon and Cytokine Research, Chicago, 2010.
‘Radiation induced thymic lymphoma in IRF5-/- mice’. NJCCR, Piscataway, 2010.
‘Identifying the tumor suppressor function of IRF-5 in human breast ductal carcinoma’. Breast Cancer symposium, San Antonio, 2009.
‘The recruitment of DNA polymerase к in response to DNA damage’. Systems Biology guest at School of Natural Science, Princeton University, 2006.
‘Genomic identification by Array-CGH of Merkel Cell Carcinoma’. Harvard School of Public Health, 2006.
X Bi, D Slater, C Vaziri. DNA trans-lesion synthesis polymerase к is required for DNA damage induced cell cycle checkpoint. The 13th conference of International Society of Differentiation, Hawaii, 2004.
Publications:
1.Bi X, Feng D, Korczeniewska J, Alper N, Hu G, Barnes BJ. Deletion of Irf5 protects hematopoietic stem cells from DNA damage-induced apoptosis and suppresses γ-irradiation-induced thymic lymphomagenesis. Oncogene. 2014 Jun 19;33(25):3288-97.
2.X Bi, M Hameed, N Mirani, EM Pimenta, J Anari, BJ Barnes. Loss of interferon regulatory factor 5 expression in human ductal correlates with disease stage and contributes to metastasis. Breast Cancer Res. 2011 Nov 4;13(6):R111.
3.Feng D, Yang L, Bi X, Stone RC, Patel P, Barnes BJ. Irf5-deficient mice are protected from pristane-induced lupus via increased Th2 cytokines and altered IgG class switching. Eur J Immunol. 2012 Jun;42(6):1477-87.
4.Yang L, Feng D, Bi X, Stone RC, Barnes BJ. Monocytes from Irf5-/- mice have an intrinsic defect in their response to pristane-induced lupus. J Immunol. 2012 Oct 1;189(7):3741-50.
5.X Bi, L Yang, ME Mancl, BJ Barnes. Modulation of IRF5 activities by the Kaposi sarcoma-associated herpesvirus-encoded vIRF3 contribute to immune evasion and lytic induction. J. Interferon Cytokine Res. 2011 Apr;31(4):373-82.
6.X Bi, LR Barkley, S Tateish, M Yamizum, H Ohmori, C Vaziri. Rad18 Regulates DNA polymerase κ and is required for recovery from bulky adduct-induced S-phase Checkpoints. Mol. Cell. Biol. 2006 May;26(9):3527-40.
7.X Bi, DM Slater, H Ohmori, and C Vaziri. DNA Polymerase κ is specifically required for recovery from the Benzo[a]pyrene-Dihydrodiol Epoxide (BPDE)-induced S-phase checkpoint. J. Biol. Chem. 2005 Jun 10;280(23):22343-55.
8.K Garneski, B Lemos, B Feng, N Jaimes, P Peñas, X. Bi, E Maher, L Cohen, JH Leonard, S Granter, L Chin, P Nghiem. Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc. J. Invest. Dermatol. 2009 Jun;129(6):1547-55.
9.P Liu, R Barkley, X Bi, D M Slater, HP Nashuer, and C Vaziri. The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/CDK2-independent mechanism. J. Biol. Chem. 2006 Oct 13;281(41):30631-44.
10.X Bi, M JiAO, W Tao and B Huang. Distribution of DNA and localization of rRNA transcription sites in G2 phase nucleolus of Physarum Polycephalum. Progress in Natural Science 2001 11(8):631-636.
11.M Jiao, X Bi, Q Zeng, Y Wang. Studies on RNA transcription activity in interphase nucleus in P. polycephalum. ACTA Botanica Sinica. 2001 43(3):227-231.
12.B Huang, Q Zeng, X Bi, Y Wang. Roles of histones and nucleosomes in gene transcription. Chinese Science Bulletin. 2001, 46:184-188.
13.L Yu, Z Li, H Wang, L Suo, X Bi, and B Huang. The AFM Characterization of Ni(phen)_3(2+)Fixing Effects on DNA. Chem.Res.Chin.Uni. 2004 (1):46-48.
Interests: Visual arts; yoga; sports; adventure travel; technology; and cultural affairs.
References: Available upon request.
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