Assistant Research

POONAM BIAWAT

**** ***** ****** *****, *** *, Shorewood, WI-53211, USA

Phone: 414-***-**** (cell)

Email: **********@*****.***; *******@***.***

OBJECTIVE

Seeking a position as a chemist that will enable me to use my research and development skills, educational background,

and ability to work well with people.

COMPENTICIES/ SCIENTIFIC SKILLS

Design and synthesized novel compounds for biological screening, scaled up from milligram to multi-kilograms of

some key ligands.

Expertise in crystallization and separation techniques like TLC, column chromatography, preparative TLC and solvent

extraction methods.

Efficient in carrying out air sensitive, moisture sensitive reactions, performing high vacuum distillation and drying of

the solvents.

Theoretical and operational knowledge of analytical instrumentation like HPLC, GC, 1H and 13C NMR, IR, mass

spectroscopy and UV/VIS spectrophotometry.

Strong ability to work in teams and collaborations.

Basic knowledge of internet, fundamentals of C, Microsoft Windows, Word, Excel, Outlook, Word Perfect, PowerPoint,

Chem Draw, NMR, IR, mass spectrometer.

Excellent verbal and communication skills.

EDUCATION

M.S. Organic/ Medicinal Chemistry University of Wisconsin Milwaukee, Milwaukee, WI August (2014)

Thesis: The Synthesis of Alpha 5 Subtype Selective GABA(A)/Benzodiazepine Receptors ligand.

Bachelor of Education (teaching) D.A.V College Abohar, Punjab (India) (2008)

M.S. Physical Chemistry Punjabi University, Patiala, Punjab (India) (2007)

Bachelor of Science (Chemistry) Rajindra College, Bathinda, Punjab (India) (2005)

RESEARCH EXPERIENCE/LAB EXPERIENCE

Research Intern (October 2014- present)

Graduate Research Assistant/Lab Assistant (January 2010- June 2014)

Mentor: Dr. James M Cook, Distinguish professor of Organic/Medicinal Chemistry, UW -Milwaukee, Milwaukee

Synthesis various benzodiazepine analogs for biological screening for finding subtype-selective GABAergic agents.

GABAA receptor complexes that contain subunits are abundantly expressed in the hippocampus and therefore

considered to be a therapeutic target for treating cognitive disorders, like Alzheimer’s and ADHD(Attentio n Deficit

Hyperactivity Disorder).

In order to search for better agents, a number of analogs of benzodiazepine were prepared in research and

were sent out for biological testing.

Design and synthesized milligrams to multi-kilograms of some key ligands for studies in higher animals

including non-human primates.

Carried out air sensitive and moisture sensitive reactions.

Performed other lab experiments like high vacuum distillation, solvent extraction methods and purification

of samples.

Followed structural elucidation techniques using analytical instruments (NMR, HRMS, IR, HPLC).

Maintained records of lab experiments using lab notebook in an accurate and concise way.

Proven ability to follow procedures with safety guidelines.

POONAM BIAWAT

4302 North Wilson Drive, Apt 5, Shorewood, WI-53211, USA

Phone: 414-***-**** (cell)

Email: **********@*****.***; *******@***.***

TEACHING EXPERIENCE (January 2010 - May 2014)

Graduate Teaching Assistant: Chem 100 (General Chemistry)

Graduate Teaching Assistant: Chem 342 (Organic Chemistry)

Tutor for Chem 100, 102, 104, 342 and 344 (General Chemistry and Organic Chemistry)

Graded exams under the supervision of instructors.

AWARDS

Chancellor’s Graduate Student Award, University of Wisconsin, Milwaukee (2010 – 2012)

COMPUTER SKILLS

Fundamentals of C, Microsoft Windows, Word, Excel, Outlook, Word Perfect, PowerPoint, Chem Draw, NMR, IR,

mass spectrometer.

AFFILIATIONS

Member of American Chemical Society (ACS), Medicinal Chemistry Division (2013-2014)

PUBLICATIONS

1. Allosteric Modulation of GABA(A) Receptors Subtypes: Effects on Visual Recognition and Visuospatial Working

Memory in Rhesus Monkeys.

Paul L Soto, Nancy A Ator, Sundari K Rallapalli, Poonam Biawat, Terry Clayton, James M Cook, Michael R

Weed;, Neuropsychopharmacology, 2013

2. PWZ-029, an inverse agonist selective for a5 GABAA receptors, improves object recognition, but not water-

maze memory in normal and scopolamine-treated rats

Marija Milić, Tamara Timić, Srđan Joksimović, Poonam Biawat, Sundari Rallapalli, Jovana Divljaković, Tamara

Radulović, James M Cook, Miroslav M Savić;, Behavioural Brain Research, 2013

3. Differential Effects of an α5 GABAA Receptor Negative Modulator On Spatial, Social And Object Recognition

Memory Impairment Induced By MK-801 In Rats

Tamara Timić Stamenić, Srđan Joksimović, Poonam Biawat, Tamara Radulović, Bojan Marković, James M. Cook,

Miroslav M. Savić. Manuscript ready for submission to Journal of Psychopharmacology (In progress)

4. A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model

Clayton, Terry; Poe, Michael M.; Rallapalli, Sundari; Biawat, Poonam; Savić, Miroslav; Rowlett, James, Gallos,

George; Emala, Charles; Kaczorowski, Catherine C.; and Cook, James M. (In progress)

POSTER AND ORAL PRESENTATIONS

ACS 245th National Meeting 2013, Synthesis and biological evaluation of Alpha 5 GABAergic subtype selective

1.

ligand PWZ-029, New Orleans, Louisiana.(Presenter)

2. Chemistry and Biochemistry Research Poster Symposium 2013, Synthesis and biological evaluation of Alpha 5

GABAergic subtype selective ligand PWZ-029, University of Wisconsin Milwaukee, Milwaukee, WI. (Presenter)

3. Chemistry and Biochemistry Research Poster Symposium 2012, Synthesis and Biological Evaluation of the

Selective Inverse Agonist RY-23 for Alpha 5 BZR/GABAergic Receptor Subtypes. This Ligand Antagonizes

Memory-Impairing Effects in Rhesus Monkeys, University of Wisconsin Milwaukee, WI. (Presenter)

POONAM BIAWAT

4302 North Wilson Drive, Apt 5, Shorewood, WI-53211, USA

Phone: 414-***-**** (cell)

Email: **********@*****.***; *******@***.***

4. European College of Neuropsychopharmacology, Acute effects of an inverse agonist selective for alpha5 GABA -

A receptors on rat behavior in the forced swim test.

LABORATORY SKILLS

Synthesis

Organic synthesis including anhydrous reaction, microwave based reaction, crystallization.

Analytical Techniques

NMR (Proton and Carbon), Chromatography techniques (Column chromatography and thin layer

chromatography, preparative TLC), HPLC, GC, MS, IR, distillation, UV/VIS spectrophotometry.

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