Cancer research, quality assurance & control, scientific writing

Summary:

EDUCATION

Ph.D. (January **** - June 2013)

St. John's University, Queens, New York

Major: Pharmacology (Cancer pharmacology and biology)

Cumulative GPA: 3.72/4.0

Master of Science, (September 2007 - December 2009)

St. John's University, Jamaica, New York

Major: Pharmacology

Cumulative GPA: 3.65/4.0

Bachelor of Science, (2002- 2006)

K.B. Institute of Pharmaceutical Education and research, India

Major: Pharmacy

Cumulative GPA: 3.9/4.0

ACADEMIC APPOINTMENTS

POST DOCTORAL FELLOW (Neurooncology and cell biology Lab) (07/2013-

CURRENT)

The Feinstein Institute for Medical research, North Shore LIJ

Delineate the role of microglia in glioblastoma growth and invasion. To

develop a drug that inhibits the microglial assistance in the glioblastoma

growth and invasion.

To find out the role of tumor microenvironment in the triple negative

breast cancer metastasis (the most aggressive form of the breast cancer)

To develop a high throughput assay for the glioblastoma stem cells

inhibitor identification.

College Of Pharmacy and Health Sciences, St. John's University, Queens, New

York 11439

TEACHING FELLOW (08/2011-05/2013)

> Taught molecular biology laboratory courses including pharmacology,

biochemistry, oncology, immunology, endocrinology, chemistry,

bacterial transformation and translation laboratory courses to

graduate pharmacy students (2nd- 5th year).

> Responsibly and effectively managed class and lab with a team of 3

assistants and implemented strategic plans into practice.

> Supervised high school, Pharm D, Master students and visiting scholar

at ZS Chen's lab, St John's University, NY.

Teaching Assistant (01/2009-07/2011)

> Teaching assistant since Spring'09, responsible for teaching and

conducting laboratory for Pharmacy undergraduate students

> Supervise students and provide instruction in Biomed-I and

Pharmaceutical Toxicology.

INDUSTRIAL APPOINTMENTS

> Quality control chemist (A&Z pharmaceutical Inc. NY) May 2009-August

2009

> Performed quality control analysis of finished, stability and

validation samples. Involved in validation and calibration of QC

laboratory equipment.

> Worked in a fast-paced environment. Familiar with GLP regulations.

ACHIEVEMENTS AND AWARDS

. Student of the year (2012) in Chen's cancer pharmacology lab for

outstanding research performance.

. 4th hottest article in Science Direct from April - Sept 2009. "Tiwari

AK and Sodani K et al (2009). Nilotinib (AMN107, Tasigna) reverses

multidrug resistance by inhibiting the activity of the ABCB1/Pgp and

ABCG2/BCRP/MXR transporters. Biochem Pharmacol"

http://top25.sciencedirect.com/subject/pharmacology-toxicology-and-

pharmaceutical-science/20/journal/biochemical

pharmacology/00062952/archive/22/

. Full scholarship with tuition waiver and stipend from St. John's

University for both M.S. and PhD - 2009 to 2013

. One of the top 20 students of Gujarat University in Pharmacy Major.

. Secured 163rd Rank in the National level exam for graduates known as

GATE'06 organized by Indian Institute of Technology, Kharagpur and

Ministry of HRD.

PROFESSIONAL AFFILIATION:

> American Association for Cancer Research (AACR) - since 2009.

> American Association for the Advancement of Science (AAAS) - since

2010

> New york academy of sciences (NYAS) - since 2012

JOURNAL REFREE

> Pharmaceutica Analytica Acta (PAA)

> J. Cancer Research Updates (JCRU)

> J. of Animal Production Advances (JAPA)

> Bioinorganic Chemistry and Applications

> Pakistan journal of Pharmaceutical Sciences (PJPS)

Editorial Board Member

> Int. J. of Toxicological and Pharmacological Res. (IJTPR)

> Vedid Research International Cell Signaling (VRI-CS)

> Translational Clinical Biology

TECHNICAL SKILLS

Pharmacology: Microglial and mammalian (cancer and normal) cell

culture, Generating and characterizing drug resistant cell lines, High

Throughput Screening (HTS) using cell viability assays i.e. colony

formation, MTT/MTS/XTT/Trypan blue assays, Inside-out membrane vesicle

preparations by Nitrogen Cavitation Methods (NCM), monolayer trans-

well transport assay, Cellular-based transport assay including rapid

filtration methods, transporter kinetics, Drug accumulation, efflux

and uptake assays, membrane permeability assays.

Whole Animal pharmacokinetics; dosing iv, ip, sc, po,; Blood

collection - Orbital sinus venipuncture; nude mice xenograft models

Stereotactic orthotopic intracranial brain cancer tumor model

Molecular biology and Biochemistry: Invasion assay, Cytokine array,

Cellular fractionation including Protein, DNA and RNA - isolation and

detection, Cell-line stabilization through Transient/Stable

transfection and electroporation techniques, Protein/RNA/DNA

purification and quantification, Plasmid restriction digest, Western

Blots, Gel preparation, ATPase assay, ELISA, Immunocytochemistry,

Enzyme activity, Kinetic assays, Chromatography, Electrophoresis of

DNA.

> Analytical: HPLC and UPLC based assay; UV, IR, Dissolution,

Disintegration, Karl fisher instrument handling.

Microbiology: Aseptic techniques, Bacterial cell culture, Bacterial

transformation, Microscopy, Kirby-Bauer antibiotic sensitivity test,

Characterizing microbial resistance and sensitivity, Gram staining.

Computers: PC operation and Microsoft office applications, database

and analytical software such as Sigma Plot, Prism5, ImageJ.

PUBLICATIONS

Published work:

. Kamlesh Sodani, Amit K. Tiwari, Satyakam Singh, Atish Patel, Zhi-Jie

Xiao, Jun-Jiang Chen, Yue-Li Sun, Tanaji T. Talele, Zhe-Sheng Chen

"GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2-

and ABCB1-mediated drug resistance." Biochem Pharmacol. 2012 Jun

15;83(12):1613-22.

. Kamlesh Sodani, Atish Patel, Rishil J Kathawala and Zhe-Sheng Chen

"Multidrug resistance associated proteins (MRPs) in multidrug

resistance." Chin J Cancer. 2012 Feb;31(2):58-72

. Amit K. Tiwari, Kamlesh Sodani, Chun-ling Dai, Satyakam Singh, Alaa H.

Abuznait, Zhi-Jie Xiao, Saurabh Vispute, Atish Patel, Tanaji T.

Talele, Amal Kaddoumi, James M. Gallo, Zhe-Sheng Chen "Nilotinib

potentiates anticancer sensitivity in murine multidrug resistance

xenograft models" Cancer Lett. 2012 Oct 9.

. Atish Patel, Amit K. Tiwari, Satyakam Singh, Kamlesh Sodani, Nagaraju

Anreddy, Tanaji T. Talele, Ralph Stephani, Suresh V. Ambudkar, Zhe-

Sheng Chen "PD173074, a selective FGFR inhibitor, reverses ABCB1

mediated drug resistance in cancer cells" Cancer Chemother Pharmacol.

2013 May 15

. Amit Kumar Tiwari, Kamlesh Sodani, Sirong Wang, Ye-Hong Kuang, Charles

R. Ashby Jr., Xiang Chen, Zhe-Sheng Chen "Nilotinib (AMN107, Tasigna)

reverses multidrug resistance by inhibiting the activity of the

ABCB1/Pgpand ABCG2/BCRP/MXR transporters" Biochem Pharmacol. 2009 Jul

15;78(2):153-6

. Yue-Li Sun, Jun-Jiang Chen, Priyank Kumar, Kang Chen, Kamlesh Sodani,

Atish Patel, Yang-Lu Chen, Si-Dong Chen, Wen-Qi Jiang and Zhe-Sheng

Chen "Reversal of MRP7 (ABCC10)-Mediated Multidrug Resistance by

Tariquidar" Accepted in Plos One.

. Dong-Mei Zhang, Chang Shu, Jun-Jiang Chen, Kamlesh Sodani, Jiao Wang,

Jaya Bhatnagar, Ping Lan, Zhi-Xiong Ruan, Zhijie Xiao, Suresh V.

Ambudkar, Wei-Min Chen, Zhe-Sheng Chen, Wen-Cai Ye "BBA, A novel 23-

hydroxybetulinic acid derivative, potently reverses ABCB1-mediated

drug resistance in vitro and in vivo" Mol Pharm. 2012 Nov 5;9(11):3147-

59.

. Jun-Jiang Chen, Yue-Li Sun, Amit K Tiwari, Zhi-Jie Xiao, Kamlesh

Sodani, Dong-Hua Yang, Wen-Qi Jiang, Si-Dong Chen, Zhe-Sheng Chen,

"PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug

resistance by inhibiting the efflux function of multidrug resistance

protein 7 (ATP-binding Cassette C10) transporter." Cancer Sci. 2012

Aug;103(8):1531-7.

. Ye-Hong Kuang, Jay P. Patel, Kamlesh Sodani, Chun-Pu Wu, Li-Qiu Liao,

Amit K. Tiwari, Chun-Ling Dai, Xiang Chen, Li-Wu Fu, Suresh V.

Ambudkar, Vijaya L. Korlipara, Zhe-Sheng Chen "OSI-930 ANALOGUES AS

POTENT ABCG2-MEDIATED MULTIDRUG RESISTANCE REVERSAL AGENTS" Biochem

Pharmacol. 2012 Sep 15;84(6):766-74.

. Ke-jun Liu, Xiaodong Su, Jing-Dun Xie, Xinggui Chen, Fang Wang, Yong-

ju Liang, Satyakam Singh, Tanaji T. Talele, Kamlesh Sodani, Zhe-Sheng

Chen,, Hai-Ying Wu and Li-wu Fu "AZD0530 (saracatinib) Reverses ABCB1-

mediated Multidrug Resistance in Cancer Cells by Inhibiting its

Transport Function" Int J Cancer. 2013 Jan 1;132(1):224-35.

. Tianwen Li,Yongchong Yang, Changmei Cheng, Amit K. Tiwari, Kamlesh

Sodani, Yufen Zhao, Ioana Abraham, and Zhe-Sheng Chen "Design,

synthesis and biological evaluation of N-arylphenyl-2,2-

dichloroacetamide analogues as a anti-cancer agents" Bioorg Med Chem

Lett. 2012 Dec 1;22(23):7268-71

Tiwari AK, Sodani K, Dai CL, Ashby CR Jr, Chen ZS "Revisiting the ABCs

of multidrug resistance in cancer chemotherapy." Curr Pharm

Biotechnol. 2011 Apr;12(4):570-94

. Ye-hong Kuang, Tong Shen, Xiang Chen, Kamlesh Sodani, Elizabeth

Hopper-Borge, Amit K Tiwari, Kevin Jeferson Lee, Zhe-Sheng Chen

"Lapatinib and erlotinib are potent reversal agents for MRP7(ABCC10)-

mediated multidrug resistance" Biochem Pharmacol. 2010 Jan

15;79(2):154-61.

. Amit Kumar Tiwari, Kamlesh Sodani, Zhe-Sheng Chen "Current advances in

modulation of ABC transporter mediated multidrug resistance in

cancer." International Journal of Toxicological and Pharmacological

Research 2009, Volume 1, Issue 1 Page 1 - 6.

. Jun-Jiang Chen, Atish patel, Kamlesh Sodani, Amit tiwari, Jiao Wang,

Zhijie Xiao, Wei-Min Chen, Zhe-Sheng Chen, Wen-Cai Ye "BBA, A novel 23-

hydroxybetulinic acid derivative reverses ABCC10-mediated drug

resistance in vitro" (accepted in Plos One)

Manuscript in progress:

. Kamlesh Sodani, Atish Patel, Satyakam singh, Nagaraju anreddy Zhe-

sheng Chen " Telatinib antagonizes ABCG2-mediated drug resistance"

(Submitted to Cancer letters).

. Kamlesh Sodani, Amit K. Tiwari, Chun-ling Dai, Alaa H. Abuznait,

Zhi-Jie Xiao, Atish Patel, Amal Kaddoumi, Charles Ashby Jr., Zhe-Sheng

Chen "Sildenafil potentiates the anticancer activity of paclitaxel in

ABCB1-mediated multidrug resistance xenograft mode" (submitted to

cancer chemotherapy and pharmacology)

. Rishil J Kathawala, Yue-Li Sun, Jun-Jiang Chen, Chun-Ling Dai,

Kang Chen, Kamlesh Sodani, Atish Patel, Charles R. Ashby Jr., Zhe-

Sheng Chen "Attenuation of ABCC10- and ABCG2- mediated multi-drug

resistance by masitinib (AB1010)" (Manuscript in preparation)

. Hui Zhang, Yun-Kai Zhang, Rishil J. Kathawala, Atish Patel, Kamlesh

Sodani, Tanaji T. Talele, Zhe-Sheng Chen, Li-Wu Fu "WHI-P154 Enhances

the Efficacy of ABCG2-substrate Chemotherapeutic Agents in ABCG2

Overexpressing Cells" (submitted to Journal of Translational Medicine)

PRESENTATION

Poster

. Kamlesh Sodani, Amit K. Tiwari, Chun-ling Dai, Alaa H. Abuznait, Zhi-

Jie Xiao, Atish Patel, Amal Kaddoumi, Charles Ashby Jr., Zhe-Sheng

Chen "Sildenafil potentiates the anticancer activity of paclitaxel in

ABCB1-mediated multidrug resistance xenograft mode" 104th American

Association for Cancer Research (AACR) 2013, Washington DC

. Kamlesh Sodani, Atish Patel, Amit K. Tiwari, Satyakam Singh, Nagaraju

Anreddy, Tanaji T. Talele, Ralph Stephani, Suresh V. Ambudkar, Zhe-

Sheng Chen "PD173074, a selective FGFR inhibitor, reverses ABCB1

mediated drug resistance in cancer cells" Gorden Research Conference:

Multi-Drug Efflux Systems, Ventura, CA

. Kamlesh Sodani, Amit K. Tiwari, Satyakam Singh, Atish Patel, Zhi-Jie

Xiao, Jun-Jiang Chen, Yue-Li Sun, Tanaji T. Talele, Zhe-Sheng Chen

"GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2-

and ABCB1-mediated drug resistance." 103rd American Association for

Cancer Research (AACR) 2012, Chicago IL

. Sodani K, Kuang YH, Shen T, Vispute S. Tiwari AK, Lei Y. Lee JW, Chen

X, Fu LW and Chen ZS Lapatinib, erlotinib, imatinib and nilotinib are

potent reversal agents for MRP7 (ABCC10)- mediated multidrug

resistance. 101st American Association for Cancer Research (AACR),

Washington, DC, USA April 17-22, 2010

Tiwari AK, Sodani K, Wang S, Kuang YH, Chen X, Chen K, Ashby CR, Chen

ZS. Nilotinib (AMN107, Tasigna) reverses multidrug resistance by

inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR

transporters. 101st American Association for Cancer Research (AACR),

Washington, DC, USA April 17-22, 2010

. Kamlesh sodani, "A Novel Dual c-Kit and KDR Tyrosine Kinase Inhibitor

And Its Analogues Reverses ABCG2- mediated Multi-drug Resistance" 7th

Annual North American ABC meeting. Maryland.

. Tiwari AK, Sodani K, Wang S, Kuang YH, Chen X, Chen K, Ashby CR, Chen

ZS. Nilotinib (AMN107, Tasigna) reverses multidrug resistance by

inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR

transporters. 6th North American ABC workshop. NCI, NIH, Bethesda, MD

20892; September 24-25, 2009

. Sodani K, Tiwari AK, Kuang YH, Shen T, D'Ambra TM, Lei Y, Lee J, Chen

X, Ashby CR, Chen ZS. Lapatinib, erlotinib, imatinib and nilotinib are

potent reversal agents for MRP7 (ABCC10)-mediated multidrug

resistance. 6th North American ABC workshop. NCI, NIH, Bethesda, MD

20892; September 24-25, 2009.

. Chen ZS, Tiwari AK, Shi Z, Dai CL, Shukla S, Wu CP, Wang SR, Abraham

I, Sodani K, Ashby CR, Kuang YH, Robey RW, Fu LW, Bates SE, Ambudkar

SV. Tyrosine kinase inhibitors as modulators of multidrug resistance

in cancer. Multidrug Resistance & ABC Transporters Conference.

Baltimore, Maryland USA, November 5th, 2009

. Tiwari AK, Sodani K, Wang S, Kuang YH, Chen X, Chen K, Ashby CR, Chen

ZS. Nilotinib (AMN107, Tasigna) reverses multidrug resistance by

inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR

transporters. St. John's University, Queens NY-11366 April 2009

Podium talk

. Kamlesh sodani, "Nilotinib potentiates anticancer sensitivity in

murine multidrug resistance xenograft models" 9th Annual North

American ABC meeting. Maryland

. Kamlesh sodani, "A Novel Dual c-Kit and KDR Tyrosine Kinase Inhibitor

And Its Analogues Reverses ABCG2- mediated Multi-drug Resistance" 7th

Annual North American ABC meeting. Maryland

. Kamlesh sodani, "Lapatinib, erlotinib, imatinib and nilotinib are

potent reversal agents for MRP7 (ABCC10)-mediated multidrug

resistance." 6th Annual North American ABC meeting. Maryland

REFERENCES

Available upon request

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