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Jyoti Srivastava- CV

Jyoti Srivastava, PhD

Senior Scientist, Arrowhead Pharmaceuticals

*** * **** **, *******, WI; Cell: 804-***-****; Email: ac851r@r.postjobfree.com, ac851r@r.postjobfree.com https://www.linkedin.com/in/jyoti-srivastava-phd-52605a95/ RESEARCH EXPERIENCE

SENIOR SCIENTIST Oct 2017 - Present

Arrowhead Pharmaceuticals, Department of Biology, Madison, WI Managed, and executed key extra-hepatic discovery, RNAi-based projects to pursue disease targets those are otherwise undruggable by small molecules and antibodies.

Conceived, developed, and successfully employed cell-based in-vitro screening assays that selected a lead of 4 compounds from a pool of over 100 compounds in Cystic Fibrosis (CF) and Renal Cancer programs.

Investigated cellular MOA and physiological functions of the lead conjugates with the help of cross-functional team.

Adapted and utilized these assays to study receptor kinetics, and predict the in-vivo activity of various compounds.

Initiated and established new programs to develop receptor internalization assays for selected cell-surface receptors.

Developed and performed quantitative and high-throughput in-vitro tracking studies in primary cells and cell lines.

Designed and developed new programs on exosome / extracellular vesicle isolation and characterization from human cells and plasma/serum samples.

Initiated two gene-therapy projects after identifying and shortlisting from 65 new genes of therapeutic interest in CF/ IPF.

Designed and executed in-vitro and in-vivo studies which facilitated target discovery and validation.

Completed several ancillary projects such as cross-species receptor expression profiling, expressional status of receptors and gene targets in normal vs IPF, CF and Renal cancer patient groups, and mechanism(s) of packaging and cellular fate of our current RNAi platforms.

ASSOCIATE RESEARCH SCIENTIST Feb 2015 - Oct 2017

Yale University, Yale School of Medicine, Department of Pharmacology, New Haven, CT PI: Dr. Benjamin E. Turk Investigated novel kinase-substrate pairs, underlying signaling pathways, drug targets, optimal therapies, and underlying MOA for B-cell lymphoma.

Uncovered new substrates and mechanisms regulated by Pim kinases in lymphoma and leukemia.

Identified and characterized epigenetic reader CBX8 and its Pim-mediated regulation of epigenetic silencing in lymphoma.

Design and validation of potential therapies based upon Pim kinase and altered histone marks is underway. Investigated novel therapies for B-cell lymphoma to overcome chemo-resistance and increase efficacy of pre-existing clinical

& pre-clinical therapies. Project sponsored by Gilead Biosciences.

Identified unique drug-resistance mechanisms for current chemotherapies using shRNA-based Kinome plus library screening in B-cell lymphoma. Secondary validation using CRISPR-Cas9 library screening is in process.

Uncovered > 100 novel targets, and validated 4 targets that were regulated in response to these chemotherapies which are currently under detailed investigation.

Designed and developed 3 potential combination therapeutic strategies for ABC-subtype Diffused Large B-cell lymphoma

(DLBCL). Identified the potential mechanism of action of these combinations using in-vitro and in-vivo approaches. POSTDOCTORAL SCIENTIST Dec 2010 – Jan 2015

Virginia Commonwealth University (VCU), Department of Human Genetics, Richmond, VA PI: Dr. Devanand Sarkar Investigated molecular mechanisms and pathobiology of Liver cancer, Obesity, and NASH. Discovered therapeutic modalities, new players/biomarkers, and their MOA.

Uncovered novel oncogenes, tumor suppressors, protein-protein interactions, and their regulations in Liver cancer.

Identified and validated oncogene AEG-1/MTDH and retinoid/rexinoid as targets of combination therapy for Liver cancer.

Established nanoparticle-conjugated siRNA delivery (drug conjugates) to safely and specifically target AEG-1/MTDH oncogene in cancer cells, and successfully inhibited tumor growth.

Uncovered co-operation of c-Myc, RXR, and NFkb genes with AEG-1/MTDH in driving oncogenesis.

Identified 3 non-coding RNAs as contributors of Liver Cancer.

Characterized AEG-1/MTDH and SND1 as potential Biomarkers for Liver cancer and NASH.

Investigated the role of Insulin like growth factor binding protein 7 (IGFBP7) in hepatocellular carcinoma. Identified unique regulators and pathways in Inflammation and Metabolic Diseases.

Determined and characterized novel targets for Obesity, Insulin resistance, and NASH.

Successfully reverted or attenuated these diseases by using 3 potential therapies in vivo and in vitro through gene targeting and small-molecule inhibitors/ activators.

Discovered AEG/MTDH-mediated regulation of lipid homeostasis, and established it as a major player in NASH. 2

Jyoti Srivastava- CV

Identified AEG/MTDH as the contributor to Non-thyroidal Illness Syndrome (NTIS) associated with Hepatocellular Carcinoma (HCC).

Investigated role of SND1 gene in metabolism and obesity. POSTDOCTORAL FELLOW Apr 2009 – Dec 2010

City of Hope National Medical Center, Department of Molecular Medicine, Duarte, CA PI: Prof. Theodore G. Krontiris Investigated minisatellites-mediated regulation of Carcinogenesis.

Explored molecular mechanisms by which minisatellites increases the cancer risk in major cancer phenotypes with a specific focus on Breast Cancer and Leukemia.

Established specific functions of tandem nucleotide repeats in regulating stress response and DNA repair pathways.

First to report intracellular localization of the HRAS-VNTR transcripts in nucleolus using RNA-FISH.

First to report miRNA processing and bidirectional transcription of the HRAS-VNTR gene. DOCTORAL RESEARCH & RESEARCH FELLOW Jan 2004 – Apr 2009 National Institute of Immunology (NII), Molecular Genetics Laboratory, New Delhi, India PI: Dr. Sher Ali & Prof. Iqbal Parwez

Investigated the organization and function of repetitive DNA sequences in genome maintenance and disease phenotypes.

Designed a PCR based method and employed it to identify mini and microsatellite-tagged DNA loci and RNA transcripts.

Identified and characterized several coding and non-coding genes tagged with repetitive DNA sequences.

Established the role of these repetitive sequences in transcription, genome organization, and functional regulation.

Uncovered a profile of novel, repeat-tagged transcripts in human patients with male infertility.

Developed IF /FISH/ qPCR methods in lab, and analyzed samples according to NII’s GLP guidelines. Analyzed the human Y chromosome in males exposed to high levels of natural radioactivity.

First to conduct comparative mutational analysis and genetic disposition of Y-linked genes in ~1000 males exposed to natural background radiation (NBR) and in ~500 infertile patients to determine NBR and infertility-specific genomic signatures and biomarkers.

Discovered a unique signature of radioactivity in form of somatic gene duplications, microdeletions, and inter-chromosomal translocations which does not affect male fertility.

First to report a unique structural organization of human Y chromosome. PROJECT ASSISTANT Jan - Aug 2003

Indian Institute of Technology, DBEB, New Delhi, India PI: Tapan K Chaudhuri

Performed cloning, protein purification, and characterization of the maltodextrin glucosidase and investigated the effects of the chaperones on its folding.

PROJECT TRAINEE Jun – Aug 2002

Sanjay Gandhi Post Graduate Inst. of Medical Sciences, Dept. of Immunology, Lucknow, India PI: Dr. Sita Naik

Assisted the project entitled “Vaccine Development against Leishmaniasis. EDUCATION

PhD, Molecular Biology, National Institute of Immunology, New Delhi, and Aligarh Muslim University, India 2008 MS, Biotechnology, Faculty of Life Sciences, Bundelkhand University, Jhansi, India 2003 MANAGEMENT EXPERIENCE

At all positions, established collaborations with multi-disciplinary researchers from inter-/intra institutes and companies.

With the help of team and collaborators, led, managed and completed 16 major and several ancillary projects for last 13 years.

At Arrowhead, Yale, VCU, and NII, responsible for project conceptualization, experimental design and implementation, data analysis, and manuscript/reports/grant proposals’ writing following GLP guidelines.

Trained and supervised 7 graduates, 5 undergraduates, 8 RA’s and 1 high school student in molecular and cell biology methods.

At all positions, presented regular research progress to team members and collaborators.

Excellent team player, critical thinker and communicator, wrote many research papers/ book chapter/ review articles, and research projects, and gave over 20 talks/poster presentations at different reputed institutes and conferences in last 15 years.

Conceived, designed and developed several Biochemistry, Molecular and Cell Biology assays and techniques in each lab.

Maintained the Licor Odyssey, fluorescence microscopy, real time PCR, cell culture, and nanodrop facilities.

Managed lab operations for ~10 years which included purchase, equipment use/maintenance, record keeping, and biosafety. 3

Jyoti Srivastava- CV

TECHNICAL SKILLS

Molecular Biology & Biochemistry: Molecular Cloning. DNA/RNA isolation & manipulation. PCR. RT-PCR. qPCR. Western Blotting. Southern/Northern blotting. Site-directed mutagenesis. Genome editing. siRNAs and shRNA mediated Gene silencing. Immunoprecipitation (IP). RACE. Chromatin Immunoprecipitation assay (ChIP). Angiogenesis and Senescence assays. Luciferase reporter assays. FRET. Protein expression and purification. Microarray. miRNA detection. Post- transcriptional and post-translational modifications. Triglyceride & FA synthesis assays. β-oxidation assay. GTT. Cell Biology & Immunology: Mammalian cell culture (immortalized and cancer cell lines, primary hepatocytes/ fibroblasts/ epithelial/ endothelial cells, & PBMCs). Lentivirus and Retrovirus packaging. Adenovirus. Transient & Stable transfection for knockdown or overexpression. Loss of function and Gain of function studies. Cell line generation. Assay development. Cell- based assays include: Cell viability, proliferation, cytotoxicity and apoptosis assays; Cell invasion, migration & transformation assays; In-cell western assay; Cell-based functional assay; IC50 and drug synergy assays. Immunoassays such as ELISA, ELISPOT, Immunohistochemistry (IHC), Immunofluorescence (IF or ICC). Live cell imaging, Matrix prep. shRNA library screening. CRISPR-Cas9 cloning. Drug screening. Drug Discovery. in vivo & in vitro Pharmacological assays. Flow cytometry. ROS detection. LTT. NK cell cytotoxicity assay. Microscopy: Bright field, Phase contrast and Laser Scanning Confocal Microscopy. Animal models and Clinical Studies: In-vivo animal model studies include Transgenic, Knockout, Knock-in, Xenograft mouse models. Clinical studies include serum/plasma and tissue samples from infertility, liver cancer, breast cancer Genetics: DNA Fingerprinting. RFLP. RAPD. MASA. DNA sequencing. Next Gen Sequencing. Mutation & SNP analysis. Chromosome prep and In-Situ hybridizations. Analyses for genetic determinants for genotype-phenotype correlation. Mapping with ENCODE, Integrative & NCBI genome browsers. Mining of TCGA, cBioPortal & Oncomine datasets. Microbiology: Bacterial genetics. Plasmid manipulation. Transformation. Recombinant protein purification. Software: MS Office, ZEN, ImageJ, Image Studio, and Statistical analyses using GraphPad and Sigma-Plot etc. AWARDS & RECOGNITIONS (SELECTED)

Novel Regulators of Liver Carcinogenesis: AEG-1/MTDH an oncogene and beyond. Invited talk at Arrowhead Pharmaceuticals, Madison, WI 2017

Polycomb group protein CBX8 as a novel substrate of Pim kinase in B-cell lymphoma. Invited talk at Signal transduction meeting, Yale University, CT 2017

Cancer Research. 74(21):6184-93. Publication was selected to appear on “cover page” of journal. 2014

Novel Regulators of Hepatic Functions and Liver Cancer. Invited talk at Department of Pathology, Memorial Sloan-Kettering Cancer Center, NY 2014

Novel players of Liver Cancer and Inflammation. Invited talk at Dept of Pharmacology, Yale University 2014

AEG-1/MTDH: a multifaceted regulator of hepatocarcinogenesis. Invited talk at Marion Bessin Liver Research Center, Albert Einstein College of Medicine, NY. 2014

“Junior Investigator Award” at Annual meeting of ILCA held at Washington, DC. 2013

“AACR-Women in Cancer Research (WICR) Scholar award” at AACR annual meeting. 2013

Best poster award at “International Symposium on Human Genomics and Public Health”, Delhi, India. 2007

DNA Cell Biol. 25(1):31-48. Publication was selected to appear on “cover page” of journal. 2006

> 50 news articles and blogs are written on my research publications. 2010- date REVIEW AND EDITORIAL EXPERIENCE

Invited Reviewer for NPG journal Lab Investigation 2017 - present Invited Reviewer for “Advances in Medical Sciences” and “Acta Biomaterialia” 2017 - present Invited Reviewer for Mol. Biology Reports 2016 - present Invited Reviewer for Cellular Physiology and Biochemistry 2016 - present Invited Reviewer for “BMJ open” and “International Journal of Molecular Sciences” 2015 - present Invited Reviewer for EBioMedicine 2015 - present

Invited Reviewer for Cancer Biotherapy and Radiopharmaceuticals 2015 - present Invited Reviewer for “PLoS ONE” and “Diabetic Reviews” 2014 - present Editorial Board member for VRI Cell Signaling 2014 - 2016 Editorial Board member for “International Journal of Medicine and Medical Sciences” 2009 - 2010 SELECTED MEMBERSHIPS

Associate Member of “Cancer Epigenetics Society (CES)” 2017 - present Member of “American Association for the Advancement of Science (AAAS)” 2017 - 2018 Member of “American Association for the Study of Liver Diseases (AASLD)” 2014 - 2017 Member of “International Liver Cancer Association (ILCA)” 2013 - present 4

Jyoti Srivastava- CV

Associate member of “American Association of Cancer Research (AACR)” 2011 - present Associate member of “Human Genome Organization (HUGO), Singapore 2008 – 2010 PUBLICATIONS

Original, Peer Reviewed:

1. Srivastava J*, Robertson CL*, Ebeid K et al (2017) A Novel Role of Astrocyte Elevated Gene-1 (AEG-1) in Regulating Non- alcoholic Steatohepatitis (NASH). Hepatology, doi.10.1002/hep.29230. 2. Srivastava J*, Rajasekaran D*, Ebeid K* et al. (2015) Combination of Nanoparticle-Delivered siRNA for Astrocyte Elevated Gene-1 (AEG-1) and All-trans Retinoic Acid (ATRA): An Effective Therapeutic Strategy for Hepatocellular Carcinoma

(HCC). Bioconjugate Chemistry, 26(8):1651-61.

3. Srivastava J, Siddiq A, Gredler R et al. (2015) Astrocyte elevated gene-1 (AEG-1) and c-Myc cooperate to promote hepatocarcinogenesis. Hepatology, 61(3):915-29.

4. Robertson CL, Srivastava J, Rajasekaran D et al. (2015) The role of AEG-1 in the development of liver cancer. Hepatic Oncology, 2(3):303-312.

5. Srivastava J*, Robertson CL*, Gredler R et al. (2015) Astrocyte Elevated Gene-1 (AEG-1) Contributes to Non-thyroidal Illness Syndrome (NTIS) Associated with Hepatocellular Carcinoma (HCC). J Biol Chem., 290(25):15549-58. 6. Robertson CL, Srivastava J, Siddiq A et al. (2015) Astrocyte Elevated Gene-1 (AEG-1) Regulates Lipid Homeostasis. J Biol Chem., 290(29):18227-36.

7. Jariwala N, Rajasekaran D, Srivastava J, Gredler R et al. Role of the staphylococcal nuclease and tudor domain containing 1 in oncogenesis (review). Int J Oncol., 2015, 46(2):465-73. 8. Srivastava J, Robertson CL, Gredler R et al. (2014) Astrocyte Elevated Gene-1 (AEG-1) Interacts with Retinoid X Receptor and Abrogates its Functions. Cancer Research, 74(16):4364-77. #Among top 5% publications. 9. Robertson CL, Srivastava J, Siddiq A et al. (2014) Genetic deletion of AEG-1 prevents hepatocarcinogenesis. Cancer Research, 74(21):6184-93.. #Among top 5% publications of the time; and on Cover Page of the journal. 10. Santhekadur PK, Akiel M, Emdad L, Gredler R, Srivastava J et al. Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling. FEBS Open Bio. 2014, 4:353-61.

11. Akiel M, Rajasekaran D, Gredler R, Siddiq A, Srivastava J et al. Emerging role of insulin-like growth factor-binding protein 7 in hepatocellular carcinoma. J. Hepatocellular Carcinoma. 2014,1 1-19. 12. Chen D, Siddiq A, Emdad L, Rajasekaran D, Gredler R, Shen XN, Santhekadur PK, Srivastava J et al. (2013) IGFBP7: a promising gene therapeutic for hepatocellular carcinoma (HCC). Molecular Therapy. Apr;21(4):758-66. 13. Srivastava J, Siddiq A, Emdad L et al. (2012) Astrocyte elevated gene-1 (AEG-1) promotes hepato-carcinogenesis: novel insights from a mouse model. Hepatology, 56(5):1782-91. 14. Santhekadur PK, Das SK, Gredler R, Chen D, Srivastava J et al. (2012) Multifunction protein SND1 promotes tumor angiogenesis in human hepatocellular carcinoma through a novel pathway which involves NF-kappaB and miR-221. J. Biol. Chem. 20;287(17):13952-8.

15. Pathak D, Srivastava J, Samad R, Parwez I et al. (2010) Genome-wide search of the genes tagged with the consensus of 33.6 repeat loci in buffalo Bubalus bubalis employing minisatellite-associated sequence amplification. Chromosome Research, 18(4):441-58.

16. Premi S, Srivastava J, Epplen JT, and Ali S (2010) AZFc region of the Y chromosome shows singular structural organization. Chromosome Research, 18(4):419-30.

17. Srivastava J, Premi S, Kumar S and Ali, S. (2009) Expressional dynamics of spermatozoal transcriptome tagged with consensus of 33.15 repeat loci in water buffalo Bubalus bubalis. BMC Genomics 10: 303. 18. Premi S, Srivastava J, Sebastian PC, Ali S (2009) Unique signatures of the natural background radiation on the human Y chromosome from Kerala (INDIA). PLoS ONE 4(2) e4541. 19. Srivastava J, Premi S, Kumar S, Ali S. (2008) Organization and differential expression of the GACA/GATA tagged somatic and spermatozoal transcriptomes in buffalo Bubalus bubalis. BMC Genomics 9: 132. 20. Premi S, Srivastava J, Panneer G. and Ali S (2008) Startling mosaicism of Y chromosome and tandem duplication of the SRY and DAZ genes in patients with Turner Syndrome. PLoS ONE 3(11): e3796. 21. Srivastava J, Premi S, Parwez I, Kumar S. and Ali S. (2007) Characterization of Smoc-1 uncovers two transcript variants showing differential tissue and age specific expression in Bubalus bubalis. BMC Genomics 8: 436. 22. Premi S, Srivastava J, Sebastian PC and Ali S. (2007) AZFc Somatic microdeletions and copy number polymorphism of the DAZ genes in human males exposed to natural background radiations. Hum. Genet. 121(3): 337-346. 23. Pathak D, Premi S, Srivastava J, Sebastian PC and Ali S. (2006) Genomic Instability of the DYZ1 Repeat in Patients with Y chromosome Anomalies and Males Exposed to Natural Background Radiation. DNA Res. 13: 103-109. 24. Srivastava J, Premi S, Garg LC and Ali S (2006) Organizational and Expressional Uniqueness of a Testis Specific mRNA transcript of Proto-oncogene c-kit Receptor in Water Buffalo Bubalus bubalis. DNA Cell Biol. 25(9): 501-513. 5

Jyoti Srivastava- CV

25. Premi S, Srivastava J, Sebastian PC, Ahmad J and Ali S (2006) Tandem Duplication and Copy Number Polymorphism of the SRY Gene in Patients with Sex Chromosome Anomalies and Males Exposed to Natural Background Radiation. Mol. Hum. Reprod. 12(2): 113-121.

26. Srivastava J, Premi S, Pathak D, Kumar S and Ali S (2006) Development of Molecular Markers for Characterization of Stem Cell Lineages, Proceedings Indian National Science Academy (PINSA) 72: 83-89. 27. Pathak D, Srivastava J, Premi S, Tiwari M, Ahsan Z, Garg LC, Kumar S and Ali S (2006) Chromosomal Localization, Copy Number Assessment and Transcriptional Status of BamHI Repeat Fractions in Water Buffalo Bubalus bubalis. DNA Cell Biol. 25(4): 206-214.

28. Srivastava J, Premi S, Pathak D et al. (2006) Transcriptional Status of Known and Novel Genes Tagged with Consensus of 33.15 Repeat Loci Employing Minisatellite Associated Sequence Amplification (MASA) and Real Time PCR in Water Buffalo Bubalus bubalis. DNA Cell Biol. 25(1): 31-48. (Appeared on cover page). Book Chapters:

1. Srivastava J, Premi S, and Ali S. Genomics of the Human Y Chromosome: Applications and Implications. Book: Genome Analysis and Human Health. Springer Press ISBN: 978-***-**-****. Chapter 7, page 133-151. Proceedings/Abstracts:

1. Bush EW, Nicholas A, Li X, Kuipers I, Hamilton H, Hegge J, Zhu R, Chen B, Srivastava J, et al. Targeting αENaC with an Epithelial RNAi Trigger Delivery Platform for the Treatment of Cystic Fibrosis at European Respiratory Society International Congress (2018).

2. Bush EW, Nicholas A, Li X, Kuipers I, Hamilton H, Hegge J, Zhu R, Chen B, Srivastava J, et al. Targeting αENaC with an Epithelial RNAi Trigger Delivery Platform for the Treatment of Cystic Fibrosis at North American Cystic Fibrosis Conference (2018).

3. Bush EW, Nicholas A, Li X, Kuipers I, Hamilton H, Hegge J, Zhu R, Chen B, Srivastava J, et al. Targeting αENaC with an Epithelial RNAi Trigger Delivery Platform for the Treatment of Cystic Fibrosis at 41st European Cystic Fibrosis Conference (2018).

4. Bush EW, Nicholas A, Pei T, Kuipers I, Cheng W, Hamilton H, Hegge J, Li X, Glebocka, Zhu R, Chen B, Srivastava J, et al. Targeting αENaC with an Epithelial RNAi Trigger Delivery Platform for the Treatment of Cystic Fibrosis. American Thoracic Society (ATS) International Conference (2018). 5. Srivastava J, Rajasekaran D, Siddik A, Gredler R et al. A novel combinatorial therapy for hepatocellular carcinoma (HCC). Cancer Research, 75(15 Suppl): Abstract nr 5400. doi:10.1158/1538-7445. AM2015-5400 (2015). 6. Cazanave S, Vincent R, Srivastava J, Asgharpour A et al. FXR resistance characterizes human and mouse model of NASH. Journal of Hepatology, Volume 62, Supplement 2, Page S703 (2015). 7. Robertson CL, Srivastava J, Siddiq A, Gredler R et al. Analyzing the role of Astrocyte elevated gene-1 (AEG-1) in Hepatocarcinogenesis using a knockout mouse model. AACR; Cancer Research,74(19 Suppl): Abstract # 72 (2014). 8. Robertson CL, Srivastava J, Gredler R, Siddiq A et al. Elucidating the Role of Astrocyte Elevated Gene-1 (AEG-1) in Lipid Metabolism. Abstract: 3010. Keystone Symposia Conference, Nuclear Receptors: Biological Networks, Genome Dynamics and Disease at Taos, New Mexico (2014).

9. Srivastava J, Robertson CL, Gredler R, Siddiq A et al. Astrocyte Elevated Gene-1 (AEG-1) interacts with retinoid X receptor

(RXR) and abrogates its function: Implications in Hepatocarcinogenesis. Abstract: P-020. Annual meeting of International Liver Cancer Research Association (ILCA), Washington, DC (2013). 10. Srivastava J, Robertson CL, Gredler R, Siddiq A et al. Astrocyte Elevated Gene-1 (AEG-1) interacts with retinoid X receptor

(RXR) and abrogates its function. Cancer Research, 73(8 Suppl):Abstract # 5437. doi:10.1158/1538-7445. AM2013-5437

(2013).

11. Srivastava J, Siddiq A, Emdad L, Santhekadur PK et al. Unraveling novel functions of the oncogene Astrocyte elevated gene-1 (AEG-1) contributing to hepatocarcinogenesis employing a transgenic mouse model. Cancer Research. 72(8 Suppl): Abstract # 1324. doi:1538-7445.AM2012-1324 (2012). 12. Santhekadur PK, Gredler R, Chen D, Srivastava J et al. Protein-protein interaction study identifies a novel mechanism of hepatocarcinogenesis. 4 th Biennial Summit on Systems Biology, Richmond, VA (2011). 13. Premi S, Srivastava J, and Ali S. “Natural radiation poses no major risk”, Nature News-India, (2009) 14. Premi S, Srivastava J, Sebastian PC and Ali S. Human Y chromosome and natural background radiation. International Seminar on “ENVIROTECH”, Postgrad Res Dept of Zoology, J.B.A.S College for Women, Chennai, India (2007). 15. Premi S, Srivastava J, Sebastian PC, Ahmad J and Ali S. “Double jeopardy for sex chromosome disorders”, Nature News- INDIA, p11 (2005).

FEATURED ORAL & POSTER PRESENTATIONS

1. Polycomb group protein CBX8 as a novel substrate of Pim kinase in B-cell lymphoma. Yale University Department of Pharmacology Retreat (Sep 9, 2016).

2. A novel combinatorial therapy for hepatocellular carcinoma (HCC). American Association of Cancer Research (AACR) Annual Meeting 2015, Philadelphia, PA (2015).

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Jyoti Srivastava- CV

3. FXR resistance characterizes human and mouse model of NASH. International Liver Congress 2015 - 50th annual meeting held at Austria, Vienna (April 22-26, 2015).

4. Novel Regulators of Hepatic Functions and Liver Cancer. Invited talk at Department of Pathology, Memorial Sloan-Kettering Cancer Center, NY (Oct 22, 2014).

5. Novel players of Liver Cancer and Inflammation. Invited talk at Department of Pharmacology, Yale University (Oct 20, 2014). 6. AEG-1/MTDH: a multifaceted regulator of hepatocarcinogenesis. Invited talk at Marion Bessin Liver Research Center, Albert Einstein College of Medicine, NY (Oct 17, 2014).

7. Analyzing the role of Astrocyte elevated gene-1 (AEG-1) in Hepatocarcinogenesis using a knockout mouse model. American Association of Cancer Research (AACR) Annual Meeting, San Diego, CA in 2014. 8. Astrocyte Elevated Gene-1 (AEG-1) Interacts with Retinoid X Receptor (RXR) and Abrogates its Function: Implications in Hepatocarcinogenesis at International Liver Cancer Association (ILCA) annual conference being held at Washington, DC in Sep 2013.

9. Retinoid X Receptor (RXR): Novel interacting partner of Oncogene AEG-1 in liver cancer. Cancer Research Retreat, Massey Cancer Center at Virginia Commonwealth University, Richmond, VA on June 13, 2013. 10. Novel molecular insights from AEG-1-/- knockout mice. Cancer Research Retreat, Massey Cancer Center at Virginia Commonwealth University, Richmond, VA on June 13, 2013. 11. Astrocyte Elevated Gene-1 (AEG-1) Interacts with Retinoid X Receptor (RXR) and Abrogates its Function. American Association of Cancer Research (AACR) Annual Meeting 2013, Washington DC in Apr 2013. 12. Unraveling novel functions of the oncogene Astrocyte elevated gene-1 (AEG-1) contributing to hepatocarcinogenesis employing a transgenic mouse model. American Association of Cancer Research (AACR) Annual Meeting 2012, Chicago, IL from Mar 31- Apr 4, 2012.

13. A transgenic mouse model unravels novel functions of astrocyte elevated gene-1 (AEG-1) contributing to hepatocarcinogenesis. Cancer Research Retreat, Massey Cancer Center at Virginia Commonwealth University, Richmond, VA on Nov 7, 2011.

14. Repeat sequences in the genome: Is Junk DNA really junk! Invited talk at Department of Zoology, Aligarh Muslim University, India (Oct 24, 2008).

15. Unique Signatures of Natural Background Radiation on Human Y chromosomes from Kerala. HUGO’s 13th human genome meeting (HGM 2008), Hyderabad, INDIA, Sep 27-30, 2008. 16. Natural Background radiation dictates extensive structural polymorphism in the human Y chromosome. 40th European Human Genetics Conference, Barcelona, SPAIN, May 31-Jun 3, 2008. 17. Smoc-1: Two transcript variants with different tissue and age specific expression. 2nd International Conference on “Trends in Cellular and Molecular Biology”, Jawaharlal Nehru University, India. Jan 5-7, 2008. 18. Mining of the minisatellite associated coding genome of water buffalo Bubalus bubalis. International symposium on

“Chromosomes to Genome”. Centre for Cellular and Molecular Biology, Hyderabad, India. Jul 3-5, 2007. 19. Indo-US workshop on “Mitochondrial Research and Medicine” organized by Centre for Cellular and Molecular Biology, Hyderabad, India, during Jan 22-24, 2007.

20. Transcriptional status of known and novel genes tagged with consensus of 33.15 repeat loci employing MASA and real time PCR in water buffalo Bubalus bubalis. International symposium on “Human genomics and Public health-2006 and XXXI annual conference of Indian Society of Human Genetics”. Jawaharlal Nehru University, India. Feb 27 – Mar 1, 2006. 21. Biology of proto-oncogene C-kit receptor in Rattus norvegicus. National conference on Deep roots and open skies: New Biology in India. National Institute of Immunology, India. Feb 25, 2004.

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