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Professional Experience Assistant

Location:
Toronto, Ontario, Canada
Salary:
50,000 to 55,000
Posted:
November 27, 2017

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Resume:

Mahnaz Yazdani, Ph.D.

** ****** ***, ***** ****, ON M2N 4M1 ●416-***-****● ac3hz8@r.postjobfree.com

PROFILE

The selection and evaluation of materials for use in solid dosage form of drugs and it is recommended that all testing comply with Good Laboratory Practice (GLP) regulations.

A thorough understanding of health Canada and FDA regulation,Canadian Pharmacuetical Law and Administration,as well as GMP,GLP and GCP guidances.

Extensive hands-on experience of a wide range of microbiological, biochemical and proteomic techniques, as well as a strong theoretical background.

Experience in various biophysical techniques in protein structure, ligand interaction characterization, spectroscopy included UV, NMR, circular Dichroism spectroscopy and Isothermal titration calorimetry (ITC).

Experience in detailed proteomic which involved the use of 2D gel electrophoresis and was performed in collaboration with scientists at the Pasteur Institute.

Familiar with methods of microbial culture; protein extraction; SDS-PAGE; immunoblotting; affinity purification; enzyme purification and assays; protein biochemistry; molecular biology, etc.,

Experience in developing analytical methods to monitor and characterize target product purity and integrity (e.g., HPLC, Western blotting, ELISA, protein quantification)

Strong computer skills and data analysis and Experience creating and interpreting phylogenic trees is an asset

Isolation and use of DNA for molecular biology.

have repeatedly shown willingness and enthusiasm to learn new methods in the pursuit of a research goal.

PROFESSIONAL EXPERIENCE

Instructor/ Research Associate, Toronto Institute of Pharmaceutical and Technology

Sep. 2015 – present

Performed sampling and analysing of Raw materials, In-process and Finished product

Carried out analytical testing including Identification, Assay(employing Waters HPLC with Empower software and UV/VIS), Uniformity of Dosage Units, Dissolution(Type I, II), Disintegration, Hardness, Friability, titration by Karl Fisher, Powder characterization and other tests

Sound knowledge of GC and TLC

Completed potency adjustment and scale up calculation of Master Formula Working Record

Conducted batch manufacturing followed by manufacturing processes of Dispensing,Mixing &Blending, Wet massing, Wet screening, Drying,Sieving, Compression and coating

Prepared SOPs for all equipment and processes, filled all logbook, Batch Folder and document in compliance with GMP guidelines, calculated process Yield and Reconciliation

Performed method development and validation, process development and validation and stability studies

Performed formulation development,Design of experiments, optimization of immediate release and controlled release technologies of Caffeine in a GMP/GLP environment

Sound knowledge of Bioburden,Microbial Culturing,Enumeration technique, Aseptic technique and Sterilization

Disassembled and performed appropriate type of cleaning and sanitizing of all equipment and parts

Prepared SOPs for all processes, filled all logbook, Batch Folder and document in compliance with GMP guidelines

Wrote protocols and reports for assigned projects and employed statistical analysis tools such as ANOVA and Regression

Empower software(HPLC)

Design Expert7.0 sofware(Biostatistics)

Proficient in MS office

Assistant Professor of Biochemistry, Department of Biology, University of Zanjan, Iran 2008-2015

Prepared lesson plans and visual aids for classes.

Handled three subjects and at least five biochemistry classes a week.

Handled and oversee laboratory exercises.

Served as thesis adviser to several students.

Conducted research work and write scientific articles.

Successfully improved student participation in the classroom through the integration of creative role-playing exercises.

Supervising laboratory exercises and thesis adviser.

Visiting Scientist, the MacNeill lab, Copenhagen University, Denmark 2007-2008

Worked as a visiting scientist on a project aimed at purifying replication protein complexes from the haloarchaeal organism Haloferax volcanii. (E.g., HPLC, SDS-PAGE, Western blotting, ELISA, protein quantification)

Visiting Scientist, Pasture Institute,Tehran,Iran 2005 -2007

proteomic analysis of a novel gamma-radiation-resistant bacterium isolation from a hot spring protein extraction; two-dimensional gel electrophoresis; Protein purification; protein biochemistry;

EDUCATION

Research & Development Drug. Diploma Sep. 2015 – Sep. 2016

Toronto Institute of Pharmaceutical and Technology

Ph.D. in Biochemistry, Tarbiat Modares University, Tehran, Iran 2004-2008

M.Sc. in Biochemistry, Tarbiat Modares University, Tehran, Iran 1996-1999

B.Sc. in Biology, Shiraz aUniversity, Shiraz, Iran 1991-1995

Experience& Presentation

2013 Attended 10th Poznan Summer School of Bioinformatics (August 19-23, 2013)

2010 Attended 8th Poznan, Summer School of Bioinformatics (July 5 -10, 2010)

Conferences attended

2015 41st Annual Meeting of the European Society for Blood and Marrow Transplantation, The assessment of MYC and particular microRNAs cooperation with signaling pathways in breast cancer in the trajectory to reveal osteolytic bone metastasis V. Pourteimoor, S. Mohammadi-Yeganeh, M. Yazdani Istanbul, Turkey 22 - 25 March.

2010 16th Annual European Meeting of PhD Students in Evolutionary Biology, 23-28 May, Wierzba, Poland.

2009 15th Annual European Meeting of PhD Students in Evolutionary Biology, 14-19 August, Schoorl, The Netherlands.

2009 VIII European Symposium of the Protein Society, June 14-18, 2009, Zurich, Switzerland

2008 15th National & International Conference of Biology, University of Tehran, Tehran, Iran, Proteomics analysis of a wild-type strain of Bacillus megaterium strain WHO DQ973298 recovering from Gamma-irradiation. Yazdani, M., Naderi-Manesh, H., Khajeh, K., Vaziri, B.

2007 First Iranian Proteomics Congress. Proteomics analysis of a new strain of Bacillus megaterium, Yazdani, M., Naderi-Manesh, H., Khajeh, K. and Vaziri, B.

1999 Protein structure function relationships, 6th international symposium. 5-7 February1999, Pakistan

Publications

1- Yazdani, M., Naderi-Manesh H, Khajeh K, Soudi MR, Asghari SM, Sharifzadeh M. (2009) Isolation and characterization of a novel gamma-radiation-resistant bacterium from a hot spring in Iran. Journal of Basic Microbiology 49, 119–127.

2- Yazdani, M., Naderi-Manesh, H., Khajeh, K. and Vaziri, B. (2012) Comparative proteomics analysis of a novel gamma-radiation-resistant bacterium wild-type Bacillus megaterium strain, WHO DQ973298 recovering from 5 KGy gamma-irradiation, Iranian Journal of Biotechnology 10, 96-105.



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