Peilin Ma

**** ********* **., **********, ** ****7

317-***-****

ac3ew7@r.postjobfree.com

Highly experienced and strong motivated MD. and PhD. biologist seeking a research scientist position in biotech/pharmaceutical industry. Worked for 12 years in cutting edge research in hematology/oncology, immunology and molecular/cellular biology and published 15 articles in top peer-reviewed journals (Cancer Cell, JCI, Blood, Leukemia, Molecular Cell).

CORE COMPETENCIES

Extensive knowledge and experience in immunology, familiar with various immunological techniques

Strong knowledge and experience in cell signaling, genetics and epigenetics research on normal and malignant hematology, especially in the development of mast cells, granular cells and B cells, and acute myeloid leukemia

Strong lab management and mentoring junior research members.

Proven ability to handle multiple projects simultaneously.

Proven experience in writing peer-reviewed manuscripts, scientific grant proposals and research protocols.

Excellent oral/written communication skills.

Familiar with statistical approaches used in assay development and results processing.

EDUCATION

PhD., Immunology, Harbin Medical University, Harbin, China, 1999-2004

MD., Clinical Medicine, Harbin Medical University, Harbin, China, 1992-1997

PROFESSIONAL EXPERIENCE

Assistant Research Professor, Department of Pathology and Laboratory Medicine at Indiana University School of Medicine, Indianapolis, IN, 2014-present

Investigated the role of chromatin remodeling by FLT3-ITD and HoxA9 in the development of acute myeloid leukemia (AML); characterized the interaction between HoxA9 and Stat5 in the development of FLT3-ITD associated AML; investigated the epigenetic effect of C/EBPα mutations in leukemogenesis

Research Investigator, Department of Pathology, University of Michigan, Ann Arbor, MI, 2012-2014

Characterized the interaction between HoxA9 and FLT3-ITD induced constitutive activation of Stat5 in the development of acute myeloid leukemia (AML); characterized the epigenetic effect of C/EBPα mutations in AML; explored the role of HoxA9-regulated transcription of FLT3 in AML

Postdoctoral fellow and Research Associate, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, 2006-2012

Characterized the role of Rho kinase (ROCK) in KIT, FLT3 and BCR-ABL associated leukemia; investigated and characterized multiple cell signaling molecules including Pak, Rac GTPases, SHP2 in oncogenic KIT–induced neoplasms; identified the role of class IA phosphatidylinositol-3-kinase and SHIP in the maturation of mast cells; characterized the role of intracellular tyrosines in activating KIT induced myeloproliferative disease; demonstrated the role of SHP2 phosphatase in KIT-induced transformation

Postdoctoral fellow, Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 2005-2006

Cloned transmembrane activator and calcium-modulator and cytophilin ligand interactor (TACI) knock-out mouse

Lecturer, PhD. student, Department of Microbiology, Harbin Medical University, Harbin, China, 1-2004

Epidemiological study of the infection of Borna disease virus (BDV) in north-east of China and isolation and characterization of BDV; demonstrated the effects of Borna disease virus infection on the transcription of the monoaminergic receptor genes in the brain tissues of neonatally inoculated rat

LEADERSHIP EXPERIENCE

Assistant Research Professor and Lab Manager, Department of Pathology and Laboratory Medicine at Indiana University School of Medicine, Indianapolis, IN, 2014-present

Independently managed the biomedical research laboratory; trained and guided two postdoctoral fellows and one undergraduate student to perform their projects

Research Investigator, Department of Pathology, University of Michigan, Ann Arbor, MI, 2012-2014

Guided two graduate students to perform their research projects

Research Associate, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, 2010-2012

Trained and guided two graduate students, two junior postdoctoral fellows and three research assistants to perform their in-vitro and in-vivo experiments

Lecturer, Harbin Medical University, Harbin, China, 1997-2004

Taught medical microbiology to medical school students

HONARS AND AWARDS

Showalter Young Investigator Award (2017-2018, $60,000), PI, Showalter Research Trust Fund, Indiana University School of Medicine, Indianapolis, IN.

ASH Abstract Achievement Award (2011), 53rd American Society of Hematology (ASH) Annual Meeting, San Diego, CA.

Second Place of Basic Science Award (2010), Indiana University Simon Cancer Center Cancer Research Day, Indianapolis, IN.

Third place of Translation/Clinical Research Award (2010), Indiana University Simon Cancer Center Annual Cancer Research Day, Indianapolis, IN.

Travel Award (2007), 49th American Society of Hematology (ASH) Annual Meeting, Atlanta, GA.

PROFESSIONAL ORGANIZATIONS

2016-present Member, American Society of Hematology (ASH)

1999-2004 Member, Chinese Immunity Society

TECHNICAL SKILLS:

Immunology

Extensive knowledge and experience in immunology, familiar with various immunological techniques, including flow cytometry, ELISA, immunoprecipitation (IP), immunohistochemistry and fluorescence microscopy.

Expertise in multiparametric flow cytometry (extra- and intracellular staining)

Instruments: BD LSRII, FACSVerse, Accuri C6 Plus

Analysis software: Flowjo, Cellquest and Accuri C6 Plus

Hematology and oncology

Extensive experience in various hematology techniques including isolation, identification and culture of primary hematopoietic stem/progenitor cells, master cells, T and B cells; colony formation assay (CFC), serial replating assay

Molecular Biology

Extensive experience in a variety of genetic and epigenetic research techniques including chromatin immunoprecipitation (ChIP), ChIP-seq, ATAC-seq, CRISPR

Experienced in RNA, DNA and protein detections, such as gene cloning, PCR, RT-PCR, site-directed-mutagenesis, transfection, transformation, transduction, western blot, pull-down assay

Cellular Biology

Experienced in cell culture of various mammalian cell lines and primary murine cells, including Chinese hamster ovary cell (CHO), 293T, 3T3, Hela, HL60, K562, 32D, Baf3, PlateE, and GP cells

Expertise in isolation and culture of hematopoietic stem cells and progenitor cells (HSC/P), B lymphocytes, neural stem cells, induction of master cells and B cells maturation, and generation of oncogene-transformed cell lines

Animal Techniques

12-year experience of in vivo research (mouse, rat and rabbit)

Experienced in maintaining colonies, genotyping, various injection (ip, iv and subcutaneous), oral gavage, surgical implantation of drug pellets, harvesting organs

Extensive experience in establishing and monitoring in vivo mouse models (solid tumor and leukemia)

SELECTED PEER-REVIEWED PUBLICATIONS

1.Ma P, Song W, Hess JL. A new target for differentiation therapy in AML. Cell Research, 2016, Nov.

2. Ghosh J, Kobayashi M, Ramdas B, Chatterjee A, Ma P, Mali RS, Carlesso N, Liu Y, Plas DR3, Chan RJ*, and Kapur R. S6K1 regulates Stem Cell Self-Renewal and Leukemia Maintenance. Journal of Clinical Investigation, 2016, 126(7): 2621-2625.

3.Zhou Bo, Wang JY, Lee SY, Xiong J, Bhanu N, Guo Q, Ma P, Sun YQ, Rao RC, Garcia BA, Hess JL. PRDM16 suppresses MLL leukemia via intrinsic histone Methyltransferase Activity. Molecular Cell, 2016, 62(2): 222-236.

4.Li XJ, Deng L, Brandt S, Goodwin CB, Ma P, Yang ZY, Mali RS, Liu ZY, Kapur R, Serezani CH and Chan RJ. Role of p85α in Neutrophil Extra- and Intra-Phagosomal ROS Generation. Oncotarget, 2016, 7(17): 23096–23105.

5.Martin H*, Mali RS*, Ma P*, Chatterjee A, Ramdas B, Sims E, Munugalavadla V, Ghosh J, Mattingly R, Visconte V, Tiu RV, Vlaar CP, Dharmawardhane S, Kapur R. Pak and Rac GTPases promote oncogenic KIT–induced neoplasms. Journal of Clinical Investigation. 2013, 123(10):4449-63. * These authors contribute equally to this paper.

6.Ma P, Mali RS, Martin H, Ramdas B, Sims E, and Kapur R. Role of intracellular tyrosines in activating KIT induced myeloproliferative disease. Leukemia. 2012, 26(7):1499-506.

7.Song W, Xiao Y, Chen H, Ashpole NM, Piekarz AD, Ma P, Hudmon A, Cummins TR, Shou W. The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity. The Journal of Physiology. 2012, 590(Pt 20):5123-39.

8.Mali RS*, Ma P*, Zeng LF, Martin H, Ramdas B, He Y, Sims E, Ghosh J, Nabinger S, Li S, Munugalavadla V, Chatterjee A, Sandusky G, Craig AW, Bunting KD, Feng GS, Chan RJ, Zhang ZY, Kapur R. Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood. 2012, 120(13):2669-78. * These authors contribute equally to this paper.

9.Krishnan S, Mali RS, Ramdas B, Sims E, Ma P, Munugalavadla V, Hanneman P, Beane JD, and Kapur R. p85β regulatory subunit of class IA PI3 Kinase negatively regulates mast cell growth, maturation and leukemogenesis. Blood. 2012, 119(17):3951-61.

10.Vemula S, Shi JJ, Mali RS, Ma P, Hanneman P, Wei L and Kapur R. ROCK1 functions as a critical regulator of stress erythropoiesis by regulating p53. Blood. 2012, 120(14):2868-78.

11.Krishnan S, Mali RS, Koehler KR, Vemula S, Chatterjee A, Ghosh J, Ramdas B, Ma P, Hashino E, Kapur R. Class IA PI3Kinase regulatory subunit, p85α, mediates mast cell development through regulation of growth and survival related genes. PLoS ONE. 2012; 7(1):e28979.

12.Ma P, Mali RS, Munugalavadla V, Krishnan S, Ramdas B, Sims E, Martin H, Ghosh J, Li S, Chan RJ, Krystal G, Craig AW, Takemoto C, Kapur R. The phosphatidylinositol-3-kinase pathway via microphthalmia transcription factor drives the maturation of mast Cells. Blood. 2011, 118(13):3459-69.

13.Ma P, Vemula S, Munugalavadla V, Chen J, Sims E, Borneo J, Kondo T, Ramdas B, Mali RS, Li S, Hashino E, Takemoto C, Kapur R. Balanced interactions between Lyn, p85α regulatory subunit of class IA phosphatidylinositol-3-kinase and SHIP is essential for mast cell growth and maturation. Molecular and Cellular Biology. 2011; 31(19):4052-62.

14.Mali RS*, Ramdas B*, Ma P, Shi J, Munugalavadla V, Sims E, Wei L, Vemula S, Nabinger SC, Goodwin CB, Chan RJ, Traina F, Visconte V, Tiu RV, Lewis TA, Stern AM, Wen Q, Crispino JD, Boswell HS, Kapur R. Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3 and BCR-ABL. Cancer Cell. 2011; 20 (3):357-69. * These authors contribute equally to this paper.

15.Orschell CM, Borneo J, Munugalavadla V, Ma P, Sims E, Ramdas B, Yoder MC and Kapur R. Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells. Experimental Hematology. 2008; 36 (5): 655-666.

SELECTED ORAL AND POSTER PRESENTATIONS

1.Ma P, Sun YQ, Wang JY, Song WH, Xu T, Kapur R, Hess JL. The role of STAT5 in HOXA9-associated leukemia. 58th American Society of Hematology (ASH) Annual Meeting, San Diego, CA, Dec 2016.

2.Martin H, Ma P, Chatterjee A, Ramdas B, Sims E, Vlaar C, Dharmawardhane S and Kapur R. Role of p21 Activated Kinase and Specific Guanine Exchange Factors of Rac Gtpases in Oncogenic KIT Induced Systemic Mastocytosis and Acute Myeloid Leukemia. 54th American Society of Hematology (ASH) Annual Meeting, Atlanta, GA. Dec 2012

3.Ma P, Mali RS, Zeng LF, Martin H, Ramdas B, He Y, Sims E, Ghosh J, Nabinger S, Li S, Munugalavadla V, Chatterjee A, Sandusky G, Craig AW, Bunting KD, Feng GS, Chan RJ, Zhang ZY and Kapur R. KIT Induced Myeloproliferative Disease Is Dependent on PI3Kinase and SHP2 Phosphatase: Identification of SHP2 as a Druggable Target for Treating MPD and AML. 53rd American Society of Hematology (ASH) Annual Meeting, San Diego, CA, Dec 2011. (Oral Presentation).

4.Ma P, Martin H, Sims E, Baskar R, Ghosh J and Kapur R. Role of Intracellular Tyrosine Residues in Oncogenic KIT-Induced Transformation. 8th Annual Midwest Blood Club Symposium, Indianapolis, IN, May 2010. (Oral Presentation)

5.Ma P, Martin H, Sims E, Baskar R, Ghosh J and Kapur R. Role of Intracellular Tyrosine Residues in Oncogenic KIT-Induced Transformation. 51st American Society of Hematology (ASH) Annual Meeting, New Orleans, LA, Dec 2009.

6.Ma P, Kapur R. Repression of ROCKII by GATA-1 Inhibits Cell Proliferation during Erythroid Maturation. 49th American Society of Hematology (ASH) Annual Meeting, Atlanta, GA, Dec 2007.

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