Research

Thilagavathi Jayapalraja

*** ***** *** *** *

Kearny, New Jersey- 07032

Email: *******@*****.***

Phone: 201-***-****

EDUCATION

M. S (Pharmaceutical Analysis) (University Gold Medalist) Apr. 2009

Anna University, Tiruchirappalli, T.N, India

B. S (Pharmaceutical Sciences), Aug. 2006

The TN Dr. M.G.R Medical University, Chennai, India

Certificate Course

Certificate in Clinical Research Management Feb. 2017

Sollers Institute, NJ & New York Academy of Sciences, NY

Clinical Data Management System (CDMS) which is widely used in the pharmaceutical industry today. It included hands on experience in Protocol Development, Case Report Form development, Clinical Database Planning, Designing, Clinical Data Entry, Definition, Discrepancy Management, and Writing Validation Procedures.

Good Clinical Practices, Roles and responsibilities of a clinical research associate, Understanding IRB’s and Informed Consent form (ICF) Process, Case Report Form, Regulatory Compliance, PHI and HIPAA, Drug Inventory Management, Sponsor/FDA Audit Preparedness, Drug Returns and Records Return Functions and Site Closeout Responsibilities, Practical training in the process of Clinical Data Management, Real time hands-on training on a Clinical Data Management System using Oracle Clinical from Study Setup to Database Lock using sample study documentation, Interactive exercises and case study projects

SAS Clinical - Completed SAS clinical course June to August 2017

WORK EXPERIENCE

Research Assistant Jun. 2012- Jun. 2015

Dept. of Microbiology, Biochemistry and Molecular Biology

Rutgers New Jersey Medical School, Newark, NJ 07101

Conducted basic research in biochemistry and molecular biology. Techniques include protein expression in bacteria, protein purification, and in vitro high through put assays identifying small molecule inhibitors of mitochondrial Lon protease. Studying post translational modifications of mitochondrial transcription factor, TFAM by in vitro assays. Familiar with techniques such as DNA and RNA isolation, PCR, Agarose and Polyacrylamide gel electrophoresis.

Senior Research Fellow Apr. 2010 – Oct. 2011 Laboratory for Molecular Reproduction & Genetics

Department of Anatomy, All India Institute of Medical Sciences,

New Delhi-29, India

Enrolled children with ocular disorders, both male and female subjects with reproductive disorders based on inclusion and exclusion criteria as per the study protocols. In addition, explaining the concept of the studies to the subjects, obtaining informed consent as per the Human ethical Institute Review board instructions. Created standard operating protocol (SOP), maintained patient’s clinical data, performed quality checks, and overviewed budget management.

Clinical Project Assistant Oct. 2009 – Apr. 2010

Dept. of Ocular Pharmacology,

Aravind Medical Research Foundation,

Madurai-20, Tamil Nadu, India

Enrolling subjects with CATARACT based on the inclusion and exclusion criteria as per the study protocol. Collected the cataract tissues during cataract surgery, and stored the samples at - 80 degree Celsius. Created standard operating procedures (SOP) and maintained patient’s clinical data in addition to performing quality checks, and overviewing budget management.

Research Trainee Jul. 2008 – Mar. 2009

Dept. of Ocular Pharmacology,

Dr. R. P. Centre for Ophthalmic Sciences

All India Institute Medical Sciences

New Delhi-29, India

Enrolled subjects with DRY EYE SYNDROME (DES) based on inclusion and exclusion criteria as per the study protocol. In addition, explained the concept of the studies to the subjects, obtained informed consent as per the Human ethical Institute Review board instructions. Analyzed the tear samples by Mass Spectrometry and developed lipid biomarker profile for both DES and control subjects.

Tutor Oct’ 2006 – Aug’ 2007

Sree Vidyanikethan College of Pharmacy,

Sree Sainath Nagar, Tirupathi, A.P, India

Taught theory and practical to the undergraduate students, subjects of biotechnology, genetic engineering, enzyme production, and tissue culture. Screening natural products for various Pharmacological (Anti-diabetic and Anti-ulcer activities)

ACADEMIC EXCELLENCE, AWARDS AND HONORS

University First –Gold medalist during Master’s (Pharmaceutical Analysis)

Second rank overall college during B. Pharm.

Second rank overall school in 10th grade public examination.

Selected for student interaction program with Ex-President Dr. A.P.J. Abdul Kalam during 55th Indian Pharmaceutical Congress, Chennai.

Organizing and Scientific committee member of the National Level Technical Symposium on Exploring the Research Platform for Pharmaceutical Product and Process Development, March 15-16, 2008, Anna University, Trichirapalli, sponsored by Indian Council of Medical Research.

PUBLICATIONS

1.Strauss KA, Jinks RN, Puffenberger EG, Venkatesh S, Singh K, Cheng I, Mikita N, Thilagavathi J, et al. 2015. CODAS Syndrome Is Associated with Mutations of LONP1, Encoding Mitochondrial AAA+ Lon Protease, The American Journal of Human Genetics 96(1):121-135

2.S. Venkatesh, J. Thilagavathi, K. Kumar, D. Deka, P. Talwar, R. Dada, Cytogenetic, Y chromosome microdeletion, sperm chromatin and oxidative stress analysis in male partners of couples experiencing recurrent spontaneous abortions, Arch Gynecol Obstet, 284 (201*-****-****.

3.S. Venkatesh, A. Singh, M.B. Shamsi, J. Thilagavathi, R. Kumar, D.K. Mitra, R. Dada, Clinical significance of sperm DNA damage threshold value in the assessment of male infertility, Reprod Sci, 18-201*-****-****.

4.S. Venkatesh, J. Thilagavathi, D. Shyam Sundar, Anti-diabetic activity of flowers of Hibiscus rosasinensis, Fitoterapia, 79 (2008) 79-81.

5.Thilagavathi J, Venkatesh S, Kumar R, Dada R. Segregation of sperm subpopulations in normozoospermic infertile men. Syst Biol Reprod Med. 2012 Dec;58(6):313-8

6.Thilagavathi J, Venkatesh S, Dada R. Telomere length in reproduction. Andrologia. 2013 Oct;45(5):289-304.

7.Thilagavathi J, Kumar M, Mishra SS, Venkatesh S, Kumar R, Dada R. Analysis of sperm telomere length in men with idiopathic infertility. Arch Gynecol Obstet. 2013 Apr;287(4):803-7.

Conference Abstracts

1.Thilagavathi J, Kumar R and Dada R. Shortened Sperm Telomere Length And Its Association With Male Infertility. 37th ASA Annual Conference April 21- 24, 2012. Tuscon, AZ, USA.

2.Dada. R, M. B. Shamsi, Kumar K, Thilagavathi J, Jhumur Pani, Swetasmita Mishra, Mohanty K and Kumar R. Seminal Reactive Oxygen Species Estimation: Is Single Reading Enough? Clinical Implications. 37th ASA Annual Conference April 21- 24, 2012. Tuscon, AZ, USA.

3.S Venkatesh, MB Shamsi, K Kumar, J Thilagavathi and R Dada. Analysis of Sperm DNA Integrity, Oxidative Stress and Its Clinical Implication In Men with Idiopathic Infertility. ASA 36th Annual Meeting, Sunday, April 03, 2011 Montreal, Canada

4.Prevalence of diabetes in Tirupati urban population and the role of risk factors associated with it - a preliminary survey” at the 59th Indian Pharmaceutical congress at BHU, Varanasi, India

5.Oral Presentation of Antioxidant enzymes in the pathogenesis of Recurrent Spontaneous Abortion (RSA). Presented at National Level Technical Symposium on Exploring the Research Platform for Pharmaceutical Product and Process Development on 15, 16, March ’08 conducted by department of Pharm. Eng & technology, Anna university, Trichy sponsored by ICMR.

ATTENDANCE AT MEETINGS AND PROFESSIONAL MEMBERSHIP

Seminar on Career Prospects in Pharmacy Profession held at, Department of Pharmacy, Sri Ramachandra Medical College & Research Institute, Chennai, India on 26th March 2005.

55th Indian Pharmaceutical Congress at Sree Ramachandra Medical College & Research Institute, Chennai, India.

Participated in workshop (26th, 27th Jan 2008) on spectral analysis conducted by department of Pharmaceutical analysis, Anna University, Trichy, India.

National Level Technical Symposium on Exploring the Research Platform for Pharmaceutical Product and Process Development on 15, 16, March ’08 conducted by department of Pharm. Eng & technology, Anna university, Trichy sponsored by ICMR.

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