PROFESSIONAL OVERVIEW

-Experience with mammalian cell culture, immunocytochemistry, confocal microscopy, RNAi, nucleic acid extraction/purification, PCR/ qRT-PCR, protein purification, enzymatic assay development, ELISA, western blotting, flow cytometry/FACS and HPLC.

-Expertise with experimental organization and design, as well as proficiency with data documentation and analysis.

-Advanced proficiency with various data and image analysis software, as well as with experience using various software packages including MS Office and Adobe products.

-Background in teaching chemistry and biochemistry concepts gained through graduate assistantships and mentoring undergraduate students.

-Experience working in highly collaborative environments.

PROFESSIONAL EXPERIENCE

Baylor University Waco, TX

Graduate Researcher;

-Development of small molecule compounds as tumor vascular disrupting agents

oUsed techniques such as mammalian cell culture, flow cytometry, immunofluorescence microscopy, western blotting, and RNAi to evaluate compounds synthesized as potential tumor vascular disrupting agents as well as elucidating cell signaling pathways by which these compounds function in cancer and normal cell lines.

oExpertise in protein purification methods.

-Development of Cysteine Protease Inhibitors

oExperienced in enzyme assay development

oUsed fluorometric enzyme assays and kinetic analysis to determine the mode of inhibition of various compounds synthesized to be inhibitors of a class of enzymes that are up-regulated in cancer cells.

oUsed cell and molecular biology techniques to determine the effects of these inhibitors on cancer cell metastasis.

-Development of Cruzipain Inhibitors as a means of Chagas Disease therapy

EDUCATION

Baylor University Waco, TX

PhD, Biomedical Studies May 2017

Baylor University Waco, TX

BA, Biochemistry. May 2009

PROFESSIONAL ASSOCIATIONS

National Scholars Honor Society

The American Association for the Advancement of Science

The American Chemical Society

American Society for Biochemistry and Molecular Biology

PUBLICATIONS

Strecker, T.E., Odutola, S.O., Lopez, R., Cooper, M.S., Tidmore, J.K., Charlton-Sevcik, A.K., Li, L., MacDonough, M.T., Ghatak, A., Liu, L., Chaplin, D.J., Mason, R.P., Pinney, K.G., and Trawick, M.L. The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts. Cancer Lett. 2015, 369(1), 229-241.

Parker, E. N., Song, J., Kumar, G. K., Odutola, S. O., Chavarria, G. E., Charlton-Sevcik, A. K., et al. Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L. Bioorganic & medicinal chemistry 2015 23(21), 6974-6992.

SELECTED CONFERENCE PRESENTATIONS

Odutola, S.O., et al. Investigation of the mechanism of inhibition of cruzain by thiosemicarbazone compounds. Poster session presented at; Texas enzyme mechanisms conference; 2016 January 8-9. Austin Texas.

Odutola, S.O., Strecker, T.E., Cooper, M.S. et al. Vascular Disrupting Activity of OXi8006 in Endothelial Cells and Its Phosphate Prodrug OXi8007 in Breast Tumor Xenografts in Vivo. The FASEB J. 2015 29(1) supplement 897.5. Poster session presented at Experimental Biology 2015, Boston, MA.

GRANTS AND AWARDS

Graduate Research Assistantship (2009-Present)

Baylor University

Dean’s Scholarship (2009-Present)

Baylor University

TEACHING EXPERIENCE

Baylor University Waco, TX

Teaching Assistant: Organic Chemistry Lab, General Chemistry Lab, Anatomy and Physiology Lab, Biology Lab, Human Physiology Lab

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