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Professional Experience Assistant

Location:
Champaign, Illinois, 61820, United States
Posted:
May 30, 2017

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Yan Wang

**** ****** ****, *********, ** ***** C: 617-***-**** ac0j5z@r.postjobfree.com

Highlights:

o Over 13 years of experience in scientific research and development. o Primary research focuses: structure and function of membrane proteins, mechanisms of blood coagulation, NMR spectroscopy development, and synthesis of lipids and lipid assemblies. o Teaching experience in undergraduate level chemistry and biochemistry courses and labs. o Hands-on expertise on analytical and chromatographic instruments including solution/solid- state NMR, HPLC, FPLC, mass spec, flash chromatography, and surface plasmon resonance. o Comprehensive knowledge and skills in protein expression and purification in bacterial/mammalian systems as well bioanalytical techniques for characterizing enzyme kinetics, substrate/cofactor interaction, and protein structure/dynamics. o Extensive experience in lab training of undergrad/graduate students, postdocs and staff. o Work experience in an industry/pharmaceutical setting; preparation of reports for quality control and IND/NDA filings to the FDA.

Education:

Sept. 2006 – Jan. 2012 University of California – San Diego, La Jolla, CA. PhD in Chemistry, Department of Chemistry and Biochemistry Sept. 2000 – May 2004 Boston College, Chestnut Hill, MA. Bachelor of Science in Biochemistry, Minor in Economics Honors: Dean’s List, National Society of Collegiate Scholars. Professional Experience:

Mar. 2012 – Present: Postdoctoral Research Associate (Advisor: James H. Morrissey) University of Illinois at Urbana-Champaign, Urbana, IL Investigating the mechanism of interaction between blood coagulation factors and cell membrane lipids; developing isotopic labeling and purification protocols for phospholipids; developing enzymatic and screening assays for characterizing protein-membrane interactions Sept. 2006 – Jan. 2012: Graduate Research Assistant (Advisor: Stanley J. Opella) University of California – San Diego, La Jolla, CA Determining high resolution structures of membrane protein using multidimensional solution and solid-state NMR techniques; developing methods for membrane protein isotope labeling, purification and lipid incorporation; maintaining of NMR spectrometers Mar. 2006 – Aug. 2006: Research Assistant (Advisor: Mary F. Roberts) Boston College, Chestnut Hill, MA

Investigating enzyme mechanism of inositol-1-phosphate synthase through site-directed mutagenesis, fluorescence spectroscopy, mass spectrometry, and circular dichroism; characterizing synthetic pathways of hyperthermophile Archaebacteria. Aug. 2004 – Mar. 2006: Research Associate, Biophysics EPIX Pharmaceuticals, Inc., Cambridge, MA

Analyzing small molecular and peptide constructs of metal chelates for the development of MRI contrast agents using NMR, mass spectrometry, light scattering, and inductive couple plasma. Jun. 2001 – May 2003 : Research Assistant

Massachusetts General Hospital, Charlestown, MA

Performing image data acquisition and reconstruction for the development of novel MRI imaging techniques on bone tissues.

Skills:

o Advanced knowledge in data collection and analysis o Excellent communication and presentation skills

o Strong ability to collaborate with people from a wide range of disciplines and background o Computer skills: Microsoft office; Adobe photoshop and illustrator; ChemDraw; MATLAB; Python; UNIX; Endnote; AKTA Unicorn; Bruker/Varian,. Selected Publications and Presentations

Wang Y, Gajsiewicz JM, Clay M, Greenwood A, Muller MP, Rienstra CM, Tajkhorshid E, and Morrissey JH. Structural basis of phosphatidylserine recognition by blood coagulation factors. Oral presentation (recipient of FASEB SRC travel award) at FASEB Science Research Conferences: Molecular Biophysics of Membrane in Snowmass, CO. July 10 – 15, 2016. Wang Y, Gajsiewicz JM, and Morrissey JH. ‘Mutating’ the procoagulant phospholipid membrane: an in-depth look at the functional groups of phosphatidylserine. Oral presentation at Thrombosis & Hemostatsis Summit of North America 2014 in Chicago, IL Apr. 10 – 14, 2014 Hebbard CF, Wang Y, Baker CJ, and Morrissey JH. (2014) Synthesis and evaluation of chromogenic and fluorogenic substrates for high-throughput detection of enzymes that hydrolyze inorganic polyphosphate. Biomacromolecules. 15, 3190-6. Wang Y, Park SH, Tian Y, and Opella SJ. (2013) Impact of histidine residue on the transmembrane helices of viroporins. Mol. Membr. Biol. 30, 360-369. Skasko M*, Wang Y*, Tokarev A, Munguia J, Ruiz A, Stephens E, Opella SJ, and Guatelli J.

(2012) HIV-1 Vpu antagonizes the innate restriction Factor BST-2/tetherin via lipid-embeded helix-helix interactions. J. Biol. Chem. 287, 58-67. *Contributed equally Wang Y, Spiller M, and Caravan P. (2010) Evidence for weak protein binding of commercial extracellular gadolinium contrast agents. Magn. Reson. Med. 63, 609-16. Rodionov DA, Kurnasov OV, Stec B, Wang Y, Roberts MF, and Osterman AL. (2007) Genomic identification and in vitro reconstitution of a complete biosynthetic pathway for the osmolyte di- myo-Inositol-Phosphate. Proc. Natl. Acad. Sci. USA. 104, 4279-84



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