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Medical Writing

Location:
Waterford, CT
Posted:
May 26, 2017

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Resume:

Krysti L. Todd

ac0h93@r.postjobfree.com

*** *** **** **** • Waterford, CT 06385 • (860)287- 6444 SUMMARY

Biomedical scientist with a strong background in neurodegeneration, stem cell biology, and developmental neuroscience. Broad and versatile expertise in numerous in vitro and in vivo techniques, project development and management, human study data analysis, grant and manuscript writing, and teaching. RESEARCH EXPERIENCE

University of Connecticut Storrs, CT

Postdoctoral Fellow Jan 2015- Present

Neurogenic stem cell niche function in development, aging and disease.

• Examined lateral ventricle expansion and periventricular pathology in normal aging and cognitive impairment using longitudinal MRI data sets and subject- matched biospecimens.

• Determined bidirectional signaling mechanisms involved in stem/progenitor cell migration in the subventricular zone and rostral migratory stream using mouse genetics and single- cell biology.

• Managed multiple research projects and served as mentor for graduate and undergraduate students;; designed research questions and wrote grants. New York University School of Medicine New York, NY Graduate Student Aug 2009- Jan 2015

Sporadic and Familial Cerebral Amyloidosis: Insights into Oligomerization, Neurotoxicity, and Therapeutics

• Elucidated the influence of familial mutations and posttranslational modifications on the biochemical/biophysical properties of amyloid- beta and the BRI peptide.

• Identified neuronal cell death signaling cascades activated by the mutated and/or posttranslationally modified amyloids.

University of Connecticut Storrs, CT

Undergraduate Researcher Jan 2008- May 2009

• Utilized in vivo and in vitro approaches to observe the effects of Eph/ephrin signaling on neuroblast migration in the subventricular zone and surrounding brain regions following injury. Pfizer Global Research and Development Groton, CT Intern, Genetically Modified Models Center of Emphasis May 2008- Aug 2008

• Optimized a protocol for the differentiation of embryonic stem cells into cardiomyocytes. Pfizer Global Research and Development Groton, CT Intern, Central Nervous System Discovery Biology May 2007- Aug 2007

• Invested the links between cholesterol metabolism and the progression of May 2006- Aug 2006 Alzheimer’s disease and general cognitive deficit. SKILLS AND TECHNIQUES

Mammalian cell culture (primary and immortalized) • Stereotaxic mouse surgery (brain) • Immunohistochemistry, immunocytochemistry, and immunofluorescence (human and mouse) • Fluorescence and confocal microscopy • RNA extraction and RT- qPCR • MRI segmentation and volumetric analysis • Single cell RT- qPCR and advanced analysis • SDS- PAGE, Native- PAGE, and Western blotting • Monoclonal antibody production and purification • Visible, UV, and Circular Dichroism Spectroscopy • ELISA (indirect, direct, sandwich) • Immunoprecipitation and MALDI- TOF mass spectrometry EDUCATION

New York University School of Medicine, Sackler Institute of Graduate Biomedical Sciences New York, NY

• Ph.D., Pathobiology (focus in Neuropathology) Jan 2015

• Vittorio Defendi Student Fellow in Pathobiology and Translational Medicine Krysti

L.

Todd

• Alzheimer’s Association International Conference Fellowship University of Connecticut Storrs, CT

• B.S., Physiology and Neurobiology;; Molecular and Cell Biology Minor May 2009

• Magna Cum Laude, Honors Scholar, Phi Beta Kappa LEADERSHIP AND TEACHING EXPERIENCE

University of Connecticut Storrs, CT

Lecturer, Honors Stem Cell Biology Jan 2015- Present

• Responsible for 3 lectures a semester on general stem cell biology, cancer stem cells, and clinical trials.

Citizen Schools Bronx, NY

Volunteer Teacher, Neuroscience Jan 2014- May 2014

• Instructed 7th grade students in advanced neuroscience topics through lectures and hands- on activities. New York University School of Medicine, Sackler Student Council New York, NY President June 2010- June 2011

• Organized various graduate student events and acted as a liaison between faculty/staff and students. PUBLICATIONS

• Todd K, Baker K, Eastman M, Kolling F, Nelson C, Conover J. 2017. EphA4 controls neuroblast and astrocyte organization in the subventricular zone and rostral migratory stream. J. Neurosci. doi: 10.1523/JNEUROSCI.3738- 16.2017. [Epub ahead of print].

• Todd K, Conover J. 2017. “Neuronal stem cell niches of the brain” in Biology and Engineering of Stem Cell Niches. Philadelphia: Elsevier, 2017.

• Conover J, Todd K. 2016. Development and aging of a brain neural stem cell niche. Exp. Gerontol. doi: 10.1016/j.exger.2016.11.007. [Epub ahead of print].

• Todd K, Ghiso J, Rostagno A. 2016. Oxidative stress and mitochondria- mediated cell death mechanisms triggered by the familial Danish dementia ADan amyloid. Neurobiol. Dis. 85:130- 43.

• Todd K, Fossati S, Ghiso J, Rostagno A. 2014. Mitochondrial dysfunction induced by a posttranslationally modified amyloid linked to a familial mutation in an alternative model of neurodegeneration. BBA Mol. Basis. Dis. (12):2457- 2467.

• Todd K, Fossati S, Sotolongo K, Ghiso J, Rostagno A. 2013. Differential contribution of isoaspartate post- translational modifications to the fibrillization and toxic properties of amyloid- β and the asparagine 23 Iowa mutation. Biochem. J. 456(3):347- 60. SELECT ABSTRACTS

• Todd K, Norton E, Brighton T, Schick S, Resnick S, Elkins W, Troncoso J, Pletnikova O, Conover J. Ventriculomegaly and accompanying gliosis associated with impaired fluid dynamics in the aging brain. Society for Neuroscience Annual Meeting, 2016.

• Todd K, Norton E, Brighton T, Schick S, Resnick S, Elkins W, Troncoso J, Pletnikova O, Conover J. Longitudinal evaluation of ventricle wall gliosis and periventricular abnormalities in age- related ventriculomegaly. Society for Neuroscience Annual Meeting, 2015.

• Todd K, Rostagno A, Ghiso J. Mitochondrial dysfunction induced by a posttranslationally modified amyloid linked to a familial mutation in an alternative model of neurodegeneration. Alzheimer’s Association International Conference, 2014.

• Todd K. Nesgaard L, Fossati S, Ghiso J, Rostagno A. Posttranslational pyroglutamate formation enhances the aggregation and neurotoxicity of amyloid peptides. International Conference on Alzheimer’s and Parkinson’s Diseases, 2013.

• Todd K, Nesgaard L, Fossati S, Ghiso J, Rostagno A. Pyroglutamate- modified ABri triggers mitochondrial dysfunction in neuronal cells. Society for Neuroscience Annual Meeting, 2012.

• Rostagno A, Fossati S, Todd K, Ghiso J. Fibrillogenesis and toxicity of Iowa- Aß is differentially driven by the D23N mutation. Alzheimer’s Association International Conference on Alzheimer’s Disease, 2010.



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