Research Pharmaceutical Sciences

Maria Ines Amaro

Phone: +353-***-***-***

E-Mail: *.****.*****@*****.***

Professional Summary

Graduated in -July 2008 in Integrated Master in Pharmaceutical Sciences. Throughout graduate studies had the opportunity to participate in research programs in the fields of Sensory analysis and Biotechnology.

From November 2008 till December 2012 (Graduation April 2013), as PhD student in Pharmaceutics, my research aimed the development of novel porous microparticulate systems designed for the pulmonary delivery of therapeutic peptides and proteins, presenting my work in worldwide conferences and in peer reviewed journals.

Specialties: Spray drying; thermalgravimetric analysis; Surface area/porosity analysis; XRPD; FTIR; particle size analysis; HPLC; GC-FID; aerodynamic characterisation by NGI; cell culture for pharmacological and permeation studies; DVS; iGC; pharmacokinetics; QbD/DOE

Core Qualifications

Results-oriented

Excel in materials physicochemical characterisation and data handling

Quick learner

Creative Problem Solving

Computer proficient: Microsoft Office, OriginLab, Minitab, DesignExpert

Reports generation and analysis

Multi-Task Management

Spoken languages: English, French, German, Spanish, Portuguese

Experience

May 2009

Prices Medical Hall Dublin, Co.Dublin

Community Pharmacist (part-time)

August 2012 to November 2012

Merck Sharp & Dohme Ballidynne, Co Tipperary

Intern at Merck Sharp & Dohme, Ballydine

As a member of the Product Development and Commercialisation team I was involved in three projects:

-Investigation of the physical properties (PS, density, IR) of a granule formulation in order to find the root cause of a tablet dissolution issue;

-Investigation on agglomerates formation of a jet milled API; defining probable causes;

-To review data and set up a protocol for the investigation of an anti-oxidant low levels upon/after compression for manufacturing operators and analytical laboratory staff.

Familiar with SOP, Memos, PP, OOS, GMP environment and rules.

October 2008 to April 2013

Trinity College Dublin Dublin, Co.Dublin

PhD in pharmaceutics

Development of novel porous microparticulate systems designed for the pulmonary delivery of therapeutic peptides and proteins. Methodologies in practice: spray drying; thermogravimetric analysis; surface area/porosity analysis; PXRD; Spectroscopy: UV-VIS, FTIR and Fluorescence; particle size analysis; SEM; HPLC; GC-FID; DVS; iGC; aerodynamic characterisation by impaction-NGI; cell culture for pharmacological and permeation studies; immunoassays (ELISA and cAMP); evaluation of the pharmacokinetics of a peptide using a rat model; DOE.

Laboratory demonstrator (certified teaching skills) of undergraduate and MSc students.

September 2003 to June 2004

ITQB Oeiras, Lisboa

Research assistant

Preparation and analysis of juice samples by HPLC and GC-MS. Member of tasting panel for juices sensory analysis.

Education

2013 School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Ireland Dublin, Co Dublin

Ph.D. Pharmaceutics

2008 Faculdade de Farmacia, Universidade de Lisboa Lisboa, Lisboa

MPharm Pharmaceutical Sciences

Professional Affiliations

Member of the Irish drug delivery network (IDDN)

American association of pharmaceutical scientist

Pharmaceutical Society of Ireland

Pharmaceutical Society of Portugal

Member of the School of Pharmacy finalist association

Accomplishments

Peer reviewed publications:

Amaro, MI, Tajber, L, Corrigan, O, Healy, AM, 2011. Optimisation of spray drying process conditions for sugar nanoporous microparticles (NPMPs) intended for inhalation. Int. J. Pharm., 421(1), 99-109. DOI:10.1016/j.ijpharm.2011.09.021

Amaro, MI, Tajber, L, Corrigan, O, Healy, AM, 2010. Design of experiment to study the effect of spray dryer operating variables on sugar powders intended for inhalation. J Pharm Pharmacol 62 (10), 1413-1414

Paluch, KJ, Tajber, L, Amaro, MI, Corrigan, MI, Healy, AM, 2012. Impact of process variables on the micromeritic and physicochemical properties of spray-dried microparticles ? Part II. Physicochemical characterisation of spray-dried materials. J Pharm Pharmacol 64 (7). DOI: 10.1111/j.2042-7158.2012.01543.x

Tewes, F, Gobbo, O, Amaro, MI, Tajber, L, Corrigan, OI, Ehrhardt, C, Healy, AM, 2011. Evaluation of HPCD?PEG Microparticles for Salmon Calcitonin Administration via Pulmonary Delivery. Molecular Pharmaceutics 8 (5), 1887-1898.

Amaro, MI, Rocha, J, Vila-Rea, HJ, Figueira, ME, Mota-Filipe, H, Sepodes, B, Ribeiro, MH, 2009. Anti-inflammatory activity of naringin and the biosynthesised naringenin by naringinase immobilized in microstructured materials in a model of DSS-induced colitis in mice. Food Research International, Vol. 42, 8, 1010-1017.

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