Assistant University

Location:

Posted:

March 30, 2013

Resume:

BACKGROUND SUMMARY

o Scientist, Master degree in organic chemistry, with 12 years of industrial experience in medicinal, combinatorial and process chemistry under GLP and/or cGMP conditions.

o Developed the synthetic multi-step route to provide drug candidates on a number of projects in a timely manner.

o Synthesized different types of organic molecules such as beta-Ketoesters,Aliphatic/Aromatic heterocyclic compound, Unnatural amino acid derivatives, Peptides, Peptoids, natural products etc in solution phase as well as on solid phase.

o Purified novel compounds through silica gel chromatography, Biotage parallel purification system, ionic exchanger adsorbent, fractional distillation, recrystallization and high performance liquid chromatography (HPLC).

o Performed structural characterization using proton and carbon Nuclear Magnetic Resonance (NMR) Spectroscopy, IR and Mass Spectroscopy (MS)

o Interpreted scientific validity of results using a variety of controls.

PROFESSIONAL EXPERIENCE

PHARMACORE, INC, High Point, North Carolina 2003 - Feb 15, 2013

Associate Research Scientist, Chemistry

o Synthesized useful building blocks on multi-step reactions.

o Worked on custom synthesis and FTE to provide Multi g to Kg of aliphatic/aromatic heterocycles and unnatural amino acid derivatives etc in a timely manner.

o Accomplished synthesis of pharmaceutical intermediates and APIs under GLPand/or cGMP conditions.

ARRAY BIOPHARMA, INC, Boulder, Colorado 2001 -2003

Research Associate II, Merck Customer Department

o Planned detailed procedures for defined projects including time-frames,methodological approaches, expected results and necessary resources.

o Synthesized intermediates and organic biologically active and selective compounds such as heterocycles, arenas, chiral acyclics, and unnatural amino acids with parallel/ combinatorial synthetic techniques.

o Investigating these compounds' physiochemical properties, toxicity and structural activity relationship (SAR)

o Interfaced in a concise and effective manner with company team members and external collaborators orally and in writing.

UNIVERSITY OF SOUTH FLORIDA, Tampa, Florida 1998-2001

Research Assistant, Department of Chemistry

o Developing Novel Methodologies on the Cesium Promoted N-Alkylation,Carbonylation and Carbamation as well as gamma-lactam synthesis.

o Synthesis of Natural products as Lactacystin, Kainic acid and Pramanicin based on our synthetic methodology of gamma-lactams.

o Synthesis of inhibitors of 20S-proteasome, Bcl-2 and MDM-2.

MYONGJI UNIVERSITY, Yongin, South Korea 1996-1998

Teaching and Research Assistant, Department of Chemistry

o Synthesis of Methyl-substituted conjugate cyclohexenones and Bicyclo

[3.3.1]nonane skeletons.

o Synthesis of polypropionate natural products.

EDUCATION

M.S.-Organic Chemistry, 2001, The University of South Florida, Tampa,Florida

M.S.-Organic Chemistry, 1998, The Myongji University, Yongin, South Korea

B.S.- Chemistry, 1996, The Myongji University, Yongin, South Korea

HONORS/AWARDS

Research Assistantship, University of South Florida, 1998-2001

Outstanding Publication award, Myongji University, 1998

Teaching and Research Assistantship, Myongji University, 1996-1998

PROFESSIONAL SOCIETIES

American Chemical Society

ACS Organic Chemists Committee

TECHNICAL SKILLS

- Modern analytical methods - NMR, Infra-Red spectroscopy, Mass

spectroscopy, Gas chromatography (GC), High performance liquid

chromatography (HPLC) and KF titration.

- Literature database searching - SciFinder and Reaxys (Beilstein).

- MS Office Word, Excel and Powerpoint

CONTINUING EDUCATION

1. Heterocyclic chemistry on June, 2002 at Array BioPharma (Albert

Padwa and William H. Pearson)

2. Heterocyclic chemistry on May, 2005 at Pharmacore (Peter Wipf)

3. Secrets of Batch Process Scale-Up: Ensuring Effective Translation of

Laboratory Processes to Pilot Plant Scale on October, 2007 at Pharmacore

(Francis X McConville)

4. GMP Basics: Orientation/Refresher on December, 2009 at Pharmacore

(Stephen Wallace)

5. Technical Writing for cGMP Activities on March, 2010 at Pharmacore

(Rosanne Sylvia-Heeter)

6. GMP Basics & Related Practices: QC Laboratory Operations on February,

2012 (Stephen Wallace)

PUBLICATIONS

A Novel Synthetic Route to Chiral gamma-Lactams from alfa-Amino Acids via Rh-Catalyzed Intramolecular C-H Insertion. Yoon, C. H.; Flanigan, D. L.; Chong, B. -D.; Jung, K. W. J. Org. Chem. 2002, 67, 6582.

Efficient and Practical Bromination of Amino alcohols. Nagle, A. S.; Salvatore, R. N.; Chong, B. -D.; Jung, K. W. Tetrahedron.Lett. 2000,41(17), 3011.

Highly Efficient Synthesis of Methyl substituted Conjugate cyclohexenones. Chong, B. -D.; Ji, Y. -I.; Oh, S. -S.; Yang, J. -D.; Baik, W.; Koo, S. J. Org. Chem. 1997, 62, 9323.

PATENT

The Synthetic methods of Alkyl-substituted Conjugate 2-Cyclohexenones. Koo,S.; Chong, B. -D.; Ji, Y. -I.; Oh, S. -S. Issued 04/11/97; Korean Patent and Trademark Office, Korea patent number 0194062.

PRESENTATIONS

Highly Regio- and Stereocontrolled gamma-Lactam Synthesis via Rh (II) Catalyzed C-H Insertion of alfa-Phenylsulfonyl- alfa-Diazoacetamides: Studies Toward an Expeditious Synthesis of Lactacystin. Yoon, C. H.; Chong, B. -D.; Dueno, E.; Jung, K. W. Presented at the 221st ACS National Meeting in San Diego,

CA, April, 2001.

The Synthesis of Various Bicyclic Structures. Chong, B. -D.; Yang, J. -D.; Koo, S. Presented at the 81st Annual Meeting of the Korean Chemical Society, Seoul, April 1998; Poster FP418.

Stereoselective synthesis of Tri-propionate Chains. Chong, B. -D.; Yang, J. -D.; Ji, Y. -I.; Oh, S. -S.; Koo, S. Presented at the 80th Annual Meeting of the Korean Chemical Society, Taeku, October 1997; Poster FP220.

Facile and Practical One Pot Synthesis of Conjugate Cyclohexenones - Mechanistic Insight. Chong, B. -D.; Yang, J. -D.; Ji, Y. -I.; Oh, S. -S.; Koo, S. Presented at the 80th Annual Meeting of the Korean Chemical Society, Taeku, October 1997; Poster FP218.

Highly Efficient One Pot Synthesis of Methyl-substituted Conjugated Cyclo-hexenones. Chong, B. -D.; Ji, Y. -I.; Oh, S. -S.; Koo, S. Presented at the 79th Annual Meeting of the Korean Chemical Society, Seoul, April 1997; PosterSP542.

Stereoselective Construction of Polypropionate Chains. Ji, Y. -I.; Chong,B. -D.; Koo, S. Presented at the 78th Annual Meting of the Korean Chemical Society, Daechon, October 1996; PosterSP575.

REFERENCES

Sangho Koo, Ph.D.

Department of Chemistry

Myongji University

Yongin, Kyeonggi-Do, South Korea

Tel: 82-31-330-****

Email: *******@**.*******.**.**

Suk Young Cho, Ph.D.

Director, Chemistry

Chemizon Inc.

Seongnam, Kyeonggi-Do, South Korea

Phone: 82-31-777-****