Engineering Control
Resume:
CD Smolke, Curriculum Vitae
Christina D. Smolke
Bioengineering Department
Y2E2 Building, Room 269A, MC 4201
Stanford University
Stanford, CA 94305-4201
P: 650-***-****
F: 650-***-****
*******@********.*******://openwetware.org/wiki/Smolke
Education
Postdoctorate, Molecular and Cell Biology, 20012003
University of California at Berkeley, Berkeley, CA
Topic: Role of Export in Nonsense -Mediated Decay in Saccharomyces cerevisiae
Mentor: Karsten Weis
Ph.D., Chemical Engineering, 2001
University of California at Berkeley, Berkeley, CA
Thesis Topic: Engineering the Stabilities of Polycistronic mRNA
Advisor: Jay D. Keasling
B.S., Chemical Engineering with Emphasis in Biology, 1997
University of Southern California, Los Angeles, CA
Professional Experience
2012-presentAssociate Professor (Dept. Bioengineering, Stanford University
)
2009-2012Assistant Professor (Dept. Bioengineering, Stanford University
)
2006-2010Adjunct Faculty (Comprehensive Cancer Center, City of Hope, Duarte
)
2003-2010Assistant Professor (Dept. Chemical Engineering, Caltech, on leave 1/1/09-
12/31/10
)
2001-2003NIH Postdoctoral Research Fellow (Dept. Molecular and Cell Biology, UCB
)
1998-2000Graduate Student Instructor (Dept. Chemical Engineering, UCB
)
1997-2001Graduate Research Assistant (Dept. Chemical Engineering, UCB
)
1997Process Engineer (Mobil Oil, Torrance, CA
)
1996Undergraduate Research Assistant (Dept. Chemical Engineering, UCLA
)
1995Facilities Engineer (Mobil Oil, Bakersfield, CA
)
1994-1997Laboratory Instructor (Information Technology Dept.,
USC)
1993-1997Undergraduate Research Assistant (D ept. Chemical Engineering, USC)
Teaching Experience
2010-present Instructor, undergraduate/graduate-level advanced synthetic biology course
(BioE 244;
newly-developed course, Stanford University)
2010-presentInstructor, undergraduate-level introduction to bioengineering course
(BioE/E 80; newly-
developed course,
Stanford University)
2004-2008Instructor, graduate-level chemical thermodynamics course listed jointly in the
Chemistry
and Chemical Engineering Departments (ChE 165; Caltech)
2005-2008Instructor, undergraduate-level biomolecular engineering laboratory (ChE 130;
newly-
developed course, Caltech)
Page 1
CD Smolke, Curriculum Vitae
2000-2003University GSI Teaching and Orientation Workshop Leader (UCB
)
1998-2000Graduate Student Instructor, graduate engineering mathematics course and
undergraduate
separations course (Dept. Chemical Engineering, UCB)
1994-1997Laboratory Instructor (Information Technology Programming Dept.,
USC)
Membership / Services
2013 Member, Organizing Committee, SBE International Conference on Biomolecular
Engineering
2012 Member, Organizing Committee, SBE International Conference on Bioengineering and
Nanotechnology
2011 Guest Editor, Special issue on Synthetic Biology, Metabolic Engineering Journal
2011 Member, Editorial Board, FEMS Yeast Research
2010-present Member, Advisory Editorial Board, Molecular Systems Biology
2010 Member, Scientific Advisory Board, Metabolic Engineering VIII
2010 Track Chair, New Frontiers in Bioengineering, BMES Annual Meeting
2010 Session Chair, Synthetic Biology, ACS National Meeting
2010-present Member, Biomedical Engineering Society
2009 Member, Steering Committee, NAKFI Synthetic Biology Symposium
2009 Member, Science Team, Innovations for Agricultural Value Chain in Africa Project,
Meridian Institute (Gates Foundation)
2009 Symposium Organizer, Synthetic Life, AAAS Annual Meeting
2009-2010 Faculty Mentor, Stanford iGEM team
2008-2009 President, Institute for Biological Engineering
2008-present Member, Editorial Board, Synt hetic Biology Journal
2008 Conference Organizer, Engineering Principles in Biological Systems, CSHL Meeting
2008-2009 Session Chair, Synthetic Biology, IBE Annual Meeting
2007-2009 Member, Scientific Advisory Board, SynBERC (Synthetic Biology Engineeri ng
Research
Center)
2007-2010 Judge, iGEM competition
2007 Session Chair, Metabolic Engineering and Synthetic Biology, Biochem Eng
Conference XV
2007 Session Chair, Metabolic Engineering, IBC Life Sciences Synthetic Biology
Conference: Transforming Life Science Research and Discovery
2007, 2011 Session Chair, Synthetic Biology, SBE Int l Conference in Biomolecular
Engineering
2007 President-Elect, Institute for Biological Engineering
2006-2009 Program Director, HHMI Undergraduate Science Education Pro gram, Caltech
2006-present Proposal reviewer and panel member, National Science Foundation, National
Institutes of
Health, Department of Defense, ARPA -E
2006-2010 Member, City of Hope NCI -sponsored Comprehensive Cancer Institute, Cancer
Immunotherapeutics Group
2006 Organizer, Synthetic Biology Workshop, LSS Comp Sys Bioinformatics Conference
2006 Session Chair, Microbial Metabolic Engineering I and II, ACS National Meeting
2006 Session Chair, Molecular Tools for the Metabolic Engineering, Society of
Industrial
Microbiology Annual Meeting
2006 Judge, TR35 (Technology Review s Top 35 Young Innovators)
2006 Invited Summer School Instructor, Quantitative approaches to gene regulatory
systems,
Center for Theoretical Biological Physics, University of Cali fornia, San Diego
2006-2010 Member, Institute for Biological Engineering
2005-2009 Member, Scientific Advisory Board, Codon Devices
2005-2009 Member, Kavli Nanoscience Institute (Caltech)
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CD Smolke, Curriculum Vitae
2005-2008 Session Chair, Synthetic Systems Biology, AIChE Annual M eeting
2004-present Steering Committee, Synthetic Biology Conference Series
2004-2008 Faculty Mentor, Caltech iGEM team
2004-2009 Member, American Chemical Society
2004-2007 Member, RNA Society
2004-2009 Member, Center for Biological Circuit Design (Calte ch)
2003, 2009 Participant, DARPA-sponsored ISAT study group on Synthetic Biology
2001-present Ad Hoc Reviewer, Nature, Science, Cell, PNAS, Nature Biotech, Nature Chem
Biol, Mol
Sys Biol, Nuc Acids Res, RNA, Met Eng, PLoS Comp Biol, Chem Biol
2000 Co-organizer/Mentor, NSF-sponsored MarBEC summer undergraduate research program
Selected Honors
2011 Finalist, Agilent Early Career Professor Award
2010 Finalist, Agilent Early Career Professor Award
2009 World Technology Award in Biotechnology (Individual)
2008 Alfred P. Sloan Foundation Fellow
2006 National Science Foundation CAREER Award
2005 Beckman Young Investigator Award
2004 TR100, Technology Review s Top 100
Young Innovators of the World
2001-2003 National Institute of Health Postdoctoral Fellowship
2001 Graduated Summa Cum Laude
2000-2001 UC Dissertation Year Fellowship
2000-2001 Shell Doctoral Fellowship
1999-2000 Chemical Engineering Departmental Citation for Outstanding Teaching
1998 DOW Prize for Excellence in Teaching
1998-1999 University Award for Outstanding Graduate Student Instructor
1997-2000 National Science Foundation Fellowship
1997 Tau Beta Pi Fellowship (Declined)
1997 Eugene Cota-Robles Fellowship (Declined)
1997 Graduated Summa Cum Laude
1997 Salutatorian
1997 Emma Josephine Bradely Bovard Student Award
1997 School of Engineering s Outstanding Service and Student Awards
1996 Golden Key Peat Marwick Junior Scholarship
1996 Unocal Scholarship
1996 Excellence Award in Biochemistry
1995 Southern California Section AIChE Outstanding Junior Award
1994 Outstanding Achievement Award in General Chemistry
1993-1997 Trustee Scholar and Merit Research Awards
Patents1. Win MN, Galloway KE, Smolke CD. 2012. Modular aptamer -regulated ribozymes. Patent No.
8,158,595. (issued)
2. Liang JC, Smolke CD. 2012. Developing a high-throughput, high-efficiency, quantitative
fluorescence-based screening strategy to generate genetic elements with specified
regulatory
activities. App. No. 13/350,597. (pending)
2. Chen YY, Jensen MC, Smolke CD. 2010. Genetic control of mammalian cells with synthetic
RNA
regulatory systems. App. No. 12/708,506. (pending)
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CD Smolke, Curriculum Vitae
3. Culler SJ, Smolke CD. 2010. Protein-responsive RNA control devices and uses thereof.
App. No.
12/943,350. (pending)
4. Beisel CL, Smolke CD. 2010. Integrated ligand -responsive miRNAs. App. No. 12/753,778.
(pending)
5. Beisel CL, Win MN, Smolke CD. 2008. Higher order cellular information processing
devices. App.
No. 12/283,614. (pending)
6. Beisel CL, Win MN, Smolke CD. 2008. General composition framework for ligand -
controlled
regulatory systems. App. No. 12/284,154. (pending)
7. Greenwood-Goodwin M, Chen YY, Brown A, Smolke CD. 2008. Selection of nucleic acid -
based
sensor domains within nucleic acid switch platform. App. No. 12/218,628. (pending)
8. Hawkins KM, Smolke CD. 2007. Compositions and methods for producing benzylisoquinoline
alkaloids. App. No. 11/875,814. (pending)
10. Hawkins KM, Smolke CD. 2006. Engineered yeast cells and uses thereof. App. No. 11/
439,876.
(pending)
11. Bayer TS, Smolke CD. 2005. Aptamer regulated nucleic acids and uses thereof. App. No.
11/243,889.
(pending)
Refereed Publications
8. Chen YY, Smolke CD. 2011. From DNA to targeted therapeutics: bringing synthetic
biology to the
clinic. Science Transl. Med. 3: 106ps42.
9. Liang JC, Bloom RJ, Smolke CD. 2011. Engineering biological systems with synthet ic
RNA
molecules. Mol. Cell. 43: 915-26.
10. Babiskin AH, Smolke CD. 2011. Synthetic RNA modules for fine-tuning gene expression
levels in
yeast by modulating RNase III activity. Nuc. Acids Res. 39: 8651-64.
11. Smolke CD, Silver PA. 2011. Informing biological design by integration of systems and
synthetic
biology. Cell. 144:855-9.
12. Babiskin AH, Smolke CD. 2011. Engineering ligand-responsive RNA controllers in yeast
through the
assembly of RNase III tuning modules. Nuc. Acids Res. 39: 5299-311.
13. Babiskin AH, Smolke CD. 2011. A synthetic library of RNA control modules for
predictable tuning
of gene expression in yeast. Mol. Sys. Biol. 7: 471.
14. Beisel CL, Culler SJ, Hoff KG, Smolke CD. 2011. Design of small molecule-responsive
miRNAs
based on structural requirements for Drosha processing. Nuc. Acids Res. 39: 2981-94.
15. Culler SJ, Hoff KG, Smolke CD. 2010. Reprogramming ce llular behavior with RNA
controllers
responsive to endogenous proteins. Science. 330: 1251-5. Perspective: Cell biology. The
case for
RNA. 330: 1185-6.
16. Chen YY, Jensen MC, Smolke CD. 2010. Genetic control of mammalian T -cell
proliferation with
synthetic RNA regulatory systems. Proc. Natl. Acad. Sci. USA. 107: 8531-6.
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CD Smolke, Curriculum Vitae
17. Culler SJ, Hoff KG, Voelker RB, Berglund JA, Smolke CD.
Selected Invited Presentations
Smolke, CD. 2012. Designing synthetic regulatory RNAs: tools for temporal and spatial
control of
biological systems. KSBMB Annual Meeting, Seoul, South Korea. (Invited Speaker)
Smolke, CD. 2012. Designing synthetic regulatory RNAs: tools for temporal and spatial
control of
biological systems. KAIST Department of Chemistry Seminar Series, Daejeon, South Korea.
(Invited
Speaker)
Smolke, CD. 2012. Designing synthetic regulatory RNAs: tools for temporal and spatial
control of
biological systems. Case Western Reserve Department of Genetics Seminar Series,
Cleveland, OH.
(Invited Speaker)
Smolke, CD. 2012. Designing synthetic regulatory RNAs: new tools for temporal and spatial
control of
biological systems. Novartis Seminar, Cambridge, MA. (Invited Speaker)
Smolke, CD. 2012. Metabolic controllers and their applications to advancing metabolic
network design in
yeast. ASBMB Annual Meeting, San Diego, CA. (Invited Speaker)
Smolke, CD. 2012. Synthetic regulatory RNAs: new tools for temporal and spatial control
of b iological
systems. EMBO Introduction to Synthetic Biology Course, Buenos Aires, Argentina.
(Invited
Speaker)
Smolke, CD. 2012. Designing synthetic regulatory RNAs: new tools for temporal and spatial
control of
biological systems. Neustar Seminar, Mountain View, CA. (Invited Speaker)
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CD Smolke, Curriculum Vitae
Smolke, CD. 2012. Designing synthetic regulatory RNAs: new languages for programming
biological
th
systems. Joint Genome Institute 7 Annual User Meeting, Walnut Creek, CA. (Invited
Speaker)
Smolke, CD. 2012. Programming cellular behavior with RNA controllers. Indo-America
Frontiers of
Engineering Symposium, Washington DC. (Invited Speaker)
Smolke, CD. 2012. Design of (small) regulatory RNAs for synthetic biology. Keystone
Symposium on
Gene Silencing for Small RNAs, Vancouver, Canada. (Invited Speaker)
Smolke CD, 2012. Designing synthetic regulatory RNAs: new tools for temporal and spatial
control in
biological systems. Duke University Bioengineering Seminar Series, Raleigh, NC. (Invited
Speaker)
Smolke CD, 2012. Designing synthet ic regulatory RNAs: tools for temporal and spatial
control in
biological systems. University of Washington Genome Sciences Seminar Series, Seattle, WA.
(Invited
Speaker)
Smolke CD, 2011. Synthetic RNA controllers for programming cell fate and function. City
of Hope
Leading Edge Lecture Seminar, Duarte, CA. (Invited Speaker)
Smolke CD, 2011. Synthetic RNA controllers for programming cell fate and function.
University of
Minnesota Chemical Biology Colloqium, Minneapolis, MN. (Invited Speaker)
Smolke CD, 2011. Designing with RNA: new tools for building input/output devices. CSHL-
Asia Design
and Synthesis of Biological Systems, Shanghai, China. (Invited Speaker)
Smolke CD, 2011. Programming cellular behavior with RNA controllers. Cell Symposium on
Regulatory
RNAs, Chicago, IL. (Invited Speaker)
Smolke CD, 2011. Molecular controllers and their application to advancing metabolic
network design in
yeast. ESF-EMBO Symposium on Synthetic Biology of Antibiotic Production, Sant Feliu de
Guixols,
Spain. (Invited Speaker)
Smolke CD, 20111. Synthetic RNA controllers for programming cell fate and function. Penn
Genomics
Frontier Institute Seminar, Philadelphia, PA. (Invited Speaker)
Smolke CD, 2011. Programming and probing cellular behavior with RNA controllers. Yale
Systems
Biology Symposium, New Haven, CT. (Plenary Speaker)
th
Smolke CD, 2011. Synthetic RNA controllers for programming cell fate and function. 70
Harden
Conference, Manchester, England. (Plenary Speaker)
Smolke CD, 2011. Synthetic RNA controllers for programmi ng cell fate and function. BioX
Undergraduate Seminar Series, Stanford, CA. (Invited Speaker)
Smolke CD, 2011. Synthetic biology: the next generation of biotechnology. NSF Wireless
Molecular
Computing Workshop, Arlington, VA. (Invited Speaker)
th
Smolke CD, 2011. Synthetic biology: the next generation of biotechnology. 12 Annual
Engineering
eDay, Stanford, CA. (Invited Speaker)
Smolke CD, 2011. Molecular tools for advancing metabolic network design. Gordon Research
Conference in Enzymes, Coenzymes, and Metab olic Pathways, Waterville Valley, NH.
(Invited
Speaker)
Smolke CD, 2011. Molecular controllers and their application in building integrated
genetic systems. BAL
Seminar, Berkeley, CA. (Invited Speaker)
Smolke CD, 2011. Synthetic RNA controllers for program ming cell fate and function. IRIC
Technological Advances in RNA Therapy Symposium, Montreal, Canada. (Plenary Speaker)
Smolke, CD. 2011. Building genetic languages for programming cells. Synthetic Biology
5.0, Stanford,
CA. (Keynote Speaker)
Smolke, CD. 2011. Synthetic genetic languages for probing and programming cells.
Department of
Defense Engineering Biology Workshop, Berkeley, CA. (Invited Speaker)
Smolke, CD. 2011. Programming living systems with RNA. NASA Synthetic Biology Seminar
Series,
Mountain View, CA. (Invited Speaker)
th
Smolke, CD. 2011. Programming living systems with RNA. 9 annual iNANO meeting, Aarhus,
Denmark. (Invited Speaker)
Smolke CD, 2010. Molecular controllers and their application in building integrated
genetic systems.
Genomatica Seminar, San Diego, CA. (Invited Speaker)
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CD Smolke, Curriculum Vitae
Smolke CD. 2010. RNA parts and devices and their implementation in integrated genetic
systems.
TARPOL International Summer School on Synthetic Biology, Basel, Switzerland. (Invited
Speaker)
Smolke CD. 2010. Programming cellular behavior with RNA controllers. BIOSS Signalling
Meets
Synthetic Biology Symposium, Freiburg, Germany. (Plenary Speaker)
Smolke CD. 2010. Programming cellular behavior with RNA controllers. National University
of Mexico
Frontiers in Genomics Seminar, Cuernavaca, Mexico. (Invited Speaker)
Smolke CD. 2010. Programming cellular behavior with RNA controllers. University of
Virginia
Department of Biomedical Engineering Departmental Seminar, Charlottesville, VA. (Invited
Speaker)
Smolke CD. 2010. Molecular controllers for programming and probing cells. Amyris Seminar,
Emeryville, CA. (Invited Speaker)
Smolke CD, 2010. Synthetic Biology: the next generation of biotechnology. The
Commonwealth Club
:
Jaw Droppers, San Francisco, CA. (Invited Speaker)
Smolke CD. 2010. Molecular controllers for programming and probing cells. Genencor
Seminar, Palo
Alto, CA. (Invited Speaker)
Smolke CD. 2010. Programming cellular behavior with RNA controllers. RoSBNet Synthetic
Biology
Workshop, Oxford, England. (Keynote Speak er)
th
Smolke CD. 2010. Engineering RNA controllers for programming cellular behavior. FEBS 35
Congress,
Goteborg, Sweden. (Invited Speaker)
Smolke CD. 2010. Programming living systems with RNA. DNA 16, Clearwater Bay, Kowloon
Hong
Kong. (Keynote Speaker)
Smolke CD. 2010. Molecular tools for advancing metabolic network design. Metabolic
Engineering VIII,
Jeju Island, Korea. (Plenary Speaker)
Smolke CD. 2010. Programming cellular behavior with RNA controllers. Agilent Technologies
Seminar,
Santa Clara, CA. (Invited Speaker)
Smolke CD. 2010. Frameworks for designing RNA controllers. EC-US Workshop on Standards in
Biotechnology, Segovia, Spain. (Invited Speaker)
th
Smolke CD. 2010. Programming cellular behavior with RNA controllers. 14 Human Genome
Meeting,
Montepellier, France. (Plenary Speaker)
Smolke CD. 2010. Programming cellular behavior with RNA control devices. University of
Iowa
Department of Chemical and Biochemical Engineering Departmental Seminar, Iowa City, IA.
(Invited Speaker)
Smolke CD. 2010. Molecular controllers supporting new disease treatment strategies.
National Institutes
of Health Workshop on Synthetic Biology and Biomedicine, Washington DC. (Invited
Speaker)
Smolke CD. 2010. Programming cellular behavior with RNA control devices. Kyoto University
Symposium on Synthetic Biology, Kyoto, Japan. (Plenary Speaker)
Smolke CD. 2010. Synthetic genetic languages for probing and programming cells. Max
Planck Institute
for Terrestrial Microbiology Symposium on Synthetic Cells, Marburg, Germany. (Plenary
Speaker)
Smolke CD. 2010. Programming cell-fate decisions with RNA controllers. Clontech Seminar,
Mountain
View, CA. (Invited Speaker)
Smolke CD. 2010. Programming cell-fate decisions with RNA control devices. University of
Southern
California Department of Chemical Engineering and Materials Science Distinguished Lecture
Series,
Los Angeles, CA. (Invited Speaker)
Smolke CD. 2009. Programming genetic systems. American Society of Cell Biology Annual
Meeting, San
Diego, CA. (Invited Speaker)
Smolke CD. 2009. Programming cell-fate decisions with RNA control devices. University of
California
at Berkeley Bioengineering Departmental Seminar, Berkeley, CA. (Invited Speaker)
Smolke CD. 2009. Programming cell-fate decisions with RNA control devices. Institute of
Systems and
Synthetic Biology Symposium, London, England. (Plenary Speaker)
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CD Smolke, Curriculum Vitae
Smolke CD. 2009. Engineering molecular information processing devices to program cellular
function.
University of Illinois Urbana -Champaign Chemical Engineering Departmental Seminar,
Urbana-
Champaign, IL. (Invited Speaker)
Smolke CD. 2009. Engineering molecular information processing devices to program cellular
function.
Evolution and Design of Biomolecula r Systems, Majorca, Spain. (Plenary Speaker)
Smolke CD. 2009. Engineering molecular information processing devices to program cellular
function.
International Conference on Systems Biology, Stanford, CA. (Invited Speaker)
Smolke CD. 2009. Technologies and tools for programming genetic systems. National Academy
of
Science Symposium on Synthetic Biology, Washington DC. (Plenary Speaker)
Smolke CD. 2009. Programming RNA devices to control cellular information processing. IRIC
Symposium Systems Biology in Immunology and Cancer, Montreal, Canada. (Plenary Speaker)
Smolke CD. 2009. Advancing synthetic metabolic network design through embedded sensing -
actuation
devices. Biochemical Engineering Conference XVI, Burlington, VT. (Plenary Speaker)
Smolke CD. 2009. Advancing synthetic metabolic network design through embedded sensing -
actuation
devices. Summit on Systems Biology, Richmond, VA. (Plenary Speaker)
Smolke CD. 2009. Engineering molecular information processing devices to program cellular
behavior .
Michigan State University Science at the Edge Seminar, Lansing, MI. (Invited Speaker)
Smolke CD. 2009. Programming RNA devices to control cellular information processing. Los
Alamos
National Laboratory Center for Nonlinear Studies Seminar, Los Alamos, NM. (Invited
Speaker)
Smolke CD. 2009. Programming RNA devices to control cellular information pr ocessing.
Stanford
University Chemical Engineering Departmental Seminar, Stanford, CA. (Invited Speaker)
Smolke CD. 2009. Programming RNA devices to control cellular information processing.
Columbia
University Chemical Engineering Departmental Seminar, New York, NY. (Invited Speaker)
Smolke CD. 2009. Programming RNA devices to control cellular information processing. IET
BioSysBio
Conference, Cambridge, England. (Plenary Speaker)
Smolke CD. 2009. Sensing-actuation and optimization technologies. DARPA ISAT Study Group
on
Synthetic Biology, Stanford, CA. (Invited Speaker)
Smolke CD. 2009. Programming RNA devices to control cellular information processing. AAAS
Symposium in Synthetic Life, Chicago, IL. (Invited Speaker)
Smolke CD. 2008. Engineering frameworks in biology: examples in RNA programming.
Engineering
Principles in Biological Systems CSHL Meeting, Cold Spring Harbor Labs, NY. (Plenary
Speaker)
Smolke CD. 2008. Genetically encoded technologies for programming integrated biosensing
and
bioactuation devices in living systems. DTRA Seminar, Fort Belvoir, VA. (Invited Speaker)
Smolke CD. 2008. Programming RNA devices to control cellular information processing.
Davidson
College Seminar, Davidson, NC. (Invited Speaker)
Smolke CD. 2008. Programming RNA informa tion processing and control devices. Synthetic
Biology 4.0,
Clearwater Bay, Kowloon Hong Kong. (Keynote Speaker)
Smolke CD. 2008. Programming RNA devices to control cellular information processing.
National
Institute for Materials Science Symposium, Kyoto, Japan. (Plenary Speaker)
Smolke CD. 2008. Foundational technologies for programming integrated biosensing and
bioactuation
devices in living systems. NSF-MEXT Young Researchers Exchange Program in Nanotechnology,
Tokyo, Japan. (Plenary Speaker)
Smolke CD. 2008. Programming RNA devices to control cellular information processing.
SynBERC Fall
Retreat, Cambridge, MA. (Invited Speaker)
Smolke CD. 2008. Programming RNA devices to control cellular information processing.
Beckman
Young Investigator Symposium, Newport Beach, CA. (Invited Speaker)
Smolke CD. 2008. Emerging technologies: synthetic biology. Gordon Research Conference in
Governing
Emerging Technologies, Big Skye, MT. (Plenary Speaker)
Smolke CD. 2008. Engineering biological circuits to program living c ell behavior.
Caltech Summer
Research Connection, Pasadena, CA. (Invited Speaker)
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CD Smolke, Curriculum Vitae
Smolke CD. 2008. Programming RNA devices to control cellular information processing. NSF
Emerging
Technologies Workshop, Amherst, MD. (Invited Speaker)
Smolke CD. 2008. Programming RNA devices to control cellular information processing. 20th
International Congress of Genetics, Berlin, Germany. (Invited Speaker)
Smolke CD. 2008. Programming RNA devices to control cellular information processing .
Penn
Bioengineering Departmental Seminar, Philadelphia, PA. (Invited Speaker)
Smolke CD. 2008. Engineering biological circuits to program living cell behavior. Caltech
Associates
Program, Pasadena, CA. (Invited Speaker)
Smolke CD. 2008. Programming RNA devices to control cellular informa tion processing.
ASBMB Annual
Meeting, San Diego, CA. (Invited Speaker)
Smolke CD. 2008. A framework for programming integrated RNA devices. University of
Chicago
Committee on Genetics Annual Symposium: Synthetic Biology, Chicago, IL. (Plenary Speaker)
Smolke CD. 2008. Programming RNA devices to control cellular information processing .
EPFL ISIC
Seminar Series, Lausanne, Switzerland. (Invited Speaker)
Smolke CD. 2008. Foundational advances in RNA engineering for constructing integrated
biosensing and
bioactuation devices in living systems. Sensors and Smart Structures Technologies for
Civil,
Mechanical, and Aerospace Systems, San Diego, CA. (Keynote Speaker)
Smolke CD. 2008. A framework for programming integrated RNA devices . Harvard University
Woodward Lectures in the Chemical Sciences/Organic Chemistry, Harvard, MA. (Invited
Speaker)
Smolke CD. 2008. Foundational advances in RNA engineering applied to control
biosynthesis. DOE-
GTL-MEWG Workshop, Bethesda, MD. (Invited Speaker)
Smolke CD. 2008. A framework for programming system behavior through integrated RNA
devices.
Princeton University Quantitative and Computational Biology Seminar, Princeton, NJ.
(Invited
Speaker)
Smolke CD. 2007. Foundational advances in RNA engineering for constructing integrated
biose nsing and
bioactuation devices in living systems. NSF Biosensing and Bioactuation Workshop,
College Park,
MD. (Invited Speaker)
Smolke CD. 2007. Foundational advances in RNA engineering applied to control biosynthesis
and T -cell
proliferation. University of Washington Biochemistry Departmental Seminar, Seattle, WA.
(Invited
Speaker)
Smolke CD. 2007. A framework for programming integrated RNA devices. Joining Forces
Symposium:
Single Cell Analytics, ETH Zurich, Switzerland. (Plenary Speaker)
Smolke CD. 2007. Foundational advances in RNA engineering applied to control
biosynthesis. Brown
University Chemistry Departmental Seminar, Providence, RI. (Invited Speaker)
Smolke CD. 2007. A framework for engineering integrated RNA devices. Brown University
Synthetic
Biology Seminar, Providence, RI. (Invited Speaker)
Smolke CD. 2007. Foundational advances in RNA engineering applied to control
biosynthesis. University
of Calgary Biological Sciences Departmental Seminar, Calgary, Canada. (Invited Speaker)
Smolke CD. 2007. A framework for programming system behavior through integrated RNA
devices.
International Conference on Systems Biology, Irvine, CA. (Invited Speaker)
Smolke CD. 2007. Engineering RNA devices as general tools in programming cellular
function .
Biomedical Engineering Society Annual Meeting, Los Angeles, CA. (Invited Speaker)
Smolke CD. 2007. A framework for programming integrated RNA devices. UC Berkeley Chemical
Engineering Departmental Seminar, Berkeley, CA. (Invited Speaker)
Smolke CD. 2007. A framework for programming integrated RNA devices. MBI Metabolic
Engineering
Workshop, Columbus, OH. (Invited Speaker)
Smolke CD. 2007. A framework for programming integrated RNA devices. Massachusetts
Institute of
Technology Biological Engineering Departmental Seminar, Cambridge, MA. (Invited Speaker)
Smolke CD. 2007. Foundational advances in RNA engineering applied to control biosynthesis
and T -cell
proliferation. Caltech Alumni College, Pasadena, CA. (Invited Speaker)
Page 10
CD Smolke, Curriculum Vitae
Smolke CD. 2007. A framework for programming inte grated RNA devices. Systematic Biology
Symposium, Edinburgh, Scotland. (Plenary Speaker)
Smolke CD. 2007. Foundational advances in RNA engineering applied to the control of
microbial
biosynthesis. SIM Annual Meeting, Denver, CO. (Invited Speaker)
Smolke CD. 2007. Molecular tools for optimizing pathway engineering applied to alkaloid
production in
yeast. Plant Metabolic Engineering Gordon Conference. Tilton, NH. (Plenary Speaker)
Smolke CD. 2007. RNA devices as general tools for advancing molecular medicine. City of
Hope Cancer
Immunotherapeutics Seminar. Duarte, CA. (Invited Speaker)
Smolke CD. 2007. Foundational advances in RNA engineering applied to control biosynthesis
and T -cell
proliferation. Arizona State University Biodesign Center Seminar . Tempe, AZ. (Invited
Speaker)
Smolke CD. 2007. Engineering RNA devices as general tools in programming cellular
function. Nucleic
Acids Gordon Conference. Newport, RI. (Plenary Speaker)
Smolke CD. 2007. Foundational advances in RNA engineering applied to control bios
ynthesis and T-cell
proliferation. Stanford Bioengineering Departmental Seminar . Stanford, CA. (Invited
Speaker)
Smolke CD. 2007. Programmable molecular sensors as general tools for optimizing flux
through
synthetic metabolic networks. ASM Annual Meeting, Toronto, Canada. (Invited Speaker)
Smolke CD. 2007. Engineering RNA devices as communication and control systems. Design
Principles
for Biological Systems, Banbury Center Meeting, Cold Spring Harbor Laboratory, NY.
(Plenary
Speaker)
Smolke CD. 2007. Advances in building RNA devices for programming cellular function.
Pierce College
Frontiers in Science Seminar Series, CA. (Invited Speaker)
Smolke CD. 2007. Engineering RNA devices as communication and control systems. UC
Berkeley
SynBERC Seminar, Berkeley, CA. (Invited Speaker)
Smolke CD. 2007. De novo synthesis of circuit elements: novel RNA devices. Tianjin
University-
sponsored iGEM Workshop, Tianjin, China. (Invited Speaker)
Smolke CD. 2007. Engineering RNA devices for probing and programming cellular syste ms.
California
State University Los Angeles Chemistry and Biochemistry Departmental Seminar, Los
Angeles, CA.
(Invited Speaker)
Smolke CD. 2007. Engineering RNA devices as general tools for programming cellular
function. Institute
of Biological Engineering Annual Conference, Saint Louis, MO. (Invited Speaker)
Smolke CD. 2007. Engineering RNA devices as general tools in cellular engineering
applications. IBC
Life Sciences Synthetic Biology Conference: Transforming Life Science Research and
Discovery,
Boston, MA. (Plenary Speaker)
Smolke CD. 2007. Design principles for building RNA devices. Massachusetts Institute of
Technology
Synthetic Biology Working Group Lunch Seminar, Cambridge, MA. (Invited Speaker)
Smolke CD. 2007. Engineering RNA devices for programmi ng and probing cellular systems.
Wayne State
Medical University Molecular Medicine and Genetics Departme ntal Seminar, Detroit, MI.
(Invited
Speaker)
Smolke CD. 2007. Engineering molecular sensors for probing and programming cellular
systems.
Harvard Medical School Systems Biology Departmental Seminar, Boston, MA. (Invited
Speaker)
Smolke CD. 2007. Engineering molecular sensors for probing and programming cellular
systems. UCSF
Systems Biology Departmental Seminar, San Francisco, CA. (Invited Speaker)
Win MN, Smolke CD. 2007. Engineering new molecular sensors and switches for programming
cellular
st
systems. SBE 1 International Conference in Biomolecular Engineering, Coronado Island, CA.
(Invited Speaker)
Smolke CD. 2006. Engineering molecular control systems for programming biological
systems.
Workshop on the Computational Worldview and the Sciences, Princeton, NJ. (Invited
Speaker)
Smolke CD. 2006. Engineering new molecules for programming cellular behavior .
Engineering
Principles in Biological Systems, Cold Spring Harbor Laboratory, NY. (Plenary Speaker)
Smolke CD. 2006. Engineering new molecules for studying and programming cellular systems.
Japan-
America Frontiers of Engineering Symposium, Tsukuba, Japan. (Plenary Speaker)
Page 11
CD Smolke, Curriculum Vitae
Smolke CD. 2006. Molecular sensors for optimizing production of alkaloid molecules in
Saccharomyces
cerevisiae. Metabolic Engineering VI, NH Leeuwenhorst, Noordwijkerhout, Netherlands.
(Plenary
Speaker)
Smolke CD. 2006. Engineering new molecules for probing and programming cellular systems .
Rice
University Bioengineering Departmental Seminar, Houston, TX. (Invited Speaker)
Smolke CD. 2006. Engineering nucleic acid -based sensors for programming and probing
cellular systems.
LSS Computational Systems Bioinformatics Conference, Stanford, CA. (Plenary Speaker)
Smolke CD. 2006. Programmable nucleic acid sensors as general tools for optimizing flux
through
synthetic metabolic networks. SIM Annual Meeting, Baltimore, MD. (Invited Speaker)
th
Smolke CD. 2006. Engineering new molecules for programming c omplex cellular systems. 15
International Workshop on Logic and Synthesis, Vail, CO. (Plenary Speaker)
Smolke CD. 2006. Engineering new molecules for studying and programming cellular systems.
Northwestern University Chemical and Biological Engineering D epartmental Seminar,
Evanston, IL.
(Invited Speaker)
Smolke CD. 2006. Programmable molecular switches and s ensors: applications in metabolic
engineering
and intelligent therapeutics. Synthetic Biology 2.0, Berkeley, CA. (Plenary Speaker)
Smolke CD. 2006. Engineering new molecules for programming cellular systems. Design
Principles for
Biological Systems, Banbury Center Meeting, Cold Spring Harbor Laboratory, NY. (Plenary
Speaker)
Smolke CD. 2006. Programmable molecular switches and s ensors: applications in metabolic
engineering
and intelligent therapeutics. Massachusetts Institute of Technology Chemical Engineering
Departmental Seminar, Cambridge, MA. (Invited Speaker)
Smolke CD. 2006. Ligand-regulated nucleic acid switches as programmable molecular
sensors. Workshop
on Biological Large Scale Integration (BioLSI -2), Pasadena, CA. (Invited Speaker)
Smolke CD. 2006. The application of programmable nucleic acid switches to cellular
engineering
strategies. Regenerate World Congress on Tissue Engineering and Regen erative Medicine,
Philadelphia, PA. (Invited Speaker)
Smolke CD. 2006. Engineering new molecules for studying and programming cellular systems.
Caltech
Discovery Day, Pasadena, CA. (Invited Speaker)
Bayer TS, Hawkins KH, Kimura Y, Lee H, Lee J, Win M -N, Smolke CD. 2006. Spatial
patterning and
hardwired memory: engineering biomolecules as cellular input/output devices. Institute of
Biological
Engineering Annual Meeting, Tuscon, AZ. (Invited Speaker)
Smolke CD. 2006. The National Academies Keck Futures Initiative: Genomics and Life
Engineering
Conferences. Board of Directors and Beckman Center Advisory Board Meeting, Irvine, CA.
(Invited
Speaker)
Smolke CD. 2006. Strategies for programming cellular behavior through molecular sensors
and switches.
Caltech Bioengineering Retreat, Warner Springs, CA. (Invited Speaker)
Smolke CD. 2005. Programmable molecular sensors and switche s: applications in
intelligent therapeutics,
biosensors, and metabolic engineering. Rensselaer Polytechnic Institute Chemical and
Biological
Engineering Departmental Seminar, Troy, NY. (Invited Speaker)
Smolke CD. 2005. Programmable molecular sensors and switches: applications in intelligent
therapeutics,
biosensors, and metabolic engineering. Cargill Incorporated Seminar, Minneapolis, MN.
(Invited
Speaker)
Smolke CD. 2005. Smart nucleic acid devices for converting diverse biochemical inputs
into programmed
cell behavior. National Academies Keck Futures Initiative Genomics Conference, Irvine,
CA. (Invited
Participant and Poster)
Smolke CD. 2005. From programmable nucleic acid devices to intelligent cells. National
Academy of
Science Frontiers of Science Symposium, Irvine, CA. (Invited Participant and Poster)
Smolke CD. 2005. Programmable nucleic acid molecules. National Academy of Engineering Fr
ontiers of
Engineering Symposium, Albany, NY. (Invited Participant and Poster)
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CD Smolke, Curriculum Vitae
Smolke CD. 2005. Programmable molecular sensors and switches: applications in metabolic
engineering,
intelligent therapeutics, and biosensors. Lawrence Berkeley National Laborat ory
Synthetic Biology
Seminar, Berkeley, CA. (Invited Speaker)
Smolke CD. 2005. Programmable molecular sensors and switches: devices for converting
biochemical
information into biological function. Caltech Kavli Nanoscience Inaugural Symposium,
Pasadena,
CA. (Invited Speaker)
Smolke CD. 2005. Programmable molecular sensors and switches: applications in metabolic
engineering,
intelligent therapeutics, and biosensors. Caltech Bioengineering Departmental Seminar,
Pasadena,
CA. (Invited Speaker)
Smolke CD. 2005. Programmable molecular sensors and switches: applications in metabolic
engineering,
intelligent therapeutics, and biosensors. University of Southern California Chemical
Engineering
Departmental Seminar, Los Angeles, CA. (Invited Speaker)
Smolke CD. 2005. Engineering alkaloid biosynthesis in Saccharomyces cerevisiae: the
application of
programmable molecular switches to pathway optimization. SIM Annual Meeting, Chicago, IL.
(Invited Speaker)
Smolke CD. 2005. Programming dynamic cellular response with engin eered molecular
sensors. NAKFI
Life Engineering Symposium, San Francisco, CA. (Plenary Speaker)
Smolke CD. 2005. Programmable molecular sensors and switches: applications in
intelligent
therapeutics and biosensors. Caltech Alumni College, Pasadena, CA. (Invited Speaker)
Smolke CD. 2005. Programmable molecular sensors and switches: applications in
intelligent
therapeutics and biosensors. DARPA: Biological Input-Output Systems Program Meeting,
Arlington,
VA. (Invited Speaker)
Smolke CD. 2005. Programmable molecular sensors and switche s: applications in
intelligent therapeutics,
biosensors, and metabolic engineering. Stanford Chemical Engineering Departmental
Colloquium,
Palo Alto, CA. (Invited Speaker)
Smolke CD. 2005. Programming dynamic cellular response with molecular sensors. Caltech
Alumni
Seminar Day, Pasadena, CA. (Invited Speaker)
Smolke CD. 2004. Programmable RNA regulators of gene expression: applications in cellular
sensors,
therapeutics, and metabolic circuits. Caltech Biology Division Retreat, Redondo Beach,
CA. (Invited
Speaker)
Selected Presentations
Liang J, Chang A, Kennedy A, Smolke CD. 2011. High-throughput cell-based strategies for
optimizing
rd
and generating new RNA component functions. SBE 3 International Conference in
Biomolecular
Engineering, San Francisco, CA. (Oral presentation)
Michener JK, Smolke CD. 2010. Riboswitch-guided enzyme engineering in Saccharomyces
cerevisiae.
SynBERC Yeast Synthetic Biology Workshop, San Francisco, CA. (Oral presentation)
Galloway KE, Smolke CD. 2010. Control of cell fate in a model MAPK pathway via induced
network
topologies. Systems Biology of Stem Cells Symposium, Irvine, CA. (Poster)
Chen YY, Smolke CD. 2010. Genetic control of T-cell proliferation with synthetic RNA
regulatory
systems. Gordon Research Conference: Immunochemistry and Immunobiology, Les Diablerets,
Switzerland. (Poster)
Michener JK, Smolke CD. 2009. Riboswitch -guided enzyme engineering in Saccharomyces
cerevisiae.
Enzyme Engineering XX, Groningen, Netherlands. (Poster; selected as a top poster and
invited for an
oral presentation)
Michener JK, Smolke CD. 2009. Construction and control of biosynthetic pathways. 10th
International
Conference in Systems Biology, Stanford, CA. (Poster)
Chen YY, Smolke CD. 2009. Genetic control of mammalian T-cell proliferation with
synthetic RNA-
based regulatory systems. IBE Annual Conference, Santa Clara, CA. (Oral Presentation)
Page 13
CD Smolke, Curriculum Vitae
Chen F, Hsiao V, Lim A, Ovadia R, Tischer D, Beisel CL, Michener JK, Smolke CD. 2009.
Engineering
multi-functional probiotic bacteria. IBE Annual Conference, Santa Clara, CA. (Oral
Presentation)
Win MN, Smolke CD. 2009. Programming synthetic RNA devices for cellular information
processing.
nd
SBE 2 International Conference on Biomolecular Engineering, Santa Barbara, CA. (Oral
Presentation)
Culler SJ, Hoff KG, Smolke CD. 2009. Engineering complex phenotypes by reprogramming
alternative
nd
splicing. SBE 2 International Conference on Biomolecular Engineering, Santa Barbara, CA.
(Poster; received the Genentech first place award for best pos ter presentation)
Culler SJ, Hoff KG, Smolke CD. 2009. Engineering complex phenotypes by reprogramming
alternative
st
splicing. Caltech Graduate Student Council 1 Annual Graduate Student Poster Session,
Pasadena,
CA. (Poster)
Galloway KE, Smolke CD. 2008. L igand-dependent regulation of transcriptional feedback
and phenotype
in a MAPK pathway via RNA control elements. Engineering Principles in Biological Systems
CSHL
Meeting, Cold Spring Harbor Laboratory, NY. (Oral Presentation)
Michener JK, Smolke CD. 2008. Construction and control of biosynthetic pathways.
Engineering
Principles in Biological Systems CSHL Meeting, Cold Spring Harbor Laboratory, NY.
(Poster)
Chen F, Hsiao V, Lim A, Ovadia R, Tischer D, Beisel CL, Michener JK, Smolke CD. 2008.
Engineering
multi-functional probiotic bacteria. iGEM Jamboree, Cambridge, MA. (Oral Presentation;
team
awarded second runner up for grand prize)
Hawkins KM, Smolke CD. 2008. Production of benzylisoquinolines in engineered yeast.
Synthetic
Biology 4.0, Clearwater Bay, Kowloon Hong Kong. (Oral Presentation)
Chen YY, Smolke CD. 2008. T-cell proliferation control with synthetic RNA devices.
Synthetic Biology
4.0, Clearwater Bay, Kowloon Hong Kong. (Poster)
Beisel CL, Smolke CD. 2008. Design principles for riboswitch function . Synthetic Biology
4.0,
Clearwater Bay, Kowloon Hong Kong. (Poster)
Beisel CL, Smolke CD. 2008. Ligand -responsive miRNAs: toward probing and programming
cellular
state. AIChE Annual Meeting, Philadelphia, PA. (Oral Presentation)
Beisel CL, Smolke CD. 2008. Design principles for riboswitch function. AIChE Annual
Meeting,
Philadelphia, PA. (Oral Presentation)
Chen YY, Smolke CD. 2008. T-cell proliferation control with small molecule -responsive
RNA-based
regulatory systems. AIChE Annual Meeting, Philadelphia, PA. (Oral Presentation)
Chen YY, Smolke CD. 2008. T-cell proliferation control with synthetic, small molecule -
responsive RNA-
based regulatory systems. First Annual City of Hope Poster Session -Collaboration: A
Catalyst for
Progress, Duarte, CA. (Poster)
Culler SJ, Hoff KG, Voelker RB, Berglund A, Smolke CD. 2008. In vivo selection of
intronic silencers
reveals a diverse set of regulatory motifs with a range of splicing efficiencies. Gordon
Research
Conference: Post-transcriptional Gene Regulation, Waterville, ME. (Poster)
D Espaux L, Smolke CD. 2008. Programmable molecular sensors for the design of intelligent
therapeutics targeted to breast cancer cells. DOD Breast Cancer Research Program Era of
Hope
Meeting, Baltimore, MD. (Poster)
Chen YY, Smolke CD. 2008. Ligand-responsive, RNA-based gene regulatory systems in
cellular
therapeutics. Caltech Chemical Engineering Economou Lecture, Pasadena, CA. (Invited
Speaker)
Beisel CL, Smolke CD. 2007. Towards programming network connectivities: ligand -regulated
shRNA
switches. AIChE Annual Meeting, Salt Lake City, UT. (Oral Presentation)
Bandyopadhyay T, Bugga P, Jiang D, Pak E, Xiao H, Brenner K, Levine J, Michener JK,
Smolke CD.
2007. Engineering viruses for targeted cell death. iGEM Jamboree, Cambridge, MA. (Oral
Presentation)
Michener JK, Smolke CD. 2007. Synthetic regulatory circuits for dynamic control of
metabolism.
International Conference on Systems Biology, Irvine, CA. (Poster)
Beisel CL, Bayer TS, Hoff KG, Smolke CD. 2007. Ligand-regulated shRNA switches as
programmable
network components. International Conference on Systems Biology, Irvine, CA. (Poster)
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CD Smolke, Curriculum Vitae
Galloway KE, Smolke CD. 2007. RNA -based control systems and their application to a model
MAPK
pathway. International Conference on Systems Biology, Irvine, CA. (Poster)
Culler SC, Smolke CD. 2007. A generalizable screen for synthetic cis -acting intr
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