Formulation/Drug delivery Scientist

Summary

Experienced Formulation Scientist with doctoral degree in Pharmaceutical Sciences. Significantly contributed for advancement of projects at various stages of drug product development cycle from conceptualization to proof-of-concept studies in animals that resulted in invention disclosures. Efficient and diligent team worker with proven track record of being problem solving and innovative. Areas of expertise include:

• Formulation and product development for ocular, transdermal and skin care area.

• Preformulation and related analytical techniques.

• SOP and report writing as per GLP compliance

• Biomaterial i.e. absorbent, contact lens and Intraocular lens

• Teaching experience in pharmaceutics and hospital pharmacy

• Serving as board member of non-profit organization and scientific journals.

Specialties: Formulation and product development (ocular, transdermal, skin care), Polymeric nanoparticles, in situ gel, pHEMA gel and emulsion based formulation development, excipient interaction and stability study, In vitro and in vivo evaluation of drug products, ocular/skin irritation studies, radiolabeling of small drug molecules, preclinical drug evaluation in rabbits and rats, Franz diffusion cell for skin/corneal permeation studies, SOP and report writing, documentation for regulatory submissions, analytical techniques such as HPLC, UV-Vis, DSC, viscometer, osmometer, DLS, SEM, ERG (Electro retinography), IR camera. Hands on instrument experience for formulation development i.e. high pressure homogenizer, lyophilizer, ultra sonicator, ultra centrifuge, autoclave, gamma sterilization, cold compression etc.

Significant accomplishments:

• Designed in situ gel formulations for ocular delivery to reduce dosing from 4-5 times daily to 1-2 times.

• Developed polymeric nanoparticulate drug delivery systems for ocular delivery.

• Developed nanoparticulate based emulsion/semisolid product for pharmaceutical industry along with its stability analysis.

• Developed hydrogel based biomaterials to reduce market price i.e. diapers, IOL, contact lenses etc.

• Optimized various radiolabelling protocols of drugs i.e timolol maleate, sparfloxacin, levofloxacin etc using Tc99m radionuclide.

• Acquired and studied gamma scintigraphic images using gamma camera and Tc labeled drug complex.

• Evaluated various formulations for in vitro, in vivo and toxicology studies i.e. transcorneal permeation (through goat cornea, human cornea), skin permeation (human skin) using Franz diffusion cells, HET-CAM assay, draize test etc

Experience

Post Doc- Visiting Research Scholar

Auburn University, Department of Pharmacal Sciences, Harrison School of Pharmacy, Auburn, AL 36849, USA June 2012- Present

• Developed micellar nanoparticle emulsion based industrial product development in GLP lab for commercialization.

• Conducted skin permeation studies using Franz diffusion cells and drug release profile studies from developed formulation.

• HPLC method validation and analysis of formulation assays and stability.

• Wrote stability and analytical protocols and follow it for dossier preparation.

Post Doc- Visiting Research Associate

University of Colorado- Anschutz Medical Campus, Department of Pharmaceutical Sciences, School of Pharmacy, Aurora, CO 80045, USA June 2011- May 2012

• Developed ocular drug delivery systems i.e. solid lipid nanoparticles, polymeric nanoparticles.

• Performed ocular preclinical studies on rats for evaluation of developed formulation systems.

• Studied toxicology effects of nanoparticles in posterior segment of rat eye by ERG and histology.

Senior Research Fellow (SRF)

Council of Scientific and Industrial research, Govt. of India April 2009 –June 2011

• Developed ocular drug delivery systems i.e. hydrogels, in situ gels, nanoparticles etc.

• Determined the bioavailability of drugs in aqueous humour samples using UPLC.

• Radiolabelling of levofloxacin and sparfloxacin with Tc-99m and study the ocular retention of formulations by gamma scintigraphy.

• Performed corneal permeation behavior of developed formulation using franz diffusion cells.

• Performed ocular irritation studies using draize test, HET CAM test, IR camera and histology.

• Wrote project proposal for Indian Council of Medical Research (ICMR), Govt. of India for grant award.

Research Associate

Shriram Institute for Industrial Research, Delhi, India Aug 2007 - April 2008

• Assisted in DST, Govt. of India projects on biomedical applications i.e. absorbent and contact lens.

• Prepared project proposals and presentations for DRDO (Govt. of India) and other funding agencies.

Lecturer in BIT, Meerut, India

UP Technical University, Lucknow, India Jun 2006 – Aug 2007

• Taught, supervised pharmaceutics and hospital pharmacy class and research projects.

• Graded lab reports, as well as proctored and graded their theory exams.

• Prepared theory examination papers and held as examiner for evaluations in University final semester examinations.

Internship

Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO, Ministry of Defence, Govt. of India, India

Research student Dec 2005 – May 2006

• Learned techniques to radiolabel drug molecules with Tc99m and carried out preclinical studies on rabbits by gamma camera.

• Formulated in situ gel based ocular formulations and evaluated it (in vitro and in vivo)

All India Institute of Medical Sciences (AIIMS), Delhi, India

Research student April 2006 – June 2006

• Formulated in situ gel ocular formulations and evaluated it (in vitro and in vivo)

• Performed HET-CAM technique and transcorneal permeation studies through goat corneas

Unichem Laboratories, Ghaziabad, India. June 2003- Jul 2003

Trainee Production Pharmacist

• Assisted in the production of conventional solid and parenteral pharmaceutical formulations

• Quality assurance and quality control of drug formulations.

Hindu Rao Hospital, Delhi India,

Dispensing Pharmacist June 2001 – Aug 2001

• Dispensing drugs, quality control

Education:

Ph.D - Pharmaceutics

Hamdard University- Delhi, India Jan 2008 – Dec 2011

Research Advisor (s) – Dr. M.Aqil, Prof R.K. Khar, Prof Asgar Ali

Thesis Title:

Novel hydrogel based ocular drug delivery systems

Master of Pharmacy - Pharmaceutics

VM University, Tamilnadu, India Aug 2004 - July 2006

Thesis Title:

Chitosan based novel hydrogel system for sustained ocular drug delivery

Certificate of General Course on Intellectual Property Rights

World Intellectual Property Organization (WIPO), Geneva, Switzerland Mar 2009 – May 2009

Post Grad. Diploma in International Business

Symbiosis University (SCDL), Pune, India Aug 2006 – April 2009

Bachelor of Pharmacy

U.P. Technical University, Lucknow, India Aug 2001 - July 2004

Diploma in Pharmacy

University of Delhi, Delhi, India July 1999 - July 2001

Publications & Citations

Citations record (>200 citations)

http://scholar.google.com/citations?user=f6RQgCAAAAAJ&hl=en

Papers Published in Indexed Journals

1. Himanshu Gupta, Sanyog Jain, Rashi Mathur, A.K. Mishra, Pushpa Mishra, T.Velpandian, Sustained ocular drug delivery from a temperature and pH triggered in-situ gel system, Drug Delivery 14(8) 2007, 507-515.

2. Himanshu Gupta, M. Aqil, R.K. Khar, Asgar Ali, Aseem Bhatnagar, Gaurav Mittal, Sanyog Jain. Development and characterization of Tc-99m timolol maleate for evaluating efficacy of in situ ocular drug delivery system, AAPS Pharm. Sci.10(2) 2009, 540-546.

3. Himanshu Gupta Dheeraj Singh, Preet Tyagi, R.K. Diwan, R.K. Khandal, Vinod Paul, Ramesh Aggarwal, Amita Malik, Performace evaluation of market available diapers: Materials and Properties, Indian Journal of Pediatrics 76(8) 2009, 859-60.

4. Himanshu Gupta, Dinesh Bhandari, Aarti Sharma, Recent Trends in Oral Drug Delivery: A Review, Recent Patents on Drug Delivery & Formulation 3 (2) 2009, 162-173.

5. Himanshu Gupta, Aarti Sharma, Tripti Dixit, Intraocular lens and biocompatibility- A Review, Recent Patents on Biomedical Engeniering 2 (2), 2009, 148-156.

6. Suresh Kumar, Sandhya Bawa, Sushma Drabu, Rajiv Kumar, Himanshu Gupta. Biological Activities of Pyrazoline Derivatives -A Recent Development. Recent Patents on Anti-Infective Drug Discovery 4 (3) 2009, 154-163.

7. Himanshu Gupta, Aarti Sharma, Ion activated bioadhesive in situ gel of clindamycin for vaginal application, International Journal of Drug Delivery 1 (1) 2009, 32-40.

8. Himanshu Gupta, M. Aqil, R.K. Khar, Asgar Ali, A. Sharma, Prakash Chander, Development and Validation of Stability Indicating RP-UPLC method for the Quantitative analysis of Sparfloxacin. Journal of Chromatographic Science 48 (1) 2010, 1-6.

9. Himanshu Gupta, Aqil Malik, R.K. Khar, Asgar Ali, Prakash Chander, A Single RP-UPLC method for quantification of Levofloxacin in aqueous humour and pharmaceutical dosage forms, Journal of chromatographic Science 48, 2010: 484-490.

10. Himanshu Gupta, Aarti Sharma, Suresh Kumar, Saroj Kumar Roy, E-tongue- A tool for taste evaluation, Recent Patents in Drug Delivery and Formulation 4 (1) 2010, 82-89.

11. A. Anand, R. Pundir, C S Pandian, S. Saraf, H. Gupta. Cefoperazone Sodium Impregnated Polycaprolactone Composite Implant for Osteomyelitis. Indian Journal of Pharmaceutical sciences 71(4) 2009, 377-381.

12. Surajpal Verma, Himanshu Gupta, Ozair alam, Pooja Mullick, Nadeem Siddiqui, Suroor A. Khan. Spectrophotometric Methods For The Estimation of Mycophenolate Mofetil. Journal of Applied Spectroscopy 76 (6) 2009, 876-882.

13. Himanshu Gupta, M.Aqil, R.K. Khar, Asgar Ali, Gaurav Mittal, Aseem Bhatnagar. Sparfloxacin loaded PLGA nanoparticles for sustained ocular drug delivery. Nanomedicine: Nanotechnology, Biology, and Medicine 6(2) 2010, 324-333.

14. Sandeep Soni, Himanshu Gupta, Neeraj Kumar, Dhruv K Nishad, Gaurav Mittal, Aseem Bhatnagar. Biodegradable biomaterial. Recent patent on biomedical engineering 3(1) 2010. 30-40.

15. Suresh Kumar, Sandhya Bawa, Himanshu Gupta. Biological activities of quinoline derivatives. Mini Reviews in medicinal chemistry 9(14) 2009, 1648-1654.

16. Himanshu Gupta, T. Velpandian, Sanyog jain. Ion- and pH- activated novel in-situ gel system for sustained ocular drug delivery. Journal of Drug Targeting 18(7) 2010, 499-505.

17. Aarti Sharma, Himanshu Gupta. Molecular Modelling. Jounal of Pharmacy and BioAllied Sciences 1(1) 2009: 23-29.

18. Neelima Garg, Himanshu Gupta, Isolation and purification of fungal pathogen (Macrophomina phaseolina) induced Chitinase from moth beans (Phaseolus aconitifolius), Journal of Pharmacy and Bioallied Sciences 2(1) 2010: 37-42.

19. Himanshu Gupta, Saroj Kumar Roy, R.S. Gaud; Suresh Kumar, The Quest for Market Exclusivity in Pharmaceutical Companies: Patent Protection Strategies. Journal of Pharmacy and Bioallied Sciences 2(1) 2010: 2-7.

20. Himanshu Gupta, M.Aqil, R.K. Khar, Asgar Ali, Gaurav Mittal, Aseem Bhatnagar. Biodegradable levofloxacin nanoparticles for sustained ocular drug delivery. Journal of Drug Targeting 19(6) 2011: 409-417.

21. Suresh Kumar, Sandhya Bawa, Sushma Drabu, Himanshu Gupta, Lalit, Rajiv Kumar. Synthesis, Antidepressant and Antifungal Evaluation of Novel 2-Chloro-8-methylquinoline amine Derivatives. European Journal of Medicinal Chemistry 46(2) 2011: 670-675.

22. Neha Gulati, Himanshu Gupta, Parenteral drug delivery- A Review, Recent Patents in Drug Delivery and Formulation 5, 2011: 133-145.

23. Gulati N, Gupta H. Two faces of carbon nanotube: toxicities and pharmaceutical applications. Crit Rev Ther Drug Carrier Syst. 29(1), 2012: 65-88.

24. Gupta H, Aqil M. Contact lenses in ocular therapeutics. Drug Discovery Today 17(9-10), 2012: 522-7.

25. N Gulati, Himanshu Gupta. Nanomedicine: Potential Devices for Diagnostics. Recent Patents on Nanomedicine 2 (2), 146-155.

National Publications

1. H. Gupta, R.M. Singh, G.N.Singh, A. Sharma, D. Kaushik, pH induced in-situ gel for periodontal anesthesia, Indian Journal of Pharmaceutical Sciences 70(6) 2008, 776-778.

2. Himanshu Gupta, Dinesh Bhandari, Kamal Dua, VK Sharma, UVS Sara, Neem-A natural boon, Pharmaceutical Reviews 6(5) 2008, http://www.pharmainfo.net/reviews/neem-natural-boon.

3. Dinesh Bhandari, Abhinav Aggarwal, Himanshu Gupta, Recent trends-Fast dissolving tablets, Pharmaceutical reviews 6(6) 2008, http://www.pharmainfo.net/reviews/recent-trends-fast-dissolving-tablets

4. Himanshu Gupta, Dinesh Bhandari, Aarti Sharma, Concept of Nutraceuticals, The Pharma Review 7 (38), Mar 2009, 111-114

5. Himanshu Gupta, Aarti Sharma, Birendra Shrivastava. Pluronic and chitosan based in situ gel system for periodontal application. Asian Journal of Pharmaceutics. 3(2) 2009, 173-175.

6. Himanshu Gupta, Aarti Sharma. Pharmacovigilence and Clinical trial. The Pharma Review 7 (39) 2009, 62-67.

7. Himanshu Gupta, Aarti Sharma, Recent trends in protein and peptide drug delivery systems, Asian Journal of Pharmaceutics 3(2) 2009, 69-75.

8. Himanshu Gupta, Anubhav Anand, Rakesh Pundir, C S Pandian, Shubhini Saraf. Fabrication of cefuroxime impregnated Calcium Sulphate Polycaprolactone composite for osteomyelitis. Asian Journal of Pharmaceutics. 3(3) 2009, 236-241.

9. Himanshu Gupta Dheeraj Singh, Preet Tyagi, R.K. Diwan, R.K. Khandal, Vinod Paul, Ramesh Aggarwal, Amita Malik. Evaluation of some commonly available marketed diapers in India. Journal of Pharmaceutical and allied sciences 5(2) 2008, 572-577.

10. Aarti Sharma, Himanshu Gupta. Quercetin- A flavanoid. Chronicles of Young Scientists 1(1) 2010; 10-15.

Web Articles

1. Aarti Sharma, Himanshu Gupta, Suresh Kumar, Birender Shrivastava, Nuclear Overhauser effect, www.Pharmainfo.net/nuclear-overhauser-effect, Oct 2008.

2. Himanshu Gupta, Tutorial on poster designing, www.pharmainfo.net/ebooks/tutorial-poster-designing, Nov 2008.

Books/chapters published

1. Himanshu Gupta, Mohd. Aqil. Chapter: 4 Drug Distribution system in hospitals, In Practice of Hospital, Clinical and Community Pharmacy. Ed. Mohd. Aqil. Elsevier India. ISBN: 813*******, 978**********.

2. Himanshu Gupta, Mohd. Aqil. Chapter 13: Introduction to Clinical Pharmacy, In Practice of Hospital, Clinical and Community Pharmacy. Ed. Mohd. Aqil. Elsevier India. ISBN: 813*******, 978**********.

3. Himanshu Gupta, Mohd. Aqil. Chapter 18: Diseases: Etiology, Pathophysiology, Symptoms and Treatment, In Practice of Hospital, Clinical and Community Pharmacy. Ed. Mohd. Aqil. Elsevier India. ISBN: 813*******, 978**********.

4. Himanshu Gupta, Mohd. Aqil. Chapter 24: Over the counter Medicines, In Practice of Hospital, Clinical and Community Pharmacy. Ed. Mohd. Aqil. Elsevier India. ISBN: 813*******, 978**********.

5. Himanshu Gupta, Mohd. Aqil. Chapter 25: Community Pharmacy Management, In Practice of Hospital, Clinical and Community Pharmacy. Ed. Mohd. Aqil. Elsevier India. ISBN: 813*******, 978**********.

Abstract published in Conferences/ Seminars/ Symposia

• Himanshu Gupta, Pushpa Mishra, A.K. Mishra, T. Velpandian, Sanyog Jain. Chitosan based novel hydrogel system for sustained ocular drug delivery, 58th Indian Pharmaceutical Congress, Mumbai, 1-3 December, 2006.

• Sanyog Jain, Himanshu Gupta, Pushpa mishra, A.K. Mishra. “Sustained ocular drug delivery from a temperature and pH triggered novel in-situ gel system” published in Indian Pharmacological Society (IPS) abstract book, 39th Annual Conference of Indian Pharmacological Society, Jaipur, 21-23 December, 2006.

• Himanshu Gupta, Aqil Malik, R. K. Khar, Asgar Ali, Sanyog Jain, Gaurav Mittal, A.K. Mishra, Aseem Bhatnagar. Development and characterization of Tc-99m timolol maleate for evaluating efficacy of in situ ocular drug delivery system, 9th Asian Oceanic congress of Nuclear medicine and biology, New Delhi published in Indian Journal of Nuclear Medicine, 2008 Vol 23, Issue 2, M24 pp 175.

• Himanshu Gupta, Aqil Malik, R. K. Khar, Asgar Ali, Pushpa Mishra, A.K. Mishra, T. Velpandian, Sanyog Jain. Chitosan based novel hydrogel system for sustained ocular drug delivery, 60th Indian Pharmaceutical Congress, New Delhi, 12-14 December, 2008.

• Aarti Sharma, Birender Shrivastava, Himanshu Gupta, Surajpal Verma, Shrinivasa Reddy S. Development and validation of RP-HPLC method for the quantification of sparfloxacin, AICTE sponsored national seminar on “Emerging trends in pharmaceutical sciences”, New Delhi, 21-22 March, 2009.

• Himanshu Gupta, M.Aqil, RK Khar, Asgar Ali, Gaurav Mittal. Levofloxacin encapsulated PLGA nanoparticles for sustained ocular drug delivery. 7th NanoDDS 09, Indopalesia, USA, 5-6 Oct 2009, pp. 53.

• Himanshu Gupta, M.Aqil, RK Khar, Asgar Ali, Aseem Bhatnagar, Gaurav Mittal. Nanoparticle laden in situ gel for sustained ocular drug delivery. Published in Abstract book of 2nd Summer School on Nanotechnology in Advanced Drug Delivery, NIPER, Chandigarh, India, 10-14 August, 2009.

• Himanshu Gupta, M.Aqil, RK Khar, Asgar Ali, Aseem Bhatnagar, Gaurav Mittal. Levofloxacin nanoparticle laden in situ gel for control ocular drug delivery. 37th Annual Meeting and Exposition of the Control Release Society, Portland, Oregon, USA 10-14 July 2010

Podium Presentations

• Delivered an oral presentation in 58th Indian Pharmaceutical Congress (IPC), 1-3 Dec 2006, Mumbai

• Delivered an oral presentation in ISTE short term training programme on Recent Trends in Ocular Drug Delivery held in Jamia Hamdard, New Delhi on 19 May 2008

• Delivered an oral presentation in 2nd Summer School on Nanotechnology in Advanced Drug Delivery, NIPER, Chandigarh, India, 10-14 August, 2009.

Poster Presentations

• Delivered presentation in 9th Asian Oceanic congress of Nuclear medicine and biology, New Delhi, 1 Nov, 2008.

• Delivered presentation in 60th Indian Pharmaceutical Congress (IPC), 12-14 Dec 2008, New Delhi.

• Delivered presentation in 37th Annual Meeting and Exposition of the Control Release Society, Portland, Oregon, USA 10-14 July 2010

Awards and Affiliations

• Awarded “Hamdard Appreciation Award 2011” for PhD research work on sparfloxacin ocular nanoparticles.

• Awarded with “Dr. P. D. Sethi Annual Award 2010” for analytical work published in Journal of Chromatographic Sciences.

• Received International travel grant from Department of Science and Technology, Ministry of Science and Technology (Govt. of India) for 37th CRS, Portland, Oregon, USA.

• Invited to Moderate “Nanotechnology I” session in 37th Annual Meeting and Exposition of the Control Release Society, Portland, Oregon, USA 10-14 July 2010

• Awarded “Budding Nanotechnologist Award” (Young Scientist Award) in DST (Ministry of Science and Technology, Govt. of India) sponsored 2nd Summer School on Nanotechnology in Advanced Drug Delivery, NIPER, Chandigarh, India, 10-14 August, 2009.

• Received SRF fellowship of Central Council of Scientific and Industrial Research (CSIR), Govt. Of India, New Delhi, India.

• Awarded SRF fellowship of Indian Council of Medical Research (ICMR), Govt. of India, New Delhi, India.

• Received conference grant from Society of Nuclear Medicine (India) for presenting paper in 9th Asian Oceanic congress of Nuclear medicine and biology, New Delhi, 31 Oct-4 Nov, 2008.

• Organized planary lectures and symposium with scientific committee in 60th IPC, 12-14 Dec 2008, New Delhi

• Awarded conference grant from IOMC for presenting paper in International online medical conference 2010.

• Elected “General Secretary” in “Organization of Pharmaceutical Unity with BioAliied Sciences (OPUBS)” registered under “The Societies registration act, 1860” www.opubs.com.

• Life member of Association of pharmaceutical teachers of India (APTI) (Membership No UP/LM-087)

• Registered Pharmacist in Delhi Pharmacy Council, Delhi, India

• Selected and Registered in World`s Who`Who 2009 edition, USA.

• Life member of Society of Nuclear Medicine (India) (Membership No G-059)

• Member of “Control Release Society”, USA (Membership No. 127856)

• Worked as team member with www.pharmainfo.net, Canada.

• Selected as “Conference student board member” in 3rd International Online medical conference (IOMC).

• Participated with rotary club in conducting National Pulse polio programs (in year 2003, 2004)

Journal Committee

• Journal of Pharmacy and Bioallied Sciences” ISSN 0975-7406--- Asst. Editor. www.jpbsonline.org

• “African Journal of Pharmacy and Pharmacology” ISSN 1996-0816. Editor www.academicjournals.com/ajpp

• “Chronicles of Young Scientists” ISSN 0975-9212. Asst. Editor. www.cysonline.org

• “Recent patents in drug delivery & formulations” ISSN: 1872-2113 --- Editorial advisory board member http://benthamscience.com/ddf/MSandI.htm

• “Recent patents on nanomedicine”, Bentham Publishers. ISSN:1877-9123 --- Editorial Board Member http://www.benthamscience.com/nanom/

• “Web Med Central”, UK --- Special Advisory Board Member www.webmedcentral.com

• Journal of ocular pharmacology and therapeutics, Mery Ann Libert Publishers, ISSN: 1080-7683- Reviewer

• Asian Journal of pharmaceutics, Wolters Kluwer Health Medknow Publisher. ISSN : 0973-8398--- Reviewer

• Talanta, Elsevier publisher ISSN: 0039-9140- Reviewer

Contact this candidate