Medical School

Summary

Passionate about the discovery and development of new drugs to prevent and

cure diseases, to ease suffering and to enhance the quality of life. Highly

experienced molecular biologist with extensive knowledge of a broad range

of techniques in cell biology research. Has led several projects from early

stage discovery up through in vivo studies.

Seeking a position combining both research and development with business,

thereby leveraging my strong analytical and communication skills with my

broad scientific knowledge, in a global organization that will encourage me

to learn and grow, create and promote products and therapies that help

improve the quality of peoples' lives.

Education

POSTDOCTORAL TRAINING, Joslin Diabetes Center, Harvard Medical School,

Boston, MA, USA 2008-Present

Principal Investigator: Prof. Susan Bonner-Weir in the Section of Islet

Cell and Regenerative Biology

. Co-wrote research grant resulting in a $250,000 award from the NIH

. Developed a new technique for isolating adult pancreatic

stem/progenitors from human and rodent pancreas

. Co-authored scientific paper (Published in Diabetes Journal, ranked

1st in the category of diabetes)

. Oral presentation at 2010 annual meeting of American Diabetes

Association (Top 10% of 15,000 participants)

. Presented oral presentation, Boston Ithaca Islet Club, 2010.

. Collaborated extensively with team at National Institute on Aging,

Baltimore

PH.D. IN MOLECULAR CELLULAR BIOLOGY, Tel Aviv University, Tel Aviv,

Israel Final Grade: 92.2/10 2001-2008 Principal Investigator:

Prof. Shimon Efrat, Department of Human Molecular Genetics and Cell

Biology

. Thesis: Expansion and re-differentiation of insulin-producing cells

from adult human pancreatic islets; published also in scientific

journal and thus far has been cited in over 60 scientific papers

. Oral presentation at the 10th EASD Oxford Workshop, Keble College

Oxford University England. August 2005

. Thesis resulted in application for a worldwide patent for Type 1

diabetes therapy

. Young Investigator Annual Award of the Hendrik and Irena Gutwith

Foundation for Diabetes Mellitus Research

. Academic excellence award (top 3 of 100+ students)

. Co-wrote research grant resulting in $100,000 grant from Juvenile

Diabetes Research Foundation International

. Co-authored two scientific papers on beta cell replacement therapy for

type 1 diabetes

M.SC. IN HUMAN MOLECULAR GENETICS, Tel Aviv University, Tel Aviv, Israel

Final Grade: 90.49/100-****-****

. Scholarship award (Top 1% of 2000+ students nation-wide)

. Awarded fellowship, Tel Aviv University Scholars Program for PhD

students

B.SC. Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel Final

Grade: 88.81/100-****-****

. Awarded 100% Scholarship, Tel Aviv University Scholars Program for

M.Sc students

Teaching Experience

HEAD TEACHING ASSISTANT, Sackler School of Medicine, Tel Aviv University,

Tel Aviv, Israel 2001-2008

. Led teams of four to six Teaching Assistants each year, teaching a

class of 70+ students

. Designed curricula and conducted tutorials in collaboration with other

Assistants

RESEARCH MENTOR, School of Education, Tel Aviv University, Tel Aviv, Israel

2001-2008

. Participated in Pre-Grad Education Training programs to promote

minority diversity in scientific research

. Developed research programs and trained students in experimental

procedures and presentation of results

. Created course curriculum, assignments, and grading schedules as part

of a 5-person teaching team for a new undergraduate course led by a

Tel Aviv School of Education faculty member

Leadership Experience

MEMBER, Fellows Council, Joslin Diabetes Center, Harvard Medical School,

Boston, MA, USA 2011-Present

. Organized events for academic and non-academic career development of

120+ M.D. and Postdoctoral fellows

MEMBER,HMS/HSDM Postdoc Association Governing Board

2011-Present

. Served on the HMS/HSDM Postdoc Association Governing Board

COMMANDER AND SERGEANT, Mandatory Service of the Israeli Defense Forces,

IDF, Israel 1990-1992

. Led and trained a class of 20+ soldier in the Israeli Infantry Force,

direct responsibility of 80+ soldiers

. Progressed to instructing commanders course; received

an acknowledgement of excellence teaching award

Research Experience

ADULT PANCREATIC PROGENITORS, Joslin Diabetes Center, Harvard Medical

School, Boston, MA, USA 2008-Present

. Designed and implemented novel approaches to identify and characterize

adult pancreatic progenitors

. Developed laboratory models to separate progenitor cells subpopulation

using flow cytometry

. Supervised foreign M.D student in research for her Masters thesis

. Supervised new MD post doctoral fellow in experimental procedures and

presentation of results

. Experienced in immunostaining, confocal microscopy, qPCR, flow

cytometry, cell culture and differentiation

EXPANSION AND DIFFERENTIATION OF STEM CELLS, Tel Aviv University, Tel Aviv,

Israel 2001-2008

. Discovered an innovative approach for the expansion and

differentiation of adult pancreatic stem cells

Skills and Interests

. MEMBER, Harvard Volunteer Consulting Group, Boston, MA, USA

. MEMBER, and served on marketing committee, WEST Women Entrepreneurs in

Science, Boston, MA, USA

. MEMBER, BiotechTuesday Boston biotechnology community

Languages: English (fluent), Hebrew (fluent)

Interests: Classical Ballet; Soccer

Publications

Published

Ouziel-Yahalom L, Cavelti-Weder C, Zalzman M, Keyzer C, Wan-Chun L, Guo

L, Sharma A, Lei J, Markmann J, Bonner-Weir S. Ductal heterogeneity

suggests a subpopulation of ductal cells as postnatal pancreatic

progenitors in human and mouse. Endocrine meeting 2011

Ouziel-Yahalom L, Li W-C, Straussman S, Guo L, Sharma A, Weir GC, Bonner-

Weir S. Ductal heterogeneity suggests a subpopulation serves as postnatal

pancreatic progenitors. Diabetes 2010, 59, Supplement1:A25.

Ouziel-Yahalom L, Zalzman M, Anker-Kitai L, Knoller S, Glandt M, Herold

K, Efrat S. Expansion and redifferentiation of adult human pancreatic

islets cells. Biochemical and Biophysical Research Communications 341,

(2006) 291-298. Times Cited: 62

Bonner-Weir S, Li W-C, Ouziel-Yahalom L, Guo L, Weir GC, Sharma A. ?-cell

growth and regeneration: replication is only part of the story. Diabetes.

2010 Oct; 59(10):2340-8.

Bar Y, Russ HA, Knoller S, Ouziel-Yahalom L, Efrat S. HES1 is involved in

adaptation of adult human beta cells to proliferation in vitro. Diabetes

57, 9-200*-****-****.

Weinberg N, Ouziel-Yahalom L, Knoller S, Efrat S, Dor Y. Lineage tracing

evidence for in-vitro dedifferentiation, but rare proliferation, of mouse

pancreatic ( cells. Diabetes 56, 5-200*-****-****. Times Cited: 31

In preparation

Ouziel-Yahalom L, Li W-C, Guo L, Sharma A, Weir GC, Bonner-Weir S: The

role of Hnf1?, Sox9 and Ngn3 in the pancreatic subpopulations that serve

as postnatal pancreatic progenitors. In preparation, 2011.

Ouziel-Yahalom L, Straussman S, Li W-C, Shaoping D, Markmann J, Bonner-

Weir S: Expansion of human pancreatic duct cells in culture results in

loss of transcriptional profile that favors neogenesis. In preparation,

2011.

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