Assistant Organic Chemistry
Resume:
Curriculum Vitae Updated:
Name: Dr. RIAZ HASAN, (DOB: 04-09-1964, INDIAN)
************@*****.***
**********@**********.***
Mobile # 0091-993-***-****
Organic Synthesis and QSAR for NCE’s/API’s
Research:
Teaching: Teachings General/Organic/Polymer and Medicinal Chemistry at UG/PG
Students
Q ualification: Ph. D Bioregulation Chemistry (Organic Synthesis/QSAR)
www.applife.kais.kyoto-u.ac.jp
“Synthesis and Mode-of-Action of Insecticidal Pyrazolines”
Title of PhD Thesis:
Objective: QSAR based design, synthesis, stereochemistry. Molecular modeling and mode of action studies of
pyrazoline compounds to make them more attractive candidate for commercialization. About 200 compounds were
prepared for lead generation and activity optimization work. One of the candidate was commercialized in 1996 by
the mutual understanding between university and Rohm and Hass of Japan
Ph. D Supervisors: Prof. Toshio Fujita, Prof. Tamio Ueno,
Prof. Keiichiro Nishimura, www.kyoto-u.ac.jp
Laboratory of Bioregulation Chemistry, Department of Agricultural Chemistry,
Division of Applied Life Scien ces, Faculty of Agriculture, Kyoto University,
JAPAN, Kyoto-606
An Inventor on Basic Chemical Research
Developed benzyloxy pyridine compounds as a novel class of insecticide. One of the representative candidate
showed LC50 at 2ppm (to develop this molecule about 300 molecules were prepared for lead generation and
optimization)
Patent Received at Otsuka Chemical JP:
New safe compound excellent in insecticidal and acaricidal effects even on insect pests having developed resistance
to chemicals, not showing environmental pollution and toxicity to mammals and fishes. Treated as an attractive
candidate for future commercialization
Patent No. : JP -10101647A2
Title : Benzyloxypyridine-A new class of Insecticides
Class : New Chemical Entities (NCE)
Inventor : Riaz Hasan, Employment No. 30375
Intellectual Property : Otsuka Chemical Co., Limited, JAPAN.
Q ualifications details :
Sec. Exam. (1980) WBSE, WB All 10th Subjects
I Sc (1982) LN M Univ., BH All 10+2 Subjects
B. Sc (1986) R. K Univ., UP (58.5% ) Chemistry Main
M. Sc (1989) G.B. Pant Univ. UP (76%) Organic Chemistry/SAR
M. Phil (1991 enrolled) IIT-Delhi Organic chemistry
Ph. D (1995) Kyoto Univ., JAPAN Organic Synthesis /QSAR
Major Achievements:
# Availed Graduate Scholarship to pursue Master Degree at G B Pant University, Pantnagar, India
(1987onward for 2 years)
# Availed GATE- Scholarship (Govt. India) and admitted for PhD in Organic Chemistry at IIT-Delhi, India
(March, 1991)
# Availed MONBUSHO Scholarship (Govt. of Japan) for PhD in Bioregulation Chemistry at Kyoto
University, Japan (Jan, 1992)
# CSIR Postdoctoral Fellowship (Govt. India) Award-IA 26953 (March, 1997& June 2003) by Government
of India to carryout independent research work on the project submitted by me that reviewed and approved
by CSIR- Delhi, India
# Research Contribution to make Pyrazoline compounds more attractive candidate for its commercialization
as safer insecticide:1996 Kyoto University, JAPAN
# Developed the synthetic route for a successful synthesis of Co Enzyme Q-10: 2003 (Strides Arcolab
Limited)
# Developed Benzyloxypiridines as novel and attractive insecticidal candidate for commercialization, 1995-
97, (Otsuka Chemical, Japan),
Applicant Skill Set:
SET-A
O Basic of searching STN: Database available from CAS co vering Int. journals, patent, patent families,
technical reports etc. (CA plus, CAS Registry, Structure Search etc) for preparation of novel compounds,
formulations and their IPR claim.
O Utilizing free websites for literature/patent search for example espacenet.com, US freepatentsearch.com etc
Literature/Patent search through Chemical Abstract/bound periodicals & Journals available in Institutional
or university libraries (using formula index, subst. index, sub index. chem. name, CAS No. etc.
O Literature/Patent search through Chemical Abstract/bound periodicals & Journals available in Institutional
or university libraries (using formula index, subst. index, sub index. chem. name, CAS No. etc.
O Literatures and patent reading to shape up the desired project for discussion and implementation.
O Supervise for directional literature/research planning and thrust
Write up of the findings of scientific data's in JOURNALS or as PATENTS for Publication and (IPR)
SET-B
O Synthesis of Off-Patented Molecules/Generic Drugs,
O Org. Synthesis, of Biologically Active Molecule/New Chemical Entities
O Herbal Extraction and semi-synthesis for structural modifications
O Structure elucidation and & stereo chemical Investigation
O Elucidation of biological activities of organic compounds
O Structure-Activity Relationship (QSAR) to study various physicochemical. Parameters responsible for
biological activity
O Activity prediction and Molecular Modeling.
O Ability to read and interpret instrumental data such as NMR, IR, LC -Mass, GC, HPLC and others that
required in the course of development of the molecules for IPR work.
Employment History in India and Abroad
Assistant Professor, Organic Chemistry, Dept. of Chemistry, Faculty of Science, Mekelle University, Mekelle
Ethiopia (Oct, 16, 2013 onwards- and continue -2014)
Assistant Professor, Organic Chemistry, Dept. of Chemistry, Faculty of Science, Tabuk University, Tabuk
(January, 26, 2010, Oct1, 2013.
Assistant Professor, Organic Chemistry Dept. of Chemistry, Selaqui Academy of Higher Education, under
Uttarakhand technical University, Dehradun, India (July, 26, 2010 - September, 4, 2010)
Assistant Prof., Organic Chemistry, Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy,Al-Arab Medical
Univ. Benghazi (October,2007- October. 2009 )
Group Leader, Research & Development, Organic Synthesis, Strides Arcolab Ltd, Bangalore, (April, 05 -May 07)
Senior Manager, Research &Development, Kopran Research Labratories Ltd, Mumbai (February, 04-February, 05)
Faculy member/head Chemistry, Kyoto Foundation Bariatu, Private Chemistry Learning Centre, India, April 2000-
January 2004 (excluding the period served for industries: Samilabs ltd(8 months) and Indswiftlab oratories ltd(1 yr)
in India)
Senior Scientist, Dr. Reddy Research Foundation, Drug Discovery Unit, Hyderabad, India (March, 1999-March,
2000),
Assistant Professor (Pool Scientist), Organic Chemistry, Department of Chemistry at G.B. Pant University, India
(Sept.1997-March1999)
Visiting Scientist, Otsuka Drug Discovery Group, Naruto Chemical Research Centre, Japan (April, 1995-March,
1997)
Graduate Teaching Assistant (GTA) Department of Chemistryat G.B. Pant University, India (June 1987-Oct.,
1989)
Work details carried out by the applicant (in Universities):
Dept. of Chemistry, Faculty of Science, Mekelle University, Mekelle, Ethiopia
Position: Assistant Professor
(Oct, 17, 2013- continue
Teaching: Medicinal, Polymer Chemistry and Organic chemistry /Preparation of course
Specification, Postgraduate seminar and Master thesis Research Work
Level: Graduate students
Research: Research Project and training on organic synthesis and application of QSAR to design
new medicinal analogs of heterocyclic or semi synthetic origin
Dept. of Chemistry, Faculty of Science, Tabuk University, Tabuk, Saudi Arabia
Position: Assistant Professor
(Dec, 26, 2010- Oct. 2013
Teaching: General Chemistry and organic chemistry (Practical and Theory)/Preparation of course
Specification
Level: Graduate students/preparatory Years
Research: Research and training on organic synthesis and application of QSAR to design new
medicinal analogs of heterocyclic origin
Dept. of Chemistry, Selaqui Academy of Higher Education, under Uttarakhand technical University,
Dehradun, India)
Position: Assistant Professor
(July, 26, 2010- September, 4, 2010
Teaching Subjects: Organic chemistry (Practical and theory)/Preparation of course Specification
Level: B.Sc engineering students
Research Supervision : not initiated
Department of Pharmaceutical Chemistry, Al-Arab Medical University, Benghazi, Libya
Position: Assistant Professor
(September, 2007- October, 2009)
Teaching: Medicinal chemistry, organic chemistry (Practical and theory)
Level: Faculty of Pharmacy, Graduate and Post graduate students
Research Supervision: Organic synthesis and application of QSAR to design new medicinal analogs
of heterocyclic origin
Department of Chemistry, Department of Chemistry at G.B. Pant University, India
Position: Assistant Professor cum Pool Scientist),
(September, 2007- October, 2009)
Teaching : organic chemistry (Practical and theory) and chemistry of pesticides
Level: Graduate and Post graduate students
Research Supervision: Synthesis of novel pyrazoline, phenylhydrazone and chalcone compounds
and evaluation of their biological activity
.
Department of Chemistry at G.B. Pant University, India
Position: Graduate Teaching Assistant (GTA)
(June 1987-Oct., 1989)
Teaching: Practical organic chemistry
Level: Graduate and Post graduate students
Work details carried out by the applicant(in Industries):
Strides Arcolab Limited, Bangalore
Position: Group Leader
(April, 2005- June 2007)
Project preparation and implementation on derivatives of Hydrocartosone and Cortisone eg. Prednisolone,
Prednisone and their derivatives at 21- position.
Extraction and purification of solanesol from tobacco waste
Project prepn. and process development of Co-Enzyme Q-10 (Ubiquinone)
Project preparation and process dev. of Hydralizine and Tranexamic acid
Project preparation and process development on lamivodine and Emtricitabine, Oseltamivir.
Designed Non-Infringing process to prepare Lamivudine, imtricit abine, hydralyzine and tranexamic acid for IPR
work.
New Initiatives: Prepared projects on DST- Initiatives to Pharmaceutical Industry ( www.dst.govt.in ) to explore
NCE and novel process development of some patented dr ugs for Intellectual Property Right (IPR).
Kopran Research Laboratories, Mumbai
Position: Sr. Manager Research & Development
(February 2004-February, 2005)
Project preparation and process development of Attorvastatin
Project preparation and process development of clarithromycin,
Preparation of cyano compound used for attorvastatin.
Implemented more economical route to prepare attorvastatin
Project preparation and implementation on non-infringing process of clarithromycin.
Chemistry faculty, Kyoto Foundation, Bariatu, India
Position: Faculty member and Head, Chemistry
(April, 2000-January, 2004)
Teaching Organic Chemistry to Graduate Students and take up chemical consultancy work for product/process
development of biopharmaceutical drug/candidates at Samilabs Limited and Ind-swift laboratories
DRF, Hyderabad, India
Position: Senior Scientist
(March, 1999-March, 2000)
Synthesis of novel open chain type of analogs of Linozolide
Synthesis of novel bicyclic and tricyclic analogs of Lenozolide
Development of new pharmacophore for anti-inflamatory activity
Synthesis of metabolites of different generic drugs for in house pharmacokinetic studies.
Otsuka Chemical Limited, Naruto Discovery Centre Japan
Position: Visiting Scientist
(April, 1995-March, 1997)
Preparation of metabolites of carbofuran Insecticide
Development of novel insecticidal analogs of pyrazoline, pyrazolone and benzyloxy pyridine. Developed benzyloxy
pyridine compounds as a novel class of insecticide. One of the representative candidate showed LC50 at 2ppm (to
develop this molecule about 300 molecules were prepared for lead generation and optimization)
Patent Received at Otsuka Chemical JP:
New safe compound excellent in insecticidal and acaricidal effects even on insect pests having developed resistance
to chemicals, not showing environmental pollution and toxicity to mammals and fishes.
Patent No. : JP -10101647A2
Title : Benzyloxypyridine-A new class of Insecticides
Class : New Chemical Entities (NCE)
Inventor : Riaz Hasan, Employment No. 30375
Intellectual Property : Otsuka Chemical Co., Limited, JAPAN.
Kyoto University, Japan
Position: Ph. D-MONBUSHO Research Student
April, 1992-March 1995)
Title of PhD Thesis: “Synthesis and Mode-of-Action of Insecticidal Pyrazolines”
Objective: QSAR based design, synthesis, stereochemistry. Molecular modeling and mode of action studies of
pyrazoline compounds to make them more attractive candidate for commercialization. About 200 compounds were
prepared for lead generation and activity optimization work.
Presentation in the International Conferences from PhD work:
1. Enantiomeric investigation of pyrazoline esters as potent insecticide: An In ternational meeting of Japan
Society for Bioscience Biotechnology and Agro Chemistry, 1994, Tokyo, JAPAN.
Quantitative Structure-Activity Relationship of Insecticidal Pyrazoline: An International meeting and 22nd
2.
Symposium on Structure-Activity Relationship, Nov. 16, 1994, Tokyo, JAPAN.
3. Effect of N-Arylcarbamoylpyrazoline derivatives on calcium uptake and release in rat brain synaptosomes:
an International meeting of Pesticide Science March 28, 1995, Tokyo, JAPAN.
4. Synthesis of Insecticidal Pyrazoline and th eir Mode-of-Action: An international meeting of Kyoto
University, January 28, 1995, Kyoto University, Kyoto, JAPAN.
5. Pyridinols Ethers as novel insecticide: An International meeting of Japan Society for Bioscience,
Biotechonology and Agrocihemistry, Nov 4, 1996, Tokoshima, JAPAN
International Publications from PhD work:
1. Quantitative Structure-Activity Relationship (QSAR) of Insecticidal Pyrazolines: Pesticide Science
(ENGLAND) 1994, 42, 291-298.
2. Stereochemical Basis for the Insecticidal Activity of Carbamoylated and Acylated Pyrazolines: Pesticide
Science (ENGLAND) 1995, 46, 105-112.
3. Structural Effects of N-Arylcarbamoylpyrazolines on calcium uptake in Rat Brain Synaptosomes: Pesticide
Science (ENGLAND) 1996, 46, 221-225.
Membership of Professional Bodies:
O Japan Society for Bioscience, Biotechnology and Agro chemistry
O Pesticide Science Society of Japan
O Pesticide Science Society of India.
O Indian Council of Chemists
O Indian Chemical Society.
Trainings:
Two months training on quality control at IFFCO-R&D, Bareilly, India
Two months training on “Application of radioisotopes to conduct Mode-of- action of drugs on freshly prepared rat
brain synaptosomes at radioisotopes research centre, Kyoto University.
Two months tr aining at cGLP at Otsuka Chemical R&D Centre to avoid infringement on IPR claims by other
organization on date/priority basis.
Literature Search by STN at Kyoto University, Otsuka Japan and kopran.
Proficiency in Languages:
English (IELTS), Hindi, Ben gali, Urdu, Japanese, Arabic
References:
Dr. Tamio Ueno
Supervisor & Professor Emeritus
Email: ********@*****.***.**.** www.applife.kais.kyoto-u.ac.jp
Laboratory of Bioregulation Chemistry
Kyoto University, Sakyu-ku, Kyoto,
University, JAPAN. www.kyoto-u.ac.jp
Tel: # 075-***-****
Fax : # 075-*******.
Prof. Akamatsu Mikki ::;www.applife.kais.kyoto-u.ac.jp
********@****.*****-*.**.**
Laboratory of Bioregulation Chemistry
Kyoto University, Sakyu-ku, Kyoto,
University, JAPAN. www.kyoto-u.ac.jp
Tel: # 075-***-****
Fax : # 075-*******.
Dr. Hisham Reda
Professor and coordinator, Department of Chemistry
Tabuk University, KSA
Mobile:059*******,
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Permanent Address: Dr. RIAZ HASAN
************@*****.***
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Mobile # 0091-993-***-****
Plot#423/A, Yellow Gate, Behind Gurunannak, Handicap Center,
Bariatu, RANCHI, JH, INDIA
Passport # J-6967872 valid up to 2022 (INDIA)
Driving License# 009189/95, valid up to 2015 (INDIA)
Contact this candidate