Project Management

OINDRILA RAHA

PhD-Andhra University, Human Genetics (PhD, March, 2013)

Address for communication

**-******** ****. ***-*

Columbus, Indiana-47201

email Id : ************@*****.***

Career Objective

To be in a leadership position in a Research and Development division, leading to innovation, strategy development and

implementation.

Professional Experience

2011– Oct. 2012 Anthropological Survey of India, Kolkata, Post-PhD, Genetic profiling of Depression and suicidal

tendency

2008– Jul. 2011 Anthropological Survey of India, Kolkata, Senior Research Fellow, PhD.

2006– 2008 Anthropological Survey of India, Kolkata, Junior Research Fellow, PhD.

2005– 2006 Anthropological Survey of India, Mysore, & Centre for Cellular & Molecular Biology(CCMB),

Hyderabad, Junior Research Fellow: Worked on National project entitled “Human Origins, Genome

& People of India-DNA Polymorphism of the Ancient Skeletal Remains and Contemporary Indian

Populations”.

Nov. 2004– Feb. 2005 Institute of Genetics & Hospital for Genetic Diseases, Osmania University, Hyderabad. Project

Trainee: Worked on project “Screening of Fragile-X- Syndrome”. .

2003 Human Genetics Department, Andhra University, Visakhapatnam. Topic on “Determining the

association between Blood Groups and Conjunctivitis”.

Title of Dissertation

Molecular Characterization of Type 1 Diabetes Patients in West Bengal Population.

Doctoral Research Summary

The study provides a possible explanation to the phenomenon of Type 1Diabetes Mellitus (T1DM) T1DM at the genetic level in

terms of association of HLA-DQ with T1DM. Apart from DQA1, four other HLA genes (HLA-DPA1, HLA-DPB1, HLA-DQB1 and

DRB1) were analyzed, out of which three genes, i.e HLA-DPB1, HLA-DQB1 and DRB1 also demonstrate an associative pattern.

The nearest neighbor of HLA genes, MICA shows a positive disposition with T1DM. The remaining one gene (INS) does not

seem to have any association with T1DM in the present study groups. The current genetic analysis of T1DM cases and controls

not only highlights the genes exhibiting a strong etiological role but also reflects the protective nature of some HLA genes

against T1DM. However, it is essential to carry out further investigations in order to validate the role of HLA genes in T1DM as

demonstrated in this study. As the morbidity and mortality of T1DM affects our society’s healthcare and economy, a key to

prediction and hopefully prevention will be just as important on the personal level as it will on a large-scale public health level.

Hence, a genome scan using SNP’s in order to reduce the number of SNP’s tested in the entire genome is an innovative

approach. A putative benefit from such studies is the possibility of excluding low-risk susceptibility genomic regions.

Papers published/submitted in Journals

Raha O, Sarkar B, Lakkakula BV, Pasumarthy V, Godi S, Chowdhury S, Raychaudhuri P, Vadlamudi RR. HLA class II SNP

1.

interactions and the association with type 1 diabetes mellitus in Bengali speaking patients of Eastern India. Journal of

Biomedical Science, 20(12), 2013. DOI 10.1186/142*-****-**-**.

Raha O, Sarkar B, Veerraju P, Sudhakar G, Raychaudhuri P, Mukhopadhyay S, Rao VR. Role of HLA Class II loci

2.

Polymorphism in the Manifestation of Type 1Diabetes in a Bengali Indian Patients Population. Genetic Testing and

Molecular Biomarkers. 17(1), 52-61, 2013. DOI 10.1089/gtmb.2012.0221.

1

Raha O, Sarkar B, Godi S, Ghoshroy A, Pasumarthy V, Chowdhury S; JDRF-India, Vadlamudi RR. Menarcheal Age of

3.

Type 1 Diabetic Bengali Indian Females. Gynecological Endocrinology. 2013.DOI:10.3109/09513590.2013.819080

Oindrila Raha, B.N.Sarkar, P.Veerraju, G. Sudhakar, P.Raychaudhuri, Soma Mukhopadhyay, V.R.Rao. Role of MICA

4.

Repeat Polymorphism in the manifestation of type 1diabetes mellitus in Bengali Indian patients. (Accepted in

Genetika. 45(2),2013)

Raha O, Sarkar BN, Raju PV, Pramanik L, Rao VR. Identification of novel single nucleotide polymorphism (SNP) in HLA-

5.

DPB1 gene in ethnic population from West Bengal. Genetika. 43 (1), 205-208, 2011. DOI 10.2298/GENSR1101205R.

Novel SNP is submitted to GenBank in March 2010 and assigned accession number (Accepted-rs111221466).

Raha O, Sarkar BN, Bhaskar LVKS, Veerraju P, Chowdhury S, Mukhopadhyay S, Biswas TK, Rao VR. Insulin (INS)

6.

promoter VNTR polymorphisms interactions and the association with type 1 diabetes mellitus in Bengali speaking

patients of Eastern India. Diabetologia Croatica. 40 (4), 99-106, 2011.

Raha O, Chowdhury S, Dasgupta S, Raychaudhuri P, Sarkar BN, Raju PV, Rao VR. Approaches in type 1 diabetes

7.

research A status report. International Journal of Diabetes in Developing Countries.29 (2), 85-101, 2009.

DOI 10.4103/0973-3930.53126. PMC2812756.

Abhishikta Ghosh Roy, Pulakes Purkait, Oindrila Raha, Gautam Das, Malay Barman, Rakesh Roy, B.N Sarkar, A.R

8.

Bandopadhyay. Association between the polymorphism of the angiotensin- converting enzyme gene and breast

cancer risk among the Bengalee caste Hindu females of West Bengal, India. (Communicated)

Abhishikta Ghosh Roy, Oindrila Raha, Gautam Das, Malay Barman, Rakesh Roy, B.N Sarkar, A.R Bandopadhyay.

9.

Association between the polymorphism of the p53 gene and breast cancer risk among the Bengalee females of West

Bengal, India. (In preparation)

Oindrila Raha, B.N.Sarkar, G. Sudhakar, P.Veerraju, Subhankar Chowdhury, JDRF India, V.R.Rao. Knowledge and

10.

Management of HbA1c among Type 1 Diabetes Patients in West Bengal. (In preparation)

Kiran Uttaravalli, Oindrila Raha, B.N.Sarkar. Genetic profiling of Depression and suicidal tendency. (In preparation)

11.

Conferences and Achievements

Poster Presentation 5 [Indian Society of Human Genetics (ISHG)-06, 07; Research Society for the Study of

Diabetes in India (RSDDI-07); European Molecular Biology Organization (EMBO6); HGM

2008]

Oral Presentation 2 (ISHG-08, 09)

Conferences Attended

National Conferences 4

International Conferences 8

Workshops 2

Other Achievements Organizing Team member, International symposium on Ethics, Culture and Population

th

Genomics and the 34 Annual Conference of the ISHG. 2009. Organized by

Anthropological Survey of India, New Delhi.

M.Sc/M.Tech Dissertation Supervised 4

Academic Achievements

PhD in Human Genetics, Thesis submitted on July 2011 and awarded February 2013, ANDHRA UNIVERSITY, Visakhapatnam,

INDIA. 2006-2013.

st

rd

M.Sc. in Human Genetics, ANDHRA UNIVERSITY, Visakhapatnam, INDIA. 2002-2004, MARKS 70% ( class 1, Rank 3 )

B.Sc. in Human Genetics, Biochemistry and Biotechnology; ANDHRA UNIVERSITY, Visakhapatnam, INDIA. 1999-2002, MARKS

st

77% (class 1 ).

2

Basic Skills / Strengths

• Extensive research experiences in advanced Molecular Biology

• Specialized training on state of the art biotechnology research tools (Sequencing, Bioinformatics)

• Strong communication skill (Oral and written) and coordination capability

• Training on Leadership Development Management Program

Laboratory Skills/Techniques Known

Molecular Biology

Isolation of DNA/RNA, gel electrophoresis of nucleic acids, Southern and Northern hybridization, primer designing, PCR and Site

specific mutagenesis, RAPD, Q-PCR, enzyme assays, DNA and RNA gel shift assays, DNA Sequencing (ABI3730), Primer walking,

Gene Scanning, Cell culture Technique, Classical Cytogenetics (Karyotyping).

Screening Techniques

Hemoglobin Estimation, G6PD, and Inborn Errors of Metabolism.

Immunogenetics

Radial Immuno-diffusion Technique, Immuno-fixation Method, Immuno-electrophoresis, High voltage Agarose gel

electrophoresis, HLA tissue typing.

Protein Methods

Estimation of proteins, native and SDS-polyacrylamide gel electrophoresis, ELISA.

Computation & Bioinformatics

Worked on Windows 98, 2000, XP, DOS, Proficient with MS office, Origin, for text, art and graphical presentation. Standard

analysis of all kinds of DNA/RNA sequence data/motifs over the internet. Arlequin v3.11, Sequence Scanner v1.0,SeqScape

Software v2.5, Haploview, Gene tool v1, SPSS v17, Statistica v3, SNP browser v1.0, Mega v3.1, Genedoc v2.6, Primer Premier 5,

Vista 6, Plink v 1.07, Python for Population Genetics (PyPop) v 1.2, Haploview v 4.1.

Personal Information

Date of Birth November, 1981

Nationality Indian

Marital Status Married

Mother’s Name Smita Raha

Father’s Name Amitava Raha

Language Known Bengali, Hindi and English (Speaking, Writing, Reading)

Telugu and Assamese (Speaking, Reading)

Hobbies Reading, Photography, Travelling, Painting, and organizing scientific symposia and meetings,

participating in conferences and scientific meetings.

OINDRILA RAHA

3

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