Assistant Research

Rekha Tulsan

*** ******* ******, ******, ** *****

(C) 857-***-****, ******@***.***

EDUCATION

- MS in Chemistry University of Massachusetts Boston, Boston, MA, GPA: 3.93/4.00 August 2012

Thesis Title: Development of multifunctional anti-Alzheimer’s compounds

- BS in Chemistry University of Massachusetts Boston, Boston, MA, GPA: 3.87/4.00

Thesis Title: Analysis of methods for arsenic detection and removal using ICP-OES

- BS in Mathematics University of Massachusetts Boston, Boston, MA, GPA: 3.87/4.00

HIGHLIGHTS

• Experienced in using, troubleshooting and data interpretation of fluorescence spectroscopy, UV-Vis, HPLC,

GC, FTIR, NMR, ICP, centrifuge, microwave synthesizer, lyophilizer, zetasizer

• Purified protein with IEC, SEC and SDS-PAGE

• Analyzed peptide or small compounds using HPLC (reverse phase, SEC), GC/MS, LC/MS

• Synthesized nanoparticles and measured particle size by zetasizer

• Conjugated of polyethylene glycol (PEG)/fluorescence to the polymer

• Performed in-vitro, ex-vivo and in-vivo studies

• Experienced in cell culture, cell counting, staining and tissue harvesting

• Experienced in writing research reports and delivering oral presentations

• Experienced in mathematical methods (data analysis, statistics, probability etc.)

• Proficient in software skills such as Windows, Microsoft Office, Origin Lab, SciFinder, ChemBio Draw

WORK EXPERIENCE

Massachusetts Institute of Technology (MIT), Cambridge, MA December 2012 to Present

Koch Institute for Integrative Cancer Research (Langer Lab)

Research Affiliate

• Conjugated PEG/fluorescence to the polymer and characterized by NMR, FTIR, fluorescence spectroscopy

• Synthesized biopolymer (chitosan) nanoparticles and characterized (particle size, zeta potential,

loading/encapsulation efficiency) by zetasizer, ICP

• Experienced in sterile technique and cell culture, passaging and growing cell, cell counting, staining

• Handled Hamsters, injected cell, treated with free drug and drug encapsulated in nanoparticle

• Studied bioavailability of drug in blood or in tissues

University of Massachusetts Boston, Boston, MA September 2007 to November 2012

Research Assistant

Protein purification

• Purified cuticle protein with IEC, SEC and SDS-PAGE (Extracted an enzyme from Drosophila)

- Prepared buffers, run substrate assay to evaluated enzyme activity

Development of multifunctional anti-Alzheimer’s compounds

• Analyzed oligomeric proteins using HPLC/Size exclusion chromatography

• Experienced in determination of enzyme inhibition and kinetics of small molecules (Publication: 1)

• Determined the antioxidant property of small molecules using enzyme and non-enzyme based assay

(Publication: 2)

• Characterized test compounds by GC/MS

Analysis of methods for arsenic detection and removal using ICP

• Analyzed concentration of arsenic in drinking water using ICP and validated method using SORAS and

ARUBA

University of Massachusetts Boston, Boston, MA September 2010 to August 2012

Teaching Assistant

• Prepared and conducted lectures, examination of more than 100 students

• Prepared reagents, buffers and setup lab

Rekha Tulsan

June 2008 – August 2008, June 2009 –August 2009

Schlumberger-Doll Research, Cambridge, MA

Research Assistant (Summer Intern)

• Studied polymer concentrations to stabilized metal sulfide nanoparticles (Patent 1)

• Characterized thermal performances of polymers at different pH and radical scavenger

• Studied stoichiometric relationships to evaluate reproducibility, repeatability of the system at RT, HT

Brockton Massasoit Community College, Brockton, MA September 2003 to January 2009

Tutor

• Tutored large number of students in math, algebra, geometry, calculus, statistics, physics and chemistry

SCHOLASTIC AWARDS

Dean’s List (Spring 2012)

Chemistry Award for Outstanding Achievement (2012)

Dean’s List (Fall 2011)

Robert W. Spayne Research Grant (2010)

Dean’s List (Spring 2011)

University Merit Scholarship (2009)

Dean’s List (Fall 2010)

Undergraduate Award in Inorganic Chemistry (2009)

Dean’s List (Spring 2009)

Undergraduate Award in Analytical Chemistry (2008)

Dean’s List (Fall 2008)

Undergraduate Research Fund (2008)

Dean’s List (Spring 2008)

Litton Industries Fund (2008)

Dean’s List (Fall 2007)

Annual Donor Scholarship (2008)

Dean’s List (Spring 2007)

Richard Hogan Scholarship (2008)

Dean’s List (Fall 2006)

Berkeley Cue Chemistry Scholarship (2007)

Foster Furcolo Scholarship (2006) Faculty Scholar Award (2006)

PUBLICATIONS

1. B. Seema, T. Rekha, S. Abha, D. Silpi, T. Marianna “Pharmacophore Modeling, Virtual and In Vitro

Screening for Acetylcholinesterase Inhibitors and their Evaluation for Inhibition of Aβ-amyloid Self-assembly

Targeting Alzheimer’s Disease” Current Computer Aided Drug Design. 2013, 9, 2-14.

2. T. Bela, S. Abha, B. Seema, T. Rekha, B. Dimitri. K. Arleen, M. Mechele, M. Richard, Z. Weihong, L. Harry,

T. Marianna “Diaryl Hydrazones as Multi-target Inhibitors of Amyloid Self-Assembly” Biochemistry, 2013, 52, 7,

1137-1148.

3. B. Seema, G. Sanjukta, T. Rekha, S. Abha, Z. Wei, S. Christine, F. Michelle. L. Harry, T. Marianna “Design,

Synthesis and Biological Activity of Multifunctional α, β-Unsaturated Carbonyl Scaffolds for Alzheimer's

Disease” Bioorganic & Medicinal Chemistry Letters. 2013, 23, 2614-2618.

4. B. Seema, Z. Weihong, T. Rekha, S. Abha, L. Harry, T. Marianna “Multi-target Inhibitors for Alzheimer’s

Disease: Inhibition of Amyloid-β Self-Assembly and Cholinesterase Activity” (in preparation).

PATENT

1. L. Jimmy, T. Huilin, L. Jane, A. Rekha, H. Ronald “Chemical Scavenger for Downhole Chemical Analysis”

US Patent 0149604. Filed on December 5th 2011 and issued on June 14th 2012.

MEMBERSHIPS

McNair Phi Theta Kappa Chemistry Club Math Club

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