Principal Program Manager, Informatics

Principal Program Manager, Informatics

Washington, DC (hybrid)

Salary Range: $150-180K + benefits

In search of Principal Program Manager, Informatics to provide strategic leadership for large-scale clinical informatics and health IT programs within a federal setting. This position requires extensive experience in clinical informatics, enterprise IT program/portfolio management, and organizational transformation across complex environments with multiple stakeholder groups.

The successful candidate will guide a suite of major initiatives, ensuring exceptional performance across scope, schedule, budget, and quality benchmarks. By coordinating clinical, operational, and technical partners, this leader will advance healthcare delivery systems, support EHR modernization, and enhance enterprise IT capabilities—ultimately contributing to improved outcomes and increased efficiency for millions of users.

Key Responsibilities

- Direct and manage a broad portfolio of clinical informatics and health IT programs.

- Act as the primary liaison with senior-level federal stakeholders.

- Promote alignment and integration across technical, clinical, and operational teams.

- Oversee program execution and performance related to cost, schedule, scope, and quality measures.

- Identify, evaluate, and mitigate risks at the enterprise level.

- Ensure programs support broader mission and strategic goals.

- Champion the adoption of Lean-Agile and SAFe methodologies across program teams.

- Apply SAFe Lean-Agile principles to increase value delivery, strengthen organizational agility, and enable high-performing Agile teams.

- Ensure adherence to all federal governance, compliance, and reporting standards.

- Hybrid work environment.

Qualifications

- Ability to pass a thorough federal government background investigation

- Bachelor’s degree with 20+ years of experience OR Master’s degree with 15+ years

- Proven experience managing clinical informatics initiatives in federal or large healthcare organizations

- Background leading diverse IT programs—both large-scale and smaller efforts—within complex environments

- Strong understanding of full SDLC processes and best practices

- Experience with enterprise architecture, network engineering, and long-term IT strategic planning

- Hands-on experience implementing SAFe Lean-Agile frameworks in enterprise contexts

- Demonstrated ability to manage cost, schedule, performance, and risk consistent with PMBOK and PMI guidelines

- Strong executive communication skills—both written and verbal—with the ability to engage senior leadership

- PMP or PgMP certification desired