Curriculum Vitae

Michael J. Van Kanegan, Ph.D.

ADDRESS

**** ******* *****

Durham, NC 27707

USA CONTACT

cell: 919-***-****

email: sy1tkl@r.postjobfree.com

EDUCATION/TRAINING

INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY

Southern Illinois University, Carbondale, Illinois B.A. 1994 Biology

The University of Iowa Carver College of Medicine, Department of Pharmacology, Iowa City, Iowa Ph.D. 2008 Pharmacology

The University of Iowa Carver College of Medicine, Department of Pharmacology, Iowa Post Doctoral 2008-09 Pharmacology

Cognosci, Inc., Research Triangle Park, NC Post Doctoral 2009-2010 Pre-clinical drug development

A. Personal Statement

My broad scientific career began with several research assistant positions in both industrial and academic settings where I garnered invaluable skills in molecular biology, biochemistry, cell culture, embryonic stem cell culture and whole animal research. I entered the Pharmacology graduate program at the University of Iowa, where I was trained in molecular neuropharmacology by a leader in the field of protein phosphatases. During my dynamic graduate work, I was awarded a PhRMA pre-doctoral fellowship to conduct studies that defined how PP2A regulates neuronal signaling cascades, which resulted in two peer-reviewed publications. I have recently extended my expertise in phosphatase and kinase regulation at Cognosci, Inc by assisting a pre-clinical development team formulate, screen and test peptide-based therapeutics for the treatment of neurodegenerative diseases, inflammatory diseases and cancers. Alongside with a talented group of experienced scientists at Cognosci, I have expanded my skills in pre-clinical drug development using several animal models, including those used to study Alzheimer’s disease, traumatic brain injury, sepsis, hematological and metastatic cancers. In addition, I was trained to write and apply for Small Business Innovation Research (SBIR) grants to fund novel research areas. In summary, I am a highly motivated and well-trained scientist with a broad knowledge of clinically relevant research. I have a history of productivity and excellence in both academic and industrial settings. I bring to a Research Scientist position the necessary experience and skills that are needed to successfully execute and supervise the completion of pre-clinical development studies.

B. Positions and Honors

Positions and Employment

05/95 – 12/96 Research Biologist at Monsanto; Contracted by Today’s Temporary, St. Louis, Missouri

12/96 – 08/98 Research Assistant, Dept. of Pharmacology, Saint Louis University, St. Louis, Missouri

08/98 – 05/00 Researcher II, Dept. of Biochemistry, Southern Illinois University, Carbondale, Illinois

05/00 – 06/01 Research Specialist, Dept. of Anatomy, University of Wisconsin, Madison, Wisconsin

06/01 – 08/01 Research Assistant II, Dept. of Pharmacology, University of Iowa, Iowa City, Iowa

08/01 – 06/08 Graduate Research Assistant, Dept. of Pharmacology, University of Iowa, Iowa City, Iowa

05/08 – 12/08 Post Doctoral Fellow, Dept. of Pharmacology, University of Iowa, Iowa City, Iowa

01/09 – 12/09 Post Doctoral Fellow, Cognosci, Inc., Research Triangle Park, NC

01/10 – 05/10 Research Scientist, Cognosci Inc., Research Triangle Park, NC

Other Experience and Professional Memberships

2001 – 2004 Graduate Student Senate - Pharmacology representative

2002 – 2004 University of Iowa Surplus Computer Allocation Committee

2005 – 2007 Society for Neuroscience - Predoctoral member

2006 Department of Pharmacology seminar speaker selection committee

2007 American Society for Cell Biology – Predoctoral member

2008-2010 Society for Neuroscience – Post doctoral member

Honors and Awards

1996 Center of Excellence Award, Monsanto; St. Louis, MO.

2005 – 2007 PhRMA Foundation Pre-Doctoral fellowship

2006 Iowa Biotechnology Association Annual Meeting Registration Scholarship

2007 American Society for Cell Biology Predoctoral Travel Award

2007 University of Iowa Graduate Student Senate Travel Award

2007 University of Iowa, Department of Pharmacology Tephly Travel Award

Teaching experience

2003-2005 Lecturer for Pharmacological Drugs: Their Nature, Action and Use

2005-2007 Course coordinator and Lecturer for Pharmacological Drugs: Their Nature, Action and Use

C. Peer reviewed publications

1. Christensen DJ, Ohkubo N, Oddo J, Van Kanegan MJ, Neil J, Wilcock D, Li F, Colton CA, Vitek MP. The protein SET links apolipoprotein-E to development of Alzheimer’s disease pathology. (In preparation).

2. Van Kanegan MJ, Strack S. The protein phosphatase 2A regulatory subunits B’beta and B’delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Mol Cell Biol. 2009 Feb;29(3):662-74.

3. Schnizler K, Shutov LP, Van Kanegan MJ, Merrill MA, Nichols B, McKnight GS, Strack S, Hell JW, Usachev YM. Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons. J Neurosci 2008, May 7;28(19):4904-17.

4. Van Kanegan MJ, Adams DG, Wadzinski BE, Strack S. Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-related kinases and Akt. J Biol Chem. 2005 Oct 28;280(43):36029-36.

5. Sengupta SM, VanKanegan M, Persinger J, Logie C, Cairns BR, Peterson CL, Bartholomew B. The interactions of yeast SWI/SNF and RSC with the nucleosome before and after chromatin remodeling. J Biol Chem. 2001 Apr 20;276(16):12636-44.

D. Presentations

1. Defining novel mechanisms of apolipoprotein-E mimetic peptides for the treatment of Alzheimer’s disease. Van Kanegan, MJ, Christensen, DJ, Oddo, JA, Colton, CA and Vitek, MP. Cognosci, Inc, Research Triangle Park, NC, Dept of Neurology, Duke Univ. Medical Center, Durham, NC. Society for Neuroscience 2009, Chicago, IL.

2. Specific PP2A heterotrimers associate with the TrkA receptor tyrosine kinase to enhance nerve growth factor-mediated signaling and neuronal differentiation. Van Kanegan, MJ and Strack S, Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City. FASEB Summer Research Conference, July 2008, Snowmass, CO. Abstract selected for short talk.

3. Specific PP2A heterotrimers associate with the TrkA receptor tyrosine kinase to enhance nerve growth factor-mediated signaling and neuronal differentiation. Van Kanegan, MJ and Strack. S, Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City. American Society for Cell Biology (ASCB) 47th Annual Meeting, December 2007, Washington D.C.

4. Bidirectional regulation of neurotrophin signal transduction by protein phosphatase 2A. Van Kanegan, MJ, Kreuger, B and Strack. S., Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City. Carver College of Medicine Research Week. March 28-31 2006. University of Iowa, Iowa City.

5. Bidirectional regulation of neurotrophin signal transduction by protein phosphatase 2A. Van Kanegan, MJ, Kreuger, B and Strack. S., Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City. 35th Annual Society for Neuroscience Meeting. November 2005. Washington, DC.

6. Molecular Mechanisms in Breast Cancer: c-Cbl’s role in modulating the PI3 Kinase pathway. Van Kanegan, MJ, Visser, G, Lill, NL, Department of Pharmacology, University of Iowa, Iowa City, IA 5th Annual Student Interdisciplinary Health Poster Session. April 22, 2002. University of Iowa, Iowa City.

7. Epidermal Growth Factor Receptor Signaling Pathways that are Modulated by the Proto-Oncogene Cbl. Van Kanegan, MJ, Hagen, J, Vemuganti, S, Visser, G, Lill, NL, 4th Annual Student Interdisciplinary Health Poster Session. April 9, 2002. University of Iowa, Iowa City.

8. The Purification and Characterization of the Chromatin Remodeling Complex Yeast SWI/SNF. Van Kanegan, MJ, Zhang, B, Jagadish, S, Lu, Q, Dang, W and Bartholomew, B. Dept. of Biochemistry, Southern Illinois Univ., Carbondale, IL. 6th Annual Molecular and Cellular Symposium of Southern Illinois University at Carbondale. March 2000, Carbondale, IL.

9. Architecture of the Swi/Snf-Nucleosome complex: Swi2 is in close proximity to the nucleosomal DNA. Sengupta, S.M., Van Kanegan, MJ, Kassabov, SR, Persinger, J, Peterson, CL and Bartholomew, B, Southern Illinois Univ., Carbondale, IL. Mechanisms of Eukaryotic Transcription Symposium, September 1999; Cold Springs Harbor, NY.

10. Purification and Characterization of the Yeast Swi/Snf Complex. Sengupta, SM, Van Kanegan, MJ and Bartholomew, B, Southern Illinois Univ., Carbondale, IL. 5th Annual Molecular and Cellular Biology Symposium of Southern Illinois University at Carbondale. March, 1999; Carbondale, IL.

11. Directed Expression of Drosophila Tyrosine Hydroxylase. Mayer, AT, Van Kanegan, MJ, and Neckameyer, WS. Dept. of Pharmacology and Physiology, Saint Louis Univ, St. Louis, MO. 39th Annual Drosophila Research Conference. March 1998; Washington DC.

12. Differential GABA Transporter immunoreactivity in three invertebrate species. Neckameyer, WS, Van Kanegan, MJ, and Cooper, RL. Dept. of Pharmacology and Physiology, Saint Louis Univ, St. Louis, MO 27th Annual Society For Neuroscience meeting. October 1997; New Orleans, LA.

13. Directed Expression of Drosophila Tyrosine Hydroxylase. Van Kanegan, MJ, Mayer, AT, and Neckameyer, WS. Dept. of Pharmacology and Physiology, Saint Louis Univ, St. Louis, MO 1997 Midwestern Drosophila Conference. September 1997; Allerton, IL.

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