Vladimir Dragan

** ***** ****, *******, ** *****; 845-***-****; e-mail: ss14ac@r.postjobfree.com

PROFILE:

• A research scientist with broad expertise in organic chemistry, directed synthesis and modern laboratory techniques.

• Process research and development, including new route identification, optimization, execution in larger scale lab reactors, technology transfer, support of Kilo Lab and Pilot Plant campaigns.

• Expertise in high-throughput reaction screening, handling of air sensitive reagents and organometallic catalysts (glove box applications), asymmetric hydrogenation, natural product synthesis, and modern analytical tools (NMR, HPLC, UPLC, LCMS, etc.) to pilot plant support.

• Enthusiastic investigator and team-player with excellent work ethics. Work equally well as an individual contributor or in a team.

• A member of the American Chemical Society since 1996.

• Citizen of the US, fluent in Russian and English languages.

PROFESSIONAL EXPERIENCE:

Pfizer (formerly Wyeth), Pearl River, NY

2001 - 2010

Principal Research Scientist

• Discovered, developed and demonstrated safe, economical and scalable processes for the synthesis, isolation and purification of active pharmaceutical ingredients (APIs): actively participated as a research scientist on more than 20 projects supporting preclinical and clinical supplies.

• Prepared technical transfer packages and supported technology transfer to the Kilo Lab, Pilot Plant, and contract manufacturers in the preparation of GMP batches of API supporting clinical and commercial supplies. Included on-site participation and support, as well as trouble-shooting and collaborating with scale up facilities to resolve processing issues.

• 2009-2010: As a member of the Chiral Hydrogenation Team, developed second-generation processes using asymmetric hydrogenation catalysis, utilizing glove box techniques to work with air sensitive organometallic catalysts, high-throughput pressure-reactor screening, and application of catalysis knowledge. Recently discovered an unprecedented asymmetric hydrogenation of a highly-substituted quinolinium intermediate (manuscript in preparation).

• Executed processes in large scale lab reactors (5 to 50 Liter cylindrical reactors) to prepare 300-500 g batches of non-GMP API used in pre-clinical studies.

Occidental Chemical Corporation, Grand Island, NY

1998 - 2000

Senior Research Chemist

• Independently optimized a route to boratabenzene that was patented and executed on multi-kilogram scale.

• Discovered, developed and demonstrated safe, economical and scalable processes for the synthesis, isolation and purification of pharmaceutical intermediates.

The Ohio State University, Columbus, OH

1996 - 1998

Postdoctoral Research Associate (Prof. D. J. Hart)

• Investigated two synthetic approaches toward the synthesis of Manzamine A, marine alkaloid with extraordinary framework and functionality, to determine relative stereochemistry in the formed intermediates.

Indiana University Purdue University, Indianapolis, IN

1995 - 1996

Postdoctoral Research Associate (Prof. M. G. Organ)

• Developed tandem allyl silane addition (Sakurai reaction) with consecutive ring annulation methodology, and applied the technology to the synthesis of molecules of pentalene series.

• Investigated the asymmetric addition to carbonyl compounds utilizing lanthanide catalysts (prepared lanthanide catalysts from chiral organic ligands and lanthanide salts)

Zelinsky Institute of Organic Chemistry, Academy of Sciences, Moscow, Russia

1988 - 1994

Research Scientist

• Developed methodology to selectively introduce sulfur-containing functional groups into isopreniods, including unprecedented in terpene series sulfonium salts preparation.

• Applied this technology to the synthesis of natural products (pheromones, fragrances, etc.).

• Demonstrated and elaborated a unique access toward tricyclic diterpenes of pimarane / rosane series.

EDUCATION:

Zelinsky Institute of Organic Chemistry, Moscow, Russia

PhD, Organic Chemistry

Thesis: "Terminal functionalization of the linear isoprenoids with some sulfur containing electrophilic reagents". Advisor: Prof. A. M. Moiseenkov

Simferopol State University, Simferopol, Ukraine

MS, Organic Chemistry

Chemistry of Natural Products. Synthesis of C30 Polyprenols with desired stereochemistry of the internal isoprenoid units by the C5-homologation approach

AWARDS AND PRESENTATIONS:

• 2006 Team Excellence Award • 2005 Above and beyond Award • 2001 Team of the Year Award

• 1994 NSF award for young scientists: visiting scholar in Prof. C. H. Heathcock’s research group, University of California at Berkeley.

• 35 Patents and research papers in major peer reviewed chemical journals (full list at http://sites.google.com/site/vladimiradraganchem/ ).

• 4 Presentations at international conferences and symposia.

SELECTED PATENTS AND PUBLICATIONS:

1. Dragan, Vladimir; Miller, Ross; McWilliams, J. Christopher; Deshmukh, Subodh; Sutherland, Karen; Dillon, John R.; O’Brien, Michael K. Asymmetric Synthesis of Vabicaserin via Oxidative Multi-Component Annulation and Asymmetric Hydrogenation of a Highly Substituted Quinolinium Salt. - Submission in preparation (2011)

2. Connolly, Terrence J.; Disharoon, Michael W.; Dragan, Vladimir; Lewis, Joseph J.; Wehrenberg, Peter; Zhao, Ralph. 2-Bromo-3-(cyclohexyloxy)acrylaldehyde: An Isolable Enol Ether of Bromomalonaldehyde Suitable for Use in the Manufacture of Imidazolecarboxaldehydes. - Organic Process Research and Development (2010), 14 (6), 1506–1511.

3. Liu, Weiguo; Dragan, Vladimir; Strong, Henry Lee; Wu, Yanzhong; Wen, Zhixin; Liang, Jessica Kangping; Durutlic, Haris; Sutherland, Karen Wiggins; Pilcher, Anthony Scott. Process for preparation of 8-piperazinyl-quinoline derivatives. PCT Int. Appl. (2007), 98 pp. CODEN: PIXXD2 WO 200-***-**** A2 20071221 CAN 148:55103 AN 2007:1454880

4. Chatlapalli, Ramarao; Nagi, Arwinder; Potoski, John; Helom, Jean Louise; Wilk, Bogdan Kazimierz; Rubezhov, Arkadiy Zinoviy; Dragan, Vladimir. Purification of tanaproget by solvents and antisolvents for uses as progesterone receptor. PCT Int. Appl. (2006), 29 pp. CODEN: PIXXD2 WO 200-***-**** A2 20061102 CAN 145:477774 AN 2006:1150600

5. Dragan, Vladimir A.; Potoski, John Richard; McMahon, Wayne G.; Helom, Jean Louise; Shi, Xinxu. Processes and compounds for the preparation of substituted naphthylindole derivatives, particularly tetrazolylmethoxy naphthylindoles. PCT Int. Appl. (2006), 45pp. CODEN: PIXXD2 WO 200-***-**** A1 20060803 CAN 145:211045 AN 2006:763585

6. Dragan, Vladimir; Krishnamurti, Ramesh. Method for Preparation of boratabenzene derivatives. U.S. Patent 6,593,498 B2. Date of Patent Jul. 15, 2003

7. Organ, M. G.; Dragan, V.; Miller, M.; Froese, R. D. J.; Goddard, J. D. Sakurai Addition and Ring Annulation of Allylsilanes with , -Unsaturated Esters. Experimental Results and ab Initio Theoretical Predictions Examining Allylsilane Reactivity. J. Org. Chem. (2000), 65 (12), 3666-3678.

8. Bland, D.; Chambournier, G.; Dragan, V.; Hart, D. Intramolecular conjugate addition reactions of amines and carbamates to 2,5-cyclohexadien-1-ones: stereoselective synthesis of perhydroindoles Tetrahedron (1999), 55 (29), 8953-8966.

9. Moiseenkov, A. M.; Dragan, V. A.; Veselovskii, V. V. Synthetic application of the Pummerer reaction. Russian Chem. Rev. (1991), 60 (6), 643-657. ISSN: 0042-1308.

Contact this candidate