YUE MENG

**** ********** **, **********, ** ***36 ● 832-***-****(Cell) ● op2nhp@r.postjobfree.com

PROFILE: Motivated and result-oriented Synthetic Organic Chemist with 15 years of hands-on research experience in academia and industry. Key strengths include:

√ Strong knowledge of Synthetic Organic Chemistry

√ Demonstrated ability and extensive hands-on experience in designing and executing multi-step synthesis, optimizing chemical processes and scale-up of synthetic methods

√ Outstanding expertise in analyzing and identifying organic compounds by modern analytical techniques (NMR, FT-IR, UV-VIS, GC/MS, LC/MS etc.)

√ Highly skilled in organic chemicals separation and purification by traditional and modern methods (Preparative LC, Flash Chromatography etc.)

√ Adept in SciFinder Scholar, Beilstein/Gmelin, ChemDraw and ISIS Draw

√ High level skills of trouble-shooting and problem-solving

PROFESSIONAL HIGHLIGHTS

√ Recipient of “2001 United States Presidential Green Chemistry Challenge Award” and “Chinese National Scientific Foundation Award”

√ 11 papers published in various scientific journals including J.Am.Chem.Soc., J.Org.Chem. and Tetrahedron. One paper was even highlighted by Science and Chemical & Engineering News

PROFESSIONAL EXPERIENCE AND ACHIEVEMENTS

Senior Research Chemist

H&S Chemical CO., Covington, KY 03/2006—present

Design and execute the syntheses of the desired organic compounds; Scale up the new processes to pilot plant; Optimize the existing chemical processes; Develop the analytical methods (GC/MS, LC/MS, HPLC etc) for all new products.

√ Successfully designed and implemented the synthesis of hexafluoro-1,3-butadiene(99.9% pure) and scaled up to 100 kilograms

√ Successfully developed the synthesis of 3-amino-1-propylphosphoric acid

√ Improved the current process of 3-Iodoprop-2-ynyl-N-butylcarbamate, reduced the byproducts and increased the yield

√ Improved the current process of Trichloromelamine

√ Developed a new process for the recovery of iodine from the wastes

Research Instructor

Department of Medicine, Tulane University, LA 02/2004-03/2006

Design and execute the syntheses of Peptide-Cytotoxin conjugates, which may be used as “smart medicine” in cancer therapy.

√ Synthesized 20 various peptides (solid phase synthesis) as analogs of hormone somatostatin

√ Synthesized five novel asymmetric amino acids to make special peptides

√ Modified natural cytotoxines and identified that two modified Maytansine derivatives have very high cytotoxic activity against many tumor cells

Research Chemist

CB Research and Development CO., New Castle, DE 09/2001-02/2004

Work for custom synthesis and independently designed and implemented the syntheses of over 40 complex organic compounds for pharmaceutical company’s drug development. Below are some examples:

√ 3-(5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid (13-steps synthesis)

√ tert-butyl-3-methyl-4-(5-bromo-3-methoxypyridine-2-yl-1,3-dicarboxylate (10-steps synthesis)

√ 3-(10,11)-dihydro-5H-dibenzo(b,f)azepine-5-yl)-N-methylpropan-1-amine (8-steps synthesis)

√ 3-methyl-6-((trimethylsilyl)ethynyl)-3H-imidazo(4,5-b)-pyridine (8-steps synthesis)

√ (6-bromofuro(3,2-b)pyridine-2-yl)methanol (6-steps synthesis)

√ 7-dimethoxymethyl-1,2,3,4-tetrahydro-(1,8)-naphthyridine (6-steps synthesis)

√ 2-amino-6-iodo-(1,8)-naphthyridine-3-carbonitrile (8-steps synthesis)

√ 2-oxo-1,2-dihydro-(1,8)-naphthyridine-3-carboxylic acid ethyl ester (6-steps synthesis)

√ 2-(chloromethyl)-1-propyl-1H-imidazo-(4,5-c)-pyridine hydrochloride (8-steps synthesis)

√ (1H-pyrrolo(2,3-b)-pyridin-5-ylmethyl)-carboxylic acid tert-butyl ester (6-steps synthesis)

√ tert-butyl 4-(1H-pyrrolo(2,3-b)-pyridin-4-yl)piperazine-1-carboxylate (6-steps synthesis)

√ (1-benzylpyrrolidin-3-ylmethyl)-carbamic acid tert-butyl ester (6-steps synthesis)

√ tert-butyl 4-(5-chloro-1H-pyrrolo(2,3-b)-pyridin-4-yl)piperazine-1-carboxylat (8-steps synthesis)

Assistant Professor

Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences 09/1988-05/1996

Synthesize insect sex pheromones and aggregation pheromones to control insects and to reduce /or avoid toxic insecticides. Cooperated with other researchers in the field tests and provided suggestions to improve the tests.

√ Synthesized 8 insect sex pheromones and aggregation pheromones

√ Published three papers about the syntheses of sex pheromones and aggregation pheromones

√ Awarded with Chinese National Scientific Foundation Award (3rd place, 1990)

EDUCATION

Ph.D. of Organic Chemistry, Tulane University, USA 2001

M.S. of Organic Chemistry, Chinese Academy of Sciences, China 1988

B.S. of Organic Chemistry, Guizhou University, China 1984

PUBLICATIONS

1 Huang, T. S.; Meng, Y. and Li, C. J.: “Remarkable Electronic Effect on Rhodium-Catalyzed Carbonyl Addition and Conjugated Additions with Organometallic Reagents”, J. Am. Chem. Soc. 2001, 123, 7451

2 Li, C. J. and Meng, Y.: “Grignard-Type Carbonyl Phenylation in Water and under an Air Atmosphere”, J. Am. Chem. Soc. 2000, 122, 9538.

3 Meng, Y.; T. J.; Chow, H. F. and Li, C. J.: “Stepwise Synthesis and Characterization of Oligomers Based on 1,1’ –Binaphthol with 3,3’–Acetylene Spacer”, Tetrahedron: Asymmetry 1998, 9, 3693

4 Li, C. J.; Meng, Y. and Chan, T. H.: “Manganese-Mediated Carbon-Carbon Bond Formation in Aqueous Media: Chemoselective Allylation and Pinacol Coupling of Aryl Aldehydes”, J. Org. Chem. 1998, 63, 7498

5 Yi, X. H.; Meng, Y. and Li, C. J.: “Regio- and Diastereoselective Allenylation of Aldehyd in Aqueous Media: Total Synthesis of (+)-Goniofufurone”, J. Org. Chem. 1998, 63, 7472

6 Li, C. J.; Meng, Y. and Chan, T. H.: “Mediated Reactions in Aqueous Media: Chemoselective Allylation and Pinacol Coupling of Aryl Aldehydes”, J. Org. Chem. 1997, 62, 8632

7 Yi, X. H.; Meng, Y. and Li, C. J.: “Indium-mediated highly Diastereoselective Allenylation in Aqueous Media: Total Synthesis of (+)-Goniofufurone”, Chem. Commun. 1998, 449

8 Yi, X .H.; Meng, Y. and Li, C. J.: “Indium-mediated Reactions in Water: Synthesis of - Hydroxyl Esters”, Tetrahedron Lett. 1997, 38, 4731

9 Teng, Y. W.; Meng, Y. and Wang, Y.: “Synthesis of the Sex Pheromone of Yellow Peach Moth”, HECHENG HUAXUE, 1993, 2, 129

10 Meng, Y.; Feng, Y. G.and Teng, Y. W.: “Synthesis of the Storage Beetle Aggregation Pheromones”, YOUJI HUAXUE, 1993, 1, 79

11 Meng, Y.; Teng, Y. W.: “Synthesis of the Monoolefinic Pheromones with Certain Ratio of cis/trans Isomers via Wittig Reaction”, SHENGTAI HUAXUE, 1988, 1, 18

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