Scientist / Manager Scientist

Xiang He, Ph.D.

________________________________________________________________________

***** ******* *** ***: 510-***-****

Fremont, CA 94555 Email: *********@*****.***

Ph.D in chemistry/Registered Patent Agent looking for patent agent job opportunities.

1. Passed patent bar exam on Feb 23rd, 2010.

2. 5 years industrial experience in analytical/bioanalytical/clinical chemistry and LC-MS-based biomarker discovery. 3 years post-doctoral experience in drug metabolism.

3. Successful bioanalytical assay developments in small molecules and peptides/proteins.

4. Expertise in drug metabolism, strong synthetic chemistry background, extensive experience with spectroscopies.

5. Excellent communication and presentation skills.

6. Productive, strong record of publications.

WORK EXPERIENCE

Strategic Marketing Specialist at ThermoFisher Scientific, San Jose, CA, Mar 2010 to present

Clinical Chemistry, toxicology and forensics application development using LC-MS.

Scientist at PPD, Biomarker Discovery Sciences, Menlo Park, CA, July 2005 to Jan 2010

1. Method development/Validation of HPLC-MS/MS-based bioanalytical/biomarker analysis of peptides and small molecules

2. Development and implementation of HPLC-MS/MS-based metabolite, proteome and lipid profiling

Postdoc Fellow at University of California, San Francisco, Aug 2002 to July 2005

Principal Investigator: Prof. Paul R. Ortiz de Montellano

Drug metabolism and mechanism-based inhibition studies of P450 enzymes

Research Assistant at State University of New York, Stony Brook, Aug 1997- Aug 2002 Principal Investigator: Prof. Peter J. Tonge

Green fluorescent protein (GFP). Organic synthesis and spectroscopy.

EDUCATION AND TRAINING

Ph.D., Chemistry, 1997-2002, Advisor: Prof. Peter J. Tonge

Department of Chemistry, SUNY at Stony Brook, Stony Brook, NY

MS Candidate in Chemistry, 1995-1997, Advisor: Prof. Huilan Chen.

BS in Chemistry, 1991-1995, Advisor: Prof. Huilan Chen.

Department of Chemistry, Nanjing University, Nanjing, China

PUBLICATIONS

1. X. He, T. Jones, P. Kumar, T. Shaler and C. Becker. “Lipid Profiling in Human Plasma with LTQ Orbitrap High Resolution Mass Spectrometry and High Performance Liquid Chromatography”, to be submitted.

2. YY Jiang, X. He, and P. R. Ortiz de Montellano. “Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes”, Biochemistry, 2006, 45, 533-542.

3. X. He, M. J. Cryle, J. J. D. Voss, and P. R. Ortiz de Montellano. “Calibrating the Channel that Determines the omega-Hydroxylation Specificity of CYP4A1. Oxidation of omega-Halododecanoic Acids”, J. Biol. Chem., 2005, 280, 226**-*****.

4. X. He, P. R. Ortiz de Montellano. “Alpha- and beta-Thujone Radical Rearrangements and Isomerizations. A New Radical Clock”, J. Org. Chem., 2004, 69, 5684-5689.

5. X. He, P. R. Ortiz de Montellano. “Radical Rebound Mechanism in Cytochrome P-450-catalyzed hydroxylation of the Multifaced Radical Clocks alpha- and beta-Thujone”, J. Biol. Chem., 2004, 279, 394**-*****.

6. M. Vengris, I. H. M. van Stokkum, X. He, A. F. Bell, P. J. Tonge, R. van Grondelle, D. S. Larsen. “Ultrafast Excited and Ground-State Dynamics of the Green Fluorescent Protein Chromophore in Solution”, J. Phys. Chem. A., 2004, 108, 4587-4598.

7. X. He, A. F. Bell, P. J. Tonge. “Ground State Isomerization of a Model Green Fluorescent Protein Chromophore”, FEBS Letters, 2003, 549, 35-38.

8. S. Boyé, H. Krogh, I. B. Nielsen, S. U. Pedersen, U. V. Pedersen, L. H. Andersen, A. F. Bell, X. He, P. J. Tonge. “Vibrationally Resolved Photoabsorption Spectroscopy of RFP chromophore Anions”, Physical Review Letters, 2003, 90, 118103.

9. S. Boyé, S. B. Nielsen, H. Krogh, I. B. Nielsen, U. V. Pedersen, A. F. Bell, X. He, P. J. Tonge, and L. H. Andersen. “Gas-Phase Absorption Properties of DsRed Model Chromophores”, Physical Chemistry Chemical Physics, 2003, 3021-3026.

10. X. He, A. F. Bell, P. J. Tonge. “Isotope Labeling and Normal Mode Analysis of a Model GFP Chromophore”, J. Phys. Chem. b, 2002, 106, 6056-6066.

11. X. He, A. F. Bell, P. J. Tonge. “Synthesis and Spectroscopic Studies of Model RFP Chromophores”, Org. Lett., 2002, 4, 1523-1526.

12. A. F. Bell, X. He, R. M. Watcher, and P. J. Tonge. “Probing the Ground State Structure of the Green Fluorescent Protein Chromophore Using Raman Spectroscopy”, Biochemistry, 2000, 39, 4423-4431.

13. W. Wu, Y. Feng, X. He, H. A. Hofstein, D. P. Raleigh, and P. J. Tonge. "Stereospecificity of the Reaction Catalyzed by Enoyl-CoA Hydratase", J. Am. Chem. Soc., 2000, 122, 4987-3994.

14. F. Bell, X. He, J. P. Ridge, G. R. Hanson, A. G. McEwan and P. J. Tonge. “Active Site Heterogeneity in DMSO Reductase from Rhodobacter capsulatus Revealed by Raman Spectroscopy”, Biochemistry, 2000, 40, 440-448.

15. X. Bao, X. He. “O-related Surface States and Their Role in Porous Silicon”, Solid State Communications, 1999, 109, 169-172.

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