S. Irene Medina, PhD

**** *. ***** ******; Philadelphia, PA 19145

Mobile: 619-***-**** - Email: gn0nav@r.postjobfree.com

OBJECTIVE

To obtain employment as a scientist at a research and development facility.

EDUCATION

University of Pennsylvania - Doctor of Philosophy - Organic Chemistry (May 2011)

Dissertation: The synthesis of enantiopure N-benzylidenze nitrone alpha-amino acids for the preparation of N-terminal hydroxylamine peptides for the chemoselective decarboxylative ligation with alpha-ketoacid peptides.

San Diego State University - Bachelor of Science - Chemistry (May 2005)

Honors: Pfizer undergraduate research fellowship (2005-2003), Pfizer summer research fellowship (2004 and 2003), McNair summer research fellowship (2004), NIH - Bridges to the Future research fellowship (2003).

EXPERIENCE

Research Associate - University of Pennsylvania - Philadelphia, PA (2006-2011)

Developed a synthetic route for the preparation of enantiopure N-terminal hydroxylamine peptides for peptide ligation with peptidyl alpha-ketoacids. Responsibilities included: small molecule synthesis, polymer-supported peptide synthesis, laboratory technique training, method development and maintenance for the following analytical instruments: HPLC, LCMS, and MALDI.

Research Associate - Pfizer - La Jolla, CA (2005)

Synthesized small molecules for high throughput screening at the department of combinatorial chemistry. Responsibilities included: synthesis and isolation of target molecules and intermediates, verification of final compounds by LCMS, NMR, and HPLC.

Research Associate - San Diego State University - San Diego, CA (2002-2005)

Synthesized linear and macrocyclic peptides for biological studies. Responsibilities included: solution phase and polymer-supported peptide synthesis, development of HPLC methods for product isolation, maintenance of LCMS, laboratory technique training, and inventory maintenance of laboratory reagents/supplies.

PUBLICATIONS

Medina, S. I.; Wu, J.; Bode J. W. Nitrone protecting groups for enantiopure N-hydroxyamino acids: synthesis of N-terminal peptide hydroxylamines for chemoselective ligations. Org. Biomol. Chem. 2010, 8, 3405-3417.

Styers, T. J.; Kekec, A.; Rodriquez, R.; Brown, J. D.; Cajica, J.; Pan, P.; Parry, E.; Carroll, C. L.; Medina, S. I.; Corral, R.; Lapera, K. O.; Pan, C., McGuire, K. L. McAlpine, S. R. Synthesis of sansalvamide A derivatives and their cytotoxicity in the MSS colon cancer cell line HT-29. Bio. Med. Chem. 2006, 14, 5625-5631.

Pan, P.; Curtis, F. A.; Carroll, C. L.; Medina, S. I.; Liotta, L. A.; Sharples, G. J.; McAlpine, S. R. Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E- coli RuvC. Bio. Med. Chem. 2006, 14, 4731-4739.

Carroll, C., Johnston, J. V. C.; Kekec, A.; Brown, J. D.; Parry, E.; Cajica, J.; Medina, S. I.; Cook, K.; Corral, R.; Pan, P.; McAlpine, S. R. Synthesis and cytotoxicity of novel sansalvamide A derivatives. Org. Lett. 2005, 7,3481-3484.

Liotta, L. A.; Medina, S. I.; Robinson, J. L.; Carroll, C. L.; Pan, P.; Corral, R.; Johnston, J. V. C.; Cook, K. M.; Curtis, F. A.; Sharples, G. J.; McAlpine, S. R. Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions. Tetrahedron Lett. 2004, 45, 8447-8450.

Robinson, J. L.; Taylor, R. E., Liotta, L. A.; Bolla, M. L.; Azevedo, E. V.; Medina, S. I.; McAlpine, S. R. A progressive synthetic strategy for class B synergimycins. Tetrahedron Lett. 2004, 45, 2147-2150.

PRESENTATIONS

236TH American Chemical Society National Meeting - Philadelphia, PA (2008)

"Solid and solution-phase synthesis of N-terminal hydroxylamines for chemoselective ligation."

229TH American Chemical Society National Meeting - San Diego, CA (2005)

"Synthesis of potential Holliday junction inhibitors."

University of California San Diego Undergraduate Research Conference - San Diego, CA (2004)

"The synthesis of first generation macrocyclic peptides designed to trap Holliday junctions."

San Diego State University Undergraduate Research Symposium - San Diego, CA (2004)

"Trapping the Holliday junction."

California State University Biotechnology Symposium - San Jose, CA (2004)

"Macrocyclic class B synergimycin derivatives for potential antibiotics."

226TH American Chemical Society National Meeting - New York, NY (2003)

"Class B synergimycin derivatives."

San Diego State University Undergraduate Research Symposium - San Diego, CA (2003)

"New Holliday junction inhibitors and class B synergimycin derivatives."

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