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Customer Service Supervisor

Location:
Westminster, CO, 80027
Salary:
$70K/yr
Posted:
November 17, 2012

Contact this candidate

Resume:

Matthew T. Morton

**** ****** **** **.

Superior, CO 80027

707-***-**** (Cell)

707-***-**** (Home)

dwn4qa@r.postjobfree.com

dwn4qa@r.postjobfree.com

Technical Skills

Biochemical assays and antibody purification: SDS-PAGE (Coomassie blue and

Silver stain) and Western blot; UV-Visible spectroscopy and Bradford and

Lowry protein assay testing; ELISA assays: antibody purification procedures

utilizing UF/DF; Tangential Flow Filtration, 10 to 50L manufacturing scale-

up using ACTA Pilot and Explorer chromatography methods and buffer

preparation in cGLP/GMP-like environment. Performed stability testing for

CMO manufactured API.

Computers: Broad experience with Microsoft Excel, Word, Outlook, and

PowerPoint, Softmax Pro and Prism Graph Pad, Endnote, File Maker Pro, Buxco

and SciReq software.

Data management, clinical and research, publications and presentations at

international meetings (ATS, AAAI, Neuroscience).

Histological and hematology procedures. Microtomy, ICC, IHC (FITC) and

special stains.

Tissue/Data Analysis: CBC, cell differential, skin and BAL fluid

collection and analysis.

Microscopy: Bright field, digital collection, DIC, SEM.

Cell Culture; Murine neonatal neuronal tissue dissection and culture.

Pulmonary deposition techniques; radioactive via Bird and Aerogen

nebulizers.

Animal Surgery: In vivo models with NHP's, murine, canine, and feline

species. Managed anesthetics, sedatives, analgesic, antibiotics and

complete therapeutic recovery.

Training of lab personnel on techniques, equipment and SOPs.

Operational/Logistical: Expeditious large and small lab set-up and

relocation experience. Including installation, repair and maintenance of

electrical, plumbing, communication and computer and recording/alarm

devices.

Managed City of Berkeley Closure process for Aerovance Lab and Offices.

Interfaced with HES consultants to ensure safe compliant closure

operations.

Maintenance: Manage lab consultants, contractors and equipment on or off

site.

Education:

B.S. University of California, Berkeley, CA, 1981

Professional Work Experience

Independent Contractor for Aerovance Inc. (5/2011 - present), Selling

Aerovance's $1M+ surplus lab equipment and office supplies, maintaining and

managing the inventory in Public Storage, assisting the relocation of

purchased equipment.

Sr. Research Associate Scientist III, Technical Operations, Aerovance Inc.,

Berkeley, CA (2008 - 4/2011): Supported the Technical Operations goals and

objectives in a cGLP/GMP-like environment. Including UV-Visible

spectroscopy, antibody purification, characterization and biotinylation, as

well as method development and testing support for the manufacturing and

protein process development of Aerovant. Assisted method optimization for

ELISA, stability, clarity, and reproducibility assays. Managed

installation, maintenance and repair of equipment, cold sample storage and

water purification systems.

. Assisted with the development of a pilot-scale downstream protein

purification process (10L) and completed analytical support utilizing UV-

Visible spectroscopy, protein assays, PAGE / Western blot and

chromatographic methods for new phase III / commercial manufacturing

process for lead clinical development program (AerovantTM). Developed,

optimized and validated all procedural changes.

. Contributed to the development of a process-specific host cell protein

(HCP) assay (including critical reagent preparation, initial method pre-

qualification and optimization, draft SOP and final method development

report) to quantify process-related impurities utilizing both ELISA and

Meso-Scale Discoveries (MSD) technology.

. Supported in-house formulation development program providing analytical

testing support (USP visible particle and clarity assessments, stability

studies, protein testing and SDS-PAGE methods).

. Assisted clinical with shipping of kits and supplies, data management and

archival.

. Ensured compliance of equipment maintenance and calibration. Maintained

surplus off-site capital equipment inventory and storage.

Sr. Res. Assoc. Scientist II, Preclinical Research Department, Aerovance

Inc., Berkeley, CA (2004 - 2008):

Implemented and assisted with numerous in vivo non-human primate (NHP) and

rodent inflammation models in support of Preclinical Research goals and

objectives; responsible for operational logistics and maintenance,

accreditation and safety practices, as well as the hands-on training

components of new laboratory staff.

. Managed relocation of NHP lab and colony from Bayer (Berkeley, CA) to

Valley Biosystems, (Sacramento, CA), and back to Aerovance. Managed final

disposition of NHP colony to retirement at a wildlife sanctuary in Texas.

. Executed critical experiments for in-house proof of principle & mechanism

of action studies, outsourced pharmacokinetic and safety pharmacology

studies, all supporting the clinical development programs of AerovantTM

(Asthma), AerodermTM (Atopic dermatitis), AerolyticTM (CF), and

PulmolyticTM (COPD).

. Contributed to experimental animal-based and tissue-based disease model

development and refinement; investigated and implemented novel techniques

and procedures to enhance throughput and efficiencies of data

acquisition, including VIP tissue bath techniques, cigarette smoke

(COPD), Nasal Potential Difference (MCC; CF), LPS and Allergen-induce

AHR & AI (Asthma), Atopic Dermatitis (skin inflammation) models.

. Laboratory logistics: Designed engineering controls for the safe usage

and supply of radioisotope (Tc99) for respiratory imaging studies.

Monitored inventory and safety regulations. Maintained high quality

research environment, ensuring compliance of all AALAC, IACUC and USDA

standards. Managed equipment and supply timelines. Trained new

investigators and colleagues. Ensured staff safety and integrity of

experimental procedures.

. Documented and analyzed research results. Communicated and presented

research findings. Maintained lab notebooks and sample logs.

Sr. Res. Assoc. Scientist II, Pharmacology, Bayer, Berkeley, CA (1997 -

2004):

Designed and refined models for respiratory diseases, allergy and pulmonary

function.

Performed procedures on NHP's to study immunological profiles of cytokine

development, including bronchoalveolar lavage (BAL), skin biopsies, Nasal

PD measurements, pulmonary function tests and plethysmography. Cytokine and

protein assays.

Collected data and performed statistical analysis on data generated from

research studies.

Prepared reports and presented the results at International Scientific

meetings (American Thoracic Society, see abstracts).

Trained staff on current experimental projects and procedures.

Sr. Research Associate Scientist, Neurology, Somatix Therapy Co., Alameda,

CA (1994 - 1997):

Designed and developed histological methods to evaluate volume, duration

and transfection efficiency of implanted genetically altered cells and

vectors.

. Performed a variety of histological procedures and microscopy

techniques to support pre-clinical studies both in vivo & ex vivo.

. Conducted statistical analysis to facilitate interpretation of

efficacy of applied therapies for the treatments of Parkinson's

disease.

. Managed lab relocation 3 times in 2.5 years

Staff Research Associate Scientist III, Neurology Service, UCSF and

Veterans Affairs Medical Center, San Francisco, CA (1985 - 1994):

Managed experimental procedures in a large neuroanatomy lab focused on

stroke and neurodegenerative disorders.

Performed animal surgeries, tissue culture, immunohistochemistry,

biochemical, protein testing and radiometric assays.

Mentored junior laboratory personnel on techniques and procedures.

Prepared reports and presented experimental data at International

scientific meetings.

Managed laboratory logistics and maintained operational supplies, capital

equipment.

Managed H3 and C14 inventory to study neurocellular metabolism; utilized

S35 for in situ hybridization studies.

Research Laboratory Technologist, Neuro-endocrine Research Laboratory,

Harvard Medical School and Massachusetts General Hospital, Boston, MA (1982

- 1985):

Managed small NIH grant supported lab for principle investigator in a

larger academic lab

Performed large and small animal neurosurgery modeling canine narcolepsy

and circadian rhythm studies.

Conducted and analyzed longitudinal behavioral circadian rhythm studies.

Performed autoradiographic and histochemical imaging of neural patterns of

protein expression.

Constructed and maintained experimental equipment involved in studies.

Collected data, processed tissues, performed immunocytochemical and

histological assays.

Attained radiation safety certificate. Used H3 and C14 to study brain

metabolism.

Other Work Experience:

General Manager, H. Pini and Company, Novato, CA (1987 - 1993)

Executed and administered responsibilities for mid-sized business and real

estate venture.

Conducted marketing, merchandising and financial operations. Monitored

customer service and relevant sales functions. Supervised clerical

workforce.

Managed numerous light industrial rental properties. Negotiated rental

contracts, maintained services and repairs agreements, administered daily

operations of business.

Certifications and Workshops:

2012 Heads Up: Concussion recognition certificate

2010 USA Hockey Coach: Ice Hockey Coach Level 4

2009 Sartorius Workshop: Downstream Bio-processing

2006/2008 Red Cross of America: CPR; Emergency medical response

2004 Safe Capture: Sedation, Immobilization and Anesthesia of Non

Human Primates

2002 American Thoracic Society: Respiratory Models; mouse to man

2000 American Thoracic Society: Novel Therapeutics in Asthma

1999 University of Vermont: 'Respiratory Mechanics'

1997 Bayer Corporation: 'Blood Borne Pathogen training'

1984 Massachusetts General Hospital: Radiation safety, use and

hazards

Awards:

Special Recognition Award, 1999, Bayer Corporation, Berkeley, CA

Volunteer Activities:

Boulder Valley Ice Hockey Club Coach; Midget minor AA (2012-present)

Tri Valley Blue Devils Ice Hockey Coach; USA Hockey (2009 - 2011)

VP, Board Member and Coach, Vacaville Jets (2006 - 2009)

Founder & Active Board Member, Benicia PAL In-Line Hockey League (1999-

2012)

Publications and Abstracts:

RE Slager, AF Diallo, GA Hawkins, A Bowden, L Stevens, M Morton, A

Tomkinson, M Longphre, EL Bleeker, DA Meyers, IL-4R Polymorphisms are

Associated with Response to IL-4/IL-13 Receptor Antagonist (Aerovant) in

Human and Non-Human Primates, Journal of Allergy and Clinical

Immunology, Letters to Editor, Oct 2010,Vol. 126, No. 4, 875-8

A. Tomkinson, J. Tepper, M. Morton, A. Bowden, L. Stevens, P. Harris, D.

Lindell, N. Fitch, R. Gundel, E. B. Getz, Inhaled vs subcutaneous effects

of a dual IL-4/IL-13 antagonist in a monkey model of asthma, Allergy 65,

(2010) 69-77

Tomkinson A, Morton M, Stevens L, Bowden A, Tepper J, Effect of

Dexamethasone on the Cutaneous Late Phase Response, Clin Exp Allergy.

2009 Jul; 39(7):1080-7

Ciricillo SP, Hill MP, Gonzalez MF, Smalley S, Morton MT, Sharp FR,

Whisker Stimulation Metabolically Activates Thalamus Following Cortical

Transplantation But Not Following Cortical Ablation, Neuroscience, Vol.

59, pp. 975-992, 1994

Swanson RA, Morton MT, Sagar SM, Sharp FR, Sensory Stimulation Induced

Local Cerebral Glycogenolysis Demonstration By Autoradiography,

Neuroscience, Vol. 51, pp. 451-461, 1992

Swanson RA, Shiraishi K, Morton MT, Sharp FR, Methioine Sulfoximine

Reduced Cortical Infarct Size in Rats After Middle Cerebral Artery

Occlusion, Stroke, Vol. 21, pp. 322-327, 1990

Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, Sharp FR, A

Semiautomated Method for Measuring Brain Infarct Volume, Journal of

Cerebral Blood flow and Metabolism, Vol. 10, pp. 290-298, 1990

Sharp JW, Gonzalez MF, Morton MT, Simon RP, Sharp FR, Decreases of

cortical and Thalamic Glucose Metabolism Produced By Parietal Cortex

Simulation in the Rat, Brain Research, Vol. 428, pp.357-362, 1988

Sharp FR, Gonzalez MF, Morgan CW, Morton MT, Sharp JW, Common Fur and

Mystacial Vibrissae Parallel Sensory Pathways: C14 2-Deoxyglucose & WGA-

HRP Studies in the Rat, Journal of Comp. Neurology, Vol. 84, pp. 1694-

1698, 1987

Schwartz WJ, Gross RA, Morton MT, The Suprachiasmatic Nuclei Contains a

Tetrodotoxin-Resistant Circadian Pacemaker, Proceedings National Academy

of Science, Vol. 84, pp. 1694-1698, 1987

Schwartz WJ, Morton MT, Williams RS, Tamarkin L, Baker TL, Dement WC,

Circadian Timekeeping in Narcoleptic Dogs, Sleep, Vol. 9, pp. 120-125,

1986

Abstracts and Communications:

Tomkinson A., Stevens L., Morton M., Bowden A., Wong T., Boisvert D.,

Delaria K., Burmeister Getz E., AER 003, a PEGlylated IL-4/IL-13

antagonist, significantly reduces allergen-induced airway

hyperresponsiveness (AHR). J. Allergy Clin Immunol. 125, AB54 2010

RE Slager, AF Diallo, GA Hawkins, A Bowden, L Stevens, M Morton, A

Tomkinson, M Longphre, EL Bleeker, DA Meyers, IL-4R Polymorphisms are

Associated with Response to IL-4/IL-13 Receptor Antagonist (Aerovant) in

Human and Non-Human Primates, American Journal of Respiratory and

Critical Care Medicine, May 2009

Stevens L, Bowden A, Morton M, Tepper J, Tomkinson A, Effects of

Cyclosporine and Dexamethasone in a Mouse Model of Atopic Dermatitis,

American Academy of Allergy Asthma and Inflammation, March 14-18, 2008

Tomkinson A, Bowden A, Stevens L, Morton M, Chen J, Wong T, Burmeister-

Getz E, Tepper J, Therapeutic Effects of Inhaled AER 001, an IL-4/IL-13

Antagonist, on Allergen-Induced Airway Hyperresponsiveness (AHR) and

Airway Inflammation, American Thoracic Society International Conference,

May 2006 (Accepted for oral presentation)

Bowden A, Morton M, Stevens L, Canivel D, Tepper J, Tomkinson A, Effects

of Serine Protease Inhibitor, Bikunin (SPINT2), On Nasal Epithelial

Potential Difference In Cynomolgus Monkeys: A Novel Treatment For Cystic

Fibrosis, American Journal of Respiratory and Critical Care Medicine, May

2005 (Abstract and Oral Presentation)

Bowden A, and Morton M, Stevens L, Canivel D, Fitzgerald M, Sturton G,

and Fitch N, Anti-Inflammatory Effect of a Selective PDE4 Inhibitor, Bay

19-8004, in a Non-Human Primate Model of LPS-Induced Pulmonary

Inflammation, American Journal of Respiratory and Critical Care Medicine,

Vol. 167, No. 7, April 2003

Bowden A, Morton M, Stevens L, Fitzgerald M, and Fitch N, Effect of

Interlukin-8 Monoclonal Antibody on LPS-Induced Airway Inflammation in

the Cynomolgus Monkey, Chronic Lung Diseases, Paris Symposium, June 27,

2001

Fitch N, Bowden A, and Morton M, Evaluation of an Interlukin-5 Receptor

Monoclonal Antibody in Primate Asthma Model, American Journal of

Respiratory and Critical Care Medicine, Vol. 163, No. 5, April 2001

Fitch N, Morton M, Bowden A, Shanafelt M-C, Shanafelt A, Wetzel G, Moy J,

Preclinical Evaluation of Bay 16-9996 a Dual IL-4/IL-13 Receptor

Antagonist, American Academy of Allergy Asthma and Immunology, March 16,

2001 (Abstract and Minisymposia)

Bowden A, Morton M, Fitzgerald M, and Fitch N, A Primate Model of Acute

Inflammation, American Journal of Respiratory and Critical Care Medicine,

Vol. 161, No. 3, p. A182, March 2000

Morton M, Harris P, Xu J, Gorina S, Roczniak S, Fitch N, and Gundel R,

The Effect of an Interlukin-4 Receptor Antagonist (Bay 16-9996) on

Antigen-Induced Cutaneous Wheal and Flare Reactions in the Primate,

American Journal of Respiratory and Critical Care Medicine, March 1999

References:

Robert Kuhn Ph.D.: Senior VP & Chief Technical Officer,

Aerovance Inc.

Aerovance Inc., Berkeley, CA; 510-***-**** cell,

dwn4qa@r.postjobfree.com

Wayne Froland Ph.D.; Executive Director, Biologics Manufacturing Sciences

and Commercialization, Merck Manufacturing Division, West Point, PA (215)

652-7095, dwn4qa@r.postjobfree.com

Michael Dumas, Sr. Scientist, Technical Operations, Aerovance

Aerovance Inc., Berkeley, CA 510-***-**** cell, dwn4qa@r.postjobfree.com

Michael P. Gregoire; Chairman & CEO, Taleo, Dublin, CA 925-***-****,

dwn4qa@r.postjobfree.com

Adrian Tomkinson Ph.D.; Former Supervisor, Director of Preclinical

Research at Aerovance, Aerovance Inc., Berkeley, CA 510-***-**** cell,

dwn4qa@r.postjobfree.com

Jeffrey Tepper Ph.D.; Former Supervisor and Director of Preclinical

Research at Aerovance, Aerovance Inc., Berkeley, CA 510-***-****

dwn4qa@r.postjobfree.com

Neil Fitch Ph.D.; Supervisor at Bayer Corp.

Aventis-Sanofi Corporation, Cambridge, Massachusetts 617-***-****

dwn4qa@r.postjobfree.com

Dea Nagy, M.D.; Supervisor at Somatix Therapy Corp.

Ventana Medical Systems, Tucson, AZ, dwn4qa@r.postjobfree.com

Raymond Swanson M.D., Professor; Vice Chair: Supervisor at UCSF

Dept. of Neurology, Univ. of California, San Francisco, CA 415-***-****

x 2492, dwn4qa@r.postjobfree.com.

William Schwartz M.D., Professor; Supervisor at Massachusetts General

Hospital

Dept. of Neurology, Univ. of Massachusetts Medical School, Worchester, MA

508-***-****, dwn4qa@r.postjobfree.com



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