Matthew T. Morton
Superior, CO 80027
707-***-**** (Cell)
707-***-**** (Home)
dwn4qa@r.postjobfree.com
dwn4qa@r.postjobfree.com
Technical Skills
Biochemical assays and antibody purification: SDS-PAGE (Coomassie blue and
Silver stain) and Western blot; UV-Visible spectroscopy and Bradford and
Lowry protein assay testing; ELISA assays: antibody purification procedures
utilizing UF/DF; Tangential Flow Filtration, 10 to 50L manufacturing scale-
up using ACTA Pilot and Explorer chromatography methods and buffer
preparation in cGLP/GMP-like environment. Performed stability testing for
CMO manufactured API.
Computers: Broad experience with Microsoft Excel, Word, Outlook, and
PowerPoint, Softmax Pro and Prism Graph Pad, Endnote, File Maker Pro, Buxco
and SciReq software.
Data management, clinical and research, publications and presentations at
international meetings (ATS, AAAI, Neuroscience).
Histological and hematology procedures. Microtomy, ICC, IHC (FITC) and
special stains.
Tissue/Data Analysis: CBC, cell differential, skin and BAL fluid
collection and analysis.
Microscopy: Bright field, digital collection, DIC, SEM.
Cell Culture; Murine neonatal neuronal tissue dissection and culture.
Pulmonary deposition techniques; radioactive via Bird and Aerogen
nebulizers.
Animal Surgery: In vivo models with NHP's, murine, canine, and feline
species. Managed anesthetics, sedatives, analgesic, antibiotics and
complete therapeutic recovery.
Training of lab personnel on techniques, equipment and SOPs.
Operational/Logistical: Expeditious large and small lab set-up and
relocation experience. Including installation, repair and maintenance of
electrical, plumbing, communication and computer and recording/alarm
devices.
Managed City of Berkeley Closure process for Aerovance Lab and Offices.
Interfaced with HES consultants to ensure safe compliant closure
operations.
Maintenance: Manage lab consultants, contractors and equipment on or off
site.
Education:
B.S. University of California, Berkeley, CA, 1981
Professional Work Experience
Independent Contractor for Aerovance Inc. (5/2011 - present), Selling
Aerovance's $1M+ surplus lab equipment and office supplies, maintaining and
managing the inventory in Public Storage, assisting the relocation of
purchased equipment.
Sr. Research Associate Scientist III, Technical Operations, Aerovance Inc.,
Berkeley, CA (2008 - 4/2011): Supported the Technical Operations goals and
objectives in a cGLP/GMP-like environment. Including UV-Visible
spectroscopy, antibody purification, characterization and biotinylation, as
well as method development and testing support for the manufacturing and
protein process development of Aerovant. Assisted method optimization for
ELISA, stability, clarity, and reproducibility assays. Managed
installation, maintenance and repair of equipment, cold sample storage and
water purification systems.
. Assisted with the development of a pilot-scale downstream protein
purification process (10L) and completed analytical support utilizing UV-
Visible spectroscopy, protein assays, PAGE / Western blot and
chromatographic methods for new phase III / commercial manufacturing
process for lead clinical development program (AerovantTM). Developed,
optimized and validated all procedural changes.
. Contributed to the development of a process-specific host cell protein
(HCP) assay (including critical reagent preparation, initial method pre-
qualification and optimization, draft SOP and final method development
report) to quantify process-related impurities utilizing both ELISA and
Meso-Scale Discoveries (MSD) technology.
. Supported in-house formulation development program providing analytical
testing support (USP visible particle and clarity assessments, stability
studies, protein testing and SDS-PAGE methods).
. Assisted clinical with shipping of kits and supplies, data management and
archival.
. Ensured compliance of equipment maintenance and calibration. Maintained
surplus off-site capital equipment inventory and storage.
Sr. Res. Assoc. Scientist II, Preclinical Research Department, Aerovance
Inc., Berkeley, CA (2004 - 2008):
Implemented and assisted with numerous in vivo non-human primate (NHP) and
rodent inflammation models in support of Preclinical Research goals and
objectives; responsible for operational logistics and maintenance,
accreditation and safety practices, as well as the hands-on training
components of new laboratory staff.
. Managed relocation of NHP lab and colony from Bayer (Berkeley, CA) to
Valley Biosystems, (Sacramento, CA), and back to Aerovance. Managed final
disposition of NHP colony to retirement at a wildlife sanctuary in Texas.
. Executed critical experiments for in-house proof of principle & mechanism
of action studies, outsourced pharmacokinetic and safety pharmacology
studies, all supporting the clinical development programs of AerovantTM
(Asthma), AerodermTM (Atopic dermatitis), AerolyticTM (CF), and
PulmolyticTM (COPD).
. Contributed to experimental animal-based and tissue-based disease model
development and refinement; investigated and implemented novel techniques
and procedures to enhance throughput and efficiencies of data
acquisition, including VIP tissue bath techniques, cigarette smoke
(COPD), Nasal Potential Difference (MCC; CF), LPS and Allergen-induce
AHR & AI (Asthma), Atopic Dermatitis (skin inflammation) models.
. Laboratory logistics: Designed engineering controls for the safe usage
and supply of radioisotope (Tc99) for respiratory imaging studies.
Monitored inventory and safety regulations. Maintained high quality
research environment, ensuring compliance of all AALAC, IACUC and USDA
standards. Managed equipment and supply timelines. Trained new
investigators and colleagues. Ensured staff safety and integrity of
experimental procedures.
. Documented and analyzed research results. Communicated and presented
research findings. Maintained lab notebooks and sample logs.
Sr. Res. Assoc. Scientist II, Pharmacology, Bayer, Berkeley, CA (1997 -
2004):
Designed and refined models for respiratory diseases, allergy and pulmonary
function.
Performed procedures on NHP's to study immunological profiles of cytokine
development, including bronchoalveolar lavage (BAL), skin biopsies, Nasal
PD measurements, pulmonary function tests and plethysmography. Cytokine and
protein assays.
Collected data and performed statistical analysis on data generated from
research studies.
Prepared reports and presented the results at International Scientific
meetings (American Thoracic Society, see abstracts).
Trained staff on current experimental projects and procedures.
Sr. Research Associate Scientist, Neurology, Somatix Therapy Co., Alameda,
CA (1994 - 1997):
Designed and developed histological methods to evaluate volume, duration
and transfection efficiency of implanted genetically altered cells and
vectors.
. Performed a variety of histological procedures and microscopy
techniques to support pre-clinical studies both in vivo & ex vivo.
. Conducted statistical analysis to facilitate interpretation of
efficacy of applied therapies for the treatments of Parkinson's
disease.
. Managed lab relocation 3 times in 2.5 years
Staff Research Associate Scientist III, Neurology Service, UCSF and
Veterans Affairs Medical Center, San Francisco, CA (1985 - 1994):
Managed experimental procedures in a large neuroanatomy lab focused on
stroke and neurodegenerative disorders.
Performed animal surgeries, tissue culture, immunohistochemistry,
biochemical, protein testing and radiometric assays.
Mentored junior laboratory personnel on techniques and procedures.
Prepared reports and presented experimental data at International
scientific meetings.
Managed laboratory logistics and maintained operational supplies, capital
equipment.
Managed H3 and C14 inventory to study neurocellular metabolism; utilized
S35 for in situ hybridization studies.
Research Laboratory Technologist, Neuro-endocrine Research Laboratory,
Harvard Medical School and Massachusetts General Hospital, Boston, MA (1982
- 1985):
Managed small NIH grant supported lab for principle investigator in a
larger academic lab
Performed large and small animal neurosurgery modeling canine narcolepsy
and circadian rhythm studies.
Conducted and analyzed longitudinal behavioral circadian rhythm studies.
Performed autoradiographic and histochemical imaging of neural patterns of
protein expression.
Constructed and maintained experimental equipment involved in studies.
Collected data, processed tissues, performed immunocytochemical and
histological assays.
Attained radiation safety certificate. Used H3 and C14 to study brain
metabolism.
Other Work Experience:
General Manager, H. Pini and Company, Novato, CA (1987 - 1993)
Executed and administered responsibilities for mid-sized business and real
estate venture.
Conducted marketing, merchandising and financial operations. Monitored
customer service and relevant sales functions. Supervised clerical
workforce.
Managed numerous light industrial rental properties. Negotiated rental
contracts, maintained services and repairs agreements, administered daily
operations of business.
Certifications and Workshops:
2012 Heads Up: Concussion recognition certificate
2010 USA Hockey Coach: Ice Hockey Coach Level 4
2009 Sartorius Workshop: Downstream Bio-processing
2006/2008 Red Cross of America: CPR; Emergency medical response
2004 Safe Capture: Sedation, Immobilization and Anesthesia of Non
Human Primates
2002 American Thoracic Society: Respiratory Models; mouse to man
2000 American Thoracic Society: Novel Therapeutics in Asthma
1999 University of Vermont: 'Respiratory Mechanics'
1997 Bayer Corporation: 'Blood Borne Pathogen training'
1984 Massachusetts General Hospital: Radiation safety, use and
hazards
Awards:
Special Recognition Award, 1999, Bayer Corporation, Berkeley, CA
Volunteer Activities:
Boulder Valley Ice Hockey Club Coach; Midget minor AA (2012-present)
Tri Valley Blue Devils Ice Hockey Coach; USA Hockey (2009 - 2011)
VP, Board Member and Coach, Vacaville Jets (2006 - 2009)
Founder & Active Board Member, Benicia PAL In-Line Hockey League (1999-
2012)
Publications and Abstracts:
RE Slager, AF Diallo, GA Hawkins, A Bowden, L Stevens, M Morton, A
Tomkinson, M Longphre, EL Bleeker, DA Meyers, IL-4R Polymorphisms are
Associated with Response to IL-4/IL-13 Receptor Antagonist (Aerovant) in
Human and Non-Human Primates, Journal of Allergy and Clinical
Immunology, Letters to Editor, Oct 2010,Vol. 126, No. 4, 875-8
A. Tomkinson, J. Tepper, M. Morton, A. Bowden, L. Stevens, P. Harris, D.
Lindell, N. Fitch, R. Gundel, E. B. Getz, Inhaled vs subcutaneous effects
of a dual IL-4/IL-13 antagonist in a monkey model of asthma, Allergy 65,
(2010) 69-77
Tomkinson A, Morton M, Stevens L, Bowden A, Tepper J, Effect of
Dexamethasone on the Cutaneous Late Phase Response, Clin Exp Allergy.
2009 Jul; 39(7):1080-7
Ciricillo SP, Hill MP, Gonzalez MF, Smalley S, Morton MT, Sharp FR,
Whisker Stimulation Metabolically Activates Thalamus Following Cortical
Transplantation But Not Following Cortical Ablation, Neuroscience, Vol.
59, pp. 975-992, 1994
Swanson RA, Morton MT, Sagar SM, Sharp FR, Sensory Stimulation Induced
Local Cerebral Glycogenolysis Demonstration By Autoradiography,
Neuroscience, Vol. 51, pp. 451-461, 1992
Swanson RA, Shiraishi K, Morton MT, Sharp FR, Methioine Sulfoximine
Reduced Cortical Infarct Size in Rats After Middle Cerebral Artery
Occlusion, Stroke, Vol. 21, pp. 322-327, 1990
Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, Sharp FR, A
Semiautomated Method for Measuring Brain Infarct Volume, Journal of
Cerebral Blood flow and Metabolism, Vol. 10, pp. 290-298, 1990
Sharp JW, Gonzalez MF, Morton MT, Simon RP, Sharp FR, Decreases of
cortical and Thalamic Glucose Metabolism Produced By Parietal Cortex
Simulation in the Rat, Brain Research, Vol. 428, pp.357-362, 1988
Sharp FR, Gonzalez MF, Morgan CW, Morton MT, Sharp JW, Common Fur and
Mystacial Vibrissae Parallel Sensory Pathways: C14 2-Deoxyglucose & WGA-
HRP Studies in the Rat, Journal of Comp. Neurology, Vol. 84, pp. 1694-
1698, 1987
Schwartz WJ, Gross RA, Morton MT, The Suprachiasmatic Nuclei Contains a
Tetrodotoxin-Resistant Circadian Pacemaker, Proceedings National Academy
of Science, Vol. 84, pp. 1694-1698, 1987
Schwartz WJ, Morton MT, Williams RS, Tamarkin L, Baker TL, Dement WC,
Circadian Timekeeping in Narcoleptic Dogs, Sleep, Vol. 9, pp. 120-125,
1986
Abstracts and Communications:
Tomkinson A., Stevens L., Morton M., Bowden A., Wong T., Boisvert D.,
Delaria K., Burmeister Getz E., AER 003, a PEGlylated IL-4/IL-13
antagonist, significantly reduces allergen-induced airway
hyperresponsiveness (AHR). J. Allergy Clin Immunol. 125, AB54 2010
RE Slager, AF Diallo, GA Hawkins, A Bowden, L Stevens, M Morton, A
Tomkinson, M Longphre, EL Bleeker, DA Meyers, IL-4R Polymorphisms are
Associated with Response to IL-4/IL-13 Receptor Antagonist (Aerovant) in
Human and Non-Human Primates, American Journal of Respiratory and
Critical Care Medicine, May 2009
Stevens L, Bowden A, Morton M, Tepper J, Tomkinson A, Effects of
Cyclosporine and Dexamethasone in a Mouse Model of Atopic Dermatitis,
American Academy of Allergy Asthma and Inflammation, March 14-18, 2008
Tomkinson A, Bowden A, Stevens L, Morton M, Chen J, Wong T, Burmeister-
Getz E, Tepper J, Therapeutic Effects of Inhaled AER 001, an IL-4/IL-13
Antagonist, on Allergen-Induced Airway Hyperresponsiveness (AHR) and
Airway Inflammation, American Thoracic Society International Conference,
May 2006 (Accepted for oral presentation)
Bowden A, Morton M, Stevens L, Canivel D, Tepper J, Tomkinson A, Effects
of Serine Protease Inhibitor, Bikunin (SPINT2), On Nasal Epithelial
Potential Difference In Cynomolgus Monkeys: A Novel Treatment For Cystic
Fibrosis, American Journal of Respiratory and Critical Care Medicine, May
2005 (Abstract and Oral Presentation)
Bowden A, and Morton M, Stevens L, Canivel D, Fitzgerald M, Sturton G,
and Fitch N, Anti-Inflammatory Effect of a Selective PDE4 Inhibitor, Bay
19-8004, in a Non-Human Primate Model of LPS-Induced Pulmonary
Inflammation, American Journal of Respiratory and Critical Care Medicine,
Vol. 167, No. 7, April 2003
Bowden A, Morton M, Stevens L, Fitzgerald M, and Fitch N, Effect of
Interlukin-8 Monoclonal Antibody on LPS-Induced Airway Inflammation in
the Cynomolgus Monkey, Chronic Lung Diseases, Paris Symposium, June 27,
2001
Fitch N, Bowden A, and Morton M, Evaluation of an Interlukin-5 Receptor
Monoclonal Antibody in Primate Asthma Model, American Journal of
Respiratory and Critical Care Medicine, Vol. 163, No. 5, April 2001
Fitch N, Morton M, Bowden A, Shanafelt M-C, Shanafelt A, Wetzel G, Moy J,
Preclinical Evaluation of Bay 16-9996 a Dual IL-4/IL-13 Receptor
Antagonist, American Academy of Allergy Asthma and Immunology, March 16,
2001 (Abstract and Minisymposia)
Bowden A, Morton M, Fitzgerald M, and Fitch N, A Primate Model of Acute
Inflammation, American Journal of Respiratory and Critical Care Medicine,
Vol. 161, No. 3, p. A182, March 2000
Morton M, Harris P, Xu J, Gorina S, Roczniak S, Fitch N, and Gundel R,
The Effect of an Interlukin-4 Receptor Antagonist (Bay 16-9996) on
Antigen-Induced Cutaneous Wheal and Flare Reactions in the Primate,
American Journal of Respiratory and Critical Care Medicine, March 1999
References:
Robert Kuhn Ph.D.: Senior VP & Chief Technical Officer,
Aerovance Inc.
Aerovance Inc., Berkeley, CA; 510-***-**** cell,
dwn4qa@r.postjobfree.com
Wayne Froland Ph.D.; Executive Director, Biologics Manufacturing Sciences
and Commercialization, Merck Manufacturing Division, West Point, PA (215)
652-7095, dwn4qa@r.postjobfree.com
Michael Dumas, Sr. Scientist, Technical Operations, Aerovance
Aerovance Inc., Berkeley, CA 510-***-**** cell, dwn4qa@r.postjobfree.com
Michael P. Gregoire; Chairman & CEO, Taleo, Dublin, CA 925-***-****,
dwn4qa@r.postjobfree.com
Adrian Tomkinson Ph.D.; Former Supervisor, Director of Preclinical
Research at Aerovance, Aerovance Inc., Berkeley, CA 510-***-**** cell,
dwn4qa@r.postjobfree.com
Jeffrey Tepper Ph.D.; Former Supervisor and Director of Preclinical
Research at Aerovance, Aerovance Inc., Berkeley, CA 510-***-****
dwn4qa@r.postjobfree.com
Neil Fitch Ph.D.; Supervisor at Bayer Corp.
Aventis-Sanofi Corporation, Cambridge, Massachusetts 617-***-****
dwn4qa@r.postjobfree.com
Dea Nagy, M.D.; Supervisor at Somatix Therapy Corp.
Ventana Medical Systems, Tucson, AZ, dwn4qa@r.postjobfree.com
Raymond Swanson M.D., Professor; Vice Chair: Supervisor at UCSF
Dept. of Neurology, Univ. of California, San Francisco, CA 415-***-****
x 2492, dwn4qa@r.postjobfree.com.
William Schwartz M.D., Professor; Supervisor at Massachusetts General
Hospital
Dept. of Neurology, Univ. of Massachusetts Medical School, Worchester, MA
508-***-****, dwn4qa@r.postjobfree.com