Amit Nayyar

NIAID/NIH ** North Dr. *W**, Bethesda. NIH. 20892. USA. ddjx3g@r.postjobfree.com

ddjx3g@r.postjobfree.com

Phone: 240-***-****; Work: 301-***-****

Profile:

Experienced professional with more than 5 years of synthetic and medicinal chemistry work experience in industry and academic setting. Have worked in team environment for drug discovery and development with emphasis on synthetic and medicinical chemistry.

Education:

• Ph.D in Medicinal Chemistry. National Institute of Pharmaceutical Education and Research (NIPER). INDIA. GPA 9.17/10. Graduated June 2006

• M.S.(Pharm.) in Medicinal Chemistry. National Institute of Pharmaceutical Education and Research (NIPER). INDIA. GPA 8. 95/10. Graduated Dec 2000

• B. Pharmacy in Pharmaceutical Sciences, L. M. College of Pharmacy. Ahmadabad, Gujarat. First division. Graduated June 1999

Job Experience:

• Visiting Fellow at the National Institutes of Health Bethesda, USA (May-07till date)

• Post Doctoral Research Fellow at Gothenburg University Sweden (May-07-Aug-07).

• Post Doctoral fellow with AstraZeneca India Ltd. (2006–2007).

• Research Chemist at Discovery Research, Dr. Reddy’s Laboratories Ltd. Hyderabad, India. (2001 to 2002).

Skills:

Synthetic organic/medicinal chemistry:

• Routine synthesis and purification of pharmaceutically/medicinally important organic compounds.

• Parallel synthesis of library of heterocyclic compounds.

• Solid and solution phase peptide synthesis, chiral synthesis.

• Hit to lead and lead optimization of pharmacophores, total synthesis of organic target compounds obtained by HTS or in silico screening.

• Scale up of preclinical compounds to gram scale.

Analytical Skills:

• Chromatography-HPLC, TLC, GCMS, LCMS, MALDI.

• NMR, IR, CS Bio Automated peptide synthesizer, Buchi automated microwave.

Biological Expertise:

• Measured the effects of Cholinergic and anti cholinergic drugs on animal models.

• Worked with DMPK teams to see the biotransformation of the lead compounds.

Computer Skills:

• Proficient in MS office, Chem. Draw, SciFinder Scholar, Basic usage of Accelrys Discovery studio.

Project management Skills:

• Experienced in working in a multidisciplinary teams collaborative and ethnically diverse environment. Worked individually and as a part of a team in pharmaceuticals and academic institutes.

Language:

• Proficient in English and Hindi

ACADEMIC ACCREDITATIONS:

• Attended ‘Principles of clinical Pharmacology’ two credit course offered by National Institutes of Health

• High citation award for my research article for year 2006-2009 by journal Bioorganic Medicinal Chemistry.

• Certificate of Merit list, Government of Himachal Pradesh (State Level) Year 1995.

• Student Fellowship, NIPER (National Level) Year 1999

• Senior Research fellowship By CSIR, Govt. of India (National Level). Year 2003

• GATE (Graduate Aptitude Test Examination): Scored 93.33 percentile in all India based (GATE) Conducted by IIT Mumbai. All India Rank 190

Scientific publications:

Patents

1. Barry, C, E.; Ha, Young.; Nayyar, A.; Choi, I.; Cherian. J.; Manjunatha, U. Synthesis of substituted nitroimidazole as anti tuberculosis agents. PCT Application.2010

2. Jain, R.; Nayyar, A.. App.No 1024/DEL/2006.

3. Jain, R.; Nayyar, A. 4App.No 1025/DEL/2006.

4. Jain, R.; Vaitilingam, B.; Nayyar, A.; Bhaskar, P. P.; Singh, P. P.; Jain, M.; Sachdeva, S.; Misra, V.; Kaur, S.; Kaul, C. L. App.No 628/DEL/2002.

Research Articles

1. Nayyar, A ; Cherian, J.; Choi, I.; .; Manjunatha, U.; Mukherjee, T.; Boshoff, H.I.; Singh, R.; Ha, Y.; Goodwin, M.; Lakshminarayana, S. B.; Niyomrattanakit, P.; Jiricek, J.; Ravindran, S.; Dick, T.; Keller; T .H.; Dartois, V.; Barry, C.E. Structure Activity Relationships of Antitubercular Nitroimidazoles. 7 substituted PA 824 analogues as second generation nitroimidazoles.. Submitted J . Med. Chem

2. Celliti, S. E., Mukherjee, T., Shaffer, J., Jones, D. H., Bursulaya, B., Choi, I., Boshoff, H. I., Singh, R. S., Nayyar, A., Manjunatha, U. H., Spraggon, G., Geierstanger, B. H., and Barry 3rd, C. E. Structure and mechanism of Rv3547, a deazoflavin-dependent nitroreductase from M. tuberculosis that activates pro-drug PA-824. Nat Struct Mol Biol., 2010 (in preparation).

3. Cherian, J.; Choi, I.; Nayyar, A.; Manjunatha, U.; Mukherjee, T.; Boshoff, H.I.; Singh, R.; Ha, Y.; Goodwin, M.; Lakshminarayana, S. B.; Niyomrattanakit, P.; Jiricek, J.; Ravindran, S.; Dick, T.; Keller; T .H.; Dartois, V.; Barry, C.E. Structure Activity Relationships of Antitubercular Nitroimidazoles. 3. (3D QSAR) Pharmacophore driven exploration of the linker and lipophilic tail of 6 amino PA 824. Submitted J . Med. Chem 2010

4. Nayyar. A.; Patel, S. R.; Shaikh, M.; Coutinho, E.; Jain, R. Eur. J. Med. Chem. . 2009, 44(5), 7303-7310.

5. Nayyar. A.; Jain. R. Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry. 2008. 47 (1), 117-128

6. Nayyar, A.; Monga, V.; Malde, A.; Coutinho, E.; Jain, R. Bioorg. Med. Chem. 2007, 15(2),626-40.

7. Nayyar, A.; Malde, A.; Coutinho, E.; Jain, R. Bioorg. Med. Chem. 2006, 14, 7303-7310.

8. Nayyar, A.; Malde, A.; Jain, R.; Coutinho, E. Bioorg. Med. Chem. 2006, 14, 847-856.

9. Monga, V.; Nayyar, A.; Vaitilingam, B.; Palde. P.B.; Jhamb, S.S.; Kaur, S.; Singh, P. P; Jain, R. Bioorg. Med. Chem. 2004, 12 (24), 6465-6472.

10. Vaitilingam, B.; Nayyar, A.; Palde, P. B.; Monga, V.; Jain, R.; Kaur, S.; Singh, P. P Bioorg. Med. Chem. 2004, 12 (15), 4179-4188.

11. Jain, R.; Vaitilingam, B.; Nayyar, A. Bioorg. Med. Chem Lett. 2003, 13(6), 1051-1054.

12. Chandana, P.; Nayyar, A.; Jain, R. Syn. Comm. 2003, 33, 2925-2933.

Review Articles

1. Nayyar, A.; Jain, R. Current Medicinal Chemistry, 2005, 12, 1873-1886.

2. Nayyar, A. Synlett 2005, 19, 3016-3017.

Book Chapters

1. Nayyar, A.; Patel, S. R.; Jain. R; Frontiers in Medicinal Chemistry, 2009, 4, 506-540.

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