Medical Officer Internal Medicine

Arain AQ *

Curriculum Vitae

Dr. Abdul Qayum Arain

MD, FCPS, PhD, CCT Medicine (UK), CCT Medical Oncology (UK)

• Personal

details and

contact

Dr. Abdul Qayum Arain

Medical Oncology, Clatterbridge Cancer Centre

65 Pembroke Pl, Liverpool L7 8YA, United Kingdom

Mobile: 0044-742-***-****

E-Mails: aduvei@r.postjobfree.com

aduvei@r.postjobfree.com

• Registrations 1. GMC UK, Full Registration in Specialist Register (General Internal Medicine & Medical Oncology).

Reg. No: 6121475. Registered on 25/05/2005. Revalidated 2017 Previous Registrations with:

2. Pakistan Medical & Dental Council, Reg No: 9302-S 3. Saudi Commission for Health Specialties. Reg No: 08-R-M- 0228850

• Qualifications 1. CCST:

Certificate of Completion of Specialist Training

( Medical Oncology), Mar 2022.

2. Specialty Certificate in Medical Oncology,

Royal College of Physicians, United Kingdom.

Oct 2012

3. CCST:

Certificate of Completion of Specialist Training

( Internal Medicine), Jan 2005

4. FCPS:

Fellow of College of Physicians & Surgeons Pakistan

(Internal Medicine), Aug 2001

5. Ph.D.

Royal {Postgraduate Medical School, University of London, UK. Jun 2001

6. M.D

State Medical University, Lviv, Ukraine. Jul 1984

• Aims and

Career

Objectives

I wish to further my clinical experience in Medical Oncology as a consultant. This includes both clinical and research parts of the specialty. I can also contribute to the academic activities in the institution and contribute to research projects.

• Employment

History

1. Specialty Doctor in Medical Oncology: 03/2013 – To date. Clatterbridge Cancer Centre, Merseyside, United Kingdom. Full-Time I am at present working at this trust since March 2013. As my main commitment, I manage new and follow-up cases in clinics. This may necessitate participation in relevant MDTs. Additionally, I participate in Arain AQ 2

all learning and teaching activities at the trust related to Medical Oncology. During this job at Clatterbridge, I gained the experience in managing the patients of all subspecialties of medical oncology., malignancies of upper & lower GI tract, breast cancer, genitourinary cancer, germ cell tumours, and testicular cancer, lung cancer and mesothelioma, melanoma, sarcomas. I was included in the rotational rota for Trainees in Medical oncology for initial 5 years. Later I preferred to do sub-specialty oriented practice in Lower GI and Breast cancers. My clinical work is supervised by the relevant Consultants. I participate in on-call rota in the management of acute oncology cases in the ward as required. My job includes also dealing with oncological emergencies including patients undergoing radiotherapy. As part of my research activities, I carried out several audits (see “recent audits” below) and made recommendations.

My teaching activities include giving lectures to junior doctors on various topics of Medical oncology. I also participate in departmental SRG meetings when possible. I have satisfactory record of completing all mandatory training required by the trust.

2. Specialty Doctor Medical Oncology: 4/2012 – 9/2012. Christie Hospital, Manchester, United Kingdom. Full-Time I worked at Christie Hospital as Specialty Doctor and accumulated additional experience in Medical Oncology. My main commitments were in the clinic s, however, I did participate in all other activities including being on an on-call rota, attending in teaching and learning activities, doing presentations o various topics

3. Specialist/Senior Registrar Medical Oncology: 5/2005 – 3/2012.

King Khalid University Hospital, Riyadh, Saudi Arabia. Full-Time During this job, I gained further experience in Medical Oncology under supervision. I was responsible for the indoor treatment of cancer patients, implementation of management plans for cancer patients, dealing with haematological malignant diseases in addition to solid tumours, running Oncology OPD, teaching medical students, Interns and attending off-time calls. I was also involved in various research activities in the department.

4. Assistant Professor Medical Oncology: 9/2003 - 2/2005. Pakistan Institute of Medical Sciences, Islamabad, Pakistan. Full-Time During this job, my responsibilities included treatment of indoor patients in the Department of Oncology, dealing with oncological/ haematological emergencies, running out-patient clinic, supervision of work of junior doctors and participation in teaching activities at the department. I supervised the work of postgraduate residents in the department.

5. Assistant Professor of Internal Medicine: 8/2002 - 9/2003. Arain AQ 3

Pakistan Institute of Medical Sciences, Islamabad, Pakistan. Full-Time Responsibilities included treatment plans for indoor patients in the Department of Medicine, running out-patient clinic, supervision of work of junior doctors, teaching activities at the department. 6. Registrar Oncology: 10/1999 - 8/2002.

Pakistan Institute of Medical Sciences, Islamabad, Pakistan. Full-Time I was responsible for the planned management of cancer patients under supervision. Duties included indoor care of the patients, running Oncology OPD, the participation of routine activities of the department, participation in teaching activities of the department. 7. Postgraduate Trainee Resident Oncology: 1/1997- 10/1999. Pakistan Institute of Medical Sciences, Islamabad, Pakistan. Full-Time During this period, My duties included supervised care of unselected indoor patients, daily ward rounds, helping consultants in running outpatient clinic, participation in routine activities of the department, including in teaching activities of the department. Particular experience achieved in the treatment of patients with diabetes mellitus, tuberculosis, COPD, bronchial asthma. My duties included management of acute emergencies of unselected medical patients. 8. Postgraduate Trainee Resident Medicine: 1/1994 - 12/1996. Pakistan Institute of Medical Sciences, Islamabad, Pakistan. Full-Time During this period, I acquired postgraduate training in Internal medicine. My duties included supervised treatment and management planning for indoor patients, making ward rounds, attending non-selected patients in medical OPD, participating in all teaching activities in the ward, supervised-learning of medical procedures, and participating in research activities of the department.

9. Medical Officer Medicine (Eq. to SHO): 7/1991 - 12/1993. Pakistan Institute of Medical Sciences, Islamabad, Pakistan. Full-Time During this period, I worked in the Medical ward. My duties were to carry out the indoor care of non-selected medical patients, to work supervised in the medical outpatient clinic, to participate in routine activities of the ward, bed rounds, seminars, and other activities. 10. Postgraduate Research Student: 08/1987 - 03/1991. Royal Postgraduate Medical School, Hammersmith Hospital, University of London, UK. Full-Time

This work was part of my Ph.D. program. The research project was to explore the mechanism of GnRH action in hormone-sensitive cell lines. It involved considerable work of tumour cell culture, protein chemistry, receptor characterization, hormone assays, hormone chemistry, Arain AQ 4

chromatographical techniques. The work resulted in a successful Ph.D. and several publications in International journals. 11. Postgraduate Research Student: 03/1987 - 07/1987. Royal Postgraduate Medical School, Hammersmith Hospital, University of London, UK. Full-Time

During this period I attended a course module of Immunology at the Department of Immunology. The course helped us to understand and carry out the latest immunological techniques in practice, including techniques for Monoclonal Antibodies and Molecular Biology. The course helped me a lot in my future work for Ph.D. 12. Medical Officer: 04/1986 - 03/1987.

Pakistan Institute of Medical Sciences, Islamabad, Pakistan. Full-Time This period was spent as Medical Officer in the departments of General Surgery, ENT, and Urology. The duties included indoor care of patients, as well as attendance of outdoor patients, attendance of regular academic sessions in the department, daily rounds, radiographic and journal clubs, and seminars.

13. Internship 1/1985 - 12/1985.

Federal Government Services Hospital, Islamabad, Pakistan. Full- Time

I was trained in Internal Medicine and General Surgery, for six months in each discipline. The training gave me an initial introduction to Medicine and Surgery and also helped in further career planning. The duties included care of indoor patients and attendance at OPD under supervision.

• Awards 1. Cultural Exchange Scholarship for Medical Education, by Govt. of Pakistan, 1977.

2. Science & Technology Scholarship for Ph.D., by Govt. of Pakistan, 1987.

• Research I have remained involved in several research projects over years. At University of London, I remained involved in a research project exploring the role of GnRH in hormone-sensitive cancers. I worked on cell lines and biopsy samples of breast cancer, endometrial cancer and prostate cancer. The work revealed that the cell lines and biopsy samples show presence of high-affinity GnRH receptors on cell surface and secrete GnRH-like peptides. This provided a hypothesis for autocrine loop of GnRH-like peptides in these cancers. I used various techniques as mentioned above. The work was published later, as shown in “ Publications”.

Later, I carried out studies on various topics. These have been mentioned in the heading “Audits”.

Arain AQ 5

• Presentations

(Selected)

24/09/2018 Efficacy of switching steroids with Abiraterone”. Presentation at Urology SRG Meeting CCC

08/02/2018 Safety and Efficacy of single-agent Ipilimumab in the treatment of uveal melanoma: Experience at CCC”.

Presentation to Skin & Melanoma SRG at CCC.

15/02/2018 Presentation: “Adjuvant chemotherapy for Early Breast Cancer: Overview”. Clatterbridge Cancer Centre

01/05/2017 “Non-Small Cell Lung Cancer- Part I”. Presentation done as part of teaching for Trainees in Medical

Oncology

15/03/2017 “Small Cell Lung Cancer”. Presentation at Clatterbridge Cancer Centre

01/02/2017 “Bladder Cancer”. Presentation done at Clatterbridge Cancer Centre

19/07/2016 “Renal Cancer”. Lecture Given to Junior Doctors at Clatterbridge Cancer Centre.

Nov 2015 “Thromboembolism in patients with localized upper Gastro-intestinal

cancers undergoing”. NCRI Poster Presentation.

12/02/2015 “Thromboembolism in patients with localized upper gastrointestinal cancers undergoing radical treatment”. Presentation in Upper GI audit meeting, Clatterbridge Cancer Center.

21/01/2013 “Ovarian Cancer Overview”. Presentation done as part of teaching for Junior doctors at Clatterbridge Cancer Centre

10/07/2012 “History & Future of GnRH use in Hormone-Responsive Cancer”.

Presentation done as part of teaching for trainees at Christie Cancer Centre

03/02/2009 “Tumor Markers in Diagnosis & Management of Cancer”. Lecture for

Oncology Unit at King Khalid University Hospital, Saudi Arabia

19/01/2008 “Head & Neck Tumour”. Lecture for Oncology Unit at King Khalid University Hospital, Saudi Arabia

• CPD courses

(selected only)

22/09/2022 Attended course “information Governance eLearning” Clatterbridge Cancer Center

22/09/2022 Attended course “Domestic Violence and Abuse Level 2”. Clatterbridge Cancer Center

22/09/2022 Attended course “NEWS-2 e-learning and Assessment” Clatterbridge Cancer Center

29/06/2022 Attending course “managing menopause symptoms” Clatterbridge Cancer Center

24/05/2022 Attended training “Adjuvant Zoledronic Acid” Clatterbridge Cancer Center

13/04/2022 Attended training “ Blood Transfusion”

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Clatterbridge Cancer Center

18/02/2021 Attended course “ Risk Management”

16/02/2021 Attended course “Administrative Skills” Feb 2021 Attended course “ Mastering Leadership: Leadership Modules”

19/02/2021 Attended course “ Certificate in Recruitment & Selection Level 1”.

26/05/2016 Attended Course “General Safety Measures” Clatterbridge Cancer Center

21/04/2016 Attended course “Good Clinical Practice” Royal College of Physicians, UK.

22/04/2016 Attended Basic Life Support course

Clatterbridge Cancer Center

08/12/2015 Attended course “Workplace-based Assessment” Liverpool Medical Institution

09/10/2015 Attended course “Individual as Leader”

Royal College of Physicians, UK.

24/10/2015 Attended workshop “Doctors as Educators” Royal College of Physicians, UK.

27/05/2014 Attended Course “Fire Induction Training” Clatterbridge Cancer Center

27/05/2014 Attended Course “Equality & Diversity Training” Clatterbridge Cancer Center

11/03/2012 Attended course “Advanced Life Support” King Khalid University Hospital, Saudi Arabia.

• Conferences

Attended

(selected)

1. 21/01/2021: Participated in Meeting “Northwest Cancer Genomics Operation”.

Christie Hospital & Clatterbridge Cancer Center.

2. 22/10/2016: Participated in BISCAY Investigator meeting, London, UK.

3. 6-9/11/2006: Attended & participated in NCRI Conference. 4. 8-9 May, 2004, Meeting Health Challenges: PIMS Symposium 2004, Islamabad, Pakistan.

5. 8-11 April 2004, Second International PAEC Oncology & Nuclear Medicine Conference, Lahore, Pakistan

6. 30 April, 2004, Bone Marrow Transplant Symposium, Aga Khan university, Karachi, Pakistan.

7. 21-22 Sep. 2002, Workshop on Tumour Registry Development & Protocols for Early Detection and Screening, WHO National Cancer Control Project, Islamabad, Pakistan.

8. 12-13 Dec. 2003. 1st Pfizer AfME Oncology Symposium, Dubai 9. 21 Aug, 2003. National Symposium on Recent Advances in the management of Breast Cancer, Islamabad.

• Audits Recent Audits:

1. “Thrombosis in patients with upper GI cancers”. Presented as abstract in NCRI meeting I Liverpool. To be submitted for publication. 2. “Toxicity of Ipilimumab in melanoma patients”. Presented in the meeting of Sub-specialty Reference Group (SRG). To be submitted for publication.

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3. “Efficacy of steroid switch in the treatment of prostate cancer with abiraterone”. Presented in the meeting of Sub-specialty Reference Group (SRG). To be submitted for publication.

• Teaching and

training

experience

At PIMS, my teaching commitments were multi-fold and included training medical students of diploma and degrees programs in Medicine. Bed-side teaching rounds were important part of department activities. I also supervised training in Medicine of postgraduate students of other disciplines like Medicine, Surgery etc. In collaboration with Department of Medicine, Pathology and Radiology, I arranged regular teaching sessions for postgraduate residents at PIMS. At PIMS, I was given additional responsibilities as supervisor of Ph.D Programs at Qaid-e-Azam University by Higher Education Commission, as supervisor, FCPS Program in Medicine by College of Physicians & Surgeons Pakistan, and as supervisor M.Sc program in Life-Sciences by Allama-Iqbal Open University, Islamabad.

At KKUH, I was involved in teaching undergraduate students of medical college and postgraduate residents in Medicine. Bed-side teaching was part of daily ward rounds.

At Clatterbridge, I am involved in the teaching of junior doctors, SHOs. Moreover, medical students are assigned for learning in the clinic as per their rotations.

• Other

Professional

activities

I participate in departmental meetings regularly at Clatterbridge Cancer Centre. Active participation in Mortality & Morbidity Meetings (M&Ms) and tumour board meeting have helped me to direct available facilities and resources effectively to better patient care. I take benefit of effective personal and other communication means to organize my work and achieve desired results. This involves considerable activities related to clinical governance: eg communication with colleagues, designing and implementing clinical templates, supervision of chemotherapies, arranging planned teaching activities for junior doctors. I make sure that such efforts are directed to produce better results of high quality. Ethnic Diversity is characteristic of UK life. I participate in the meetings of Ethnic & Diversity Committee meetings at Clatterbridge Cancer Center. This helps to deal effectively with the diversity in the CCC staff and also with patients from differing cultural backgrounds. I also participate in the proceedings of Drugs and Therapeutics Committee at Clatterbridge Cancer Center. This committee discusses and designs guidelines for new drugs, and also necessary changes in accepted therapeutic protocols, including chemotherapy protocols. I also take responsibilities as interviewer for Medical students at University of Liverpool since 3 years.

• Skills Skill Name Skill Level Experience

Chest Drain Intermediate Current /10 years

Bone marrow aspiration

& Trephine

Intermediate Current /5 years

ascites drain Expert Current/15 years

Cardiopulmonary resuscitation Intermediate Current/15 years Central Venous Access Expert Current /13 years

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Liver biopsy Intermediate +4 years ago/5 years

Nasogastric intubation Expert Current /20 years

Urinary catheterization Expert Current /20 years

Chemotherapy administration Expert Currently used

Cell Culture Intermediate +20 yrs ago/4 yrs

Receptor assays Intermediate +20 yrs ago/4 yrs

Protein chemistry Intermediate +20 yrs ago/4 yrs

Hormone assays Intermediate +20 yrs ago/3 yrs

Gel & column chromatography Intermediate +20 yrs ago/4 yrs Western blotting Intermediate +20 yrs ago/4 yrs

ELISA Intermediate +20 yrs ago/4 yrs

Southern Blottings Intermediate +20 yrs ago/2 yrs

Computer skills Intermediate Currently /20 years

• Publications 1. Al Diab AR, Aleem A, Qayum A, et al. (2011). Clinico-pathological pattern of extranodal non-Hodgkin’s Lymphoma in Saudi Arabia. Asian Pac J Cancer Prev. 2011; 12(12):3277-82.

2. Qayum. A., Aleem. A., Al-Diab A., et al. (2010). Rapid Improvement In Renal Function In Patients With Multiple Myeloma And Renal Failure Treated With Bortezomib. Saudi J KD & Transportation, 21:63-8. 3. Aleem A., Saidu A., Huda A., Al-Diab A., AlSagheer A., Qayum A., alMomen A. (2009). Rituximab as a single agent in the management of adult patients with hemophilia A and inhibitors: marked reduction in inhibitor level and clinical improvement in bleeding but failure to eradicate the inhibitor. Haemophilia. 15; 210-16.

4. Qayum, A. Gullick. W., Clayton. R., Sikora. K., Waxman. J. (1990). The effects of Gonadotrophin Releasing Hormone analogs in prostatic cancer are mediated through specific receptors. Br J Cancer, 62:96-99 5. Qayum, A. Gullick. W., Melon. K., Krautz. T., Neal. D., Sikora. K., Waxman.J. (1990). The partial purification and characterization of GnRH- like activity from prostatic biopsy specimens and prostatic cancer cell lines. J Steroid Biochem, 37:899-902.

6. Qayum. A., Scaletsky. R., Waxman. J., (1990). Autocrine stimulation by Gonadotrophin-releasing Hormone-like factors of human hormone- responsive prostatic cancer cells in culture. Prog Clin Biol Res. 357:121-8. 7. Qayum A, Gullick WJ, Waxman J. (1991). Gonadotrophin-releasing hormone: physiological significance and relevance to cancer. Prog Growth Factor Res. 3(2):115-30.

8. Qayum, A. (1991), The role of gonadotrophin-releasing hormone and its receptors in hormone-sensitive cancer, Ph.D. Thesis, University of London.

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9. Qayum, A. (1994) The functional status of thyroid in patients with multinodular goiter. FCPS Dissertation, College of Physician & Surgeons, Pakistan.

10. Qayum. A., Zarina. M. (1993). Structure and function of analogs of the gonadotrophin-releasing hormone. JPIMS, 4:226. 11. Qayum. A., Zarina. M. (1994). Analogs of Gonadotrophin-releasing hormone: Applications in Clinical Oncology. JPIMS, 5:298. 12. Waxman. J., Qayum. A. (1990). GnRH analogs: Treatment paradigm for the autocrine hypothesis. In “Genes and Cancer”, eds: Carney. D., Sikora. K. pp255-262.

13. Waxman. J., Qayum. A. (1990). Tumor flare: A pointer towards an understanding of the biological basis of response in prostatic cancer. In

“Progress in Urological Oncology”, eds Khoury. M.

14. Farooque. A., Qayum. A., et al. (1992). Analysis of acute renal failure patients treated in the Nephrology unit. FGSH Souvenir Silver Jubilee, FGSH Islamabad, p63.

15. Zafar. J., Shahab. A., Qayum. A., et al (1995). Typhoid Orchitis. JPMA, 4:106.

16. Zafar. J., Qayum. A., et 1l. (1997). Snake-bite: A review of 100 cases. JPMA, 7:93.

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