Medical Clinical Research

VIKTORIA GAGARIN, Ph.D., MS

***** ********* ***, *********, ** 20853

+1-202-***-**** * adcr28@r.postjobfree.com

PROFESSIONAL SUMMARY

Skilled researcher with a strong experience in the field of molecular and cell biology specialized in cartilage/bone biology (MD/Ph.D. in Medical Sciences with postdoctoral research fellowship at the NIH).

In-depth knowledge of current medical technologies and health information systems (MS in Computer Information Systems with a concentration in Health Informatics (graduated in September, 2019)).

More than seven year experience in Medical Advising of international projects.

EDUCATION

M.S. in Computer Information Systems with a concentration in Health Informatics,

Boston University, Boston, MA, USA

Ph.D. in Medical Sciences,

Saint-Petersburg I. I. Mechnicov State Medical Academy, St. Petersburg, Russian Federation

M.D. in Internal Medicine,

St. Petersburg State I.P. Pavlov Medical University – Russian Federation

EXPERIENCE

Medical Advisor

PhCAgency LLC (2012 – present, Rockville, Maryland)

Evaluate important medical / scientific information related to the company's projects

Assist clinical research teams, provide training and supporting the sales force

Provide a medical opinion regarding medical based questions, legal and regulatory matters, based on the CMS regulations, FDA regulations, HIPAA compliance

Provide a communication between clinicians, researchers and IT specialists involved in the projects

Work with the marketing departments to develop project’s marketing strategies and materials

Provide medical input into the strategic planning of the health information projects, with consideration of HIS (Health Information System) deployment and redesign

Participate in evaluation process of HIS implementation, such as clinical decision support systems, in primary care practices

Provide searching of scientific and technical literature, have an experience in electronic database search

Analyze medical data and information, approve scientific materials for the clinical research teams

Organize meetings representing the projects to health care providers and stakeholders

Postdoctoral Research Fellow

National Institutes of Health, NIAMS (2006- 2011, Bethesda, MD)

Planned, designed and conducted research projects on novel pathways of chondrocytes’ protection in osteoarthritis at Cartilage Biology and Orthopedics Branch of Dr. R. Tuan (professor in the Department of Orthopedics Surgery and Director of Cellular and Molecular Engineering Lab, at University of Pittsburg):

Discovered novel antiapoptotic mechanisms of COMP (Cartilage Oligomeric Matrix Protein)

Studied the role of SirT1 in chondrocytes pathology

Studied MMP-13 gene regulatory network in pathogenesis of osteoarthritis

The projects resulted in 8 scientific papers in peer-reviewed journals, such as Journal of Biological Chemistry, Osteoarthritis and Cartilage, Arthritis and Rheumatism

Supervised medical students, participated in local and international scientific conferences

TECHNICAL SKILLS

Skills in working with Health Information Technologies and Systems

oKnowledge of current Information Technologies’ design, data bases, networks, principals of IT project management, data privacy and security

oTraining in an evaluation of the health information system implementation, such as a clinical decision support system, to address the challenges and minimize the risks of system deploying

oAbility to build a medical algorithm and programming skills to design a Clinical Decision Support System

Advanced skills in molecular, cell biology, pathology of cartilage diseases:

oMolecular biology techniques: DNA, RNA isolation, cloning, sequencing, Northern and Southern blotting, transfection of siRNA, microRNA, and overexpression constructs, Lenti-/Retrovirus infection, PCR, RT-PCR, real-time qPCR, protein extraction, immunoblot, protein overexpression and purification in bacterial system;

oCell biology techniques: cell cultures, immunocytochemistry, immunohistochemistry, proteomics of cell and tissue samples, cell apoptosis assay (PI/Annexin, TUNEL staining), cell proliferation and viability assay, Flow Cytometry

oImmunology techniques: enzyme-linked immunosorbent assay (ELISA), immunofluorescence, immunoprecipitation, isolation and cultures of primary bone cells from calvarias and bone marrow, osteoblast differentiation/staining (Alkaline Phosphatase, Alizarin Red, etc.), osteoclast differentiation/staining (TRAP staining), micro-computer tomography (μ-CT) analysis, primary human chondrocytes isolation, MMP13 assay

oAnimal models techniques: conditional knock-out mice, inflammation-induced diseases mouse models

Strong organizational and interpersonal communication skills

Ability to work independently and within the international team

Attention to details, especially to accuracy and reliability of research data

Experience to work with Microsoft Word, Excel, Visio, Lucidchart, PowerPoint, other programs

Fluent in English and Russian

RESEARCH HONORS

The Young Investigator Travel Award. (2009). OARSI World Congress on Osteoarthritis, Montreal, Canada.

The ORS New Investigator Recognition Award (NIRA). (2009). Annular 55TH meeting of Orthopedic Research Society, Las Vegas, NV.

PUBLICATIONS

1.HTTP://WWW.NCBI.NLM.NIH.GOV/PUBMED/23587642Gabay O, Sanchez C, Dvir-Ginzberg M, Gagarina V, Zaal KJ, Song Y, He X, McBurney MW. Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse. Arthritis and Rheumatism, 2013.

2.Gabay O, Zaal K, Sanchez C, Dvir-Ginzberg M, Gagarina V, Song Y, He X, McBurney MW. Sirt1-deficient mice exhibit an altered cartilage phenotype. JBC, 2013.

3.Oppenheimer H, Gabay O, Meir H, Haze A, Kandel L, Liebergall M, Gagarina V, Lee EJ, Dvir-Ginzberg M. 75-kd SirT1 blocks tumor necrosis factor α-mediated apoptosis in human osteoarthritic chondrocytes. Arthritis and Rheumatism, 2012.

4.Dvir-Ginzberg M, Gagarina V, Lee EJ, Booth R, Gabay O, Hall D. Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes. Arthritis and Rheumatism, 2011.

5.Gagarina V, Gabay O, Dvir-Ginzberg M, Lee EJ, Brady J, Quon M, Hall D. SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor (IGF) receptor pathway. Arthritis and Rheumatism, 2010.

6.Gabay O, Gagarina V, Lee EJ, Dvir-Ginzberg M, Onodera J, Hall D. A reduction in SirT1 levels in OA articular cartilage is associated with increase in PTP1B, MMP13 and chondrocyte apoptosis. Osteoarthritis and Cartilage, 2009.

7.Dvir-Ginzberg M, Gagarina V, Lee EJ, Hall D. Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyl transferase (NAMPT). JBC, 2008.

8.Gagarina V, Carlberg A, Pereira-Mouries L, Hall D. Cartilage Oligomeric Matrix Protein (COMP) protects cells against death by elevating members of the IAP family of survival proteins. JBC, 2008.

SCIENTIFIC PRESENTATIONS

Gagarina V. (May 28-31, 2006). Cartilage oligomeric matrix protein (COMP) block TNF-alpha-mediated death by inducing XIAP, a caspase3 inhibitor. Poster presented at: NIAMS Intramural Scientific Retreat, Bethesda, MD.

Gagarina V. (June 11-15, 2006). Cartilage Oligomeric Matrix Protein (COMP): an ECM molecule that regulates chondrocyte proliferation. Poster presented at: The International Workshop on the skeletal growth plate. Portland, OR.

Dvir-Ginzberg M, Gagarina V. (October 17-20, 2006). The SIR2a histone deacetylase enhances cartilage gene expression via its association with SOX9. Poster presented at: NIH Research Festival, Bethesda, MD.

Gagarina V. (November1-4, 2006). COMP enhances cell survival by elevating the IAPs proteins. Poster presented at: American Society for Matrix Biology Biennial Meeting. Nashville, TN.

Gagarina V. (May 30-31, 2007). COMP blocks death of human chondrocytes by elevating the IAP family of antiapoptotic proteins. Poster presented at: NIAMS Intramural Scientific Retreat. Bethesda, MD.

Dvir-Ginzberg M, Gagarina V. (March 4-9, 2007). The SIR2a histone deacetylase enhances cartilage gene expression while inhibiting both proliferation and apoptosis. Poster presented at: Gordon Research Conference on Cartilage Biology and Pathology, Ventura, CA.

Gagarina, V. (February 11-14, 2007). Cartilage Oligomeric Matrix Protein’s upregulation of IAP proteins by (COMP)/Thrombospondin 5 protection of cells against apoptosis. Conference speech at Orthopedic Research Society, 53rd Annual Meeting. San Diego, CA.

Gagarina V. (May 28-30, 2007). COMP blocks human chondrocytes’ death by elevating the IAP family of antiapoptotic proteins. Conference speech at American Association of Anatomists, FASEB conference, Washington, DC.

Dvir-Ginzberg M, Gagarina V. (September 24-28, 2008). The chromatin remodeling enzyme SirT1: role in human cartilage gene expression and disease. Poster presented at: Molecular Genetics of Aging conference, Cold Spring Harbor, NY.

Gagarina V. (February 22-25, 2009). SirT1 blocks apoptosis in human chondrocytes via activation of the IGF-1 Receptor/Akt pathway. Conference speech at Orthopedics Research Society, 55th Annual Meeting. Las Vegas, NV.

Dvir-Ginzberg M, Gagarina V. (May 27-28, 2009). TNF alpha-mediated cleavage and inactivation of SirT1: role in arthritis pathology. Conference presentation at NIAMS Intramural Scientific Retreat. Bethesda, MD.

Gabay O, Gagarina V, Hall D. (September 10- 13, 2009). A reduction in SirT1 level in osteoarthritic cartilage is associated with an increase in PTP1B, MMP-13 and chondrocyte apoptosis. Conference presentation at OARSI World Congress on Osteoarthritis. Montreal, Canada.

Gabay O, Gagarina V, Hall D. (October, 2009). Decreased levels of Sirt1 in OA articular cartilage is associated with an increase in MMP-3, -13 and apoptosis. Conference speech at American College of Rheumatology. Philadelphia, PA.

Dvir-Ginzberg M, Gagarina V. (February 1, 2010). SirT1 in arthritis. Conference presentation at Department of Cartilage Biology, Institute of Dental Sciences Faculty of Dental Medicine, Hebrew University- Hadassah Ein Kerem. Jerusalem, Israel.

Gabay O, Gagarina V. (September 23-26, 2010). Increased expression of arthritic marker genes in the cartilage of SirT1 null mice. Poster presented at: Osteoarthritis Research Society International annual meeting. Brussels, Belgium.

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