Address: An der Johanniskirche *, ***** Hannover; Germany
Date of birth: 28.03.1989 Nasywajewsk (Russia; nat. German) Tel.: 017******** Email: adc134@r.postjobfree.com Available from: immediately
Dmitrij Malcev, PhD
Professional experience
10/2015 – 09/2019
Research associate, Medizinische Hochschule Hannover, Hanover, Germany
Design and synthesis of molecular library with inhibitory activity towards the movement protein myosin of malaria parasite. Increase of the inhibitory potency to low nanomolar concentrations in-vitro. Protection of designed molecules by patent ongoing.
Successful explanation and determination of chemo-mechanical properties of the parasitic protein changed by synthetized compounds in-vitro.
Successful in-silico determination of backgrounds for the increased and selective activity of a carbazolic small molecule inhibitor towards the movement protein involved in the cancer progression.
Proactive and successful instruction and managing of three thesises and trainees. 09/2014 – 12/2014
Trainee, Production, Honeywell Specialty Chemicals GmbH, Seelze, Germany
Increase of production system and 40% cost optimization based on statistical, software-supported evaluation of representative experiments.
Leading of laboratory technicians in the evaluation and accomplishment of anaerobic, large-scale industrial production processes. Risk assessments and enhancement of security measures.
Optimization of an innovative, but risk prone scale-up process and successful establishment of an alternative synthesis approach in laboratory scale.
07/2012 – 08/2017
Volunteering Chairman and co-trainer, Sport Club JSV07“ e. V., Hanover, Germany
Coordination and managing of volunteering stuff. Acquisition, development and ongoing maintenance of contacts with sponsors and investor associations in the area of sport and health. Management and moderation of sports events. Organization, lead of meetings, written reporting to tax office and other instances. 02/2013 – 06/2013 und 10/2013 – 11/2013
Scientific Assistant, Leibniz Universität Hannover, Hanover, Germany
Risk assessments, correction of experimental protocols, and instruction of experiments in organic chemistry. Academic education
10/2015 – 09/2019
Leibniz Universität Hannover, Dr. rer. nat. (PhD) (Grade:1.0), Hanover, Germany
PhD thesis: “Design and Synthesis of Allosteric Inhibitors for apicomplexan Movement Machinery”; Supervisor: Prof. Dr. Matthias Preller.
10/2013 – 09/2015
Leibniz Universität Hannover, M.Sc. Wirk- und Naturstoffchemie (Grade:1.8), Hanover, Germany
Organic synthesis, analytic methods, principles of fermentation, characteristics and specificity of natural and pharmaceutical products.
Master thesis: Research on the DIELS-ALDER-Cycloadditions and FRIEDEL-CRAFTS-Reactions Under High Pressure and High Temperature Conditions in Flow-Systems in Presence of Water” Supervisor: Prof. Dr. Andreas Kirschning.
10/2010 - 02/2014
Leibniz Universität Hannover, B. Sc. Chemie (Grade: 1.9), Hanover, Germany
Bachelor thesis: Studies on the Optimization of DIELS-ALDER-Cycloadditions for Chemo- Hyperthermic Cancer Therapy“
Supervisor: Prof. Dr. Andreas Kirschning.
Skills and interests
Languages: German (native), Russian (native), English (fluent), Spanish (basic) IT: MS Office, ChemDraw, Pymol, VMD, Schroedinger, MestreNova, TopSpin, MGL-Tools, MaterialStudio, Origin
Interests:
Martial arts (since 1998); won several German championship medals; top five results at World and European Championships.
Traveling to learn about other cultures and traditions, visit of nearby natural and cultural sights. Further education
11,25/02 und 3,17/03/2016 Training seminar: “Patent Law in Natural Science”
Intellectual Property (IP)
German, European and international proceedings
“Freedom-to-operate”
How to read, write and destroy a patent
Exploration strategy
German Employee Invention Act and Contracts
Agent's job
Cooperation: research - development - patent division 24–28/03/2013 Seminar: “Intercultural Communication”
Outlining of own and foreign cultural standards
Sensibilization of intercultural situations
Development of intercultural communication strategies 4.09.2014 Seminar: Management of Cost, Quality and Ecology in Chemical and Pharmaceutical Industry“
Systems of quality management (DIN/ISO9000ff&GMP, EN45001/17025&GLP
ChemG&REAChV, AMG&AMWHV
International Law and GMP-guidelines (ICH, PIC, FDA)Intellectual Property (IP) Conferences and publications
7/06 – 08/06/2016
HSBDR Retreat, Burg Warberg, Germany
Presentation of progress in design and synthesis of parasitic inhibitors. 16/06 – 17/06/2017
HSBDR Summer School, Burg Warberg, Germany
Presentation about backgrounds of anti-malarial drug research and characterization of the rational approach in the design of active compounds.
4/11/2017
DESY Day Hamburger Nacht des Wissens, Hamburg, Germany
Presentation about general aspects of malaria disease and depiction of the rational approach in development of drugs against malaria inhibition.
30/01 – 31/01/2018
DECHEMA, Advances in Chemical Biology, Frankfurt am Main, Germany
Poster presentation about the studies on the explanation of structure-activity relationship of inhibitory activity of asymmetric, biarylic compounds on the movement machinery of the malaria parasite Plasmodium falciparum.
17/02 – 21/02/2018
Biophysical Society 62nd Annual Meeting, San Francisco, USA
Poster presentation about the benefits of molecular dynamics inclusion in the docking approach for the determination of structure-activity relationships of a selective compound.