PROFILE

Molecular Biologist, Biochemist · Computational Chemist · Molecular Modeler · AMBER Software · Clinical Trial Analysis · Statistical Analysis · Scientific instruction, writing and consulting Published first author in top-tier biomedical journals Strong editing/proofreading skills Bioinformatician, Cell Biologist · Cellular and Molecular Biology · Cloning · Recombinant Proteins · High-Resolution Binding Assays · High Throughput Screening ·Tissue and Cell Culture · PCR, Western Blotting · ELISA · Drug Discovery Using In Silico Molecular Simulations · Bioinformatics including Homology Modeling · Presenter at conferences, seminars, poster sessions Strong editing/proofreading skills Proficient in Zoom, Webex, and Microsoft Office Suite

PROFESSIONAL EXPERIENCE

New Jersey Department of Community Affairs, Somerville, NJ – June 2019 - Present

Case Manager, Auditor

New Jersey Educational Services Commission, Somerville, NJ – July 2018 – June 2019

Instructor in Adult Education in Science

Axa Solutions, Incorporated, New York, NY (Remote) – June 2003 – Present

Research Analyst / Scientist

●Consulting/Reporting on Educational Software Used in K-12 Science and Mathematics Education

Georgia State University – August 2001 – May 2003

Atlanta, Georgia

Research Associate

●Development of Novel Antibiotics Using DNA-Drug Simulations: molecular modeling of complexes of planar aromatic antibiotics with major and minor grooves of DNA oligonucleotides using energy minimization and molecular dynamics

●Ran 10 nanosecond molecular dynamics simulations with detailed analysis of RMS variation from starting atom positions, bond length, angle and torsion variations to show stability of bound complex

The University of Georgia – June 1999 – July 2001

Athens, Georgia

Research Associate

●DNA-Protein Simulations: molecular dynamics simulations of transcription factors bound to oligonucleotides; gained detailed insight into conformational variability from crystal structure

●Structure-Function Studies on Glycoproteins including those involved in rheumatoid arthritis using energy minimization and molecular dynamics

Emory University – June 1998 – May 1999 and Oct 1992 – Mar 1995

Atlanta, Georgia

Research Associate

●Ab initio calculations of enzyme active site conformations including electronic charge distribution using quantum mechanics/molecular mechanics (QM/MM)

●Used molecular dynamics on DNA oligonucleotides containing dihydrouridine-cytidine pairs, discovered new possible DNA backbone conformations caused by distortion of thymine to dihydrouracil and the resulting carcinogenic and mutagenic effects

Pacific Northwest National Laboratories – April 1995 – May 1998

Richland, Washington

Postdoctoral Fellow

●DNA Repair Studies: Molecular modeling of DNA oligonucleotides containing chemically modified bases; interfaced with bioinformaticians and performed bioinformatics computations to analyze genomics data for the purpose of understanding pathways of resistance and differentiation to anticancer drugs

●Performed sophisticated energy minimization and molecular dynamics simulations of up to 10 nanoseconds to show energetic of structural modification of backbone and bases

Stanford University – June 1991 – Sept 1992 Stanford, California

Postdoctoral Fellow

●Investigation of effects on liver enzyme CYPIA1 gene transcription caused by carcinogens such as dioxin; techniques included in vitro transcription assays, preparation of nuclear extracts from mouse hepatoma cells, chromatography and gel electrophoresis; evaluated mechanisms of drug resistance

University of California – Dec 1989 – May 1991 San Diego, California

Postdoctoral Fellow

●Development of Novel Cyclic Opioid Analogs: Determined optimal configuration for binding of opioid analogs to mu and kappa receptors in the rat brain based on NMR structures by means of energy minimization and molecular dynamics of cyclic opioid peptides in conjunction with in vitro opioid assays

EDUCATION, TEACHING & VOLUNTEER SERVICE

Ph.D. Degree / Master’s Degree - Princeton University · Princeton, New Jersey

Molecular Biology

Doctoral Thesis Research · Princeton University · Princeton, New Jersey

Triplex formation of double stranded DNA with RNA oligomers, characterized binding affinity

and base sequence requirements

Used DNAse and diethyl pyrocarbonate footprinting, gel retardation and transcription

assays to determine structural / functional effects of third strand binding

Assistant in Instruction – Princeton University

Instructed and managed groups of 10 to 12 undergraduate students in core biochemistry laboratory

and lecture courses, including office hours and grading of lab reports and problem sets

Bachelor of Arts Degree - Columbia University · New York, New York

Chemistry

High School Diploma - The Dalton School · New York, New York

Valedictorian

PUBLICATIONS

Cooney, Michael G. & Miller, J.H. (1997). Calculated Distortions of Duplex DNA by a Cis, Syn Cyclobutane Thymine Dimer Are Unaffected by a 3 TpA Step. Nucleic Acids Research (25) 7, pp.1432-1436. PMID: 9060440 (https://www.ncbi.nlm.nih.gov/pubmed/9060440)

Miaskiewicz, K., Miller, J., Cooney, Michael & Osman, R. (1996). Computational Simulations of DNA Distortions by a cis,syn-Cyclobutane Thymine Dimer Lesion. Journal of the American Chemical Society.118 (38),

pp 9156–9163. doi: 10.1021/ja9611304

Cooney, Michael G. & Doetsch, P.W. (1994). Molecular modeling Studies of a Deoxyoctanucleotide Containing a Dihydrouridine Lesion. Volume 726, DNA Damage: Effects on DNA Structure and Protein Recognition. Annals of the New York Academy of Sciences, July 1994, pp. 299–302. doi: 10.1111/j.1749-6632.1994.tb52832.x

Polinsky, A., Cooney, Michael G., Toy-Palmer, A., Osapay, G., & Goodman, M. (1992). Kahneman, D.

Synthesis and conformational properties of the lanthionine-bridged opioid peptide [D-AlaL2,AlaL5] enkephalin as determined by NMR and computer simulations. Journal of Medicinal Chemistry 35 (22), 4185-4194. doi: 10.1021/jm00100a026

Michael Cooney, G. Czernuszewicz, E.H. Postel, S. J. Flint and M.E. Hogan.(1988) Site-specific oligonucleotide binding represses transcription of the human c-myc gene in vitro. Science 22 July 1988: Vol. 241 no. 4864, pp. 456-459. doi: 10.1126/science.3293213

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