Harrison Tam, PhD

**** ******* ***. **, ******* MN 55432

763-***-**** / acvxoo@r.postjobfree.com

PhD level clinical and laboratory scientist seeking a career in clinical research

Summary

* ***** ** *aboratory and clinical research experience in various fields including brain cancer, obesity, cardiovascular disease, and drug metabolism.

Demonstrated leadership and teaching experience at all stages of career from undergraduate to post doctoral scholar

Passion for helping people by discovering breakthroughs that help save lives

Work and Research Experience

Post-Doctoral Scholar February 2015-February 2016

University of Kentucky, College of Pharmacy

Project: Regulation of P-gp and BCRP to Improve Efficacy of Chemotherapeutics for Treatment of Brain Cancer

Supervisor: Dr. Bjoern Bauer

Established a cell-culture lab and a cell-culture based model of brain cancer in mice

Developed IACUC and IRB protocols for an in-vivo imaging system to quantitate cancer growth in mice

Isolated brain capillaries of mice and rats for use as an ex-vivo model of the blood-brain barrier and to measure transport function

Research Assistant September 2010 –February 2015

University of Minnesota, College of Pharmacy

Project: The Effect of Obesity on Drug Clearance and Cardiovascular Disease Risk Factors

Supervisor: Dr. L’Aurelle Johnson

Developed and implemented pre-clinical and clinical protocols for assessing changes in drug pharmacokinetics in obesity

Assessed expression and activity levels of xenobiotic metabolizing enzymes in animal models of obesity

Designed and optimized analytical assays for measuring UGT substrates and their metabolites using mass spectrometry, high performance liquid chromatography, and gas chromatography

Teaching Assistant January 2011-May 2014

University of Minnesota, College of Pharmacy

Facilitated teaching support (such as developing comprehensive exam questions) for graduate and professional courses in Pharmacotherapy, Nutrition, Critical Care, and Herbal and Natural Medicines

Summer Research Intern July 2013 – October 2013

Janssen Research and Development, Drug Metabolism and Pharmacokinetics Department

Project: Development and Optimization of Screening Assays for Drug-Drug Interactions

Supervisor: Dr. Carlo Sensenhauser

Designed and optimized novel screening assays for UDP-glucuronosyltransferase inhibition in human liver microsomes and recombinant enzymes used for drug-drug interaction studies

Assessed cytochrome p450 mechanism based inactivation in primary hepatocyte cell culture

Laboratory Technician October 2010 – May 2013

Clinical and Pharmacological Analytical Services

Project: The Effect of Cytochrome P450 2C9 Genetic Variation on Drug-Drug Interactions with Warfarin

Supervisor: James Fisher

Extracted and analyzed warfarin and its metabolites from plasma and urine using liquid-liquid extraction and high performance liquid chromatography-mass spectrometry

Performed general maintenance and repairs on high performance liquid chromatography-tandem mass spectrometers

Harrison Tam, PhD acvxoo@r.postjobfree.com

Work and Research Experience Continued

Research Assistant January 2008 – September 2010

University of Minnesota, College of Pharmacy

Project: Characterization of Cytochrome P450 Oxidoreductase and Cytochrome P450 2C9 variants

Supervisor: Dr. Timothy Tracy

Expressed and purified genetic variants of human cytochrome p450 enzymes for drug-drug interaction studies

Trained lab personnel on in-vitro utilization of cytochrome P450 enzymes

Collaborated with researchers at the University of California, San Francisco to study genetic variants in cytochrome P450 oxidoreductase and their effects on drug metabolism

Leadership Positions and Committees

Society of Postdoctoral Scholars Executive Committee September 2015- February 2016

University of Kentucky

Set up workshops on presentation skills/job searches/networking and social events for fellow post docs

Graduate Education Policy Committee September 2013- September 2014

University of Minnesota, College of Pharmacy

Created new policies for the structural reorganization of graduate teaching assistantships

Web Coordinator September 2012- September 2013

American Association of Pharmaceutical Scientists, University of Minnesota Chapter

Updated and maintained the chapter’s websites and set up workshops on presentation skills and job searches for fellow graduate students in related fields

Education

Doctorate of Philosophy in Experimental and Clinical Pharmacology January 2015 University of Minnesota, College of Pharmacy

Dissertation Title: The Effect of Obesity and High Fat Diet on Cardiovascular Risk and Intestinal Drug Metabolism

Bachelor’s of Science May 2008

University of Minnesota, College of Biological Sciences

Publications

Tam HK, Kelly AS, Fox CK, Nathan BM, Johnson LA. Weight Loss Mediated Reduction in Xanthine Oxidase Activity and Uric Acid Clearance in Adolescents with Severe Obesity.Child Obes. 2016 Mar 15. [Epub ahead of print]

Tam HK, Kelly AS, Metzig AM, Steinberger J, Johnson LA. Xanthine Oxidase and Cardiovascular Risk in Obese Children. Child Obes. 2014 Apr;10(2):175-80

Subramanian M, Agrawal V, Sandee D, Tam HK, Miller WL, Tracy TS. Effect of P450 oxidoreductase variants on the metabolism of model substrates mediated by CYP2C9.1, CYP2C9.2, and CYP2C9.3. Pharmacogenet Genomics. 2012 Aug;22(8):590-7

Sandee D, Morrissey K, Agrawal V, Tam HK, Kramer MA, Tracy TS, Giacomini KM, Miller WL. Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro. Pharmacogenet Genomics. 2010 Nov;20(11):677-86

Subramanian M, Tam H, Zheng H, Tracy TS. CYP2C9-CYP3A4 protein-protein interactions: role of the hydrophobic N terminus. Drug Metab Dispos. 2010 Jun;38(6):1003-9.

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