Mohammed Zamiruddin

actgwr@r.postjobfree.com 416-***-****(C), 416972077 (H)

** ****** *****, *********, **, Canada, M9V5B2

A dependable professional with 10+ years of analytical research and quality control experience having strong scientific knowledge and technical skills, dynamic team player strongly focused on USP, FDA, GMP & GLP, compliance; proficient communications in multi-cultural environments and at all levels within organization.

Achieved success though:

• Planning, organizing, and prioritizing tasks/resources to optimize productivity, meet deadlines, and deliver results

• Building strong working relationships to gain people's trust and cooperation

• Problem/issue identification, research, root cause and alternative solutions analysis and decisive action to bring resolution

• Multitasking in a competitive and fast paced environment

• Effective development of open oral/written communication channels; fluent in English and able to communicate in most south Asian languages. Good command in public speaking and oral presentation.

• Very good knowledge of MS office and analytical software

Technical Skills Overview

Excellent command on operation and trouble shooting of laboratory instruments, like HPLC, LC-MS, FTIR, TLC, Karl Fisher, UV-Visible, Dissolution Apparatus and other wet chemistry process of sample preparation and analysis.

Developed and implemented effective and sustainable analytical methods and procedure in the development of products and in the improvement of maintenance and operation of an existing system using HPLC, LC-MS and wet Chemistry procedures.

Carried out research work for formulation development for immediate release (IR) and controlled release (CR) drug solid dosage form as a student project to pursue pharmaceutical research and development diploma in drug product formulation development.

Routine analysis of Chemical product by using analytical equipment like HPLC, LC-MS, UV, FTIR, TLC and other wet chemistry technique. Written and issued report of analysis according to SOP.

Investigated, identified and resolved problem for OOS (out of specification); troubleshoot and resolved analytical issues, whether technical or conceptual and motivated people by building their trust and confidence through training, teaching and practical demonstration.

Very good understanding of stability prognosis of drug substances and drug products, release and stability specification of drug products and ICH and FDA guide lines about drug stability

Set up and conducted chemical experiments, tests and analyses, operated and maintained laboratory equipment, prepared solution, reagents, and drug samples of different matrix.

Compiled records and interpreted experimental or analytical results,

Developed and conducted programs of sampling and analysis, assist in developing chemical engineering processes,

Operated water treatment plant, desalination plant to purify water for municipal supply system.

Assisted in development of standards, health and safety measures

Work Experience

Research Scientist October 26 2015 –Nov 05 2015

Biopharma Services Inc. Toronto, ON, Canada

Analytical method development and validation by LC-MS/MS (ABSciex4000 and 5500)for small molecule in blood plasma sample, collected from clinical trial, for pharmacokinetic study of modified formulations for bioequivalence study.

Analytical Chemist 2002 – Aug 2015

Toronto Institute of Pharmaceutical Technology, Toronto, ON, Canada

Conducted research work on many projects as HPLC analytical development chemist to develop and validate analytical methods for new drug formulation or product from new clients.

Developed and validated method for pharmacokinetic study for few compounds by using ABSciex2000, HPLC-FL (waters), Waters Micromass single quadrupole,

Documented and interpreted all research work with comments in line with objective.

Discussed any immediate issues with supervisor; Completed research works in target time.

Attended R&D meeting and follow up the proceedings

Mastered excellent analytical and presentation skills through teaching pharmaceutical analytical chemistry subject to students from different programs of Toronto Institute of Pharmaceutical Technology (TIPT)

Supervised and guided students in conducting, evaluating, and validating analytical data for HPLC method development and validation according to USP and ICH guide lines

Led the analytical project team and received special appreciation from supervisor

Set up and conducted complex chemical experiments, tests and analyses, operated, maintained laboratory equipment, prepared solution, reagents, and samples

Performed release test for raw materials, in-process, finished product and stability study test samples according to USP, ICH guide lines and in-house SOP.

Investigated, identified and resolved problem for OOS (out of specification) results; troubleshoot and resolved analytical issues.

Chemist Feb 1980- Feb1994

Abu-Dhabi Water and Electricity Department, Abu Dhabi, United Arab Emirates

Responsibilities:

Analysis of water samples from different part of power and desalination cogeneration plant.

Operated water treatment and condensate polishing plant for high pressure boiler; adjustment of chemical dosing to maintain potable water quality.(Certified as Operator in Training for Water Treatment, Water Distribution, Wastewater Treatment, Wastewater Collection, from Ontario Environmental Training Consortium, Ontario, Canada in 2000).

Desalination Plant Operation Supervisor, 1994-1998

Abu-Dhabi Water and Electricity Department, Abu Dhabi, United Arab Emirates

Supervisor:

Supervised and operated 10 units of multi-stage flash water distillation units involving 10 operator stuffs

Operated electronic control panel, Monitored and optimized physical and chemical process parameters and control quality of distilled water, brine concentration and maintain over all safe operation of all control devices.

Start-up, shut down and trouble shoot the operation of distillation units.

Issued defect card for any defective equipments for maintenance with due care to isolation procedures.

Operated, and trouble shoot various small and big pumps; manual, electrical, and pneumatic valves; turbine pumps, chlorination plants and ejector systems, Worked with high pressure water and high pressure steam system.

Organized, supervised and conducted acid cleaning of heat exchangers.

Sampled and perform chemical and physical tests. Record data and used control chart to determine efficiency of the process and equipments.

Arranged and conducted training program for junior employees.

Chemical Analyst September 1977 to November 1979

Lyyah Steam Power Station, Sharjah, United Arab Emirates

Responsibilities: Analysis of water, lube oil, furnace oil and corrosion samples.

Trainee May 1977 to August 1977

Eastern Peroleum Refinery, Chittagong, Bangladesh

Responsibilities: Analysis of petroleum refinery products

Research Associate January 1977 to March 1977

Pharmacy and Nutrition Department, Dhaka University, Dhaka, Bangladesh

Responsibilities

Extraction and identification of biologically important compound from plant roots and seeds

Education

Diploma in Analytical and Formulation Research, Pharmaceuticals products 2002 Toronto Institute of Pharmaceutical Technology (TIPT.com), Toronto, ON, Canada

Certificate in Basic Gas Chromatography 2002

Seneca College, Toronto, Canada

M. Sc in Organic Chemistry 1976

University of Chittagong, Chittagong, Bangladesh

(Synthesis of biologically important sugar derivatives)

B. Sc. Hons. in Chemistry 1974

Chittagong Government College, Chittagong, Bangladesh

Skills

Analytical Research Chemist (10+ years),

LC-MS, LC-MS/MS method development and Validation (1 year),

HPLC (Waters Empower) Method Development and Validation (10+ years),

Pharmaceutical GMP Analysis (10+ years),

Pharmaceutical Wet Chemistry (10+ years),

GMP, GLP, USP, ICH, FDA regulation (10+ years),

Operation of Desalination, Water treatment plant (10+ years),

Analysis of water, oil, petroleum products (10+ years),

Teaching QA/QC student pharmaceutical program (7 years),

Organic Synthesis (Less than 1 year),

Additional Information

RESEARCH EXPERIENCE

Developed analytical method (LC-MS) for Phosphatidyl Inositol (PI) to analyze the compound in enteric coated granules and also developed a simple liquid/liquid extraction procedure for this lipid compound from aqueous phase, was used for dissolution test 2006 - 2007

Synthesized an intermediate compound and scaled-up the batch size. Batch size was scaled up from 1000 mg to 20g. 2013-2014. Batch size again scaled up to 60 g. 2015.

Isolated and purified new drug compounds from a plant source which is a potential lead compound for cancer treatment. This work led to make a successful patent application 2008-2009

Developed a procedure to analyze calcium, iron and folic acid in the same formulation, and a dissolution method was developed for enteric coated Calcium Carbonate granules, both acid and buffer stage 2011-2013.

Developed LC-MS method to quantify Sodium Lauryl Sulphate in blood plasma samples 2007-2009

Developed TLC -method to identify Gabapentin, drug substance and drug product by derivitization on the TLC plate through conjugation of amino group in gabapentin molecule. The derivitized product is a deep blue colored spot on the plate. 2005

Derivatized successfully the poorly soluble Sebacic acid (a dicarboxylic acid) directly in the aqueous media (without extraction) and then a chromatographic (HPLC-UV) analytical method was developed to quantify the acid.

Developed an analytical method (HPLC-Fl) for Gabapentin, the method was used to quantify the drug through a derivatization procedure in plasma sample. 2006 - 2007

Developed a simple HPLC-UV method for vitamin D3 analysis, in this method vitamin D3, D2 and pre-vitamin D3 were separated according to USP. This method is used for enteric coated vitamin D3 tablets analysis as formulation development and for stability samples. 2012 - 2014.

A new HPLC-UV method was developed for oxytocin nasal spray product analysis, containing methyl paraben, propyl paraben and chloro butanol, as preservative and Oxytocin as the active. 2013 -2014.

Developed and validated a LC-MS/MS method to quantify Metformin HCl in plasma samples for pharmacokinetic studies. 2007-2009

Few of the works mentioned, there are other works.

Reference available upon request

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