CURRICULUM VITAE

M. Abdul Sattar c/o Dr. S. Chandrasekhar, Director

CSIR- IICT, Tarnaka, Hyderabad-500 607,

Telangana, India.

Phone No: +91-40-271*****,

Fax: +91-40-271*****.

OBJECTIVE

To pursue a post doctoral research position in the area of Synthetic organic chemistry / Bio organic chemistry / Medicinal chemistry.

EDUCATION

Ph.D in Organic chemistry Thesis submitted

Indian Institute of Chemical Technology (CSIR-IICT)

Hyderabad, India.

Research supervisor: Dr. S. Chandrasekhar, Director, (FNASc, FNA)

CSIR- IICT, Hyderabad, INDIA.

Thesis Title: “ New synthesis of Spiro oxindole analogues as GSK-3β inhibitors & Aldol applications towards the synthesis of Gabosine A, 4-epi Gabosine A and piperidone derivatives ’’

NET (National Eligibility Test) June 2007

Conducted by the CSIR-UGC, Govt. of INDIA.

M. Sc. (Organic Chemistry) May 2004

Arts and Science College, Kakatiya University,

Warangal(Dist), Andhra Pradesh.

B. Sc. (Maths, Chemistry, Comp science) May2002

Osmania University, Andhra Pradesh.

CAREER EXPERIENCE

Pharma industry (more than two years): From July 2013 onwards to October 2015 worked as a Senior Research Associate (SRA) in GVK Bio-Sciences(CRO) Pharmaceutical industry, Nacharam, Hyderabad.

International exposure: Worked from Nov 2009 to March 2010 with Dr. Rene Gree in university of Renne1, Rennes, (FRANCE) as a part of INDO-FRENCH collaboration.

As a Lecturer (Three academic years):

As a Lecturer in organic chemistry in PG studies at Shanthinikethan Degree and P.G. College, Miryalguda, from 2004 July to 2005 May.

As a Lecturer in organic chemistry at Siddipet Government P.G. college on contact basis from August 2005 to May 2007.

RESEARCH EXPERIENCE:

As a Junior Research Fellow (JRF) from 2008 January to 2010 Jan at Indian Institute of Chemical Technology (IICT).

As a Senior Research Fellow (SRF) from 2010 January to 2013 Jan at Indian Institute of Chemical Technology (IICT).

Worked as a Project assistant in IICT from February 2013 to July 2013

ANALYTICAL TECHNIQUES:

Spectroscopy: Analysis of 1H, 13C NMR, 2D (COSY, NOESY), IR, UV and Mass

Chromatography: Experienced in flash chromatography, preparative HPLC and various column packing methods.

Instruments: HPLC (Agilent), FTIR, SOR, MC (KF-Method),Wet Analysis

Other relevant experience: Computer software: MS Word, PowerPoint and Excel. Chem-Draw, Reaxys, Sci-Finder and preparation of research reports and manuscripts.

HONORS & AWARDS:

Bronze medal awarded by GSK-US client in GVK bio pharmaceutical industries for the year of 2014-2015.

Awarded Senior Research Fellowship (SRF) from the Council for Scientific and Industrial Research (CSIR), New Delhi, India (2010 to Jan 2013).

Awarded Junior Research Fellowship (JRF) from the Council for Scientific and Industrial Research (CSIR), New Delhi, India (2008-2010).

PROFESSIONAL & PERSONAL STRENGTHS

Expert in handling air and moisture sensitive reagents and reactions and their purification and preparation procedures.

Ability to identify research problems and their solutions.

Experienced in spectroscopic and chromatographic techniques.

Capable of collaborative and independent research.

Experienced in projects estimations and e-LNB writing.

LIST OF PUBLICATIONS

Total synthesis of Gabosines via an Iron –catalyzed intermolecular tandem Aldol process (Tetrahedron, 2011, 67, 9305-9310).

Synthesis of new 4-methyl-3-piperidones via an Iron-catalyzed intramolecular tandem Isomerisation -Aldolisation process (Tetrahedron, 2012, 68, 8863-8868).

Direct asymmetric Michael addition of ketones catalyzed by hydroxy phthalimde derived triazole pyrrolidine (Tetrahedron Asymmetry, 2013, 24, 1615-1619)

New synthesis of Spiro Oxindole and analogues as GSK-3β inhibitors. ( Script work

Submitted to CSIR - Patent cell of India for filing.)

Aldol application to synthesis of 3-piperidone & 4-Methyl 3-piperidone (Script work is under preparation)

Aldol application to enantio selective hydroxymethylation of Allyl oxindoles, catalyzed by organo thiourea catalysts. (Script work is under preparation)

CONFERENCE ATTENDED

Participated the conference (ASOMPS)XIII – 2008 titled “Asian symposium on Medicinal Plants, Spices and Other Natural Products” held at Indian institute of chemical technology (IICT), 3-6 November, 2008, Hyderabad.

Participated the conference CCBNP -2012 titled “Chemistry and Chemical Biology of Natural Products” held at Indian institute of chemical technology (IICT), 2-4 August, 2012, Hyderabad.

Participated the conference and Oral presented in ICEHT-2012 titled “International Conference on Environmental Impact on Human Health and Therapeutic Challenges” held at Sri Venkateshwara University (SVU), 20-22 December, 2012, Tirupati.

PERSONAL DATA

Date of Birth : 18th May 1981.

Fathers Name : M. Abdul Jabbar.

Nationality/Sex/Marital Status : Indian/Male/Married

Permanent Address : Lingagiri(v),Huzurnagar(M), Nalgonda (Dist), Pin: 508204, Telangana

E-mail : acskud@r.postjobfree.com

Mobile No : +919*********

Pass port No : G0548209

REFERENCES:

Dr. S. Chandrasekhar Dr. Ch. Raji Reddy Dr.Prathama mainkar

Director, principal scientist, Scientist QRS,

CSIR-IICT DNPC, CSIR-IICT, DNPC, CSIR-IICT,

Tarnaka, Hyderabad, Tarnaka, Hyderabad, Tarnaka, Hyderabad,

India-500 607 India-500 60,7 India-500 607

acskud@r.postjobfree.com acskud@r.postjobfree.com prathama@ iict.res.in

Ph: 91-40-271*****/27193434 Ph: +91-40-271***** Ph: +91-800*******

Dr. Srihari Dr. T.Pavan

Principal scientist, Inspire scientist,

CSIR-IICT, DNPC, CSIR-IICT,

Tarnaka, Hyderabad, Tarnaka, Hyderabad,

India-500 607, India-500 607

acskud@r.postjobfree.com pavantogapur @ iict.res.in

Ph: 91-40-271***** Ph: +91-40-271*****

RESEARCH SUMMARY:

Total synthesis of gabosines via an iron-catalyzed intramolecular tandem Aldol Process

(Tetrahedron, 2011, 67, 9305-9310)

gabosines belonging to polyhydroxy-cyclohexenone and cyclohexanone class of natural products synthesized in various stereo forms using an intramolecular iron-catalyzed tandem aldol process. Vinylic pyranoses were used as precursors in tandem isomerisation and aldolisation reaction, six different gabosine molecules have been prepared by this route starting from D-Glucose, D-Mannose, and D-Galactose derivatives.

Synthesis of new 4-methyl-3-piperidones via an iron-catalyzed intramolecular Tandem isomerisation Aldolisation process: (Tetrahedron, 2012, 68, 8863-8868).

A new versatile synthesis of 3-piperidones is described, starting from amino acids. It uses an iron carbonyl-mediated intramolecular tandem isomerisation aldolisation reaction as key step. These new heterocycles appear as useful scaffolds for the total synthesis of various types of bioactive molecules.

Direct asymmetric Michael addition of ketones to chalcones catalyzed by hydroxyphthalimide derived triazole-pyrrolidine: (Tetrahedron Asymmetry, 2013, 24, 1615-1619)

An efficient protocol for enantioselective, Michael addition of ketones to chalcones catalyzed by hydroxyphthalimide linked triazole-pyrrolidine derivative has been developed. The corresponding products, 1, 5-dicarbonyl compounds were obtained in good yields with high levels of stereoselectivities under mild reaction conditions, employing benzoic acid as an additive.

.

Aldol application to synthesis of 3-piperidone and 4-Methyl 3-piperidone (Manuscript under preparation)

Different allylic alcohols used as precursors for the synthesis 3-piperidone and 4-Methyl 3- piperidone. These are very crucial intermedites to synthesise naturally availble aza sugars. The key steps involved are a Sharpless asymmetric epoxidation, intramolecular Aldol reaction.

Enantio selective hydroxymethylation of oxindoles, catalyzed by organo thiourea catalysts: (Manuscript under preparation)

Direct catalytic asymmetric Aldol reactions is relatively limited, an efficient protocol for enantioselective hydroxyl methylation of Allyl oxindoles at the 3 rd position by using Para formaldehyde, which catalyzed by chiral thiourea derivatives and were able to transform the intermolecular reaction into an intramolecular-like, with good Yield and highly stereo selectivity.

Synthesis of novel spirofuran oxindole derivatives and their biological studies as GSK-3β inhibitors. (Patent application submitted to patent cell, CSIR. India for filing)

Naturally available biologically active compounds possess the spiro(pyrrolidine-3,3’-oxindoles) ring system which were extracted from the plants, marine and fungal sources, Few of the new spiro oxindole derivatives were prepared in the laboratory with cheaply available oxindole, and their biological studies carried GSK-3β

Inhibitor activity, which proved worthy.

Figure: Few synthetic analogues of spiro oxindole triazoles.

Figure: Few synthetic analogues of spiro oxindole piperazines

Along the above research experience:

I have gained sound knowledge in organic synthesis, bioorganic and medicinal Chemistry. By this training and experience, I can work confidently in any organic laboratory either individually or as group.

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